Diagnosis and management of autonomic failure in neurodegenerative disorders.

Abstract:

BACKGROUND:One of the hallmarks of the α-synucleinopathies is the degeneration of the autonomic nervous system. SUMMARY:This review discusses the diagnosis and management of cardiovascular autonomic failure within the context of the α-synucleinopathies. In addition, it outlines the utility of various laboratory assessments including cardiovascular reflex tests for the differential diagnoses of these disorders, as well as general disease management strategies. Key Messages: Laboratory investigations assessing the autonomic control of the cardiovascular system are useful in the differential diagnosis of α-synucleinopathies, especially in early stages of disease. CLINICAL IMPLICATIONS:The characterization of the different features of AF in patients with α-synucleinopathies is challenging because it might help to improve the accuracy of the differential diagnosis between these diseases at onset. Further cardiovascular AF has been demonstrated to have a negative prognostic role in α-synucleinopathies, therefore an early detection of cardiovascular dysautonomia allows to positively impact the disease course guiding the appropriate therapy.

journal_name

Eur Neurol

journal_title

European neurology

authors

Sambati L,Calandra-Buonaura G,Doria A,Cortelli P

doi

10.1159/000368828

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

126-33

issue

1-2

eissn

0014-3022

issn

1421-9913

pii

000368828

journal_volume

73

pub_type

杂志文章,评审
  • Nomogram for the prediction of unbound phenytoin concentrations in patients on a combined treatment of phenytoin and valproic acid.

    abstract::The interpretation of the total phenytoin (PT) concentration can be problematic if valproic acid (VPA) is given as a comedication, because VPA displaces PT from the protein binding sites and can increase the free fraction of PT. In order to estimate the free or unbound PT concentration (PTf) from the total PT concentr...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116647

    authors: May TW,Rambeck B,Nothbaum N

    更新日期:1991-01-01 00:00:00

  • Electromyographic and computed tomographic findings in five patients with monomelic spinal muscular atrophy.

    abstract::Five patients with monomelic spinal muscular atrophy are described. Clinical features included insidious onset of wasting and weakness of one limb, lack of involvement of the cranial nerves, brain stem, pyramidal tracts and sensory system, and a stable condition over a period of 4-20 years. Clinical findings, electrom...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116249

    authors: de Visser M,Ongerboer de Visser BW,Verbeeten B Jr

    更新日期:1988-01-01 00:00:00

  • The Contribution of Diffusion Tensor Imaging to Quantitative Assessment on Multilevel Cervical Spondylotic Myelopathy.

    abstract:BACKGROUND/AIMS:This study aimed at assessing the feasibility of diffusion tensor imaging (DTI) in multilevel cervical spondylotic myelopathy (MCSM) and quantifying the association between DTI parameters and neuronal status as a whole. METHODS:Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were ob...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000443270

    authors: Ying J,Zhou X,Zhu M,Zhou Y,Huang K,Zhou B,Teng H

    更新日期:2016-01-01 00:00:00

  • Management of cerebral arteriovenous malformations associated with symptomatic congestive intracranial hypertension.

    abstract::We report on management strategies and clinical outcomes in 4 cases of acute symptomatic congestive intracranial hypertension associated with cerebral arteriovenous malformations (AVMs). Congestion resulted from high-volume shunts exhausting the drainage capacity of the cerebral venous system in 3 patients, and from s...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000109263

    authors: Rosenkranz M,Regelsberger J,Zeumer H,Grzyska U

    更新日期:2008-01-01 00:00:00

  • Continuous muscle activity and distal spinal muscular atrophy.

    abstract::A young man presented with myokymias, cramp-like difficulty in muscle relaxation and peroneal atrophy. EMG studies revealed continuous muscle activity (CMA) manifested as grouped potentials and high frequency discharges. Sensory nerve conduction studies and sural nerve biopsy gave normal results, and he was thought to...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116667

    authors: Castilla JM,Alberca R,Chinchon I,Gil-Neciga E,Rafel E

    更新日期:1991-01-01 00:00:00

  • Assessment of cognitive function in asymptomatic HIV-positive subjects.

    abstract::This retrospective study aims to assess cognitive involvement in pre-AIDS, not drug abuser subjects and to determine whether CD4 status or disease stage best correlates with cognitive changes that may portend development of ADC. 328 cases were analyzed. No differences in psychometric performance in relation to CDC sta...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000008112

    authors: Grassi MP,Perin C,Borella M,Mangoni A

    更新日期:1999-01-01 00:00:00

  • CT techniques.

