Self-treatment of acute migraine with subcutaneous sumatriptan using an auto-injector device. The Sumatriptan Auto-Injector Study Group.

Abstract:

:The efficacy and safety of sumatriptan, a selective 5-HT1-like receptor agonist, were studied in a randomized, double-blind, placebo-controlled, parallel-group, multicentre, multinational clinical trial of 235 patients suffering a moderate to severe migraine attack. Patients were randomized to treat a single migraine attack at home with 6 mg sumatriptan or placebo using an auto-injector. If the migraine had not improved at 1 h, patients had the option of taking a second identical injection. The primary measure of treatment efficacy was based on a comparison of the number of patients in the two treatment groups who had a reduction in headache severity from severe or moderate to mild or none at 1 and 2 h. At 1 h, 77% of patients treating with 6 mg sumatriptan compared to 26% treating with placebo (p less than 0.001) had mild headache or none. At 2 h, the response rates for all patients had risen to 83 and 30%, respectively. Of those patients requiring a second dose at 1 h, improvement to mild or no headache at 2 h was achieved in 61% of patients receiving sumatriptan compared to 15% of those receiving placebo. Other migraine symptoms were more effectively treated by sumatriptan and patients were able to return to work or normal activities earlier. Migraine recurrence within 48 h was a feature of 46% of attacks treated by patients with either treatment. Adverse events were more frequent using sumatriptan but were minor and transient.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Eur Neurol

journal_title

European neurology

authors

doi

10.1159/000116760

keywords:

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

323-31

issue

5

eissn

0014-3022

issn

1421-9913

journal_volume

31

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
  • No mutation of G209A in the alpha-synuclein gene in sporadic Parkinson's disease among Taiwan Chinese.

    abstract::The role of genetics in Parkinson's disease (PD), previously controversial, is now supported by several studies. A major breakthrough has been the discovery of a single gene defect in familial Parkinson's disease. A single base pair change at position 209 from G to A (G209A) in the fourth exon of the alpha-synuclein g...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000008008

    authors: Hu CJ,Sung SM,Liu H,Chang JG

    更新日期:1999-01-01 00:00:00

  • Reduced serum caeruloplasmin levels in non-wilsonian movement disorders.

    abstract::Reduction in caeruloplasmin (Cp) levels is sometimes found in other sporadic movement disorders, not limited to Wilson's disease (WD). Serum levels of Cp, copper, iron and gamma-glutamyl transpeptidase were measured in 71 patients with various diagnoses of movement disorders, including Parkinson's disease (PD), atypic...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000330538

    authors: Ling H,Bhidayasiri R

    更新日期:2011-01-01 00:00:00

  • Emerging treatments in dementia.

    abstract::Dementia is one of the most common organic mental syndromes, usually caused by Alzheimer's disease (AD) or vascular dementia (VD) or both. Regarding AD we review the state or the art of the cholinergic approach and discuss some future options regarding preventive and nonsymptomatic strategies. Therapy for VD will cons...

    journal_title:European neurology

    pub_type: 杂志文章,评审

    doi:10.1159/000113372

    authors: Scheltens P,van Gool WA

    更新日期:1997-01-01 00:00:00

  • Medical versus surgical treatment of patients with cerebrovascular insufficiency. A retrospective comparative study.

    abstract::Report on a series of patients suffering from cerebrovascular insufficiency caused by stenosis and/or occlusion of one or several major cerebral vessels. The patients were divided in two groups, one being medically treated with anticoagulants, the other operated on either a carotid artery thrombosis by thromboendarter...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000115140

    authors: Auer L,Gallhofer B,Ladurner G,Ott E,Heppner F,Lechner H

    更新日期:1980-01-01 00:00:00

  • Effects of nicorandil in neuroprotective activation of PI3K/AKT pathways in a cellular model of Alzheimer's disease.

