Effects of acyclovir on sensory axonal neuropathy, segmental motor paresis and postherpetic neuralgia in herpes zoster patients.

Abstract:

:The effect of oral treatment with acyclovir (ACV) on sensory axonal neuropathy, segmental motor paresis and postherpetic neuralgia (PHN) was studied in 105 patients with herpes zoster. Forty-seven patients were treated with ACV at a dose of 4 g/day in 5 doses for at least a week; the others did not undergo any kind of treatment. Electrodiagnostic examination of the nerves and muscles corresponding to the dermatomeric lesions was performed, including sensory and motor nerve conduction studies, blink reflex and electromyography (EMG). The patients treated with ACV showed a significant reduction in the number of cases in which there was electrophysiological evidence of axonal damage in afferent fibres of nerves arising from roots corresponding to affected dermatomes. The treated group also showed a smaller incidence of segmental motor neuritis, clinically evident or only detectable by EMG as denervation. However, there was no significant difference between groups as far as the incidence of PHN was concerned. Oral treatment with ACV therefore reduces peripheral sensory axonopathy due to ganglion damage and prevents the possibility of spread to anterior roots and spinal motoneurones. In this way it reduces the incidence of segmental motor neuritis, but does not reduce the incidence of PHN.

journal_name

Eur Neurol

journal_title

European neurology

authors

Mondelli M,Romano C,Passero S,Porta PD,Rossi A

doi

10.1159/000117274

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

288-92

issue

5

eissn

0014-3022

issn

1421-9913

journal_volume

36

pub_type

临床试验,杂志文章
  • Concentrations of carbamazepine and carbamazepine-10, 11-epoxide in serum, brain tumors and paratumorous cortex: a prospective study of 37 neurosurgically treated epileptic patients.

    abstract::Concentrations of carbamazepine (CBZ) and its metabolite carbamazepine-10, 11-epoxide (CE) were determined in serum (free and total), brain tumors and paratumorous cortex from 37 epileptic patients. Tumor biopsies were available from 25 different gliomas, 5 hamartomas and 1 angioma. The free serum concentrations of CB...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000117041

    authors: Schnabel R,Rambeck B,May TW,Jürgens U,Lahl R

    更新日期:1994-01-01 00:00:00

  • Subacute combined degeneration of the cord: Putnam-Dana syndrome.

    abstract::The association of anaemia and gastro-intestinal abnormalities with disorders of the brain, spinal cord, and peripheral nerves has been recognized since the mid 19th century. In early reports interpretable as subacute combined degeneration, anaemia was overlooked, and conversely in Addison's and other early reports of...

    journal_title:European neurology

    pub_type: 历史文章,杂志文章

    doi:10.1159/000131715

    authors: Pearce JM

    更新日期:2008-01-01 00:00:00

  • Muscle pathology in the early stage of Guillain-Barré syndrome.

    abstract::Although many studies have been performed on nervous tissue pathology in Guillain-Barré syndrome (GBS), much less is known about pathological changes in skeletal muscle in this disorder. We have studied muscle biopsies from 5 patients with GBS, 5 patients with amyotrophic lateral sclerosis (control A), and 5 patients ...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000007924

    authors: Ono S,Inoue K,Munakata S,Nagao K,Shimizu N

    更新日期:1998-01-01 00:00:00

  • Location-dependent patterns in cardio-autonomic dysfunction in ischaemic stroke.

    abstract:BACKGROUND AND STUDY PURPOSE:Autonomic nervous system dysfunction is a common complication of acute cerebrovascular disorders. The aim of this study was to investigate a possible location-dependent difference in cardio-autonomic function in patients with ischaemic stroke. PATIENTS AND METHODS:Sympathetic function was ...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000070856

    authors: Strittmatter M,Meyer S,Fischer C,Georg T,Schmitz B

    更新日期:2003-01-01 00:00:00

  • Increment of the platelet count in temporal arteritis: response to therapy and ischemic complications.

    abstract::Temporal arteritis (TA) is a vasculitis involving mainly cranial branches of the aorta that can lead to ischemic complications such as amaurosis or ischemic stroke. Increment in the platelet count has been described in the acute period of the disease. We studied retrospectively the platelet count in patients with TA, ...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000052088

    authors: Gonzalez-Alegre P,Ruiz-Lopez AD,Abarca-Costalago M,Gonzalez-Santos P

    更新日期:2001-01-01 00:00:00

  • Effect of hypocapnia on cerebral oxygen metabolism and blood flow in ischemic cerebrovascular disorders.