    abstract::Since the advent of whole-body CT scanning in 1974, many studies have been made in its application to all parts of the body. One of the most fruitful areas has been CT of the spinal cord. The only limitation appears to be the technique used; there is no substitute for a good technique. We shall first review standard C...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000115482

    authors: Ledley RS

    更新日期:1982-01-01 00:00:00

  • Clinical and radiological characteristics in multiple sclerosis patients with large cavitary lesions.

    abstract:BACKGROUND:Large cavitary lesions are not typical for multiple sclerosis (MS). Cavitary white matter changes may be seen in megalencephalic leukoencephalopathy with subcortical cysts, Alexander disease, mitochondrial leukoencephalopathies, vanishing white matter disease, leukoencephalopathy with calcifications and cyst...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000338476

    authors: Renard D,Brochet B,Vukusic S,Edan G,Deburghgraeve V,Goizet C,Dupuy D,Touze E,Deschamps R,Zephyr H,Creange A,Castelnovo G,Boespflug-Tanguy O,Labauge P

    更新日期:2012-01-01 00:00:00

  • Haem derivatives in the cerebrospinal fluid after intracranial haemorrhage.

    abstract::During the first 5 days after an intracranial haemorrhage, the red blood cells slowly haemolyse. Most of the oxyhaemoglobin, released in the cerebrospinal fluid, is transformed into bilirubin by an enzyme-dependent process. After 5 days, the haemolysis increases without a corresponding enhancement in the formation of ...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116339

    authors: Wahlgren NG,Lindquist C

    更新日期:1987-01-01 00:00:00

  • Presentation, etiology, diagnosis, and management of camptocormia.

    abstract::Camptocormia (bent spine syndrome, cyphose hystérique) is an abnormality characterized by severe forward flexion of the thoracolumbar spine which typically increases during walking or standing and completely disappears in supine position. Camptocormia can be due to central nervous system diseases, such as Parkinson's ...

    journal_title:European neurology

    pub_type: 杂志文章,评审

    doi:10.1159/000314897

    authors: Finsterer J,Strobl W

    更新日期:2010-01-01 00:00:00

  • Synaesthesia.

    abstract::Synaesthesia is the intriguing, involuntary experience of feeling one sensation in response to a different sensory stimulus. Recognised since described in 1890 by John Locke and clarified by Galton in the 1880s, it has been analysed in the last 50 years. Grapheme-colour synaesthesia is the commonest form, but many oth...

    journal_title:European neurology

    pub_type: 历史文章,杂志文章,评审

    doi:10.1159/000098101

    authors: Pearce JM

    更新日期:2007-01-01 00:00:00

  • Diffusion tensor imaging findings of optic radiation in patients with putaminal hemorrhage.

    abstract:OBJECTIVES:Little is known about optic radiation (OR) injury in intracerebral hemorrhage (ICH). We attempted to investigate OR injury in patients with ICH by diffusion tensor imaging (DTI). METHODS:Forty-three consecutive patients with putaminal hemorrhage and 40 normal healthy control subjects were recruited. DTI dat...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000345271

    authors: Seo JP,Choi BY,Chang CH,Jung YJ,Byun WM,Kim SH,Kwon YH,Jang SH

    更新日期:2013-01-01 00:00:00

  • Characteristics and outcomes of patients with seizures according to the time of onset in relation to stroke.

    abstract:BACKGROUND/AIM:Although most late-onset seizures (LS) appear within 2 years after stroke, some of them occur later and their characteristics are unknown. The aim of this study was to compare the characteristics of patients with very-late-onset seizures (VLS) to those with early-onset seizures (ES) and those with LS. P...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000115635

    authors: De Reuck J,Sieben A,Van Maele G

    更新日期:2008-01-01 00:00:00

  • Prognosis after therapy discontinuation in children with epilepsy.

    abstract::Anticonvulsant therapy was stopped in 191 epileptic children (109 males and 82 females) after a seizure-free period of at least 2 years, independent of EEG findings, followed up for a minimum of 2 years after withdrawal. Overall, 43 (22.5%) had recurrence of seizures; of these, 79% relapsed within the 1st year after d...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116811

    authors: Mastropaolo C,Tondi M,Carboni F,Manca S,Zoroddu F

    更新日期:1992-01-01 00:00:00

  • White matter hyperintensity as a factor associated with delayed mood disorders in patients with acute ischemic stroke.