    abstract::Nicorandil, an ATP-sensitive potassium (KATP) channel opener, is known to have protective effects on ischemic injury in heart and brain. One of the most important protective mechanisms is the anti-apoptotic effect on cardiomyocytes and neurons. This study explored the anti-apoptotic effect of nicorandil against neurot...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000351247

    authors: Kong J,Ren G,Jia N,Wang Y,Zhang H,Zhang W,Chen B,Cao Y

    更新日期:2013-01-01 00:00:00

  • Recurrent alternating ophthalmoplegia with iridoplegia in a young diabetic.

    abstract::Regressive painless left third nerve paralysis with pupillary involvement was followed 6 months later by a right painful complete ophthalmoplegia. The two attacks resolved without treatment. The patient, 22 years old, was recognized diabetic and no other cause was found. It is suggested that this clinical pattern is c...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000115554

    authors: Davous P,Demierre B,Massiou H

    更新日期:1983-01-01 00:00:00

  • Brain enzymes and ischemia.

    abstract::Changes in the maximal rate of some cerebral enzymatic activities related to 400ene transduction and neurotransmission (lactate dehydrogenase; citrate synthase and malate dehydrogenase; total NADH-cytochrome c reductase and cytochrome oxidase; glutamate dehydrogenase; acetylcholine esterase) were assayed both in the c...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000115242

    authors: Villa RF

    更新日期:1981-01-01 00:00:00

  • Myoglobin RIA in detecting carriers of Duchenne's muscular dystrophy.

    abstract::In a prospective study we evaluated myoglobin (MG) and serum creatine kinase (CK) levels in two groups of subjects different in age and carrier status. CK and MG values were significantly lower in the older group. Whereas both parameters fully coincided in the younger group, CK was detected in a higher number of carri...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116017

    authors: Sabria-Leal M,Gimeno-Leal JM,Paret-Masana A,Rey-Joly Barroso C

    更新日期:1986-01-01 00:00:00

  • Drug-Level Monitoring on Admission for Presurgical Epilepsy Evaluation.

    abstract:OBJECTIVE:Evaluation for surgical treatment is offered to patients who do not respond to antiepileptic drugs. Pseudo-pharmacoresistance (PPR) has been described in the context of impaired compliance, incorrect diagnosis of epilepsy or pharmacological interference resulting in too low blood levels. We were interested to...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000479003

    authors: Constantinescu I,Korff CM,Vulliemoz S,Picard F,Seeck M

    更新日期:2017-01-01 00:00:00

  • Dopamine, noradrenaline and serotonin spinal fluid metabolites in temporal lobe epileptic patients with schizophrenic symptomatology.

    abstract::Cerebrospinal fluid metabolites of dopamine, norepinephrine and serotonin were studied in two groups of left temporal lobe epileptic patients, the only difference between the two groups being that one group had paranoid schizophrenic symptomatology. Homovanillic acid accumulation was decreased in this group. This find...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000115048

    authors: Peters JG

    更新日期:1979-01-01 00:00:00

  • Effects of acyclovir on sensory axonal neuropathy, segmental motor paresis and postherpetic neuralgia in herpes zoster patients.

    abstract::The effect of oral treatment with acyclovir (ACV) on sensory axonal neuropathy, segmental motor paresis and postherpetic neuralgia (PHN) was studied in 105 patients with herpes zoster. Forty-seven patients were treated with ACV at a dose of 4 g/day in 5 doses for at least a week; the others did not undergo any kind of...

    journal_title:European neurology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000117274

    authors: Mondelli M,Romano C,Passero S,Porta PD,Rossi A

    更新日期:1996-01-01 00:00:00

  • Somatosensory dysfunction in cystic fibrosis.

    abstract::Posterior tibial somatosensory evoked potentials were obtained in a group of cystic fibrosis patients and age-matched controls. A small but significant delay of the lumbar potential and larger delays of the early scalp potentials were observed. These findings are consistent with earlier pathological studies demonstrat...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116651

    authors: Staley K,Iragui VJ

    更新日期:1991-01-01 00:00:00

  • Independent role of hypertension in Bell's palsy: a case-control study.