    abstract::Effects of hypocapnia on cerebral oxygen consumption (CMRO2) and blood flow (CBF) in cerebral ischemia were studied in 19 patients. The CMRO2 did not change significantly during hypocapnia within the whole group of patients, because 10 out of 19 cases showed a decrease (p less than 0.001) and other 9 showed an increas...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116149

    authors: Tsuda Y,Kimura K,Yoneda S,Hartmann A,Etani H,Hashikawa K,Kamada T

    更新日期:1987-01-01 00:00:00

  • Marie-Jean-Pierre Flourens (1794-1867) and cortical localization.

    abstract::The child prodigy Marie-Jean-Pierre Flourens received his medical degree at Montpellier when aged 19. As a young promising physician Flourens was asked to investigate Gall's controversial views on cerebral localization. To test Gall's assertions, Flourens developed ablation as a procedure to explore the workings of th...

    journal_title:European neurology

    pub_type: 传,历史文章,杂志文章

    doi:10.1159/000206858

    authors: Pearce JM

    更新日期:2009-01-01 00:00:00

  • Therapies in muscular dystrophy: current concepts and future prospects.

    abstract::In the fast moving field of muscular dystrophy, therapeutic matters are now high on the agenda. Despite little progress made in the understanding of the exact pathogenesis, hopes have been raised with the advent of molecular medicine applied to such disorders. A constellation of techniques or therapeutic solutions are...

    journal_title:European neurology

    pub_type: 杂志文章,评审

    doi:10.1159/000008150

    authors: Urtizberea JA

    更新日期:2000-01-01 00:00:00

  • Correlations between clinical and magnetic resonance imaging findings in multiple sclerosis.

    abstract::40 patients with multiple sclerosis were investigated by magnetic resonance imaging (MRI) and computer tomography (CT). Additionally, cerebrospinal fluid (CSF) findings and evoked potentials (EPs; visual, brainstem) were evaluated. MRI findings were abnormal in 85% of the patients, whilst CT scan showed pathological c...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116269

    authors: Boné G,Ladurner G,Artmann W,Bsteh C

    更新日期:1988-01-01 00:00:00

  • Primary intracerebral hemorrhages in the Besançon stroke registry. Initial clinical and CT findings, early course and 30-day outcome in 350 patients.

    abstract::The purpose of this study was to estimate the risk factors, early course, outcome and neuroimaging patterns in primary intracerebral hemorrhages (PIH). Using the Besançon Stroke Registry, 350 patients with first PIH documented by computed tomography (CT) between 1987 and 1993 were included in the present study. Patien...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000008177

    authors: Tatu L,Moulin T,El Mohamad R,Vuillier F,Rumbach L,Czorny A

    更新日期:2000-01-01 00:00:00

  • Homonymous defect of macular vision in ischemic stroke.

    abstract::It is generally believed that a homonymous defect of macular vision (HMV) is caused by a small lesion restricted to the occipital lobe tip and rarely results from ischemic stroke. The incidence of HMV was studied retrospectively in 54 patients with infarction of the posterior cerebral artery territory who underwent Go...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000050785

    authors: Isa K,Miyashita K,Yanagimoto S,Nagatsuka K,Naritomi H

    更新日期:2001-01-01 00:00:00

  • Chronic partial denervation is more widespread than is suspected clinically in paralytic poliomyelitis. Electrophysiological study.

    abstract::Clinical evaluation, quantitative analysis of the EMG, and motor unit fiber density were carried out on 34 selected patients that suffered paralytic poliomyelitis. 50% of the subjects developed a late and slowly progressive weakness. Automatic analysis of the electromyogram showed a great increase in mean amplitude in...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000115578

    authors: Cruz Martínez A,Pérez Conde MC,Ferrer MT

    更新日期:1983-01-01 00:00:00

  • Quadriceps atrophy after knee traumatisms and immobilization: electrophysiological assessment.

    abstract::Automatic analysis of EMG (T/A analysis) and invasive muscle fiber conduction velocity in situ (MFCV) were performed in 15 patients after traumatic lesions of the knee and immobilization with quadriceps atrophy. T/A analysis showed transient reduced number of turns, consistent with inhibition of quadriceps motoneurons...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000008145

    authors: Cruz-Martínez A,Ramírez A,Arpa J

    更新日期:2000-01-01 00:00:00

  • Behavioral and psychological symptoms of dementia: factor analysis and relationship with cognitive impairment.

