Inhibition of the tyrosine hydroxylase system by MPTP, 1-methyl-4-phenylpyridinium ion (MPP+) and the structurally related compounds in vitro and in vivo.

abstract：BACKGROUND/AIM:Although most late-onset seizures (LS) appear within 2 years after stroke, some of them occur later and their characteristics are unknown. The aim of this study was to compare the characteristics of patients with very-late-onset seizures (VLS) to those with early-onset seizures (ES) and those with LS. P...

journal_title：European neurology

authors： De Reuck J,Sieben A,Van Maele G

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:The pathogenesis of card game-induced reflex epilepsy has not been determined so far. The aim of this study was to evaluate structural abnormalities using voxel-based morphometry (VBM) analysis, which may give some clue about the pathogenesis in card game-induced reflex epilepsy. METHODS:The 3 subjects were...

journal_title：European neurology

authors： Park KM,Kim SE,Lee BI

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Large cavitary lesions are not typical for multiple sclerosis (MS). Cavitary white matter changes may be seen in megalencephalic leukoencephalopathy with subcortical cysts, Alexander disease, mitochondrial leukoencephalopathies, vanishing white matter disease, leukoencephalopathy with calcifications and cyst...

journal_title：European neurology

authors： Renard D,Brochet B,Vukusic S,Edan G,Deburghgraeve V,Goizet C,Dupuy D,Touze E,Deschamps R,Zephyr H,Creange A,Castelnovo G,Boespflug-Tanguy O,Labauge P

更新日期：2012-01-01 00:00:00

abstract：:We describe a case presenting continuous muscle fiber activity syndrome, which was slightly reduced by the blocking of nerve conduction and abolished by ischemia. Clinical, electromyographical and bioptical evidence of marked abnormalities of peripheral motoneurons were observed. Association with central motoneuron le...

journal_title：European neurology

authors： Cotrufo R,Di Iorio G,Ammendola A,Bravaccio F

更新日期：1982-01-01 00:00:00

abstract：:A 9-year-old girl with huge, double arachnoid cysts at the cerebellopontine angle is reported. After a cyst-peritoneal shunt operation, she developed fine, high-frequency gaze nystagmus towards the lesion side combined with coarse, large amplitude nystagmus in the opposite direction, which is the reverse of the Bruns'...

journal_title：European neurology

authors： Yokota J,Imai H,Okuda O,Sato K

更新日期：1993-01-01 00:00:00

abstract：:Two cases of lithium neurotoxic effects are reported. Both cases are expressed by choreoathetotic movements and in both of them intoxication was caused by combined drug therapy. In our opinion caution is advised when lithium is administered in combination with drugs, especially in elderly patients. ...

journal_title：European neurology

authors： Walevski A,Radwan M

更新日期：1986-01-01 00:00:00

abstract：:This study investigates the remote effects of botulinum toxin injections by examining the motor unit architecture of noninjected distant muscles. In 21 dystonia patients treated with botulinum toxin (n = 11, mean cumulative dose = 815 mU; n = 10, mean cumulative dose = 7,207 mU) and 10 control individuals, a blinded s...

journal_title：European neurology

authors： Fertl E,Schnider P,Schneider B,Auff E

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Previous studies showed that late-life depression with subjective memory complaints (SMC) may be associated with an increased risk of developing dementia. However, not all such patients have cognitive decline. The aim of this longitudinal study was to identify possible clinical determinants of progressive de...

journal_title：European neurology

authors： von Gunten A,Giannakopoulos P,Duc R

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Cardiac myxomas may present clinically with many different features. Since highly effective treatments exist, it is important that they are diagnosed quickly in order to avoid further complications. Our aim was to determine the influence of neurological presentation in diagnosis and prognosis of car...

journal_title：European neurology

authors： Alvarez-Sabín J,Lozano M,Sastre-Garriga J,Montoyo J,Murtra M,Abilleira S,Codina A

更新日期：2001-01-01 00:00:00

abstract：:Within non-rapid eye movement sleep, two complementary modalities of arousal organization may be identified: (1) the cyclic alternating pattern (CAP), correlated with successive upward (phase A) and downward (phase B) fluctuations of arousal and arousal-related vegetative functions, and (2) non-CAP, corresponding to a...

