Madopar HBS: slow-release levodopa and benserazide in parkinsonian patients presenting marked fluctuations in symptoms on standard L-dopa treatment.

Abstract:

:In this open study patients with advanced Parkinson's disease, who experienced pronounced fluctuations in symptoms while on standard L-dopa, were switched from Madopar/Sinemet to Madopar HBS. The dosage was adjusted until optimal response was obtained. The effect was unsatisfactory in 4 cases and side effects intervened in another 2. The remaining 16 patients exhibited substantial and frequently significant improvements with regard to both akinetic and dyskinetic phenomena. L-Dopa dosage was increased in all cases, and addition of standard L-dopa was required in one third of the cases. These benefits continued in the majority of patients.

journal_name

Eur Neurol

journal_title

European neurology

authors

Jensen NO,Dupont E,Hansen E,Mikkelsen B,Mikkelsen BO

doi

10.1159/000116195

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

68-72

eissn

0014-3022

issn

1421-9913

journal_volume

27 Suppl 1

pub_type

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