Is the ipsilateral cortex surrounding the lesion or the non-injured contralateral cortex important for motor recovery in rats with photochemically induced cortical lesions?

Abstract:

PRIMARY OBJECTIVE:To determine whether the ipsilateral cortex surrounding the lesion or the non-injured contralateral cortex is important for motor recovery after brain damage in the photochemically initiated thrombosis (PIT) model. RESEARCH DESIGN:We induced PIT in the sensorimotor cortex in rats and examined the recovery of motor function using the beam-walking test. METHODS AND PROCEDURES:In 24 rats, the right sensorimotor cortex was lesioned after 2 days of training for the beam-walking test (group 1). After 10 days, PIT was induced in the left sensorimotor cortex. Eight additional rats (group 2) received 2 days training in beam walking, then underwent the beam-walking test to evaluate function. After 10 days of testing, the left sensorimotor cortex was lesioned and recovery was monitored by the beam-walking test for 8 days. MAIN OUTCOMES AND RESULTS:In group 1 animals, left hindlimb function caused by a right sensorimotor cortex lesion recovered within 10 days after the operation. Right hindlimb function caused by the left-side lesion recovered within 6 days. In group 2, right hindlimb function caused by induction of the left-side lesion after a total of 12 days of beam-walking training and testing recovered within 6 days as with the double PIT model. The training effect may be relevant to reorganization and neuromodulation. Motor recovery patterns did not indicate whether motor recovery was dependent on the ipsilateral cortex surrounding the lesion or the cortex of the contralateral side. CONCLUSION:The results emphasize the need for selection of appropriate programs tailored to the area of cortical damage in order to enhance motor functional recovery in this model.

journal_name

Eur Neurol

journal_title

European neurology

authors

Takata K,Yamauchi H,Tatsuno H,Hashimoto K,Abo M

doi

10.1159/000095700

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

106-12

issue

2

eissn

0014-3022

issn

1421-9913

pii

95700

journal_volume

56

pub_type

杂志文章
  • Physiologic analysis of central motor pathways--simultaneous recording from multiple relaxed muscles.

    abstract::The central motor pathways were studied with the technique of percutaneous electrical stimulation of the central nervous system in 40 normal volunteers. There were no significant differences between the right and left sides, or between males and females. A linear correlation between the cortical latency (Lcor) or the ...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116396

    authors: Ugawa Y,Genba K,Shimpo T,Mannen T

    更新日期:1989-01-01 00:00:00

  • Neurofibrillary tangles and Alzheimer's disease.

    abstract::The neuropathological diagnosis of Alzheimer's disease relies on the presence of both neurofibrillary tangles and senile plaques. The number of neurofibrillary tangles is tightly linked to the degree of dementia, suggesting that the formation of neurofibrillary tangles more directly correlates with neuronal dysfunctio...

    journal_title:European neurology

    pub_type: 杂志文章,评审

    doi:10.1159/000007969

    authors: Brion JP

    更新日期:1998-10-01 00:00:00

  • Multiple sclerosis. A clinical study of 70 cases.

    abstract::70 cases of multiple sclerosis were seen at the Department of Neurology of the Capital Hospital in 1949--1977. There were 25 males and 45 females averaging 30.6 years of age. The most frequent sites of the lesions based on the clinical symptomatology were the spinal cord and optic nerve, the cerebellum was much less f...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000115267

    authors: Zhao BX,Liu XQ,Guo YP,Yang YC,Huang HF

    更新日期:1981-01-01 00:00:00

  • Transitory alexia without agraphia in an HIV-positive patient suffering from toxoplasma encephalitis: a case report.

    abstract::An HIV-positive patient presented the classical syndrome of pure alexia. Neuroradiologic investigation by computed tomography showed a ring-like lesion in the left posterior white matter. The clinical manifestations as well as the radiologic findings resolved after antiprotozoal treatment. ...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116783

    authors: Lüscher C,Horber FF

    更新日期:1992-01-01 00:00:00

  • Levodopa-responsive parkinsonism in a patient with Down's syndrome.

    abstract::We report a patient with Down's syndrome (DS) who developed progressive parkinsonian symptomatology at the age of 43 years. His parkinsonism was responsive to levodopa/carbidopa, but he developed end of dose wearing off. We discuss basal ganglia and dopamine abnormalities in DS and suggest that DS may be associated wi...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000117355

    authors: Singer C,Sanchez-Ramos J,Weiner WJ

    更新日期:1990-01-01 00:00:00

  • Neurological complications in patients with malignant tumors of the nasopharynx.