    abstract:BACKGROUND:Mood disorder is a frequent complication of stroke. Comorbid depressive and anxiety disorders are very common, indicating that it is advisable to assess both disorders at the same time. The aim of the present study was to examine the prevalence of post-stroke depression (PSD) and poststroke anxiety (PSA) at ...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000332585

    authors: Kim JT,Park MS,Yoon GJ,Jung HJ,Choi KH,Nam TS,Lee SH,Choi SM,Kim BC,Kim MK,Cho KH

    更新日期:2011-01-01 00:00:00

  • Effect of rivastigmine or memantine add-on therapy is affected by butyrylcholinesterase genotype in patients with probable Alzheimer's disease.

    abstract:BACKGROUND:The K variant of butyrylcholinesterase (BCHE-K) exhibits a reduced acetylcholine-hydrolyzing capacity; so the clinical response to rivastigmine may differ in Alzheimer's disease (AD) patients with the BCHE-K gene. OBJECTIVE:To investigate the clinical response to rivastigmine transdermal patch monotherapy o...

    journal_title:European neurology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1159/000366198

    authors: Han HJ,Kwon JC,Kim JE,Kim SG,Park JM,Park KW,Park KC,Park KH,Moon SY,Seo SW,Choi SH,Cho SJ

    更新日期:2015-01-01 00:00:00

  • Basal ganglia calcification and psychosis in mongolism.

    abstract::An 18-year-old mongoloid girl (trisomy 21) of Asian descent presented two symptoms rarely associated with mongolism (Down's syndrome). (1) Brain stem calcification; the first case diagnosed in vivo in mongolism on computerized axial tomography. (2) Hallucinatory psychotic depression; the first case successfully treate...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000114963

    authors: Jakab I

    更新日期:1978-01-01 00:00:00

  • Concentrations of carbamazepine and carbamazepine-10, 11-epoxide in serum, brain tumors and paratumorous cortex: a prospective study of 37 neurosurgically treated epileptic patients.

    abstract::Concentrations of carbamazepine (CBZ) and its metabolite carbamazepine-10, 11-epoxide (CE) were determined in serum (free and total), brain tumors and paratumorous cortex from 37 epileptic patients. Tumor biopsies were available from 25 different gliomas, 5 hamartomas and 1 angioma. The free serum concentrations of CB...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000117041

    authors: Schnabel R,Rambeck B,May TW,Jürgens U,Lahl R

    更新日期:1994-01-01 00:00:00

  • Familial young-adult-onset arteriosclerotic leukoencephalopathy with alopecia and lumbago without arterial hypertension.

    abstract::Here we review a total of 17 patients, including 4 of our own, with young-adult-onset arteriosclerotic leukoencephalopathy, alopecia and lumbago without hypertension. All were Japanese and the illness seemed to be transmitted in an autosomal recessive fashion. The male to female ratio was 7.5:1. The age of onset usual...

    journal_title:European neurology

    pub_type: 杂志文章,评审

    doi:10.1159/000117096

    authors: Fukutake T,Hirayama K

    更新日期:1995-01-01 00:00:00

  • Calcium in physiological and pathological cell function.

    abstract::Calcium ions play a major role in the regulation of cell functions. Minor alterations of the cellular calcium ion homeostasis lead to major functional aberrations. Alterations of the calcium homeostasis occur under conditions of hypoxia, the major cause being an extracellular increase of potassium ions which gate volt...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116059

    authors: Peters T

    更新日期:1986-01-01 00:00:00

  • Effect of hypocapnia on cerebral oxygen metabolism and blood flow in ischemic cerebrovascular disorders.

    abstract::Effects of hypocapnia on cerebral oxygen consumption (CMRO2) and blood flow (CBF) in cerebral ischemia were studied in 19 patients. The CMRO2 did not change significantly during hypocapnia within the whole group of patients, because 10 out of 19 cases showed a decrease (p less than 0.001) and other 9 showed an increas...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116149

    authors: Tsuda Y,Kimura K,Yoneda S,Hartmann A,Etani H,Hashikawa K,Kamada T

    更新日期:1987-01-01 00:00:00

  • A nation-wide collaborative study on the long-term effects of bromocriptine in patients with Parkinson's disease. First interim report in Japan.

    abstract::Two prospective projects were started in May 1985 to evaluate the long-term effects of bromocriptine in patients with Parkinson's disease. One of the projects is to see if combination therapy with levodopa and bromocriptine is superior to levodopa alone with regard to the prevention of late side effects of levodopa th...

