Abstract:
:We report a patient with Down's syndrome (DS) who developed progressive parkinsonian symptomatology at the age of 43 years. His parkinsonism was responsive to levodopa/carbidopa, but he developed end of dose wearing off. We discuss basal ganglia and dopamine abnormalities in DS and suggest that DS may be associated with parkinsonism.
journal_name
Eur Neuroljournal_title
European neurologyauthors
Singer C,Sanchez-Ramos J,Weiner WJdoi
10.1159/000117355subject
Has Abstractpub_date
1990-01-01 00:00:00pages
247-8issue
5eissn
0014-3022issn
1421-9913journal_volume
30pub_type
杂志文章abstract::Automatic analysis of EMG (T/A analysis) and invasive muscle fiber conduction velocity in situ (MFCV) were performed in 15 patients after traumatic lesions of the knee and immobilization with quadriceps atrophy. T/A analysis showed transient reduced number of turns, consistent with inhibition of quadriceps motoneurons...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000008145
更新日期:2000-01-01 00:00:00
abstract:AIM:To determine whether corpus callosum atrophy predicts future clinical deterioration in multiple sclerosis. METHODS:In 39 multiple sclerosis patients the area of corpus callosum in the sagittal plane, T2 and T1 lesion volumes, brain parenchymal fraction and brain atrophy were determined at baseline and 1 year after...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000337683
更新日期:2012-01-01 00:00:00
abstract::Fatigue is one of the most frequent and most disabling symptoms in multiple sclerosis (MS). We investigated the possible association of the MS-related fatigue syndrome with the available disease-modifying therapies and the main disease characteristics in a cross-sectional study on 320 consecutive patients. The prevale...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000111876
更新日期:2008-01-01 00:00:00
abstract::Although repetitive transcranial magnetic stimulation (rTMS) for hemiparesis is beneficial, so far no study has examined the usefulness of rTMS for apathy. Thirteen patients with chronic stroke were assigned randomly to 2 groups: rTMS group (n = 7) and sham stimulation group (n = 6). The patients received 5 sessions o...
journal_title:European neurology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000477440
更新日期:2017-01-01 00:00:00
abstract::A 47-year-old woman presented with paralysis of upward gaze associated with Addison's pernicious anaemia. Administration of cyanocobalamin resulted in significant improvement of eye movements and haematological parameters. Isolated paralysis of upward gaze may be a feature of vitamin B12 deficiency. ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115702
更新日期:1984-01-01 00:00:00
abstract::Calcium ions play a major role in the regulation of cell functions. Minor alterations of the cellular calcium ion homeostasis lead to major functional aberrations. Alterations of the calcium homeostasis occur under conditions of hypoxia, the major cause being an extracellular increase of potassium ions which gate volt...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116059
更新日期:1986-01-01 00:00:00
abstract::We report a 17-year-old patient who presented a chronic relapsing sensorimotor demyelinating neuropathy with 6 relapses over a 7-year period, preceding by 4 years the diagnosis of a multicentric angiofollicular lymph node hyperplasia. A role for Epstein-Barr virus (EBV) as a trigger of the neuropathy may be suggested ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000117156
更新日期:1995-01-01 00:00:00
abstract::We present a long-term follow-up examination concerning patients with isolated extra-ocular muscle involvement in thyroid-related orbitopathy. Within the previous 13 years we observed 7 patients with endocrine orbitopathy and marked myopathy of the extra-ocular muscles. Five of these patients had no detectable proptos...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000131894
更新日期:2008-01-01 00:00:00
abstract::The clinical severity of EAE is enhanced by pre-treatment with distemper, measles and BCG vaccine, measles vaccine gives a more severe onset of disease. Rubella vaccine and TAB leads to mild disease which recurs on re-treatment with the appropriate vaccine. These findings and their possible significance in MS are brie...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000114898
更新日期:1977-01-01 00:00:00
abstract::The purpose of this pilot study was to determine whether 20 mg oral 311C90 can prevent the development of migraine headache when taken during the aura phase of a migraine attack. The study also aimed to provide an initial safety profile for 311C90 when taken during the aura. Forty patients (31 females, 9 males) were e...
journal_title:European neurology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1159/000119101
更新日期:1996-01-01 00:00:00
abstract::Although multifocal motor neuropathy (MMN) is now recognized as a distinct, albeit rare, neurological condition, the path to its recognition was long and winding. This article provides an insight into the medical history of MMN "patient zero" and the first scientific publication that led to the recognition of MMN by t...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000511732
更新日期:2020-11-11 00:00:00
abstract:BACKGROUND/AIM:In this case-control study, our aim was to check for a possible independent role of hypertension in increasing the risk of developing Bell's palsy. METHODS:All patients diagnosed as having Bell's palsy referred to a neurology clinic were enrolled as cases. Controls were selected among other patients ref...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000151701
更新日期:2008-01-01 00:00:00
abstract::The present paper is a study of a microcystic intraspinal tumour that developed in a 4-year-old child. The histologic examination showed the presence of neuroblastic elements developing next to smooth muscle fibers. The tumour had diffusely invaded the meninges, presenting a marked collagen reaction. Ultrastructurally...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000114682
更新日期:1975-01-01 00:00:00
abstract:BACKGROUND:Platelet counts (PCs) <100,000/µl are considered as a contraindication for intravenous thrombolysis (IVT). While US guidelines recommend IVT initiation before the availability of clotting tests, the guidelines of the European Stroke Organization give no such practical advice. We aimed to assess the incidence...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000345702
更新日期:2013-01-01 00:00:00
abstract::In recent years, the involvement of the immune system in acquired forms of cerebellar ataxia has been frequently demonstrated. In this study, we describe 6 out of 49 patients with subacute or chronic progressive cerebellar ataxia in whom antibodies against neuronal and non-neuronal antigens were identified. Two women ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000242010
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Tetrahydrocannabinol:cannabidiol (THC:CBD) oromucosal spray (Sativex®) is an add-on therapy for moderate-to-severe multiple sclerosis (MS)-related drug-resistant spasticity (MSS). AIM:The MOVE-2 EU study collected data from everyday clinical practice concerning the effectiveness and tolerability of THC:CBD....