    abstract::Of 150 new cases of nasopharyngeal carcinoma diagnosed in Israel during a 9-year period (nationwide study 1960--1968), 74 patients developed neurological complications. In 92% of the cases, neurologic deficits were confined exclusively to cranial nerves. The majority of these patients presented general symptoms of dis...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000114938

    authors: Turgman J,Braham J,Modan B,Goldhammer Y

    更新日期:1978-01-01 00:00:00

  • Rabies encephalitis mimicking the electrophysiological pattern of brain death. A case report.

    abstract::A 48-year-old woman was referred from Zaire with suspected rabies encephalitis. Survival was 34 days after the onset of symptoms and the diagnosis of rabies was ultimately proven after brain autopsy. Serial neurophysiological investigations, including EEG and multimodality evoked potentials and radiological examinatio...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116939

    authors: Hantson P,Guérit JM,de Tourtchaninoff M,Deconinck B,Mahieu P,Dooms G,Aubert-Tulkens G,Brucher JM

    更新日期:1993-01-01 00:00:00

  • Diagnosis of Vertigo and Dizziness Syndromes in a Neurological Outpatient Clinic.

    abstract:BACKGROUND:Dizziness and vertigo are frequent complaints of outpatients in the neurological department. Our objective was to explore the epidemiological category and clinical features of patients with dizziness or vertigo in the neurological outpatient department of a tertiary hospital. METHODS:We consecutively recrui...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000489639

    authors: Pan Q,Zhang Y,Long T,He W,Zhang S,Fan Y,Zhou J

    更新日期:2018-01-01 00:00:00

  • Morphologic aspects of the neurofibrosarcoma (neurogenic sarcoma).

    abstract::Two cases of malignant tumours of the nerve sheaths are reported. In the first patient, who had von Recklinghausen's disease, light- and electron-microscopic investigations showed an undifferentiated mesenchymal tumour of the radial nerve with the property of producing collagen fibres, an aspect characteristic of sarc...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000114873

    authors: Vuia O

    更新日期:1977-01-01 00:00:00

  • Diagnostic problems in multiple sclerosis. Two cases with clinical diagnosis of MS showing only a diffusely growing malignant astrocytoma.

    abstract::Two cases are presented with a long clinical history of multiple sclerosis (MS) before the diagnosis of an intracranial brain tumor. In the subsequent brain autopsy, however, both cases presented a diffusely growing anaplastic astrocytoma, only, and no changes similar to MS were seen. Diffuse tumor growth was noted in...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116009

    authors: Röyttä M,Latvala M

    更新日期:1986-01-01 00:00:00

  • Alfred Vulpian and Jean-Martin Charcot in each other's shadow? From Castor and Pollux at La Salpêtrière to neurology forever.

    abstract::While Alfred Vulpian (1826-1887) is not completely forgotten, he cannot match the uninterrupted celebrity which Jean-Martin Charcot (1825-1893) still enjoys today. After becoming interne (residents) at the same institute in 1848, both were involved in shaping the cradle of what would become modern neurology. Both star...

    journal_title:European neurology

    pub_type: 传,历史文章,杂志文章

    doi:10.1159/000325733

    authors: Bogousslavsky J,Walusinski O,Moulin T

    更新日期:2011-01-01 00:00:00

  • Inverted Bruns' nystagmus in arachnoid cysts of the cerebellopontine angle.

    abstract::A 9-year-old girl with huge, double arachnoid cysts at the cerebellopontine angle is reported. After a cyst-peritoneal shunt operation, she developed fine, high-frequency gaze nystagmus towards the lesion side combined with coarse, large amplitude nystagmus in the opposite direction, which is the reverse of the Bruns'...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116903

    authors: Yokota J,Imai H,Okuda O,Sato K

    更新日期:1993-01-01 00:00:00

  • Movement disorders associated with chronic GM2 gangliosidosis. Case report and review of the literature.

    abstract::A 24-year-old man presented with dystonia, dementia, amyotrophy, choreoathetosis, and ataxia. Partial hexosaminidase A deficiency was documented in serum and leukocytes and confirmed by rectal biopsy with ganglion cells containing membranous cytoplasmic bodies. A brief review of the literature reveals that tremor, dys...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116100

    authors: Oates CE,Bosch EP,Hart MN

    更新日期:1986-01-01 00:00:00

  • Effects of acyclovir on sensory axonal neuropathy, segmental motor paresis and postherpetic neuralgia in herpes zoster patients.

