Contribution of nerve biopsy to unclassified neuropathy.

Abstract:

OBJECTIVES:To evaluate the diagnostic yield of nerve biopsy in patients with peripheral neuropathy of undetermined cause despite extensive diagnostic workup. METHODS:From November 2001 through January 2004, 38 patients underwent nerve biopsy because of unclassified neuropathy. RESULTS:The etiology of the neuropathies could be defined in 14 patients (37%), i.e. in 15% of chronic symmetric, 30% of chronic asymmetric, 50% of subacute symmetric and 62.5% of subacute asymmetric neuropathies. The biopsy was diagnostic in 6 patients (16%), where it showed a vasculitis, and supportive in 8 patients (21%). CONCLUSIONS:The contribution of nerve biopsy to the diagnosis of peripheral neuropathy was highest in acute and subacute asymmetric forms of neuropathy and lowest in chronic symmetric forms. The main indication for nerve biopsy remains the diagnosis of vasculitic neuropathy, a potentially treatable disorder.

journal_name

Eur Neurol

journal_title

European neurology

authors

Schweikert K,Fuhr P,Probst A,Tolnay M,Renaud S,Steck AJ

doi

10.1159/000098057

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

86-90

issue

2

eissn

0014-3022

issn

1421-9913

pii

000098057

journal_volume

57

pub_type

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