Diagnostic problems in multiple sclerosis. Two cases with clinical diagnosis of MS showing only a diffusely growing malignant astrocytoma.

Abstract:

:Two cases are presented with a long clinical history of multiple sclerosis (MS) before the diagnosis of an intracranial brain tumor. In the subsequent brain autopsy, however, both cases presented a diffusely growing anaplastic astrocytoma, only, and no changes similar to MS were seen. Diffuse tumor growth was noted in periventricular brain tissue and extended down to pons or medulla. Immunohistochemically, a positive staining for glial fibrillar acidic protein was observed in both cases and in the second case, which presented an increased amount of cerebrospinal fluid IgG, also a positive staining for immunoglobulins was seen. These case histories and subsequent neuropathological findings are presented as examples of diagnostic difficulties in MS, especially in cases with diffusely growing gliomas.

journal_name

Eur Neurol

journal_title

European neurology

authors

Röyttä M,Latvala M

doi

10.1159/000116009

subject

Has Abstract

pub_date

1986-01-01 00:00:00

pages

197-207

issue

3

eissn

0014-3022

issn

1421-9913

journal_volume

25

pub_type

杂志文章
  • Ultrastructural Changes of Brain Tissues Surrounding Hematomas after Intracerebral Hemorrhage.

    abstract::Our knowledge about pathophysiology of intracerebral hemorrhage (ICH) mainly originates from preclinical models of ICH. In this study, cerebral ultrastructure surrounding hematoma and its correlation with clinical severity were investigated in ICH patients. Thirty patients with basal ganglia hemorrhage and 6 control s...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000434631

    authors: Wang KY,Wu CH,Zhou LY,Yan XH,Yang RL,Liao LM,Ge XM,Liao YS,Li SJ,Li HZ,Gao LL,Lin JS,Huang SY

    更新日期:2015-01-01 00:00:00

  • Chronic relapsing neuropathy associated with Castleman's disease (angiofollicular lymph node hyperplasia).

    abstract::We report a 17-year-old patient who presented a chronic relapsing sensorimotor demyelinating neuropathy with 6 relapses over a 7-year period, preceding by 4 years the diagnosis of a multicentric angiofollicular lymph node hyperplasia. A role for Epstein-Barr virus (EBV) as a trigger of the neuropathy may be suggested ...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000117156

    authors: Vingerhoets F,Kuntzer T,Delacrétaz,Steck AJ,Knecht H,Bogousslavsky J,Meier C,Regli F

    更新日期:1995-01-01 00:00:00

  • Pharmacological approaches in the treatment of senile dementia.

    abstract::The pathogenesis of primary degenerative dementia is still unknown and current therapeutic approaches can aim only at ameliorating some of the symptoms associated with this brain disease. At present, most approaches, attempt to correct a cholinergic deficit. Although the therapeutic benefits obtained so far with curre...

    journal_title:European neurology

    pub_type: 杂志文章,评审

    doi:10.1159/000116479

    authors: Markstein R

    更新日期:1989-01-01 00:00:00

  • Angelman syndrome: a case series assessing neurological issues in adulthood.

    abstract:BACKGROUND:This study aimed to evaluate the clinical symptoms of Angelman syndrome (AS) in adults and to identify the neurological pathways affected in this disease. AS is a neurogenetic disorder resulting due to the deletion or inactivation of the ubiquitin-protein-ligase E3A gene on maternal chromosome 15. SUMMARY:A...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000369454

    authors: Giroud M,Daubail B,Khayat N,Chouchane M,Berger E,Muzard E,Medeiros de Bustos E,Thauvin-Robinet C,Faivre L,Masurel A,Darmency-Stamboul V,Huet F,Béjot Y,Giroud M,Moulin T

    更新日期:2015-01-01 00:00:00

  • Involvement of cytokines in N-methyl-N'-nitro-N-nitrosoguanidine-induced plasminogen activator activity in acute disseminated encephalomyelitis and multiple sclerosis lymphocytes.

    abstract::In order to examine the plasminogen activator (PA) induction involved in the pathogenesis of acute disseminated encephalomyelitis (ADEM) and multiple sclerosis (MS), PA activity in peripheral blood lymphocytes derived from 5 ADEM and 3 MS patients was investigated. There was no PA induction in any ADEM, MS or control ...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116971

    authors: Sugita K,Suzuki N,Shimizu N,Takanashi J,Ishii M,Niimi N

    更新日期:1993-01-01 00:00:00

  • Highly sensitive troponin T in patients with acute ischemic stroke.

