Abstract:
BACKGROUND:A marked proportion of multiple sclerosis (MS) relapses is followed by incomplete recovery. Our aim was to considerably increase the evidence of the clinical use of immunoadsorption (IA) as escalation therapy for patients with MS relapse. METHODS:A retrospective multicenter study was performed in MS patients with steroid refractory relapse who were treated with tryptophan IA. The main outcome parameter was change of acute relapse-related disability assessed by Expanded Disability Status Scale (EDSS) and visual acuity (VA) measurements for patients with optic neuritis (ON). IA treatments were performed using single-use tryptophan adsorbers. RESULTS:Data of 147 MS patients and 786 single IA treatments were analyzed. Treatment with IA was commenced in mean 32 ± 35 days after the onset of relapse. One hundred and five out of 147 patients (71.4%) improved functionally after mean 5.4 IA treatments within 7-10 days. EDSS improved from median 5 (interquartile range, IQR 3.5) to 4 (IQR 2.5) (p < 0.001). In patients with ON (n = 32), VA improved after the IA series in 84% of cases from median 0.2 (IQR 0.6) to 0.6 (IQR 0.66) (p < 0.001). In 98.9% of IA treatments, no clinically relevant side effect was reported. CONCLUSION:Tryptophan IA was found to be effective and well tolerated as escalation therapy for MS relapse.
journal_name
Eur Neuroljournal_title
European neurologyauthors
Schimrigk S,Faiss J,Köhler W,Günther A,Harms L,Kraft A,Ehrlich S,Eberl A,Fassbender C,Klingel R,Galle J,Riedlinger A,Hoffmann Fdoi
10.1159/000447059subject
Has Abstractpub_date
2016-01-01 00:00:00pages
300-6issue
5-6eissn
0014-3022issn
1421-9913pii
000447059journal_volume
75pub_type
杂志文章,多中心研究abstract::Divers may be at risk of long-term CNS damage from non-symptomatic hyperbaric exposure. We investigated the effect of severe, controlled hyperbaric exposure on a group of healthy goats with similar histories. Thirty goats were exposed to various dive profiles over a period of 5 years, with 17 experiencing decompressio...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000079254
更新日期:2004-01-01 00:00:00
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journal_title:European neurology
pub_type: 杂志文章
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journal_title:European neurology
pub_type: 杂志文章
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journal_title:European neurology
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journal_title:European neurology
pub_type: 杂志文章,评审
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更新日期:1994-01-01 00:00:00
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pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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pub_type: 历史文章,杂志文章
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journal_title:European neurology
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journal_title:European neurology
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pub_type: 杂志文章
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更新日期:2011-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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pub_type: 历史文章,杂志文章
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journal_title:European neurology
pub_type: 杂志文章
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更新日期:2001-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1988-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1995-01-01 00:00:00