Pure eye muscle involvement in endocrine orbitopathy.

Abstract:

:We present a long-term follow-up examination concerning patients with isolated extra-ocular muscle involvement in thyroid-related orbitopathy. Within the previous 13 years we observed 7 patients with endocrine orbitopathy and marked myopathy of the extra-ocular muscles. Five of these patients had no detectable proptosis, 2 of them showed a minimal unilateral proptosis. Five patients showed elevated thyroid-stimulating hormone (TSH) receptor auto-antibodies and 6 patients a marked swelling of the extra-ocular eye muscles on CT or MRI scans. One patient had elevated antibodies against thyroid peroxidase and against thyroglobulin and normal TSH receptor auto-antibodies. Four of 7 patients underwent clinical and radiological follow-up examination 1-9 years later. In 3 of these 4 patients, the clinical syndrome had completely resolved. None of the patients had developed any proptosis. The swelling of the eye muscles on radiological imaging had at least partially resolved. We conclude from our results that apart from the frequent subtype of endocrine orbitopathy with predominant proptosis there is a separate subtype in which proptosis neither exists initially nor develops in the further course. Probably these subtypes have a specific immunological antibody profile although they do not differ concerning the thyroid-stimulating antibodies.

journal_name

Eur Neurol

journal_title

European neurology

authors

Gerlach M,Ferbert A

doi

10.1159/000131894

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

67-72

issue

2

eissn

0014-3022

issn

1421-9913

pii

000131894

journal_volume

60

pub_type

杂志文章
  • Migraine and Headache Prevalence and Associated Comorbidities in a Large Saudi Sample.

    abstract:BACKGROUND:We aimed to assess the prevalence of headache and migraine, along with comorbidities, in a large -Saudi sample. METHODS:Self-reported information was collected about headache, migraine and migraine comorbidities including depression, restless legs syndrome (RLS), syncope, bruxism, hypertension and ischaemic...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000487317

    authors: Muayqil T,Al-Jafen BN,Al-Saaran Z,Al-Shammari M,Alkthiry A,Muhammad WS,Murshid R,Alanazy MH

    更新日期:2018-01-01 00:00:00

  • Effect of live attenuated vaccines on the course of experimental allergic encephalomyelitis. A pilot study.

    abstract::The clinical severity of EAE is enhanced by pre-treatment with distemper, measles and BCG vaccine, measles vaccine gives a more severe onset of disease. Rubella vaccine and TAB leads to mild disease which recurs on re-treatment with the appropriate vaccine. These findings and their possible significance in MS are brie...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000114898

    authors: Caspary EA

    更新日期:1977-01-01 00:00:00

  • Immediate transition from a petit mal absence into a grand mal seizure. Case report.

    abstract::Petit mal absences in childhood are often followed by grand mal seizures in adolescence and a coexistence of both types of seizures is not uncommon at all. It is noteworthy, however, that such a coexistence does not imply immediate transition from one type of seizure into the other one. Hence, a grand mal attack may b...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000114721

    authors: Niedermeyer E

    更新日期:1976-01-01 00:00:00

  • Wernicke's disease. A catamnestic study of 50 patients.

    abstract::A catamnestic study of 50 patients with Wernicke's disease showed that nearly all patients retained residual symptoms and that the prognosis as to life expectancy and social functioning was poor, even after early institution of vitamin B-complex medication. It is advisable to give vitamin B-complex prophylactically in...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000114797

    authors: Groen RH,Hoff HC

    更新日期:1977-01-01 00:00:00

  • Chorea and polycythaemia.

    abstract::An analysis is presented of 35 cases of chorea as a symptom of polycythaemia. This analysis reveals: (a) whereas polycythaemia occurs predominantly in males (3:2), polycythaemic chorea (PC) occurs predominantly in females (5:2), at a real ratio of female:male = 4:1, the prevalence being 1-2.5% of polycythaemic patient...

    journal_title:European neurology

    pub_type: 杂志文章,评审

    doi:10.1159/000115674

    authors: Bruyn GW,Padberg G

    更新日期:1984-01-01 00:00:00

  • Transcriptome-wide characterization of gene expression associated with unruptured intracranial aneurysms.

