Abstract:
:A double-blind controlled trial was performed on 6 patients affected with Steinert's disease in order to evaluate the efficacy of two different dosages of diphenylhydantoin (PHT, 200 and 300 mg/day) and carbamazepine (CBZ, 600 and 800 mg/day) on the myotonic afterdischarge. Both dosages of PHT and CBZ induced a significant improvement of myotonia. For PHT a trend towards decreased efficacy is pointed out at toxic or at high dosages.
journal_name
Eur Neuroljournal_title
European neurologyauthors
Sechi GP,Traccis S,Durelli L,Monaco F,Mutani Rdoi
10.1159/000115546subject
Has Abstractpub_date
1983-01-01 00:00:00pages
113-8issue
2eissn
0014-3022issn
1421-9913journal_volume
22pub_type
临床试验,杂志文章abstract::The urinary clearance of pyridostigmine was studied in six patients with myasthenia gravis. In three patients on pyridostigmine alone, renal clearance ranged from 349 to 481 ml/min, corresponding to a pyridostigmine:creatinine clearance ratio of 2.64 to 3.46. In a patient on bendrofluazide as well as pyridostigmine, a...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000114882
更新日期:1977-01-01 00:00:00
abstract::MPTP, 1-methyl-4-phenyl-pyridinium ion (MPP+) and the structurally related compounds including N-methyltetrahydroisoquinilinium ion inhibited the tyrosine hydroxylase (TH) system in tissue slices of rat striatum at 10(-5) M. Mouse striatum is more susceptible to MPTP than rat striatum. A similar degree of inhibition b...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116350
更新日期:1987-01-01 00:00:00
abstract:AIM:To determine whether corpus callosum atrophy predicts future clinical deterioration in multiple sclerosis. METHODS:In 39 multiple sclerosis patients the area of corpus callosum in the sagittal plane, T2 and T1 lesion volumes, brain parenchymal fraction and brain atrophy were determined at baseline and 1 year after...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000337683
更新日期:2012-01-01 00:00:00
abstract::The case of an 8-year-old boy presenting diffuse, prevalently right-sided nevus flammeus, venous angioma of the right cerebral hemisphere, right-sided facial hyperplasia, lef-handedness and recurring strokes is reported together with the clinical, angiographic and CT features. ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115201
更新日期:1981-01-01 00:00:00
abstract::Dementia is one of the most common organic mental syndromes, usually caused by Alzheimer's disease (AD) or vascular dementia (VD) or both. Regarding AD we review the state or the art of the cholinergic approach and discuss some future options regarding preventive and nonsymptomatic strategies. Therapy for VD will cons...
journal_title:European neurology
pub_type: 杂志文章,评审
doi:10.1159/000113372
更新日期:1997-01-01 00:00:00
abstract::A randomized, double-blind trial on the effects of GM1 ganglioside in cerebrovascular diseases was done on 40 patients; the treatment (40 mg/day i.m. injection) began after the acute phase and lasted 6 weeks. 18 cases took the drug and 16 the placebo. The evaluation of the cases was made by graduating the severity of ...
