Directional asymmetries of saccadic hypometria in patients with early Parkinson's disease and unilateral symptoms.

Abstract:

BACKGROUND:Saccade may be abnormal in Parkinson's disease (PD), but there have been no systematic studies on directional asymmetries of horizontal saccades in early PD. The aims of this study were to determine the saccadic abnormalities and their directional asymmetries. METHODS:We recorded visually guided horizontal prosaccades with random (random amplitudes and irregular time intervals) and regular (fixed amplitude and regular time interval) paradigms using video-oculography in 44 patients with unilateral symptoms and signs from early PD and in 26 controls. RESULTS:PD patients showed decreased saccadic amplitude compared to the controls, especially during regular paradigm while the saccadic latency did not differ between the groups. Patients with unilateral PD tended to show more severe saccadic hypometria toward the symptomatic side during the regu- lar paradigm, compared to normal control. CONCLUSION:Even in early PD patients, saccadic accuracy may be abnormal. Asymmetries in saccadic hypometria are more likely to be detected during the anticipatable saccadic paradigm, which could be a useful adjunct in the diagnosis of early-stage PD.

journal_name

Eur Neurol

journal_title

European neurology

authors

Choi SM,Lee SH,Choi KH,Nam TS,Kim JT,Park MS,Kim BC,Kim MK,Cho KH

doi

10.1159/000330671

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

170-4

issue

3

eissn

0014-3022

issn

1421-9913

pii

000330671

journal_volume

66

pub_type

杂志文章
  • Immunological reactivity against neuronal and non-neuronal antigens in sporadic adult-onset cerebellar ataxia.

    abstract::In recent years, the involvement of the immune system in acquired forms of cerebellar ataxia has been frequently demonstrated. In this study, we describe 6 out of 49 patients with subacute or chronic progressive cerebellar ataxia in whom antibodies against neuronal and non-neuronal antigens were identified. Two women ...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000242010

    authors: Fancellu R,Pareyson D,Corsini E,Salsano E,Laurà M,Bernardi G,Antozzi C,Andreetta F,Colecchia M,Di Donato S,Mariotti C

    更新日期:2009-01-01 00:00:00

  • Loss of dopamine uptake sites labeled with [3H]GBR-12935 in Alzheimer's disease.

    abstract::The binding of the dopamine uptake inhibitor [3H]GBR-12935 to postmortem putamen from a control group and patients with Alzheimer's disease/senile dementia of Alzheimer type (AD/SDAT) or vascular dementia (VD) was studied. The binding density (Bmax) in AD/SDAT was significantly reduced to 50% of control. A reduction o...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000117341

    authors: Allard P,Alafuzoff I,Carlsson A,Eriksson K,Ericson E,Gottfries CG,Marcusson JO

    更新日期:1990-01-01 00:00:00

  • Appearance of new lesions in two nonfamilial cerebral cavernoma patients.

    abstract::Cavernomas are vascular malformations mostly observed in the central nervous system. They occur in sporadic and familial forms. Familial forms are characterized by the presence of multiple lesions, an autosomal dominant pattern of inheritance and possible de novo lesions. We report two sporadic cases whose follow-up s...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000052100

    authors: Labauge P,Brunereau L,Coubes P,Clanet M,Tannier C,Laberge S,Lévy C

    更新日期:2001-01-01 00:00:00

  • Reduced serum caeruloplasmin levels in non-wilsonian movement disorders.

    abstract::Reduction in caeruloplasmin (Cp) levels is sometimes found in other sporadic movement disorders, not limited to Wilson's disease (WD). Serum levels of Cp, copper, iron and gamma-glutamyl transpeptidase were measured in 71 patients with various diagnoses of movement disorders, including Parkinson's disease (PD), atypic...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000330538

    authors: Ling H,Bhidayasiri R

    更新日期:2011-01-01 00:00:00

  • Central neuroblastic tumour associated with smooth muscle fibers. A study in the optic and electron microscopes.

    abstract::The present paper is a study of a microcystic intraspinal tumour that developed in a 4-year-old child. The histologic examination showed the presence of neuroblastic elements developing next to smooth muscle fibers. The tumour had diffusely invaded the meninges, presenting a marked collagen reaction. Ultrastructurally...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000114682

    authors: Vuia O,Hager H

    更新日期:1975-01-01 00:00:00

  • Inverted Bruns' nystagmus in arachnoid cysts of the cerebellopontine angle.