    abstract:BACKGROUND:The biological mechanisms by which cerebral aneurysms emerge, enlarge and rupture are not totally understood. In the present study, we analyzed the genome-wide gene expression profile in human intracranial aneurysms using cDNA microarrays. METHODS:Affymetrix HU133 Plus 2.0 microarrays were used to compare g...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000236911

    authors: Li L,Yang X,Jiang F,Dusting GJ,Wu Z

    更新日期:2009-01-01 00:00:00

  • Antioxidant status in acute stroke patients and patients at stroke risk.

    abstract:BACKGROUND AND PURPOSE:Antioxidant enzymes like copper/zinc superoxide dismutase (SOD), catalase and gluthatione peroxidase (GSHPx) are part of intracellular protection mechanisms to overcome oxidative stress and are known to be activated in vascular diseases and acute stroke. We investigated the differences of antioxi...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000077662

    authors: Zimmermann C,Winnefeld K,Streck S,Roskos M,Haberl RL

    更新日期:2004-01-01 00:00:00

  • Increased visual impairment after exercise (Uhthoff's phenomenon) in multiple sclerosis: therapeutic possibilities.

    abstract::The Uhthoff symptom, a transient impairment of visual function after exercise, is demonstrated in 2 multiple sclerosis patients. Following exercise, impairment of visual function, as documented most clearly by the testing of contrast sensitivity, was less obvious after body surface cooling and after treatment with ora...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116830

    authors: van Diemen HA,van Dongen MM,Dammers JW,Polman CH

    更新日期:1992-01-01 00:00:00

  • Calcified cerebral hydatid cyst.

    abstract::A 32-year-old patient with a lifelong history of epileptic attacks is described. A skull X-ray showed a round calcified nonhomogenous left frontotemporal mass. A CT scan confirmed its presence, as well as displacement of the left lateral and the third ventricles. At surgery a calcified inactive hydatid cyst was totall...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116120

    authors: Micheli F,Lehkuniec E,Giannaula R,Caputi E,Paradiso G

    更新日期:1987-01-01 00:00:00

  • Refractory epilepsy: a clinically oriented review.

    abstract::About one third of patients with newly diagnosed epilepsy do not achieve seizure control despite medical therapy and should be assessed in detail to confirm the diagnosis, to determine the epilepsy syndrome and to plan treatment strategy. Refractory epilepsy is established when there is inadequate seizure control desp...

    journal_title:European neurology

    pub_type: 杂志文章,评审

    doi:10.1159/000222775

    authors: Beleza P

    更新日期:2009-01-01 00:00:00

  • Myoglobin RIA in detecting carriers of Duchenne's muscular dystrophy.

    abstract::In a prospective study we evaluated myoglobin (MG) and serum creatine kinase (CK) levels in two groups of subjects different in age and carrier status. CK and MG values were significantly lower in the older group. Whereas both parameters fully coincided in the younger group, CK was detected in a higher number of carri...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116017

    authors: Sabria-Leal M,Gimeno-Leal JM,Paret-Masana A,Rey-Joly Barroso C

    更新日期:1986-01-01 00:00:00

  • Total recovery after bilateral paramedian thalamic infarct.

    abstract::Bilateral paramedian thalamic infarcts are characterised initially by the association of acute vigilance disorders and vertical gaze palsy, followed by persisting dementia with severe mnemic disturbance, global aspontaneity and apathy. We describe a patient with a dramatic neuropsychological recovery, confirmed by tes...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000008239

    authors: Krolak-Salmon P,Croisile B,Houzard C,Setiey A,Girard-Madoux P,Vighetto A

    更新日期:2000-01-01 00:00:00

  • Chorea and systemic lupus erythematosus. A critical review.

    abstract::A critical analysis of cases of systemic lupus erythematosus (SLE) and chorea is presented. Choreatic movements occurred early in the course of the disease in most cases; the duration varied from several days to 3 years. No sex predominance was found and no relationship could be demonstrated between chorea and other n...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000115743

    authors: Bruyn GW,Padberg G

    更新日期:1984-01-01 00:00:00

  • Drainage of thoracic duct lymph in twelve patients with myasthenia gravis.

    abstract::The effect of thoracic duct lymph drainage (5-34 days) in 12 patients with myasthenia gravis on muscular function has been followed for 5-43 months. Among the results obtained were: (1) During the drainage the myasthenic symptoms decreased markedly after 1-4 days and remained so during the drainage. (2) The doses of c...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000114659

    authors: Bergström K,Franksson C,Matell G,Nilsson BY,Persson A,von Reis G,Stensman R