journal_title：European neurology

authors： Terzano MG,Parrino L,Spaggiari MC

更新日期：1990-01-01 00:00:00

abstract：:The purpose of this study was to evaluate the contribution of the postsynaptic mechanism to the development of motor fluctuation in advanced Parkinson's disease (PD). We used 123I-iodobenzamide single-photon emission computed tomography to measure the striatal dopamine D2 receptor densities in early levodopa-naïve PD,...

journal_title：European neurology

authors： Hwang WJ,Yao WJ,Wey SP,Shen LH,Ting G

更新日期：2002-01-01 00:00:00

abstract：:Current treatment options for restless legs syndrome (RLS), based on the American Academy of Sleep Medicine practice parameters, favor dopaminergic agents. The drug of first choice is levodopa, which is now licensed for RLS in two European countries. However, the short duration of action and augmentation of symptoms u...

journal_title：European neurology

authors： Stiasny K

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND/AIMS:Whereas insomnia is frequent in restless legs syndrome (RLS), little is known about daytime sleepiness. We studied a series of 27 consecutive patients with idiopathic RLS in order to identify the characteristics and evolution of excessive daytime sleepiness (EDS) under dopaminergic treatment. METHODS:P...

journal_title：European neurology

authors： Kallweit U,Siccoli MM,Poryazova R,Werth E,Bassetti CL

更新日期：2009-01-01 00:00:00

abstract：:Percussion of the skull dates from a time when there were virtually no radiological methods for examining the skull and brain. Three apparently independent contributions appeared within the years 1893-1895. The sound elicited, tenderness, and auscultatory percussion have each been employed for diagnostic purposes, but...

journal_title：European neurology

authors： Pearce JM

更新日期：2008-01-01 00:00:00

abstract：:The interpretation of the total phenytoin (PT) concentration can be problematic if valproic acid (VPA) is given as a comedication, because VPA displaces PT from the protein binding sites and can increase the free fraction of PT. In order to estimate the free or unbound PT concentration (PTf) from the total PT concentr...

journal_title：European neurology

authors： May TW,Rambeck B,Nothbaum N

更新日期：1991-01-01 00:00:00

abstract：:In recent years, the involvement of the immune system in acquired forms of cerebellar ataxia has been frequently demonstrated. In this study, we describe 6 out of 49 patients with subacute or chronic progressive cerebellar ataxia in whom antibodies against neuronal and non-neuronal antigens were identified. Two women ...

journal_title：European neurology

authors： Fancellu R,Pareyson D,Corsini E,Salsano E,Laurà M,Bernardi G,Antozzi C,Andreetta F,Colecchia M,Di Donato S,Mariotti C

更新日期：2009-01-01 00:00:00

abstract：:13 patients with spinal dural arteriovenous fistulas (DAVF) diagnosed in our Institution have been the object of this study. The necessity to include the disease in the differential diagnosis with other pathologies affecting the lower thoracic cord, particularly in middle-aged and old males, is emphasized. Involvement...

journal_title：European neurology

authors： Bradac GB,Daniele D,Riva A,Bracchi M,Stura G,Riccio A,Pagni CA

更新日期：1994-01-01 00:00:00

abstract：:The Uhthoff symptom, a transient impairment of visual function after exercise, is demonstrated in 2 multiple sclerosis patients. Following exercise, impairment of visual function, as documented most clearly by the testing of contrast sensitivity, was less obvious after body surface cooling and after treatment with ora...

journal_title：European neurology

authors： van Diemen HA,van Dongen MM,Dammers JW,Polman CH

更新日期：1992-01-01 00:00:00

abstract：:A 47-year-old woman presented with paralysis of upward gaze associated with Addison's pernicious anaemia. Administration of cyanocobalamin resulted in significant improvement of eye movements and haematological parameters. Isolated paralysis of upward gaze may be a feature of vitamin B12 deficiency. ...

journal_title：European neurology

authors： Sandyk R

更新日期：1984-01-01 00:00:00

abstract：:Machado-Joseph disease (MJD) is a dominantly inherited cerebellar ataxia associated with spasticity, ophthalmoplegia, dystonia and peripheral neuropathy. Presented here are 5 MJD cases. A morphometric analysis of the histopathology of their sural nerves was carried out to know the relationship between axon size and my...

journal_title：European neurology

authors： Lin KP,Soong BW

更新日期：2002-01-01 00:00:00

abstract：:Three patients with cerebral tumor involving diencephalic midline structures (2 malignant gliomas, 1 craniopharyngioma) and no metabolic abnormalities developed disorientation in time and place or coma with triphasic waves (TW) seen on electroencephalograms. Serial EEG recordings showed persistence or disappearance of...