journal_title:European neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000115823
更新日期:1985-01-01 00:00:00
abstract::Experimental results suggested a modulation or 'programming' interaction of delta sleep-inducing peptide (DSIP) with endogenous opioid-peptidergic systems and exogenous intracerebrally or systemically administered morphine and amphetamine. The induction of cerebral MAO-A activity, a pronounced influence on the circadi...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115716
更新日期:1984-01-01 00:00:00
abstract::13 patients with spinal dural arteriovenous fistulas (DAVF) diagnosed in our Institution have been the object of this study. The necessity to include the disease in the differential diagnosis with other pathologies affecting the lower thoracic cord, particularly in middle-aged and old males, is emphasized. Involvement...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000117015
更新日期:1994-01-01 00:00:00
abstract::We report a patient who showed exaggerated responses to external cues (utilization behavior), motor impersistence, and a right-hand-predominant instinctive grasp reaction after right thalamic infarction. High-resolution computed tomography with stereotaxic lesion localization revealed almost complete destruction of th...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000117092
更新日期:1995-01-01 00:00:00
abstract::In the last 2 years we have systematically treated 31 sleep apnea patients with 25-50 mg imipramine HCl given 30 min before bedtime. Imipramine treatment was attempted for nonoverweight patients with negative ear, nose and throat (ENT) findings and for patients who had not responded to weight reduction or ENT surgery ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115991
更新日期:1986-01-01 00:00:00
abstract::The cerebral hemispheres show prominent involvement in hypertensive encephalopathy far more frequently than the brainstem. Two patients with severe paroxysmally accelerated hypertension associated with brainstem hyperintensity in T2-weighted magnetic resonance images are presented. Both present hyperintense lesions im...
journal_title:European neurology
pub_type: 杂志文章,评审
doi:10.1159/000100015
更新日期:2007-01-01 00:00:00
abstract:INTRODUCTION:We investigated the predictive value of standard neurological evaluation, a commercially available biomarker assay and neuroimaging in the subacute phase for outcome after thrombolytic therapy in ischemic stroke. METHODS:Thirty-four consecutive ischemic stroke patients were evaluated by means of the NIH S...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000215876
更新日期:2009-01-01 00:00:00
abstract::We report a laser microprobe mass analysis of aluminum and iron content in the hippocampus and in the inferior temporal cortex in 2 cases of dementia pugilistica (DP), 4 cases of Alzheimer's disease (AD), and 3 controls. There was a predominant accumulation of Al and Fe within neurofibrillary tangles (NFT) in both DP ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000112903
更新日期:1997-01-01 00:00:00
abstract::This study aimed at examining correlations between quantitative REM sleep EEG, regional cerebral blood flow measured by single photon emission computerized tomography (SPECT) and global cognitive functioning in nine patients with mild to moderate Alzheimer's disease. REM sleep EEG was not correlated with SPECT measure...
journal_title:European neurology
pub_type: 临床试验,杂志文章
doi:10.1159/000117247
更新日期:1996-01-01 00:00:00
abstract::31 children aged between 6 weeks and 15 years, who had suffered a stroke, were investigated by computer tomography (CT). 8 patients had suffered transient ischemic attacks (TIA), 17 had completed ischemic strokes and 6 had hemorrhagic strokes. The mean interval between the stroke and the first CT investigation was 5 d...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115486
更新日期:1982-01-01 00:00:00
abstract:AIMS:We conducted this study to investigate the independent association of medial temporal atrophy (MTA) and white matter hyperintensities (WMH) with cognitive impairments of Alzheimer's disease (AD) patients and the interaction between MTA and WMH. METHODS:From 13 centers, a total of 216 AD patients were consecutivel...
