Abstract:
BACKGROUND/AIMS:This study aimed at assessing the feasibility of diffusion tensor imaging (DTI) in multilevel cervical spondylotic myelopathy (MCSM) and quantifying the association between DTI parameters and neuronal status as a whole. METHODS:Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were obtained from 32 patients with MCSM and 21 healthy volunteers at each level. The extent of cervical cord compression was evaluated by maximum spinal cord compression (MSCC). The DTI parameters were correlated with myelopathy severity based on modified Japanese Orthopedic Association (mJOA) score in comparison with anatomic morphological and signal changes on MRI. RESULTS:There were significant differences in the DTI values between the patients and those in the control group (p < 0.001). The general mean FA values correlated with mJOA scores strongly (r = 0.507, p = 0.003), even more than MSCC (r = -0.361, p = 0.042); however, such an association was not detected between ADC values and clinical findings (p > 0.05). CONCLUSION:DTI shows a higher potential to quantitatively evaluate the whole neurological deficits of patients with MCSM. It helps us better understand the minor pathological changes within the spinal cord at an earlier stage than abnormal signal changes on MRI.
journal_name
Eur Neuroljournal_title
European neurologyauthors
Ying J,Zhou X,Zhu M,Zhou Y,Huang K,Zhou B,Teng Hdoi
10.1159/000443270subject
Has Abstractpub_date
2016-01-01 00:00:00pages
67-74issue
1-2eissn
0014-3022issn
1421-9913pii
000443270journal_volume
75pub_type
杂志文章abstract::The effect of oral treatment with acyclovir (ACV) on sensory axonal neuropathy, segmental motor paresis and postherpetic neuralgia (PHN) was studied in 105 patients with herpes zoster. Forty-seven patients were treated with ACV at a dose of 4 g/day in 5 doses for at least a week; the others did not undergo any kind of...
journal_title:European neurology
pub_type: 临床试验,杂志文章
doi:10.1159/000117274
更新日期:1996-01-01 00:00:00
abstract::Mitochondrial abnormalities and effectiveness of replacement therapy were examined in a murine model of systemic carnitine deficiency, namely the juvenile visceral steatosis (JVS) mouse. Homozygous JVS mice revealed severe lipid deposition and abnormal mitochondria in liver, heart, skeletal muscle, and kidney, but the...
journal_title:European neurology
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journal_title:European neurology
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journal_title:European neurology
pub_type: 杂志文章,随机对照试验
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更新日期:2017-01-01 00:00:00
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journal_title:European neurology
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更新日期:1987-01-01 00:00:00
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pub_type: 杂志文章
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journal_title:European neurology
pub_type: 历史文章,杂志文章,评审
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更新日期:2008-01-01 00:00:00
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pub_type: 杂志文章
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abstract::Many gadolinium-enhanced magnetic resonance imaging (MRI) studies focusing on the anatomy and pathology of the 7th cranial nerve have already been published. However, only scattered cases of herpes zoster oticus (HZO) have been described and only the MRI appearance of the soft temporal bone structures has been reporte...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000007900
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pub_type: 杂志文章
doi:10.1159/000115508
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journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116280
更新日期:1988-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1978-01-01 00:00:00
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journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115534
更新日期:1983-01-01 00:00:00
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doi:10.1159/000115108
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pub_type: 杂志文章
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更新日期:2008-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1159/000116373
更新日期:1989-01-01 00:00:00