    abstract:BACKGROUND/AIMS:Behavioral and psychological symptoms of dementia (BPSD) affect almost all people with dementia at some stage during the progression of disease. The current study aimed at replicating previous findings on BPSD clustering in behavioral sub-syndromes. METHODS:One hundred and sixty-six consecutive outpati...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000341956

    authors: Poletti M,Nuti A,Cipriani G,Bonuccelli U

    更新日期:2013-01-01 00:00:00

  • Single photon emission computed tomography with technetium-99m hexamethyl propylenamino oxime in the pain-free interval of migraine and cluster headache.

    abstract::Thirty-three headache-free patients (19 F/14 M) suffering from common (n = 9) and classic migraine (n = 19) as well as cluster headache (n = 5) were investigated using the flow tracer 99mTc-hexamethyl propylenamino oxime and single photon emmission computed tomography. A regional decrease of cerebral tracer uptake was...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000117334

    authors: Schlake HP,Böttger IG,Grotemeyer KH,Husstedt IW,Vollet B,Schober O,Brune GG

    更新日期:1990-01-01 00:00:00

  • Frontal stroke syndromes.

    abstract::The frontal lobe is the largest lobe of the brain, and it is thus commonly involved in stroke. Moreover, almost one in five strokes is limited to the prerolandic areas. This high frequency of anatomical involvement is in sharp contrast with the apparent rarity of clinical frontal dysfunction in stroke. It is remarkabl...

    journal_title:European neurology

    pub_type: 杂志文章,评审

    doi:10.1159/000117068

    authors: Bogousslavsky J

    更新日期:1994-01-01 00:00:00

  • Morphologic aspects of the neurofibrosarcoma (neurogenic sarcoma).

    abstract::Two cases of malignant tumours of the nerve sheaths are reported. In the first patient, who had von Recklinghausen's disease, light- and electron-microscopic investigations showed an undifferentiated mesenchymal tumour of the radial nerve with the property of producing collagen fibres, an aspect characteristic of sarc...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000114873

    authors: Vuia O

    更新日期:1977-01-01 00:00:00

  • Assessment of cognitive function in asymptomatic HIV-positive subjects.

    abstract::This retrospective study aims to assess cognitive involvement in pre-AIDS, not drug abuser subjects and to determine whether CD4 status or disease stage best correlates with cognitive changes that may portend development of ADC. 328 cases were analyzed. No differences in psychometric performance in relation to CDC sta...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000008112

    authors: Grassi MP,Perin C,Borella M,Mangoni A

    更新日期:1999-01-01 00:00:00

  • Urinary retention and space-occupying lesions of the frontal cortex.

    abstract::The authors present 2 cases in which urinary retention was related to supratentorial cortical lesions. These cases support the presence and function of a supratentorial center involved in control of the voiding reflex loop and indicate that lesions affecting this center can result in urinary retention rather than the ...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000117199

    authors: Lang EW,Chesnut RM,Hennerici M

    更新日期:1996-01-01 00:00:00

  • Angiographical findings and risk factors in cerebral ischaemia. A retrospective study.

    abstract::Reviewing the angiograms of 100 patients with RIA or stroke we found intracranial lesions in 67%, extracranial lesions in 64%, and normal angiograms in 13% of the cases. Risk factors occurred more often as the angiographic lesions were more extensive. These findings confirm the importance of angiographic examination o...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000115177

    authors: van Oudenaarden WF,Tans JT,Hoogland PH

    更新日期:1980-01-01 00:00:00

  • Blood Pressure Variability in Acute Ischemic Stroke: Influence of Infarct Location in the Insular Cortex.

    abstract:BACKGROUND:The aim of this study was to elucidate the influence of insular infarction on blood pressure (BP) variability and outcomes according to the region of the insular cortex affected. METHODS:A total of 90 patients diagnosed with acute unilateral ischemic stroke were registered. The BP variability was calculated...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000486306

    authors: Kitamura J,Ueno H,Nagai M,Hosomi N,Honjo K,Nakamori M,Mukai T,Imamura E,Nezu T,Aoki S,Ohshita T,Nomura E,Wakabayashi S,Maruyama H,Matsumoto M

    更新日期:2018-01-01 00:00:00

  • Contribution of PET studies in diagnosis of corticobasal degeneration.

    abstract::Five patients with clinical features of corticobasal degeneration (CBD) were studied with PET imaging. The main clinical findings included a unilateral extrapyramidal motor disorder, without significant response to levodopa, as well as clumsiness, dysarthria, apraxia and a clear asymmetry of neurological signs. PET st...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000008187

    authors: Lutte I,Laterre C,Bodart JM,De Volder A

    更新日期:2000-01-01 00:00:00

  • Diagnosis of Vertigo and Dizziness Syndromes in a Neurological Outpatient Clinic.

