Abstract:
BACKGROUND:Newly developed troponin assays have superior diagnostic and prognostic performance in acute coronary syndrome (ACS), when compared to conventional troponin assays; however, highly sensitive troponin has not been evaluated in patients with acute ischemic stroke. METHODS:Highly sensitive troponin T (hsTnT) was measured daily during the first 4 days in 193 consecutive patients with acute ischemic stroke without overt ACS or atrial fibrillation. The patients were previously tested normal with a fourth-generation TnT assay. The patients were followed for 47 months, with all-cause and cardiovascular mortality end-points. RESULTS:A total of 33.7% of the patients had hsTnT levels >14 ng/l following admission. Patients with increased hsTnT were older, had decreased hemoglobin levels and increased creatinine, NT-proBNP and CRP levels. hsTnT concentrations at admission were significantly higher in decedents than in survivors. After adjustment for stroke severity, C-reactive protein, age, NT-proBNP and prior heart and/or renal failure, hsTnT levels were not a significant predictor of long-term all-cause or cardiovascular mortality. CONCLUSION:Elevated levels of hsTnT are frequently present in patients with acute ischemic stroke previously tested normal with a fourth-generation TnT assay. hsTnT did not provide additional prognostic information in these subjects.
journal_name
Eur Neuroljournal_title
European neurologyauthors
Jensen JK,Ueland T,Aukrust P,Antonsen L,Kristensen SR,Januzzi JL,Ravkilde Jdoi
10.1159/000341340subject
Has Abstractpub_date
2012-01-01 00:00:00pages
287-93issue
5eissn
0014-3022issn
1421-9913pii
000341340journal_volume
68pub_type
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journal_title:European neurology
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pub_type: 杂志文章,随机对照试验
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