Abstract:
:Previous findings regarding the role of TNF-alpha-308 gene polymorphism in multiple sclerosis (MS) are contradictory. The aim of this study was to investigate the possible influence of TNF-alpha-308 polymorphism on MS susceptibility and the MS disease process in a Croatian and Slovenian population. Genotyping was performed in 338 patients and 460 healthy controls. The TNF2 allele was present in 123 (26.8%) healthy controls vs. 67 (19.9%) MS patients (p = 0.023, odds ratio = 0.68, 95% confidence interval = 0.48-0.95), suggesting that carriage of the TNF2 allele might decrease MS risk. The difference in TNF2 allele carrier frequency between patients and controls was identified in the relapsing-remitting MS group. There was no association between TNF2 allele carrier status and age at disease onset or disease progression. Our results suggest that, in the study populations, the TNF-alpha-308 polymorphism may play a role in MS susceptibility.
journal_name
Eur Neuroljournal_title
European neurologyauthors
Ristić S,Lovrecić L,Starcević-Cizmarević N,Brajenović-Milić B,Sega Jazbec S,Sepcić J,Kapović M,Peterlin Bdoi
10.1159/000099159subject
Has Abstractpub_date
2007-01-01 00:00:00pages
203-7issue
4eissn
0014-3022issn
1421-9913pii
000099159journal_volume
57pub_type
杂志文章abstract::Nocturnal sleep patterns were registered from 6 parkinsonian patients treated with bromocryptine, ("-Br-L-ergocryptine, C.B.-154) a dopamine-like agonist. No significant differences in their sleep patterns were found in comparison with patients treated with L-dopa. Since bromocryptine acts direct on the dopaminergic r...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000114973
更新日期:1978-01-01 00:00:00
abstract:AIMS:To perform a large and detailed epidemiologic study on restless legs syndrome (RLS) during pregnancy in a European country. METHODS:A cross-sectional questionnaire survey. The questionnaire was distributed by the medical staff in different outpatient waiting rooms (obstetrics and gynecology department of the univ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000321413
更新日期:2010-01-01 00:00:00
abstract::We have recently observed a diffuse slowing of brain waves using serial quantitative electroencephalographic (qEEG) examinations in interferon (IFN)-alpha-treated chronic hepatitis C patients. However, it remains unclear how this alteration could be assessed. We evaluated the correlation between the qEEG changes and t...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000062997
更新日期:2002-01-01 00:00:00
abstract::We report a 17-year-old patient who presented a chronic relapsing sensorimotor demyelinating neuropathy with 6 relapses over a 7-year period, preceding by 4 years the diagnosis of a multicentric angiofollicular lymph node hyperplasia. A role for Epstein-Barr virus (EBV) as a trigger of the neuropathy may be suggested ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000117156
更新日期:1995-01-01 00:00:00
abstract::An HIV-positive patient presented the classical syndrome of pure alexia. Neuroradiologic investigation by computed tomography showed a ring-like lesion in the left posterior white matter. The clinical manifestations as well as the radiologic findings resolved after antiprotozoal treatment. ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116783
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND/AIMS:We prospectively assessed the frequency, type, severity and cause of treatment among the long-term residents of the Kork Epilepsy Centre in the year 2005. METHODS:All long-term residents were exclusively referred to the general surgeon practicing on the campus. Patients were divided into 2 groups compr...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000318171
更新日期:2010-01-01 00:00:00
