Dopamine uptake sites and dopamine receptors in Parkinson's disease and schizophrenia.

Abstract:

:Dopamine uptake sites, labelled by 3 nM [3H]GBR 12935, were reduced by 28-34% in post-mortem Parkinson's diseased striata (n = 22) compared to control striata (n = 28). There was no significant difference between post-mortem striata from schizophrenics (n = 16) and controls. Both dopamine D1 and D2 receptors are consistently elevated in Parkinson's diseased striata from patients who have not been medicated with L-dopa pre-mortem. Both these receptors are down-regulated by L-dopa pre-mortem. In schizophrenia, however, while the density of D1 receptors is similar to control, the D2 receptors are consistently elevated.

journal_name

Eur Neurol

journal_title

European neurology

authors

Pearce RK,Seeman P,Jellinger K,Tourtellotte WW

doi

10.1159/000117168

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

9-14

eissn

0014-3022

issn

1421-9913

journal_volume

30 Suppl 1

pub_type

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