    abstract::A 9-year-old girl with huge, double arachnoid cysts at the cerebellopontine angle is reported. After a cyst-peritoneal shunt operation, she developed fine, high-frequency gaze nystagmus towards the lesion side combined with coarse, large amplitude nystagmus in the opposite direction, which is the reverse of the Bruns'...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116903

    authors: Yokota J,Imai H,Okuda O,Sato K

    更新日期:1993-01-01 00:00:00

  • Primary intracerebral hemorrhages in the Besançon stroke registry. Initial clinical and CT findings, early course and 30-day outcome in 350 patients.

    abstract::The purpose of this study was to estimate the risk factors, early course, outcome and neuroimaging patterns in primary intracerebral hemorrhages (PIH). Using the Besançon Stroke Registry, 350 patients with first PIH documented by computed tomography (CT) between 1987 and 1993 were included in the present study. Patien...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000008177

    authors: Tatu L,Moulin T,El Mohamad R,Vuillier F,Rumbach L,Czorny A

    更新日期:2000-01-01 00:00:00

  • Multiple sclerosis. A clinical study of 70 cases.

    abstract::70 cases of multiple sclerosis were seen at the Department of Neurology of the Capital Hospital in 1949--1977. There were 25 males and 45 females averaging 30.6 years of age. The most frequent sites of the lesions based on the clinical symptomatology were the spinal cord and optic nerve, the cerebellum was much less f...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000115267

    authors: Zhao BX,Liu XQ,Guo YP,Yang YC,Huang HF

    更新日期:1981-01-01 00:00:00

  • Verbal working memory deficit in Parkinson's disease subjects.

    abstract::The aim of the present work was to evaluate verbal working memory in patients affected by Parkinson's disease (PD). In particular, tests that explore the functionality of the Articulatory Loop and of the Central Executive during verbal tasks were given. PD patients displayed normal phonological similarity, word length...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000069417

    authors: Graceffa AM,Carlesimo GA,Peppe A,Caltagirone C

    更新日期:1999-01-01 00:00:00

  • Normal functional capacity of blood lymphocytes in multiple sclerosis measured by stimulation with mitogens.

    abstract::The effect of phytohemagglutinin (PHA) and pokeweed mitogen (PWM) on blood lymphocytes was studied in multiple sclerosis, patients with acute CNS infections, and healthy controls. No significant differences in lymphocyte proliferation were registered between the group of MS patients and the two other groups, irrespect...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000115075

    authors: Kinnman J,Link H,Frydén A

    更新日期:1979-01-01 00:00:00

  • Choreoathetosis as toxic effect of lithium treatment.

    abstract::Two cases of lithium neurotoxic effects are reported. Both cases are expressed by choreoathetotic movements and in both of them intoxication was caused by combined drug therapy. In our opinion caution is advised when lithium is administered in combination with drugs, especially in elderly patients. ...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116044

    authors: Walevski A,Radwan M

    更新日期:1986-01-01 00:00:00

  • Is there a need for alternative approaches in the therapy of cerebrovascular disorders?

    abstract::Acute ischemia of the brain induces a cascade of biochemical and physiological events. The final consequences depend on the fact whether ischemia is of transient or permanent, total or partial nature. Alteration of extracellular potassium concentration, intracellular calcium and potassium concentration, development of...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116058

    authors: Hartmann A

    更新日期:1986-01-01 00:00:00

  • Antioxidant status in acute stroke patients and patients at stroke risk.

    abstract:BACKGROUND AND PURPOSE:Antioxidant enzymes like copper/zinc superoxide dismutase (SOD), catalase and gluthatione peroxidase (GSHPx) are part of intracellular protection mechanisms to overcome oxidative stress and are known to be activated in vascular diseases and acute stroke. We investigated the differences of antioxi...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000077662

    authors: Zimmermann C,Winnefeld K,Streck S,Roskos M,Haberl RL

    更新日期:2004-01-01 00:00:00

  • Transitory alexia without agraphia in an HIV-positive patient suffering from toxoplasma encephalitis: a case report.

    abstract::An HIV-positive patient presented the classical syndrome of pure alexia. Neuroradiologic investigation by computed tomography showed a ring-like lesion in the left posterior white matter. The clinical manifestations as well as the radiologic findings resolved after antiprotozoal treatment. ...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116783

    authors: Lüscher C,Horber FF

    更新日期:1992-01-01 00:00:00

  • Thoracic hematomyelia secondary to coumadin anticoagulant therapy: a case report.