    abstract::The effect of oral treatment with acyclovir (ACV) on sensory axonal neuropathy, segmental motor paresis and postherpetic neuralgia (PHN) was studied in 105 patients with herpes zoster. Forty-seven patients were treated with ACV at a dose of 4 g/day in 5 doses for at least a week; the others did not undergo any kind of...

    journal_title:European neurology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000117274

    authors: Mondelli M,Romano C,Passero S,Porta PD,Rossi A

    更新日期:1996-01-01 00:00:00

  • Unaltered respiratory chain enzyme activity and mitochondrial DNA in skeletal muscle from patients with idiopathic Parkinson's syndrome.

    abstract::There is good evidence that patients with Parkinson's disease have respiratory chain dysfunction in their substantia nigra. Since mitochondrial cytopathies due to enzyme defects in the respiratory chain are predominantly manifested in tissues with a high oxidative metabolism we analyzed oxidative energy metabolism in ...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000117053

    authors: Reichmann H,Janetzky B,Bischof F,Seibel P,Schöls L,Kuhn W,Przuntek H

    更新日期:1994-01-01 00:00:00

  • Errors in recognition and management are still frequent in patients with cluster headache.

    abstract:OBJECTIVES:To analyze the trajectory to diagnosis and information provided in a series of cluster headache (CH) patients from five headache clinics. METHODS:CH patients were asked to fill in an ad hoc questionnaire. RESULTS:Seventy-five patients (mean age 41.5 years, 67 males) completed the questionnaire. Patients ha...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000362517

    authors: Sánchez Del Rio M,Leira R,Pozo-Rosich P,Laínez JM,Alvarez R,Pascual J

    更新日期:2014-01-01 00:00:00

  • Focal neurological deficit with sudden onset as the first manifestation of sarcoidosis: a case report with MRI follow-up.

    abstract::Stroke as a presenting manifestation of sarcoidosis has rarely been reported. This contrasts with the frequent anatomopathological findings of cerebrovascular involvement in neurosarcoidosis. We present a patient who developed acutely a right brachiofacial weakness and dysarthria. Pulmonary sarcoidosis was found. A br...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116697

    authors: Michotte A,Dequenne P,Jacobovitz D,Hildebrand J

    更新日期:1991-01-01 00:00:00

  • Tetrahydrocannabinol:Cannabidiol Oromucosal Spray for Multiple Sclerosis-Related Resistant Spasticity in Daily Practice.

    abstract:BACKGROUND:Tetrahydrocannabinol:cannabidiol (THC:CBD) oromucosal spray (Sativex®) is an add-on therapy for moderate-to-severe multiple sclerosis (MS)-related drug-resistant spasticity (MSS). AIM:The MOVE-2 EU study collected data from everyday clinical practice concerning the effectiveness and tolerability of THC:CBD....

    journal_title:European neurology

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000449413

    authors: Vermersch P,Trojano M

    更新日期:2016-01-01 00:00:00

  • Epilepsies with diffuse slow spikes and waves of late onset.

    abstract::26 adult epileptic patients with diffuse slow spikes and waves and start of seizures after the age of 6 years were analyzed. The seizure spectrum encompasses generalized and focal seizures. The occurrence of several types of seizures is the rule. Epileptic drop attacks are most characteristic. Atonic, tonic and myoclo...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000115581

    authors: Bauer G,Aichner F,Saltuari L

    更新日期:1983-01-01 00:00:00

  • Spontaneous pain, hyperpathia and wasting of the hand due to parietal lobe haemorrhage.

    abstract::A woman who had spontaneous pain, hyperpathia and wasting of her left hand due to a subcortical lesion in the right parietal lobe is reported. The presentation and evaluation of this most unusual case are discussed. ...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000115753

    authors: Sandyk R

    更新日期:1985-01-01 00:00:00

  • Positive Predictive Value of French Hospitalization Discharge Codes for Stroke and Transient Ischemic Attack.

    abstract:BACKGROUND:We aimed at measuring the positive predictive value (PPV) of data in the French Hospital Medical Information Database (FHD). SUMMARY:This retrospective multicenter study included 31 hospitals from where 56 hospital stays were randomly selected among all hospitalizations for the years 2009 and 2010 with at l...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000438859

    authors: Giroud M,Hommel M,Benzenine E,Fauconnier J,Béjot Y,Quantin C,FRESCO Study.

