Polymorphisms of the parkin gene in sporadic Parkinson's disease among Chinese in Taiwan.

Abstract:

:The role of genetics in Parkinson's disease (PD), previously controversial, is now documented by several studies. A major breakthrough has been the discovery of two single-gene defects in familial PD. A single base pair change at position 209 from G to A (G209A) in the fourth exon of the alpha-synuclein gene has been identified in cases of autosomal dominant familial PD. Mutations in the Parkin gene can induce autosomal recessive juvenile parkinsonism. A polymorphism of R/W366 in the Parkin gene was found to be associated with a protective factor for sporadic PD. We surveyed the polymorphisms of the Parkin gene, including S/N167, R/W366 and V/L380, in 92 cases of sporadic PD and 98 nonaffected individuals in Taiwanese Chinese. The allele frequencies of these polymorphisms are not significantly different between PD and nonaffected controls. We conclude that polymorphisms of the Parkin gene, S/N167, R/W366, V/L380, are not genetic factors for sporadic PD among Chinese in Taiwan.

journal_name

Eur Neurol

journal_title

European neurology

authors

Hu CJ,Sung SM,Liu HC,Lee CC,Tsai CH,Chang JG

doi

10.1159/000008203

keywords:

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

90-3

issue

2

eissn

0014-3022

issn

1421-9913

pii

8203

journal_volume

44

pub_type

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