Abstract:
AIMS:We conducted this study to investigate the independent association of medial temporal atrophy (MTA) and white matter hyperintensities (WMH) with cognitive impairments of Alzheimer's disease (AD) patients and the interaction between MTA and WMH. METHODS:From 13 centers, a total of 216 AD patients were consecutively recruited and their MTA and WMH were visually rated. We evaluated the association of MTA and WMH with the various cognitive domains, and the interaction between MTA and WMH. RESULTS:MTA independently correlated with scores of the Mini-Mental State Examination (MMSE), Clinical Dementia Rating scale (CDR), delayed recalls of the Seoul Verbal Learning Test (SVLT), the Boston Naming Test (BNT), and Word Fluency. WMH independently correlated with MMSE, CDR, Digit Span, and Stroop word reading, but not with delayed recall. There were interactions of WMH and MTA on CDR (p = 0.004), SVLT (p = 0.023), BNT (p = 0.002) and the semantic Word Fluency (p = 0.007). CONCLUSION:MTA and WMH independently affected cognitive deficits in AD patients, with somewhat different patterns where MTA was associated mostly with memory and language, while WMH were associated with attention and frontal executive functions. This study also showed interactions between MTA and WMH on some cognitive deficits and dementia severity, suggesting that they synergistically contribute to cognitive impairment in AD.
journal_name
Eur Neuroljournal_title
European neurologyauthors
Shim YS,Youn YC,Na DL,Kim SY,Cheong HK,Moon SY,Park KW,Ku BD,Lee JY,Jeong JH,Kang H,Kim EJ,Lee JS,Go SM,Kim SH,Cha KR,Seo SWdoi
10.1159/000329277subject
Has Abstractpub_date
2011-01-01 00:00:00pages
75-82issue
2eissn
0014-3022issn
1421-9913pii
000329277journal_volume
66pub_type
杂志文章,多中心研究abstract:AIMS:To perform a large and detailed epidemiologic study on restless legs syndrome (RLS) during pregnancy in a European country. METHODS:A cross-sectional questionnaire survey. The questionnaire was distributed by the medical staff in different outpatient waiting rooms (obstetrics and gynecology department of the univ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000321413
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Profound cellular and biochemical remodeling processes occur in the brain following an ischemic stroke, raising the possibility that we may be able to promote neurological recovery by harnessing the brain's endogenous recovery processes with pharmacological or cell-based therapies. There is a compelling body...
journal_title:European neurology
pub_type: 杂志文章,评审
doi:10.1159/000365171
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Intravenous thrombolysis (IVT) with urokinase is the standard reperfusion therapy for acute cerebral infarction (ACI) in China. Only about 30% patients who use urokinase for IVT can recanalize. Therefore, this study aimed to analyze the influencing factors of recanalization after IVT using urokinase in ACI p...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000507288
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:The K variant of butyrylcholinesterase (BCHE-K) exhibits a reduced acetylcholine-hydrolyzing capacity; so the clinical response to rivastigmine may differ in Alzheimer's disease (AD) patients with the BCHE-K gene. OBJECTIVE:To investigate the clinical response to rivastigmine transdermal patch monotherapy o...