    abstract:BACKGROUND:Dizziness and vertigo are frequent complaints of outpatients in the neurological department. Our objective was to explore the epidemiological category and clinical features of patients with dizziness or vertigo in the neurological outpatient department of a tertiary hospital. METHODS:We consecutively recrui...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000489639

    authors: Pan Q,Zhang Y,Long T,He W,Zhang S,Fan Y,Zhou J

    更新日期:2018-01-01 00:00:00

  • Carbamazepine versus diphenylhydantoin in the treatment of myotonia.

    abstract::A double-blind controlled trial was performed on 6 patients affected with Steinert's disease in order to evaluate the efficacy of two different dosages of diphenylhydantoin (PHT, 200 and 300 mg/day) and carbamazepine (CBZ, 600 and 800 mg/day) on the myotonic afterdischarge. Both dosages of PHT and CBZ induced a signif...

    journal_title:European neurology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000115546

    authors: Sechi GP,Traccis S,Durelli L,Monaco F,Mutani R

    更新日期:1983-01-01 00:00:00

  • Modifications of cyclic alternating pattern in sleep apnea syndrome.

    abstract::Within non-rapid eye movement sleep, two complementary modalities of arousal organization may be identified: (1) the cyclic alternating pattern (CAP), correlated with successive upward (phase A) and downward (phase B) fluctuations of arousal and arousal-related vegetative functions, and (2) non-CAP, corresponding to a...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000117353

    authors: Terzano MG,Parrino L,Spaggiari MC

    更新日期:1990-01-01 00:00:00

  • Sleep disorders and multiple sclerosis: a clinical and polysomnography study.

    abstract:BACKGROUND:Patients with multiple sclerosis (MS) report sleep disturbances (SD) and excessive daytime sleepiness (EDS) more frequently than the general population. Our objectives were to evaluate SD and EDS in MS patients and to test the reliability of subjective sleep questionnaires. METHODS:Demographic and clinical ...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000335076

    authors: Neau JP,Paquereau J,Auche V,Mathis S,Godeneche G,Ciron J,Moinot N,Bouche G

    更新日期:2012-01-01 00:00:00

  • Coenzyme Q10 treatment in mitochondrial encephalomyopathies. Short-term double-blind, crossover study.

    abstract::We report a short-term double-blind, crossover study of CoQ10 in 8 patients with mitochondrial encephalomyopathies. Four patients had myoclonus epilepsy with ragged-red fibers syndrome, 3 had mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes syndrome, and 1 had chronic progressive extern...

    journal_title:European neurology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000117445

    authors: Chen RS,Huang CC,Chu NS

    更新日期:1997-01-01 00:00:00

  • Observations on the blink reflex.

    abstract::The blink reflex and its equivalent glabella tap reflex are behavioural motor responses normally found in neonates and in the physiological startle reflex. Historically, it was described by Overend in 1896 and soon afterwards by McCarthy and by Bekhterev who disputed its origins. Kugelberg in 1952 recorded the early-l...

    journal_title:European neurology

    pub_type: 历史文章,杂志文章,评审

    doi:10.1159/000114053

    authors: Pearce JM

    更新日期:2008-01-01 00:00:00

  • The Topography of Cortical Microinfarcts in Neurodegenerative Diseases and in Vascular Dementia: A Postmortem 7.0-Tesla Magnetic Resonance Imaging Study.

    abstract:BACKGROUND:Cortical microinfarcts (CoMIs) are considered as barely visible lesions in clinical-neuroradiological correlation studies. On postmortem 7.0-tesla MRI, however, CoMIs of different size are easily detected. SUMMARY:The present MRI study investigates 84 postmortem brains with different neurodegenerative disea...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000447297

    authors: De Reuck JL,Auger F,Durieux N,Cordonnier C,Deramecourt V,Pasquier F,Maurage CA,Leys D,Bordet R

    更新日期:2016-01-01 00:00:00

  • Neurology and the lupus anticoagulant.

    abstract::The lupus anticoagulant, an immunoglobulin of the IgG or IgM class, is one of a group of antiphospholipid antibodies. Although an anticoagulant in vitro, its action in vivo is that of a procoagulant. This procoagulant activity may involve many organ systems including the nervous system. Thus far cerebral thrombosis, s...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000115836

    authors: Englert H,Derue G,Hughes GR

    更新日期:1985-01-01 00:00:00