No mutation of G209A in the alpha-synuclein gene in sporadic Parkinson's disease among Taiwan Chinese.

Abstract:

:The role of genetics in Parkinson's disease (PD), previously controversial, is now supported by several studies. A major breakthrough has been the discovery of a single gene defect in familial Parkinson's disease. A single base pair change at position 209 from G to A (G209A) in the fourth exon of the alpha-synuclein gene has been identified in cases of familial PD. We looked for this mutation in 65 cases of sporadic PD in Taiwan Chinese patients but found none of these patients with this mutation. We conclude that mutation of G209A in the alpha-synuclein gene plays no role in sporadic PD among Taiwan Chinese.

journal_name

Eur Neurol

journal_title

European neurology

authors

Hu CJ,Sung SM,Liu H,Chang JG

doi

10.1159/000008008

keywords:

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

85-7

issue

2

eissn

0014-3022

issn

1421-9913

pii

8008

journal_volume

41

pub_type

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