journal_title:European neurology
pub_type: 杂志文章,多中心研究
doi:10.1159/000329277
更新日期:2011-01-01 00:00:00
abstract::The serum concentration of S-100B is reported to reflect the severity of brain damage. The purpose of this study was to determine whether elevated serum S-100B concentrations were related to neuropsychological test performance of patients in the subacute phase of recovery from mild traumatic brain injury (TBI). S-100B...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000083678
更新日期:2005-01-01 00:00:00
abstract::In a group of 60 patients of which 30 were affected by myasthenia, we used the regional curare test. The results were evaluated from a critical point of view and were then compared with the results obtained by the repetitive stimulation of the circumflex nerve, deriving from deltoid muscle. We considered too the speci...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000114813
更新日期:1977-01-01 00:00:00
abstract:BACKGROUND AND STUDY PURPOSE:Autonomic nervous system dysfunction is a common complication of acute cerebrovascular disorders. The aim of this study was to investigate a possible location-dependent difference in cardio-autonomic function in patients with ischaemic stroke. PATIENTS AND METHODS:Sympathetic function was ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000070856
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND/AIMS:We prospectively assessed the frequency, type, severity and cause of treatment among the long-term residents of the Kork Epilepsy Centre in the year 2005. METHODS:All long-term residents were exclusively referred to the general surgeon practicing on the campus. Patients were divided into 2 groups compr...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000318171
更新日期:2010-01-01 00:00:00
abstract::Many gadolinium-enhanced magnetic resonance imaging (MRI) studies focusing on the anatomy and pathology of the 7th cranial nerve have already been published. However, only scattered cases of herpes zoster oticus (HZO) have been described and only the MRI appearance of the soft temporal bone structures has been reporte...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000007900
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Mood disorder is a frequent complication of stroke. Comorbid depressive and anxiety disorders are very common, indicating that it is advisable to assess both disorders at the same time. The aim of the present study was to examine the prevalence of post-stroke depression (PSD) and poststroke anxiety (PSA) at ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000332585
更新日期:2011-01-01 00:00:00
abstract::Kearns-Sayre syndrome has been associated with large heteroplasmic mitochondrial DNA deletions and morphological alterations at the cytological level. We have measured the activities of different respiratory chain complexes in 3 patients presenting mitochondrial DNA deletions and found no close correlation between gen...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116656
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:The pathogenesis of card game-induced reflex epilepsy has not been determined so far. The aim of this study was to evaluate structural abnormalities using voxel-based morphometry (VBM) analysis, which may give some clue about the pathogenesis in card game-induced reflex epilepsy. METHODS:The 3 subjects were...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000447537
更新日期:2016-01-01 00:00:00
abstract::Lumbar CSF concentrations of homovanillic acid (HVA) and 5-hydroxyindole-acetic acid (5HIAA) have been determined in ten patients suffering from chronic brain post-traumatic syndromes, at various length of time after the brain trauma. Lower concentrations of HVA (mean 21 +/- 14 mug/ml) compared to controls (mean 46 +/...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000114709
更新日期:1975-01-01 00:00:00
abstract::To clarify the function of human atrial natriuretic peptide (hANP) in the cerebrospinal fluid (CSF), we examined hANP levels in the CSF of patients with various neurological diseases. The subjects were 16 controls without neurological disease and 45 patients with neurological disease. The 45 patients with neurological...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000113166
更新日期:1997-01-01 00:00:00
abstract::Three patients with cerebral tumor involving diencephalic midline structures (2 malignant gliomas, 1 craniopharyngioma) and no metabolic abnormalities developed disorientation in time and place or coma with triphasic waves (TW) seen on electroencephalograms. Serial EEG recordings showed persistence or disappearance of...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116614
更新日期:1990-01-01 00:00:00
abstract:OBJECTIVE:The history of Sayk's cell sedimentation chamber is examined and reviewed in the context of clinically utilizable cerebrospinal fluid (CSF) cytology. METHODS:A review of the literature was undertaken in PubMed and Google Scholar to search for primary and secondary sources on the history of CSF diagnosis. Mor...
journal_title:European neurology
pub_type: 历史文章,杂志文章
doi:10.1159/000456003
更新日期:2017-01-01 00:00:00
abstract::Although many studies have been performed on nervous tissue pathology in Guillain-Barré syndrome (GBS), much less is known about pathological changes in skeletal muscle in this disorder. We have studied muscle biopsies from 5 patients with GBS, 5 patients with amyotrophic lateral sclerosis (control A), and 5 patients ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000007924
更新日期:1998-01-01 00:00:00
abstract::The pathogenesis of Parkinson's disease (PD) has been linked to oxidative-mediated events including increased monoamine oxidase (MAO) and free-radical generation. We are investigating the ability of the MAO inhibitor, selegiline (deprenyl), and of the free-radical scavenger, tocopherol, to delay the onset of disabilit...
journal_title:European neurology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1159/000116869
更新日期:1992-01-01 00:00:00