    abstract:BACKGROUND:Newly developed troponin assays have superior diagnostic and prognostic performance in acute coronary syndrome (ACS), when compared to conventional troponin assays; however, highly sensitive troponin has not been evaluated in patients with acute ischemic stroke. METHODS:Highly sensitive troponin T (hsTnT) w...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000341340

    authors: Jensen JK,Ueland T,Aukrust P,Antonsen L,Kristensen SR,Januzzi JL,Ravkilde J

    更新日期:2012-01-01 00:00:00

  • Histological and immunohistological changes of the skeletal muscles in older SJL/J mice.

    abstract::SJL/J mice have been studied as the model animals for autoimmunological diseases. Recently it was clarified that SJL/J mice have a defect of dysferlin. Human limb girdle muscular dystrophy 2B and Miyoshi myopathy also have a defect of dysferlin. In this study we present the histological and immunohistological changes ...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000097005

    authors: Nemoto H,Konno S,Nakazora H,Miura H,Kurihara T

    更新日期:2007-01-01 00:00:00

  • Calcified cerebral hydatid cyst.

    abstract::A 32-year-old patient with a lifelong history of epileptic attacks is described. A skull X-ray showed a round calcified nonhomogenous left frontotemporal mass. A CT scan confirmed its presence, as well as displacement of the left lateral and the third ventricles. At surgery a calcified inactive hydatid cyst was totall...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116120

    authors: Micheli F,Lehkuniec E,Giannaula R,Caputi E,Paradiso G

    更新日期:1987-01-01 00:00:00

  • Effect of hypocapnia on cerebral oxygen metabolism and blood flow in ischemic cerebrovascular disorders.

    abstract::Effects of hypocapnia on cerebral oxygen consumption (CMRO2) and blood flow (CBF) in cerebral ischemia were studied in 19 patients. The CMRO2 did not change significantly during hypocapnia within the whole group of patients, because 10 out of 19 cases showed a decrease (p less than 0.001) and other 9 showed an increas...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116149

    authors: Tsuda Y,Kimura K,Yoneda S,Hartmann A,Etani H,Hashikawa K,Kamada T

    更新日期:1987-01-01 00:00:00

  • Multiple sclerosis in childhood: report of 16 cases.

    abstract::Sixteen children with definite multiple sclerosis (MS; aged 6-17 years, mean 11.4 +/- 2.7; 8 boys, 8 girls) were reviewed. Cerebellar symptoms and signs were frequent at initial presentation. Among laboratory studies, the cerebrospinal fluid (CSF) IgG index or oligoclonal bands were informative in 75%, evoked potentia...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000117213

    authors: Selcen D,Anlar B,Renda Y

    更新日期:1996-01-01 00:00:00

  • Incidence and mortality prognosis of dysnatremias in neurologic critically ill patients.

    abstract:BACKGROUND:Dysnatremia, which is associated with increased mortality in general intensive care units (ICU), has not been thoroughly studied in neurologic ICU (NICU). METHODS:Prevalence of dysnatremia was retrospectively assessed. The multivariable binary logistic regression model was used to determine the influence of...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000368353

    authors: Zhang YZ,Qie JY,Zhang QH

    更新日期:2015-01-01 00:00:00

  • Brief remission periods in visuospatial neglect: evidence from long-term follow-up.

    abstract::Ten patients with left-sided visuospatial neglect due to cerebrovascular accident were monitored using the Behavioural Inattention Test (BIT) at weekly intervals, on a long-term basis. The novel finding was that some patients showed occasional but transitory marked improvement in their visuospatial neglect at times pr...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000117028

    authors: Small M,Ellis S

    更新日期:1994-01-01 00:00:00

  • Familial young-adult-onset arteriosclerotic leukoencephalopathy with alopecia and lumbago without arterial hypertension.

    abstract::Here we review a total of 17 patients, including 4 of our own, with young-adult-onset arteriosclerotic leukoencephalopathy, alopecia and lumbago without hypertension. All were Japanese and the illness seemed to be transmitted in an autosomal recessive fashion. The male to female ratio was 7.5:1. The age of onset usual...

    journal_title:European neurology

    pub_type: 杂志文章,评审

    doi:10.1159/000117096

    authors: Fukutake T,Hirayama K

    更新日期:1995-01-01 00:00:00

  • Quadriceps atrophy after knee traumatisms and immobilization: electrophysiological assessment.

    abstract::Automatic analysis of EMG (T/A analysis) and invasive muscle fiber conduction velocity in situ (MFCV) were performed in 15 patients after traumatic lesions of the knee and immobilization with quadriceps atrophy. T/A analysis showed transient reduced number of turns, consistent with inhibition of quadriceps motoneurons...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000008145

    authors: Cruz-Martínez A,Ramírez A,Arpa J

    更新日期:2000-01-01 00:00:00

  • Migraine and Headache Prevalence and Associated Comorbidities in a Large Saudi Sample.