    abstract::A case of thoracic hematomyelia secondary to anticoagulant therapy is presented. Clinical features, similar to 2 other previously reported cases, are discussed. A high index of suspicion may lead to a quick diagnostic procedure and successful decompressive surgery. ...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116804

    authors: Constantini S,Ashkenazi E,Shoshan Y,Israel Z,Umansky F

    更新日期:1992-01-01 00:00:00

  • Utilization behavior after right thalamic infarction.

    abstract::We report a patient who showed exaggerated responses to external cues (utilization behavior), motor impersistence, and a right-hand-predominant instinctive grasp reaction after right thalamic infarction. High-resolution computed tomography with stereotaxic lesion localization revealed almost complete destruction of th...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000117092

    authors: Hashimoto R,Yoshida M,Tanaka Y

    更新日期:1995-01-01 00:00:00

  • Effects of nicorandil in neuroprotective activation of PI3K/AKT pathways in a cellular model of Alzheimer's disease.

    abstract::Nicorandil, an ATP-sensitive potassium (KATP) channel opener, is known to have protective effects on ischemic injury in heart and brain. One of the most important protective mechanisms is the anti-apoptotic effect on cardiomyocytes and neurons. This study explored the anti-apoptotic effect of nicorandil against neurot...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000351247

    authors: Kong J,Ren G,Jia N,Wang Y,Zhang H,Zhang W,Chen B,Cao Y

    更新日期:2013-01-01 00:00:00

  • On the legacy of Joseph Babiński.

    abstract::Joseph Babiński pioneered development of French neurosurgery and world clinical neurology. Although he was best known for his discovery of the extensor plantar response, his foundations in the modern semiology of neurology are unequivocal. He introduced the concepts and terminology of cerebellar symptoms and discovere...

    journal_title:European neurology

    pub_type: 传,历史文章,杂志文章

    doi:10.1159/000117107

    authors: Gasecki AP,Kwieciński H

    更新日期:1995-01-01 00:00:00

  • Positive Predictive Value of French Hospitalization Discharge Codes for Stroke and Transient Ischemic Attack.

    abstract:BACKGROUND:We aimed at measuring the positive predictive value (PPV) of data in the French Hospital Medical Information Database (FHD). SUMMARY:This retrospective multicenter study included 31 hospitals from where 56 hospital stays were randomly selected among all hospitalizations for the years 2009 and 2010 with at l...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000438859

    authors: Giroud M,Hommel M,Benzenine E,Fauconnier J,Béjot Y,Quantin C,FRESCO Study.

    更新日期:2015-01-01 00:00:00

  • Effects of Metabolic Syndrome on Cognitive Impairment with White Matter Lesions.

    abstract:OBJECTIVE:To explore the relationship between metabolic syndrome (MetS) and cognitive impairment in elderly patients with white matter lesions (WML). METHODS:From -January 2016 to June 2017, a cross-sectional study was conducted on the clinical data of 358 WML patients over 65 years old in the Department of Neurology ...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000505242

    authors: Chen L,Hong W,Yang H,Dong S,Peng Z,Zhou H

    更新日期:2019-01-01 00:00:00

  • Fisher's syndrome following trigeminal herpes zoster.

    abstract::A case of Fisher's syndrome associated with trigeminal herpes zoster is reported for the first time. Retrograde propagation of the virus to the brainstem through the trigeminal root was thought to be the most probable pathogenic mechanism. We provide additional evidence suggesting that the focus of Fisher's syndrome i...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000115817

    authors: Uematsu D,Satoh T,Tanahashi N,Koto A,Gotoh F

    更新日期:1985-01-01 00:00:00

  • Lack of association between Leber's hereditary optic neuropathy primary point mutations and multiple sclerosis in Iran.

    abstract::The hypothesis that mitochondrial genes may implicate susceptibility to multiple sclerosis (MS) is supported by an increasing number of case reports on Leber's hereditary optic neuropathy (LHON)-associated mitochondrial DNA (mtDNA) point mutations in patients with MS. A number of mtDNA mutations with primary pathogeni...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000075518

    authors: Houshmand M,Sanati MH,Rashedi I,Sharifpanah F,Asghari E,Lotfi J

    更新日期:2004-01-01 00:00:00

  • Blood Pressure Variability in Acute Ischemic Stroke: Influence of Infarct Location in the Insular Cortex.