    journal_title:European neurology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Nakanishi T,Mizuno Y,Goto I,Iwata M,Kanazawa I,Kowa H,Mannen T,Nishitani H,Ogawa N,Takahashi A

    更新日期:1988-01-01 00:00:00

  • Human slow wave sleep.

    abstract::Human slow wave sleep (hSWS) is an important form of sleep that seems to take priority over REM sleep. Although hSWS is commonly thought to be associated with enhanced tissue repair, evidence supporting this view is questioned. For example, total sleep deprivation and loss of hSWS have little or no adverse effect on b...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116076

    authors: Horne JA

    更新日期:1986-01-01 00:00:00

  • Increased visual impairment after exercise (Uhthoff's phenomenon) in multiple sclerosis: therapeutic possibilities.

    abstract::The Uhthoff symptom, a transient impairment of visual function after exercise, is demonstrated in 2 multiple sclerosis patients. Following exercise, impairment of visual function, as documented most clearly by the testing of contrast sensitivity, was less obvious after body surface cooling and after treatment with ora...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116830

    authors: van Diemen HA,van Dongen MM,Dammers JW,Polman CH

    更新日期:1992-01-01 00:00:00

  • Frequency of epilepsies in family members of patients with different epileptic syndromes.

    abstract:AIM:To determine the frequency of epilepsies in the family members of epileptic patients. METHODS:The records of 4,851 patients with epilepsy were reviewed. The frequency and patterns of different epilepsies and epileptic syndromes in the patients, number of affected relatives and consanguinity were studied. RESULTS:...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000322125

    authors: Sozmen V,Baybas S,Dirican A,Koksal A,Ozturk M

    更新日期:2011-01-01 00:00:00

  • Therapies in muscular dystrophy: current concepts and future prospects.

    abstract::In the fast moving field of muscular dystrophy, therapeutic matters are now high on the agenda. Despite little progress made in the understanding of the exact pathogenesis, hopes have been raised with the advent of molecular medicine applied to such disorders. A constellation of techniques or therapeutic solutions are...

    journal_title:European neurology

    pub_type: 杂志文章,评审

    doi:10.1159/000008150

    authors: Urtizberea JA

    更新日期:2000-01-01 00:00:00

  • Adult metachromatic leukodystrophy. III. Clinical course, final stages and first biochemical results.

    abstract::Continuing the previously published clinical development of a case of adult metachromatic leukodystrophy (MLD), we now describe the terminal phase and death (at 46 years of age) of our patient. The final phase was characterized clinically by progression of generalized peripheral neuropathy, advanced extrapyramidal and...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000115164

    authors: Seidel D,Heipertz R,Goebel HH,Duensing I,Pilz H

    更新日期:1980-01-01 00:00:00

  • Triphasic waves and cerebral tumors.

    abstract::Three patients with cerebral tumor involving diencephalic midline structures (2 malignant gliomas, 1 craniopharyngioma) and no metabolic abnormalities developed disorientation in time and place or coma with triphasic waves (TW) seen on electroencephalograms. Serial EEG recordings showed persistence or disappearance of...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116614

    authors: Aguglia U,Gambardella A,Oliveri RL,Lavano A,Camerlingo R,Quattrone A

    更新日期:1990-01-01 00:00:00

  • Rate of cerebral embolic events in relation to antibiotic and anticoagulant therapy in patients with bacterial endocarditis.

    abstract::To quantitate embolic risk we studied a retrospective series of 61 patients with strictly defined bacterial endocarditis. Eighteen patients had neurological complications attributable to cerebral embolism. Seventeen embolic episodes occurred prior to antibiotic treatment and 8 episodes after its commencement. The rate...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000117317

    authors: Paschalis C,Pugsley W,John R,Harrison MJ

    更新日期:1990-01-01 00:00:00

  • Comparisons between SPECT and quantitative EEG measures of cortical impairment in mild to moderate Alzheimer's disease.

    abstract::This study aimed at examining correlations between quantitative REM sleep EEG, regional cerebral blood flow measured by single photon emission computerized tomography (SPECT) and global cognitive functioning in nine patients with mild to moderate Alzheimer's disease. REM sleep EEG was not correlated with SPECT measure...

    journal_title:European neurology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000117247

    authors: Montplaisir J,Petit D,McNamara D,Gauthier S

    更新日期:1996-01-01 00:00:00