    abstract:BACKGROUND:We aimed to assess the prevalence of headache and migraine, along with comorbidities, in a large -Saudi sample. METHODS:Self-reported information was collected about headache, migraine and migraine comorbidities including depression, restless legs syndrome (RLS), syncope, bruxism, hypertension and ischaemic...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000487317

    authors: Muayqil T,Al-Jafen BN,Al-Saaran Z,Al-Shammari M,Alkthiry A,Muhammad WS,Murshid R,Alanazy MH

    更新日期:2018-01-01 00:00:00

  • Indications for surgical treatment of cerebrovascular insufficiency.

    abstract::197 cases of patients with CVI, subjected to surgery by carotid endarterectomy, are examined. The results were nearly always good and hence the technique is recommended. Particular interest is attached to the risk connected with carotid clamping, through intraoperative study of CBF with 133Xe, such a risk is practical...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000115010

    authors: Fiorani P,Pistolese GR,Faraglia V,Spartera C

    更新日期:1978-01-01 00:00:00

  • Revisiting Clinical Utility of Chest Radiography and Electrocardiogram to Determine Ischemic Stroke Subtypes: Special Reference on Vascular Pedicle Width and Maximal P-Wave Duration.

    abstract:BACKGROUNDS:It is often difficult to diagnose stroke subtypes at admission, particularly in sinus rhythm cases. Vascular pedicle width (VPW) on chest X-ray (CXR) and maximal P-wave duration (P-max) on electrocardiogram (ECG) are again realized as useful parameters reflecting intravascular volume and atrial conduction s...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000382127

    authors: Sugie M,Kamiya Y,Iizuka N,Murakami H,Kawamura M,Ichikawa H

    更新日期:2015-01-01 00:00:00

  • Therapeutic Potential of Wnt-3a in Neurological Recovery after Spinal Cord Injury.

    abstract:BACKGROUND:Spinal cord injury (SCI) is a constant challenge in medical research and a global therapeutic problem. Treatment of this condition remains difficult in clinical practice. Hence, prevention, treatment, and rehabilitation of SCI have become imminent tasks in the medical field. SUMMARY:Recent evidence suggest ...

    journal_title:European neurology

    pub_type: 杂志文章,评审

    doi:10.1159/000502004

    authors: Gao K,Zhang T,Wang F,Lv C

    更新日期:2019-01-01 00:00:00

  • Thalamic Lesions Caused by Deep Cerebral Venous Thrombosis: A Retrospective Study.

    abstract:BACKGROUND:Thalamic lesion due to deep cerebral venous thrombosis (DCVT) is an uncommon cause of stroke. Until now, only a few case reports have been published. The aim of the study is to report the clinical and radiological findings of thalamic lesion with DCVT. METHODS:We reviewed our computerized stroke database of...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000439167

    authors: Caplan LR,Wang Q

    更新日期:2015-01-01 00:00:00

  • Ineffectiveness of folic acid supplementation against phenytoin-induced decrease in salivary immunoglobulin A concentration of epileptic patients.

    abstract:AIMS:This study was designed to investigate if folate treatment is able to reverse the phenytoin-induced deficiency of salivary immunoglobulin A (IgA). METHODS AND MATERIAL:Twenty-five epileptic patients who had been under phenytoin therapy for at least the last 6 months were randomly selected and subjected to folic a...

    journal_title:European neurology

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000121419

    authors: Zare M,Ghazvini MR,Yazdi HR,Nezhad VS,Chitsaz A

    更新日期:2008-01-01 00:00:00

  • Corpus callosum atrophy--a simple predictor of multiple sclerosis progression: a longitudinal 9-year study.

    abstract:AIM:To determine whether corpus callosum atrophy predicts future clinical deterioration in multiple sclerosis. METHODS:In 39 multiple sclerosis patients the area of corpus callosum in the sagittal plane, T2 and T1 lesion volumes, brain parenchymal fraction and brain atrophy were determined at baseline and 1 year after...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000337683

    authors: Vaneckova M,Kalincik T,Krasensky J,Horakova D,Havrdova E,Hrebikova T,Seidl Z

    更新日期:2012-01-01 00:00:00

  • Mitochondrial abnormalities in a murine model of primary carnitine deficiency. Systemic pathology and trial of replacement therapy.

    abstract::Mitochondrial abnormalities and effectiveness of replacement therapy were examined in a murine model of systemic carnitine deficiency, namely the juvenile visceral steatosis (JVS) mouse. Homozygous JVS mice revealed severe lipid deposition and abnormal mitochondria in liver, heart, skeletal muscle, and kidney, but the...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000113399

    authors: Kaido M,Fujimura H,Ono A,Toyooka K,Yoshikawa H,Nishimura T,Ozaki K,Narama I,Kuwajima M