    更新日期:2015-01-01 00:00:00

  • CT techniques.

    abstract::Since the advent of whole-body CT scanning in 1974, many studies have been made in its application to all parts of the body. One of the most fruitful areas has been CT of the spinal cord. The only limitation appears to be the technique used; there is no substitute for a good technique. We shall first review standard C...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000115482

    authors: Ledley RS

    更新日期:1982-01-01 00:00:00

  • Concentrations of carbamazepine and carbamazepine-10, 11-epoxide in serum, brain tumors and paratumorous cortex: a prospective study of 37 neurosurgically treated epileptic patients.

    abstract::Concentrations of carbamazepine (CBZ) and its metabolite carbamazepine-10, 11-epoxide (CE) were determined in serum (free and total), brain tumors and paratumorous cortex from 37 epileptic patients. Tumor biopsies were available from 25 different gliomas, 5 hamartomas and 1 angioma. The free serum concentrations of CB...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000117041

    authors: Schnabel R,Rambeck B,May TW,Jürgens U,Lahl R

    更新日期:1994-01-01 00:00:00

  • Poor outcome of bilateral congenital choroid plexus papillomas with extreme hydrocephalus.

    abstract::Bilateral choroid plexus papillomas, or villous hypertrophy of the choroid plexus, is a very rare entity that presents serious therapeutical problems in the management of secondary oversecretive hydrocephalus. The authors report the cases of 2 infants affected by this condition, and cured with removal of the lateral v...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000117402

    authors: Di Rocco C,Iannelli A

    更新日期:1997-01-01 00:00:00

  • A refined method to relate morphological and functional aspects of aphasia.

    abstract::A method is described to relate brain morphology and neuropsychological disturbances such as aphasia. By mapping lesions with computerized tomography onto a grid model of five brain slices, it is possible to compare aphasiological information and lesion site by data processing, allowing the quantitative and qualitativ...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000115210

    authors: Blunk R,De Bleser R,Willmes K,Zeumer H

    更新日期:1981-01-01 00:00:00

  • Remote effects of chronic botulinum toxin treatment: electrophysiologic results Do not indicate subclinical remodelling of noninjected muscles.

    abstract::This study investigates the remote effects of botulinum toxin injections by examining the motor unit architecture of noninjected distant muscles. In 21 dystonia patients treated with botulinum toxin (n = 11, mean cumulative dose = 815 mU; n = 10, mean cumulative dose = 7,207 mU) and 10 control individuals, a blinded s...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000008222

    authors: Fertl E,Schnider P,Schneider B,Auff E

    更新日期:2000-01-01 00:00:00

  • Age-associated T-lymphocyte activation through mitogens in patients with multiple sclerosis and blood donors.

    abstract::In 128 patients with multiple sclerosis (MS) and 204 blood donors (control persons) the in vitro activation of 'Ficoll-purified' peripheral blood T lymphocytes was measured using the 3H-thymidine incorporation rate without (spontaneous proliferation) and with mitogen addition (concanavalin A, phytohemagglutinin). Mito...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116228

    authors: Trenn G,Kreuzfelder E,Hierholzer E,Scheiermann N,Bauer HJ,Bushart W

    更新日期:1988-01-01 00:00:00

  • Neurosarcoidosis presenting as benign intracranial hypertension.

    abstract::A patient who on presentation fulfilled diagnostic criteria for benign intracranial hypertension subsequently developed a lymphocytic meningitis. A final diagnosis of neurosarcoidosis was made and the patient responded well to oral steroids. ...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000117381

    authors: Redwood MD,Winer JB,Rossor M

    更新日期:1990-01-01 00:00:00

  • Positron emission tomography: applications in the study of lacunar infarcts.

    abstract::Positron emission tomography (PET) has opened new fields of investigation on clinicometabolic correlations in subcortical infarcts. Functional changes occurring in structurally unaffected brain regions represent one of the most interesting aspects of PET application. So far, the only one PET study on lacunar infarcts ...

    journal_title:European neurology

    pub_type: 杂志文章,评审

    doi:10.1159/000116466

    authors: Di Piero V,Lenzi GL,Fieschi C

    更新日期:1989-01-01 00:00:00

  • Malpighi and the discovery of capillaries.

    abstract::Leonardo da Vinci clearly observed and described capillaries. Using the microscope, Marcello Malpighi examined the brain and major organs to demonstrate their finer anatomical features. This led to his discovery in 1661, of capillaries that proved fundamental to our understanding of the vascular system in the brain an...

    journal_title:European neurology

    pub_type: 传,历史文章,杂志文章

    doi:10.1159/000107974

    authors: Pearce JM

    更新日期:2007-01-01 00:00:00