journal_title:European neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1159/000366198
更新日期:2015-01-01 00:00:00
abstract::The hypothesis that mitochondrial genes may implicate susceptibility to multiple sclerosis (MS) is supported by an increasing number of case reports on Leber's hereditary optic neuropathy (LHON)-associated mitochondrial DNA (mtDNA) point mutations in patients with MS. A number of mtDNA mutations with primary pathogeni...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000075518
更新日期:2004-01-01 00:00:00
abstract::Fatigue is one of the most frequent and most disabling symptoms in multiple sclerosis (MS). We investigated the possible association of the MS-related fatigue syndrome with the available disease-modifying therapies and the main disease characteristics in a cross-sectional study on 320 consecutive patients. The prevale...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000111876
更新日期:2008-01-01 00:00:00
abstract::We examined interleukin-2 (IL-2) production by phytohemagglutinin (PHA)-stimulated peripheral blood mononuclear cells (PBMs) from 75 untreated myasthenia gravis (MG) patients and 48 control patients. Patients with MG consisted of those with elevated PBM IL-2 production (>1,250 pg/ml; mean + 2SD of the controls) (n = 2...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000069079
更新日期:2003-01-01 00:00:00
abstract::In 167 patients with cerebrovascular disorders 323 carotid bifurcations were investigated by Duplex ultrasound. In 100 of these patients, additionally intravenous digital subtraction angiography (DSA) was performed and in 35 patients, also intra-arterial DSA was carried out. In 32 patients all three procedures were pe...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116233
更新日期:1988-01-01 00:00:00
abstract::Increased levels of lactic dehydrogenase (LDH) in cerebrospinal fluid (CSF) have been reported in association with several intracranial pathologies. We studied LDH isoenzymes in the CSF of children with infantile spasms. CSF samples collected from 12 patients (aged 4-9 months) with infantile spasms were analyzed for t...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000070192
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Dysnatremia, which is associated with increased mortality in general intensive care units (ICU), has not been thoroughly studied in neurologic ICU (NICU). METHODS:Prevalence of dysnatremia was retrospectively assessed. The multivariable binary logistic regression model was used to determine the influence of...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000368353
更新日期:2015-01-01 00:00:00
abstract::Trials of pharmacological intervention for acute stroke show several points of similarity with legal trials by jury. The relationships between sponsoring organisation and regulatory authorities and the roles of the many other participants are described. Only through a partnership can the common aim of developing impro...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000068509
更新日期:2003-01-01 00:00:00
abstract::The serum concentration of S-100B is reported to reflect the severity of brain damage. The purpose of this study was to determine whether elevated serum S-100B concentrations were related to neuropsychological test performance of patients in the subacute phase of recovery from mild traumatic brain injury (TBI). S-100B...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000083678
更新日期:2005-01-01 00:00:00
abstract::Mitochondrial abnormalities and effectiveness of replacement therapy were examined in a murine model of systemic carnitine deficiency, namely the juvenile visceral steatosis (JVS) mouse. Homozygous JVS mice revealed severe lipid deposition and abnormal mitochondria in liver, heart, skeletal muscle, and kidney, but the...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000113399
更新日期:1997-01-01 00:00:00
abstract::This lecture is mainly concerned with questions about how hemodynamic conditions in atherosclerotic arteries affect arriving platelets that aggregate there and about the chemical agents responsible for making the platelets reactive. The effects of hemodynamic conditions and the agents are known mainly from in vitro ex...
journal_title:European neurology
pub_type: 杂志文章,评审
doi:10.1159/000115608
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND:Mood disorder is a frequent complication of stroke. Comorbid depressive and anxiety disorders are very common, indicating that it is advisable to assess both disorders at the same time. The aim of the present study was to examine the prevalence of post-stroke depression (PSD) and poststroke anxiety (PSA) at ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000332585
更新日期:2011-01-01 00:00:00
abstract::The child prodigy Marie-Jean-Pierre Flourens received his medical degree at Montpellier when aged 19. As a young promising physician Flourens was asked to investigate Gall's controversial views on cerebral localization. To test Gall's assertions, Flourens developed ablation as a procedure to explore the workings of th...
journal_title:European neurology
pub_type: 传,历史文章,杂志文章
doi:10.1159/000206858
更新日期:2009-01-01 00:00:00
abstract::Two cases of lithium neurotoxic effects are reported. Both cases are expressed by choreoathetotic movements and in both of them intoxication was caused by combined drug therapy. In our opinion caution is advised when lithium is administered in combination with drugs, especially in elderly patients. ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116044
更新日期:1986-01-01 00:00:00
abstract::Dementia is one of the most common organic mental syndromes, usually caused by Alzheimer's disease (AD) or vascular dementia (VD) or both. Regarding AD we review the state or the art of the cholinergic approach and discuss some future options regarding preventive and nonsymptomatic strategies. Therapy for VD will cons...
journal_title:European neurology
pub_type: 杂志文章,评审
doi:10.1159/000113372
更新日期:1997-01-01 00:00:00
abstract::Two prospective projects were started in May 1985 to evaluate the long-term effects of bromocriptine in patients with Parkinson's disease. One of the projects is to see if combination therapy with levodopa and bromocriptine is superior to levodopa alone with regard to the prevention of late side effects of levodopa th...