    更新日期:1997-01-01 00:00:00

  • Evaluation of the carotid bifurcation by duplex ultrasound, intravenous and intra-arterial digital subtraction angiography.

    abstract::In 167 patients with cerebrovascular disorders 323 carotid bifurcations were investigated by Duplex ultrasound. In 100 of these patients, additionally intravenous digital subtraction angiography (DSA) was performed and in 35 patients, also intra-arterial DSA was carried out. In 32 patients all three procedures were pe...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116233

    authors: Boné G,Ladurner G,Karas I,Grobovschek M,Punzengruber J

    更新日期:1988-01-01 00:00:00

  • Natalizumab as a Disease-Modifying Therapy in Chronic Inflammatory Demyelinating Polyneuropathy - A Report of Three Cases.

    abstract:BACKGROUND:Several treatments are available to treat the immune-mediated chronic inflammatory demyelinating polyneuropathy (CIDP). Among these treatments, intravenous immunoglobulins, corticosteroids and plasma exchanges are validated and widely used. A few immunosuppressive drugs have been tried, but they had little e...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000381767

    authors: Vallat JM,Mathis S,Ghorab K,Milor MA,Richard L,Magy L

    更新日期:2015-01-01 00:00:00

  • The Pivotal Role of the Parieto-Occipital Lobe in Card Game-Induced Reflex Epilepsy: A Voxel-Based Morphometry Study.

    abstract:BACKGROUND:The pathogenesis of card game-induced reflex epilepsy has not been determined so far. The aim of this study was to evaluate structural abnormalities using voxel-based morphometry (VBM) analysis, which may give some clue about the pathogenesis in card game-induced reflex epilepsy. METHODS:The 3 subjects were...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000447537

    authors: Park KM,Kim SE,Lee BI

    更新日期:2016-01-01 00:00:00

  • Rate of cerebral embolic events in relation to antibiotic and anticoagulant therapy in patients with bacterial endocarditis.

    abstract::To quantitate embolic risk we studied a retrospective series of 61 patients with strictly defined bacterial endocarditis. Eighteen patients had neurological complications attributable to cerebral embolism. Seventeen embolic episodes occurred prior to antibiotic treatment and 8 episodes after its commencement. The rate...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000117317

    authors: Paschalis C,Pugsley W,John R,Harrison MJ

    更新日期:1990-01-01 00:00:00

  • Muscle pathology in the early stage of Guillain-Barré syndrome.

    abstract::Although many studies have been performed on nervous tissue pathology in Guillain-Barré syndrome (GBS), much less is known about pathological changes in skeletal muscle in this disorder. We have studied muscle biopsies from 5 patients with GBS, 5 patients with amyotrophic lateral sclerosis (control A), and 5 patients ...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000007924

    authors: Ono S,Inoue K,Munakata S,Nagao K,Shimizu N

    更新日期:1998-01-01 00:00:00

  • No mutation of G209A in the alpha-synuclein gene in sporadic Parkinson's disease among Taiwan Chinese.

    abstract::The role of genetics in Parkinson's disease (PD), previously controversial, is now supported by several studies. A major breakthrough has been the discovery of a single gene defect in familial Parkinson's disease. A single base pair change at position 209 from G to A (G209A) in the fourth exon of the alpha-synuclein g...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000008008

    authors: Hu CJ,Sung SM,Liu H,Chang JG

    更新日期:1999-01-01 00:00:00

  • Madopar HBS: slow-release levodopa and benserazide in parkinsonian patients presenting marked fluctuations in symptoms on standard L-dopa treatment.

    abstract::In this open study patients with advanced Parkinson's disease, who experienced pronounced fluctuations in symptoms while on standard L-dopa, were switched from Madopar/Sinemet to Madopar HBS. The dosage was adjusted until optimal response was obtained. The effect was unsatisfactory in 4 cases and side effects interven...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116195

    authors: Jensen NO,Dupont E,Hansen E,Mikkelsen B,Mikkelsen BO

    更新日期:1987-01-01 00:00:00

  • Respiratory patterns during sleep in mitochondrial myopathies with ophthalmoplegia.

    abstract::Nocturnal polygraphic recordings (electroencephalography, electro-oculography, submental and intercostal muscle electromyography, electrocardiography, respiration by thoracic strain gauges and oronasal thermistors) with continuous monitoring of arterial oxyhemoglobin saturation by pulse oximeter were performed in 8 pa...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116627

    authors: Manni R,Piccolo G,Banfi P,Cerveri I,Bruschi C,Zoia C,Tartara A

    更新日期:1991-01-01 00:00:00