    更新日期:1975-01-01 00:00:00

  • Multiple sclerosis in childhood: report of 16 cases.

    abstract::Sixteen children with definite multiple sclerosis (MS; aged 6-17 years, mean 11.4 +/- 2.7; 8 boys, 8 girls) were reviewed. Cerebellar symptoms and signs were frequent at initial presentation. Among laboratory studies, the cerebrospinal fluid (CSF) IgG index or oligoclonal bands were informative in 75%, evoked potentia...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000117213

    authors: Selcen D,Anlar B,Renda Y

    更新日期:1996-01-01 00:00:00

  • Three cases of focal embouchure dystonia: classifications and successful therapy using a dental splint.

    abstract:BACKGROUND:Focal embouchure dystonia (FED) is a type of task-specific dystonia affecting wind instrument players, and it frequently ends their professional careers. The results of the treatments of FED in the reported literature are disappointing. OBJECTIVE:We report 3 patients with FED who were brass instrument playe...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000329578

    authors: Satoh M,Narita M,Tomimoto H

    更新日期:2011-01-01 00:00:00

  • Errors in recognition and management are still frequent in patients with cluster headache.

    abstract:OBJECTIVES:To analyze the trajectory to diagnosis and information provided in a series of cluster headache (CH) patients from five headache clinics. METHODS:CH patients were asked to fill in an ad hoc questionnaire. RESULTS:Seventy-five patients (mean age 41.5 years, 67 males) completed the questionnaire. Patients ha...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000362517

    authors: Sánchez Del Rio M,Leira R,Pozo-Rosich P,Laínez JM,Alvarez R,Pascual J

    更新日期:2014-01-01 00:00:00

  • Histological, enzymatic and mitochondrial DNA studies in patients with Kearns-Sayre syndrome and chronic progressive external ophthalmoplegia.

    abstract::Kearns-Sayre syndrome has been associated with large heteroplasmic mitochondrial DNA deletions and morphological alterations at the cytological level. We have measured the activities of different respiratory chain complexes in 3 patients presenting mitochondrial DNA deletions and found no close correlation between gen...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116656

    authors: Reichmann H,Degoul F,Gold R,Meurers B,Ketelsen UP,Hartmann J,Marsac C,Lestienne P

    更新日期:1991-01-01 00:00:00

  • Effect of multiple sclerosis serum on ventral root responses in isolated frog spinal cord.

    abstract::Serum from patients with multiple sclerosis (MS) and other diseases was added to the medium perfusing isolated hemisected frog spinal cord, and the effect on ventral root responses (VRR) tested. As control, a standardized commercial human serum (Moni-trol I) was used. In 25 out of 40 spinal cord preparations Moni-trol...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000114824

    authors: Schmutz M,von Hahn HP,Honegger CG

    更新日期:1977-01-01 00:00:00

  • Cognitive and demographic determinants of dementia in depressed patients with subjective memory complaints.

    abstract:BACKGROUND:Previous studies showed that late-life depression with subjective memory complaints (SMC) may be associated with an increased risk of developing dementia. However, not all such patients have cognitive decline. The aim of this longitudinal study was to identify possible clinical determinants of progressive de...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000090104

    authors: von Gunten A,Giannakopoulos P,Duc R

    更新日期:2005-01-01 00:00:00

  • Synaesthesia.

    abstract::Synaesthesia is the intriguing, involuntary experience of feeling one sensation in response to a different sensory stimulus. Recognised since described in 1890 by John Locke and clarified by Galton in the 1880s, it has been analysed in the last 50 years. Grapheme-colour synaesthesia is the commonest form, but many oth...

    journal_title:European neurology

    pub_type: 历史文章,杂志文章,评审

    doi:10.1159/000098101

    authors: Pearce JM

    更新日期:2007-01-01 00:00:00

  • Basal ganglia calcification and psychosis in mongolism.

    abstract::An 18-year-old mongoloid girl (trisomy 21) of Asian descent presented two symptoms rarely associated with mongolism (Down's syndrome). (1) Brain stem calcification; the first case diagnosed in vivo in mongolism on computerized axial tomography. (2) Hallucinatory psychotic depression; the first case successfully treate...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000114963

    authors: Jakab I

    更新日期:1978-01-01 00:00:00

  • Nocturnal complex partial seizures precipitated by REM sleep. A case report.

