Familial young-adult-onset arteriosclerotic leukoencephalopathy with alopecia and lumbago without arterial hypertension.

Abstract:

:Here we review a total of 17 patients, including 4 of our own, with young-adult-onset arteriosclerotic leukoencephalopathy, alopecia and lumbago without hypertension. All were Japanese and the illness seemed to be transmitted in an autosomal recessive fashion. The male to female ratio was 7.5:1. The age of onset usually ranged from 25 to 30 years. Acute lumbago, spondylosis deformans, diffuse baldness, and progressive motor and mental deterioration were common clinical features. Cerebral arteriosclerosis and white mater disease were demonstrated pathologically or radiologically. Although the pathogenesis has remained obscure, we think this is a new clinico-pathological entity distinct from the classic type of Binswanger's disease.

journal_name

Eur Neurol

journal_title

European neurology

authors

Fukutake T,Hirayama K

doi

10.1159/000117096

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

69-79

issue

2

eissn

0014-3022

issn

1421-9913

journal_volume

35

pub_type

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