journal_title:European neurology
pub_type: 杂志文章,多中心研究
doi:10.1159/000449413
更新日期:2016-01-01 00:00:00
abstract:AIMS:We conducted this study to investigate the independent association of medial temporal atrophy (MTA) and white matter hyperintensities (WMH) with cognitive impairments of Alzheimer's disease (AD) patients and the interaction between MTA and WMH. METHODS:From 13 centers, a total of 216 AD patients were consecutivel...
journal_title:European neurology
pub_type: 杂志文章,多中心研究
doi:10.1159/000329277
更新日期:2011-01-01 00:00:00
abstract::18F-Dopa positron emission tomography (PET) provides a sensitive means of quantitating the loss of nigrostriatal dopaminergic fibres in Parkinson's disease and so can be used to diagnose its presence and to objectively follow the rate of disease progression. It can also be used, in principle, to determine the efficacy...
journal_title:European neurology
pub_type: 杂志文章,评审
doi:10.1159/000113473
更新日期:1997-01-01 00:00:00
abstract::We report on management strategies and clinical outcomes in 4 cases of acute symptomatic congestive intracranial hypertension associated with cerebral arteriovenous malformations (AVMs). Congestion resulted from high-volume shunts exhausting the drainage capacity of the cerebral venous system in 3 patients, and from s...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000109263
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:We investigated the predictive value of standard neurological evaluation, a commercially available biomarker assay and neuroimaging in the subacute phase for outcome after thrombolytic therapy in ischemic stroke. METHODS:Thirty-four consecutive ischemic stroke patients were evaluated by means of the NIH S...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000215876
更新日期:2009-01-01 00:00:00
abstract::Dopamine uptake sites, labelled by 3 nM [3H]GBR 12935, were reduced by 28-34% in post-mortem Parkinson's diseased striata (n = 22) compared to control striata (n = 28). There was no significant difference between post-mortem striata from schizophrenics (n = 16) and controls. Both dopamine D1 and D2 receptors are consi...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000117168
更新日期:1990-01-01 00:00:00
abstract::The purpose of this study was to estimate the risk factors, early course, outcome and neuroimaging patterns in primary intracerebral hemorrhages (PIH). Using the Besançon Stroke Registry, 350 patients with first PIH documented by computed tomography (CT) between 1987 and 1993 were included in the present study. Patien...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000008177
更新日期:2000-01-01 00:00:00
abstract::Within non-rapid eye movement sleep, two complementary modalities of arousal organization may be identified: (1) the cyclic alternating pattern (CAP), correlated with successive upward (phase A) and downward (phase B) fluctuations of arousal and arousal-related vegetative functions, and (2) non-CAP, corresponding to a...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000117353
更新日期:1990-01-01 00:00:00
abstract::Thirty-three headache-free patients (19 F/14 M) suffering from common (n = 9) and classic migraine (n = 19) as well as cluster headache (n = 5) were investigated using the flow tracer 99mTc-hexamethyl propylenamino oxime and single photon emmission computed tomography. A regional decrease of cerebral tracer uptake was...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000117334
更新日期:1990-01-01 00:00:00
abstract::Morphological findings of 3 cases of Kaeser's scapulo-peroneal muscular atrophy are described. 1 of them is the first complete autopsy report on this disease. While the number of motor neurons in the spinal cord was grossly normal, the neuropil of the anterior horn exhibited axonal swellings, accumulations of possibly...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000114899
更新日期:1977-01-01 00:00:00
abstract:BACKGROUND:Effective management of multisymptomatic chronic diseases such as multiple sclerosis (MS) requires a multimodal, interdisciplinary approach. At MS clinics, numerous healthcare specialties are coordinated to provide patients with quality clinical care for all aspects of their disease. Settings and resource av...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000367620
更新日期:2014-01-01 00:00:00
abstract::In order to quantitatively assess the motor performance characteristics of 14 patients with congenital myotonia, the reaction time, speed of movement, synergy of different muscle groups and accuracy were measured. The Human Performance Measurement/Basic Elements of Performance device was used for recordings. Warned si...
journal_title:European neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000117129
更新日期:1995-01-01 00:00:00
abstract::The sensory conduction velocity of the median nerve has been determined according to the technique described by Buchthal and Rosenfalck in 32 pneumatic tool workers and in 32 normal controls of the same age group. In each worker and in 8 normals of the same age group the Meissner corpuscles of the skin of the thumb of...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000114887
更新日期:1977-01-01 00:00:00
abstract::The urinary clearance of pyridostigmine was studied in six patients with myasthenia gravis. In three patients on pyridostigmine alone, renal clearance ranged from 349 to 481 ml/min, corresponding to a pyridostigmine:creatinine clearance ratio of 2.64 to 3.46. In a patient on bendrofluazide as well as pyridostigmine, a...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000114882
更新日期:1977-01-01 00:00:00
abstract:BACKGROUND/AIMS:Newer Scandinavian data on intracerebral hemorrhage (ICH) are scarce. We aimed at providing updated community-based data on the incidence, characteristics and outcome of ICH leading to hospitalization in the southernmost region in Norway. METHODS:We analyzed data from all consecutive patients hospitali...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000336299
更新日期:2012-01-01 00:00:00