journal_title:European neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:The aim of this study was to elucidate the influence of insular infarction on blood pressure (BP) variability and outcomes according to the region of the insular cortex affected. METHODS:A total of 90 patients diagnosed with acute unilateral ischemic stroke were registered. The BP variability was calculated...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000486306
更新日期:2018-01-01 00:00:00
abstract::The gradual intraneuronal accumulation of an insoluble fibrous material which partly consists of abnormally phosphorylated tau protein (neurofibrillary change) represents an important neuropathological hallmark of Alzheimer's disease. Neurofibrillary tangles and neuropil threads formed from this material develop in on...
journal_title:European neurology
pub_type: 杂志文章,评审
doi:10.1159/000116984
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:The association between edentulism and cerebral small vessel disease is controversial. We aimed to assess this relationship in community-dwelling older adults living in rural Ecuador. METHODS:MRI was performed in 311 (81%) of 385 individuals ≥60 years enrolled in the Atahualpa Project. Participants were cla...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000448839
更新日期:2016-01-01 00:00:00
abstract::This study investigates the remote effects of botulinum toxin injections by examining the motor unit architecture of noninjected distant muscles. In 21 dystonia patients treated with botulinum toxin (n = 11, mean cumulative dose = 815 mU; n = 10, mean cumulative dose = 7,207 mU) and 10 control individuals, a blinded s...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000008222
更新日期:2000-01-01 00:00:00
abstract::A method is described to relate brain morphology and neuropsychological disturbances such as aphasia. By mapping lesions with computerized tomography onto a grid model of five brain slices, it is possible to compare aphasiological information and lesion site by data processing, allowing the quantitative and qualitativ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115210
更新日期:1981-01-01 00:00:00
abstract::In a previous retrospective study, we demonstrated that falls are common and often injurious in dominant spinocerebellar ataxias (SCAs) and that nonataxia features play an important role in these falls. Retrospective surveys are plagued by recall bias for the presence and details of prior falls. We therefore sought to...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000342907
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND AND STUDY PURPOSE:Autonomic nervous system dysfunction is a common complication of acute cerebrovascular disorders. The aim of this study was to investigate a possible location-dependent difference in cardio-autonomic function in patients with ischaemic stroke. PATIENTS AND METHODS:Sympathetic function was ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000070856
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVE:The history of Sayk's cell sedimentation chamber is examined and reviewed in the context of clinically utilizable cerebrospinal fluid (CSF) cytology. METHODS:A review of the literature was undertaken in PubMed and Google Scholar to search for primary and secondary sources on the history of CSF diagnosis. Mor...
journal_title:European neurology
pub_type: 历史文章,杂志文章
doi:10.1159/000456003
更新日期:2017-01-01 00:00:00
abstract::Three patients with cerebral tumor involving diencephalic midline structures (2 malignant gliomas, 1 craniopharyngioma) and no metabolic abnormalities developed disorientation in time and place or coma with triphasic waves (TW) seen on electroencephalograms. Serial EEG recordings showed persistence or disappearance of...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116614
更新日期:1990-01-01 00:00:00
abstract::The efficacy of the 5-HT1 receptor agonist sumatriptan in the acute treatment of migraine has been investigated in an extensive programme of controlled clinical trials. Sumatriptan provided rapid relief from migraine headache with onset of relief occurring within 10 min of a 6 mg subcutaneous injection and within 30 m...
journal_title:European neurology
pub_type: 杂志文章,评审
doi:10.1159/000119529
更新日期:1994-01-01 00:00:00
abstract::Fluctuations in motor performance and dyskinesias are a common problem in the long-term management of Parkinson's disease. The pharmacokinetics and the pharmacodynamics of levodopa, loss of presynaptic dopamine terminals, alterations in postsynaptic dopamine receptor sensitivity, or changes in the modulatory influence...
journal_title:European neurology
pub_type: 杂志文章,评审
doi:10.1159/000118882
更新日期:1996-01-01 00:00:00