    abstract::A 16-year-old patient presenting with complex partial seizures occurring in the transition from a REM period to wakefulness is described. His baseline EEG showed generalized and symmetrical slow spike and wave complexes, on a normal background activity, activated by NREM sleep. Polygraphic and videotape recordings, ca...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116383

    authors: Silvestri R,De Domenico P,Musolino R,Mento G,Marabello L,Longo M,Di Perri R

    更新日期:1989-01-01 00:00:00

  • Pharmacological approaches in the treatment of senile dementia.

    abstract::The pathogenesis of primary degenerative dementia is still unknown and current therapeutic approaches can aim only at ameliorating some of the symptoms associated with this brain disease. At present, most approaches, attempt to correct a cholinergic deficit. Although the therapeutic benefits obtained so far with curre...

    journal_title:European neurology

    pub_type: 杂志文章,评审

    doi:10.1159/000116479

    authors: Markstein R

    更新日期:1989-01-01 00:00:00

  • Lateralization as a factor in the prognosis of middle cerebral artery territorial infarct.

    abstract::The consequences of cerebral infarcts involving the left hemisphere differ from those of the right homologue areas. Data of 337 consecutive, unselected patients with acute ischaemic stroke in the territory of the right or left middle cerebral artery were analysed. Furthermore, lesion locations of 77 stroke patients wi...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000065515

    authors: Aszalós Z,Barsi P,Vitrai J,Nagy Z

    更新日期:2002-01-01 00:00:00

  • Self-treatment of acute migraine with subcutaneous sumatriptan using an auto-injector device. The Sumatriptan Auto-Injector Study Group.

    abstract::The efficacy and safety of sumatriptan, a selective 5-HT1-like receptor agonist, were studied in a randomized, double-blind, placebo-controlled, parallel-group, multicentre, multinational clinical trial of 235 patients suffering a moderate to severe migraine attack. Patients were randomized to treat a single migraine ...

    journal_title:European neurology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1159/000116760

    authors:

    更新日期:1991-01-01 00:00:00

  • Myasthenia gravis: protective effect of ipratropiumbromide (Atrovent) on airways obstruction caused by edrophonium chloride (Tensilon).

    abstract::The preventive effect of Atrovent Dosier-Aerosol on the airway flow resistance (Raw) caused by Tensilon was studied on 10 patients suffering from myasthenia gravis. Atrovent completely prevented the increase of Raw in 8 cases and considerably decreased it in 2 cases. The measure of the reaction observed may be influen...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000115206

    authors: Szathmáry I,Magyar P,Szobor A

    更新日期:1981-01-01 00:00:00

  • An interim report of the effect of selegiline (L-deprenyl) on the progression of disability in early Parkinson's disease. The Parkinson Study Group.

    abstract::The pathogenesis of Parkinson's disease (PD) has been linked to oxidative-mediated events including increased monoamine oxidase (MAO) and free-radical generation. We are investigating the ability of the MAO inhibitor, selegiline (deprenyl), and of the free-radical scavenger, tocopherol, to delay the onset of disabilit...

    journal_title:European neurology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1159/000116869

    authors: Shoulson I

    更新日期:1992-01-01 00:00:00

  • Sensory signs and symptoms in scapuloperoneal atrophy: a report of a family.

    abstract::A Norwegian family with asymmetrical scapuloperoneal atrophy is described. Chronic, aching shoulder pain, slight proximal and distal sensory dysfunction, and atrophy of the extensor digitorum brevis muscle occurred in some individuals. The proband had slightly impaired sensory conduction velocity, and his father exhib...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000115834

    authors: Sand T,Hestnes A

    更新日期:1985-01-01 00:00:00

  • Madopar HBS: slow-release levodopa and benserazide in parkinsonian patients presenting marked fluctuations in symptoms on standard L-dopa treatment.

    abstract::In this open study patients with advanced Parkinson's disease, who experienced pronounced fluctuations in symptoms while on standard L-dopa, were switched from Madopar/Sinemet to Madopar HBS. The dosage was adjusted until optimal response was obtained. The effect was unsatisfactory in 4 cases and side effects interven...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116195

    authors: Jensen NO,Dupont E,Hansen E,Mikkelsen B,Mikkelsen BO

    更新日期:1987-01-01 00:00:00