    abstract:BACKGROUND:The aim of this study was to elucidate the influence of insular infarction on blood pressure (BP) variability and outcomes according to the region of the insular cortex affected. METHODS:A total of 90 patients diagnosed with acute unilateral ischemic stroke were registered. The BP variability was calculated...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000486306

    authors: Kitamura J,Ueno H,Nagai M,Hosomi N,Honjo K,Nakamori M,Mukai T,Imamura E,Nezu T,Aoki S,Ohshita T,Nomura E,Wakabayashi S,Maruyama H,Matsumoto M

    更新日期:2018-01-01 00:00:00

  • Immediate transition from a petit mal absence into a grand mal seizure. Case report.

    abstract::Petit mal absences in childhood are often followed by grand mal seizures in adolescence and a coexistence of both types of seizures is not uncommon at all. It is noteworthy, however, that such a coexistence does not imply immediate transition from one type of seizure into the other one. Hence, a grand mal attack may b...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000114721

    authors: Niedermeyer E

    更新日期:1976-01-01 00:00:00

  • Intracranical aneurysm and cerebral embolism.

    abstract::Embolism from the aneurysmal sac is a rare but possible manifestation of intracranial aneurysm; thrombus formation is probably related to the combined action of turbulent flow and a 'stagnant zone'. Three cases are presented: 2 with giant aneurysms (1 internal carotid and 1 sylvian) and 1 with a large aneurysm of the ...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116824

    authors: Parenti G,Fiori L,Marconi F

    更新日期:1992-01-01 00:00:00

  • Neurophysiological findings and serum aluminium in dialysis encephalopathy.

    abstract::64 patients on hemodialysis were investigated. The mean duration of dialysis was 43 months. In all the patients, serum aluminium levels, systolic blood pressure (averaged over a period of 6 weeks) and the EEG were investigated. Psychological testing to assess the level of intelligence (IQ) was also performed. The seru...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000115500

    authors: Ladurner G,Wawschinek O,Pogglitsch H,Petek W,Urlesberger H,Holzer H

    更新日期:1982-01-01 00:00:00

  • A nation-wide collaborative study on the long-term effects of bromocriptine in patients with Parkinson's disease. First interim report in Japan.

    abstract::Two prospective projects were started in May 1985 to evaluate the long-term effects of bromocriptine in patients with Parkinson's disease. One of the projects is to see if combination therapy with levodopa and bromocriptine is superior to levodopa alone with regard to the prevention of late side effects of levodopa th...

    journal_title:European neurology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Nakanishi T,Mizuno Y,Goto I,Iwata M,Kanazawa I,Kowa H,Mannen T,Nishitani H,Ogawa N,Takahashi A

    更新日期:1988-01-01 00:00:00

  • Autosomal dominant familial Parkinson disease: older onset of age, and good response to levodopa therapy.

    abstract::Autosomal dominant Parkinson's disease in 5 generations of a family living in Sagamihara City is reported. Clinical features of this family did not differ from common PD, however, neuropathological findings were different from PD. In autopsied cases, the loss of melanin-containing cells was mild to moderate, and the n...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000113460

    authors: Hasegawa K,Kowa H

    更新日期:1997-01-01 00:00:00

  • Sensory signs and symptoms in scapuloperoneal atrophy: a report of a family.

    abstract::A Norwegian family with asymmetrical scapuloperoneal atrophy is described. Chronic, aching shoulder pain, slight proximal and distal sensory dysfunction, and atrophy of the extensor digitorum brevis muscle occurred in some individuals. The proband had slightly impaired sensory conduction velocity, and his father exhib...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000115834

    authors: Sand T,Hestnes A

    更新日期:1985-01-01 00:00:00

  • Escalation Therapy of Steroid Refractory Multiple Sclerosis Relapse with Tryptophan Immunoadsorption - Observational Multicenter Study with 147 Patients.

    abstract:BACKGROUND:A marked proportion of multiple sclerosis (MS) relapses is followed by incomplete recovery. Our aim was to considerably increase the evidence of the clinical use of immunoadsorption (IA) as escalation therapy for patients with MS relapse. METHODS:A retrospective multicenter study was performed in MS patient...

    journal_title:European neurology

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000447059

    authors: Schimrigk S,Faiss J,Köhler W,Günther A,Harms L,Kraft A,Ehrlich S,Eberl A,Fassbender C,Klingel R,Galle J,Riedlinger A,Hoffmann F

    更新日期:2016-01-01 00:00:00