abstract::Neuropathological changes such as dystrophic neurites and the presence of abnormal tau protein in the olfactory system, including primary sensory cells and nerve fibres have previously been demonstrated in nasal mucosa tissue of patients with Alzheimer's disease (AD). These changes were detected in autopsy-derived mat...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000007953
更新日期:1998-07-01 00:00:00
abstract::Increased levels of lactic dehydrogenase (LDH) in cerebrospinal fluid (CSF) have been reported in association with several intracranial pathologies. We studied LDH isoenzymes in the CSF of children with infantile spasms. CSF samples collected from 12 patients (aged 4-9 months) with infantile spasms were analyzed for t...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000070192
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Statins inhibit the production of 2,3-dimethoxy,5-methyl,6-polyisoprene parabenzoquinone also known as ubiquinone or coenzyme Q10 (CoQ10), which is required for mitochondrial electron transport. Idiopathic or primary CoQ10 deficiencies have been known to cause mitochondrial encephalomyopathy. METHODS:We pre...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000101287
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:The pathogenesis of card game-induced reflex epilepsy has not been determined so far. The aim of this study was to evaluate structural abnormalities using voxel-based morphometry (VBM) analysis, which may give some clue about the pathogenesis in card game-induced reflex epilepsy. METHODS:The 3 subjects were...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000447537
更新日期:2016-01-01 00:00:00
abstract::Transient ischemic attacks (TIAs) are warning episodes predicting that such patients are at high risk for stroke which potentially could be life-threatening or leave an individual with substantial disability. TIAs result from large or small vessel disease, cardiogenic embolic events and hematological abnormalities. Th...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000052065
更新日期:1998-01-01 00:00:00
abstract::The authors report a case of a giant aneurysm of the distal portion of the posterior inferior cerebellar artery presenting the classical picture of a tumor of the posterior fossa. CT scan of a giant aneurysm reveals the clear margin and high density area of aneurysm wall, and the homogeneous and high density area of t...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115108
更新日期:1979-01-01 00:00:00
abstract::Dopamine uptake sites, labelled by 3 nM [3H]GBR 12935, were reduced by 28-34% in post-mortem Parkinson's diseased striata (n = 22) compared to control striata (n = 28). There was no significant difference between post-mortem striata from schizophrenics (n = 16) and controls. Both dopamine D1 and D2 receptors are consi...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000117168
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:Dizziness and vertigo are frequent complaints of outpatients in the neurological department. Our objective was to explore the epidemiological category and clinical features of patients with dizziness or vertigo in the neurological outpatient department of a tertiary hospital. METHODS:We consecutively recrui...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000489639
更新日期:2018-01-01 00:00:00
abstract::Magnetic resonance imaging and angiography is the technique of choice in the diagnosis and follow-up of cerebral venous thrombosis: Thrombosis appears as an absence of flow void on spin echo images and lack of signal in angiographic techniques. The thrombus signal intensity is different on T1 and T2 spin echo weighted...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000007978
更新日期:1998-11-01 00:00:00
abstract::The importance of patent foramen ovale (PFO) has long been discussed in the literature in relation to different coexisting medical conditions. Many researchers focused on the occurrence of PFO in ischemic stroke patients, especially in the subgroup of young patients with a recurrent event. Unfortunately, before establ...