journal_title：European neurology

authors： Aguglia U,Gambardella A,Oliveri RL,Lavano A,Camerlingo R,Quattrone A

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:To examine the therapeutic effect of intravenous recombinant tissue plasminogen activator (rt-PA) therapy for stroke patients receiving maintenance hemodialysis (HD). methods: Of 600 stroke patients receiving intravenous rt-PA using 0.6 mg/kg alteplase who were enrolled in a multicenter observational study i...

journal_title：European neurology

authors： Naganuma M,Mori M,Nezu T,Makihara N,Koga M,Okada Y,Minematsu K,Toyoda K,SAMURAI Study Investigators.

更新日期：2011-01-01 00:00:00

abstract：:A 20-year-old woman with Kearns-Sayre syndrome (KSS) suddenly experienced two episodes of diabetic coma. She was studied to determine whether diabetes mellitus (DM) resulted from insulin resistance or from an insulin secretion abnormality, using the euglycemic glucose clamp technique and the glucagon tolerance test. S...

journal_title：European neurology

authors： Tanabe Y,Miyamoto S,Kinoshita Y,Yamada K,Sasaki N,Makino E,Nakajima H

更新日期：1988-01-01 00:00:00

abstract：:A young man presented with myokymias, cramp-like difficulty in muscle relaxation and peroneal atrophy. EMG studies revealed continuous muscle activity (CMA) manifested as grouped potentials and high frequency discharges. Sensory nerve conduction studies and sural nerve biopsy gave normal results, and he was thought to...

journal_title：European neurology

authors： Castilla JM,Alberca R,Chinchon I,Gil-Neciga E,Rafel E

更新日期：1991-01-01 00:00:00

abstract：:We report a patient with Down's syndrome (DS) who developed progressive parkinsonian symptomatology at the age of 43 years. His parkinsonism was responsive to levodopa/carbidopa, but he developed end of dose wearing off. We discuss basal ganglia and dopamine abnormalities in DS and suggest that DS may be associated wi...

journal_title：European neurology

authors： Singer C,Sanchez-Ramos J,Weiner WJ

更新日期：1990-01-01 00:00:00

abstract：:About one third of patients with newly diagnosed epilepsy do not achieve seizure control despite medical therapy and should be assessed in detail to confirm the diagnosis, to determine the epilepsy syndrome and to plan treatment strategy. Refractory epilepsy is established when there is inadequate seizure control desp...

journal_title：European neurology

authors： Beleza P

更新日期：2009-01-01 00:00:00

abstract：:The pathogenesis of Parkinson's disease (PD) has been linked to oxidative-mediated events including increased monoamine oxidase (MAO) and free-radical generation. We are investigating the ability of the MAO inhibitor, selegiline (deprenyl), and of the free-radical scavenger, tocopherol, to delay the onset of disabilit...

journal_title：European neurology

authors： Shoulson I

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Transient ischemic attacks (TIAs) bear a presumed high risk of early recurrence of stroke. Data in the literature, however, are inconsistent, as recurrence rates range from 9.5 to 20%, at 90 days. AIMS:The study was designed to determine the risk of stroke after TIA. METHODS:94 consecutive patients referre...

journal_title：European neurology

authors： Tari Capone F,Cavallari M,Casolla B,Caselli G,Pieroni A,Di Lazzaro V,Napolitano S,Stanzione P,Puca E,Toni D,Rasura M,Orzi F

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:Evaluation for surgical treatment is offered to patients who do not respond to antiepileptic drugs. Pseudo-pharmacoresistance (PPR) has been described in the context of impaired compliance, incorrect diagnosis of epilepsy or pharmacological interference resulting in too low blood levels. We were interested to...

journal_title：European neurology

authors： Constantinescu I,Korff CM,Vulliemoz S,Picard F,Seeck M

更新日期：2017-01-01 00:00:00

abstract：:The association of anaemia and gastro-intestinal abnormalities with disorders of the brain, spinal cord, and peripheral nerves has been recognized since the mid 19th century. In early reports interpretable as subacute combined degeneration, anaemia was overlooked, and conversely in Addison's and other early reports of...

journal_title：European neurology

authors： Pearce JM

更新日期：2008-01-01 00:00:00