journal_title:European neurology
pub_type: 杂志文章,评审
doi:10.1159/000342900
更新日期:2013-01-01 00:00:00
abstract::Nerve conduction of single impulses and the ability to transmit frequent trains of stimuli were studied in sensory median and in sural nerves of controls and patients with diabetes mellitus. Decrease of relative amplitudes and increase of relative latencies were more marked in the diabetics as compared with normal con...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115123
更新日期:1980-01-01 00:00:00
abstract::Electrophysiological findings in 10 patients with polyneuropathy and nonmalignant IgMk plasma cell dyscrasia are reported. The amplitude of sensory action potentials and maximum conduction velocity along the sural and median nerves are related to the structural changes found at the biopsy and to the immunologic result...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115979
更新日期:1986-01-01 00:00:00
abstract::The effects of biologically active light (BL) on subjective and objective quality of sleep and awakening, as well as circadian rhythms in cortisol, temperature and well-being were studied in 10 hospitalized normal female volunteers as compared with partial sleep deprivation (PSD). After 2 adaption days, three 24-hour ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116088
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:Thalamic lesion due to deep cerebral venous thrombosis (DCVT) is an uncommon cause of stroke. Until now, only a few case reports have been published. The aim of the study is to report the clinical and radiological findings of thalamic lesion with DCVT. METHODS:We reviewed our computerized stroke database of...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000439167
更新日期:2015-01-01 00:00:00
abstract::Human slow wave sleep (hSWS) is an important form of sleep that seems to take priority over REM sleep. Although hSWS is commonly thought to be associated with enhanced tissue repair, evidence supporting this view is questioned. For example, total sleep deprivation and loss of hSWS have little or no adverse effect on b...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116076
更新日期:1986-01-01 00:00:00
abstract::A method is described to relate brain morphology and neuropsychological disturbances such as aphasia. By mapping lesions with computerized tomography onto a grid model of five brain slices, it is possible to compare aphasiological information and lesion site by data processing, allowing the quantitative and qualitativ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115210
更新日期:1981-01-01 00:00:00
abstract:BACKGROUNDS:It is often difficult to diagnose stroke subtypes at admission, particularly in sinus rhythm cases. Vascular pedicle width (VPW) on chest X-ray (CXR) and maximal P-wave duration (P-max) on electrocardiogram (ECG) are again realized as useful parameters reflecting intravascular volume and atrial conduction s...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000382127
更新日期:2015-01-01 00:00:00
abstract::The Uhthoff symptom, a transient impairment of visual function after exercise, is demonstrated in 2 multiple sclerosis patients. Following exercise, impairment of visual function, as documented most clearly by the testing of contrast sensitivity, was less obvious after body surface cooling and after treatment with ora...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116830
更新日期:1992-01-01 00:00:00
abstract:AIM:To determine the association between interleukin-6 (IL-6) and soluble E-selectin (sE-selectin) levels with the electrodiagnostic abnormalities in patients with impaired fasting glucose (IFG) and impaired glucose tolerance (IGT). METHODS:Serum HbA1c, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), f...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000444661
更新日期:2016-01-01 00:00:00
abstract::The effect of oral treatment with acyclovir (ACV) on sensory axonal neuropathy, segmental motor paresis and postherpetic neuralgia (PHN) was studied in 105 patients with herpes zoster. Forty-seven patients were treated with ACV at a dose of 4 g/day in 5 doses for at least a week; the others did not undergo any kind of...
journal_title:European neurology
pub_type: 临床试验,杂志文章
doi:10.1159/000117274
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:Focal embouchure dystonia (FED) is a type of task-specific dystonia affecting wind instrument players, and it frequently ends their professional careers. The results of the treatments of FED in the reported literature are disappointing. OBJECTIVE:We report 3 patients with FED who were brass instrument playe...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000329578
更新日期:2011-01-01 00:00:00
abstract::To investigate the association between APOE-epsilon4 allele and memory phenotype in the preclinical stage of Alzheimer's disease (AD). We compared an extensive preclinical memory profile at the baseline evaluation of 2 AD genotype groups: APOE-epsilon4 allele carriers and patients with APOE-epsilon3 homozygosity. Base...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000078486
更新日期:2004-01-01 00:00:00
abstract::In 128 patients with multiple sclerosis (MS) and 204 blood donors (control persons) the in vitro activation of 'Ficoll-purified' peripheral blood T lymphocytes was measured using the 3H-thymidine incorporation rate without (spontaneous proliferation) and with mitogen addition (concanavalin A, phytohemagglutinin). Mito...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116228
更新日期:1988-01-01 00:00:00
abstract::Divers may be at risk of long-term CNS damage from non-symptomatic hyperbaric exposure. We investigated the effect of severe, controlled hyperbaric exposure on a group of healthy goats with similar histories. Thirty goats were exposed to various dive profiles over a period of 5 years, with 17 experiencing decompressio...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000079254
更新日期:2004-01-01 00:00:00