    abstract:BACKGROUND/AIM:In this case-control study, our aim was to check for a possible independent role of hypertension in increasing the risk of developing Bell's palsy. METHODS:All patients diagnosed as having Bell's palsy referred to a neurology clinic were enrolled as cases. Controls were selected among other patients ref...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000151701

    authors: Savadi-Oskouei D,Abedi A,Sadeghi-Bazargani H

    更新日期:2008-01-01 00:00:00

  • Nomogram for the prediction of unbound phenytoin concentrations in patients on a combined treatment of phenytoin and valproic acid.

    abstract::The interpretation of the total phenytoin (PT) concentration can be problematic if valproic acid (VPA) is given as a comedication, because VPA displaces PT from the protein binding sites and can increase the free fraction of PT. In order to estimate the free or unbound PT concentration (PTf) from the total PT concentr...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116647

    authors: May TW,Rambeck B,Nothbaum N

    更新日期:1991-01-01 00:00:00

  • Recurrent Fisher's syndrome with immunological abnormalities and replicated laterality.

    abstract::A case of Fisher's syndrome which recurred 10 years apart was reported. Laterality of cranial nerve findings in the initial episode was replicated in the recurrence. Some kind of localized immune sensitization is supposed to play a role in replicating such a laterality. Increased CD4/CD8 ratio and elevated IgE were no...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116688

    authors: Uchihara T,Ikeda M,Tsukagoshi H

    更新日期:1991-01-01 00:00:00

  • Increased visual impairment after exercise (Uhthoff's phenomenon) in multiple sclerosis: therapeutic possibilities.

    abstract::The Uhthoff symptom, a transient impairment of visual function after exercise, is demonstrated in 2 multiple sclerosis patients. Following exercise, impairment of visual function, as documented most clearly by the testing of contrast sensitivity, was less obvious after body surface cooling and after treatment with ora...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116830

    authors: van Diemen HA,van Dongen MM,Dammers JW,Polman CH

    更新日期:1992-01-01 00:00:00

  • The Impact of Methylprednisolone Pulses during Relapses of Multiple Sclerosis on the Kinetics of Anti-Interferon-Beta Antibodies.

    abstract:BACKGROUND/AIMS:We assessed the, hitherto unknown, impact of intravenous methylprednisolone (ivMP) pulses during relapses of multiple sclerosis (MS) on the kinetics of anti-interferon-beta neutralizing antibodies (Nabs) and binding antibodies (Babs). METHODS:Babs (ELISA) and Nabs (antiviral cytopathic effect assay) ti...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000444319

    authors: Giantzi V,Karapanayiotides T,Lagoudaki R,Poulatsidou KN,Lourbopoulos A,Daniilidis M,Taskos N,Milonas I,Grigoriadis N

    更新日期:2016-01-01 00:00:00

  • White matter hyperintensity as a factor associated with delayed mood disorders in patients with acute ischemic stroke.

    abstract:BACKGROUND:Mood disorder is a frequent complication of stroke. Comorbid depressive and anxiety disorders are very common, indicating that it is advisable to assess both disorders at the same time. The aim of the present study was to examine the prevalence of post-stroke depression (PSD) and poststroke anxiety (PSA) at ...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000332585

    authors: Kim JT,Park MS,Yoon GJ,Jung HJ,Choi KH,Nam TS,Lee SH,Choi SM,Kim BC,Kim MK,Cho KH

    更新日期:2011-01-01 00:00:00

  • Low doses of insulin as a treatment of tardive dyskinesia: conjuncture or conjecture?

    abstract::Tardive dyskinesia (TD) induced by antipsychotic drugs represents a great concern for patients and psychiatrists. Considering its pathophysiological mechanisms, there exists a convergence towards the development of postsynaptic dopaminergic hypersensitivity as a possible cause of TD. Hypersensitivity following recepto...

    journal_title:European neurology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000116678

    authors: Mouret J,Khomais M,Lemoine P,Sebert P

    更新日期:1991-01-01 00:00:00

  • Risk factors for central pontine and extrapontine myelinolysis following orthotopic liver transplantation.

    abstract:BACKGROUND:Central pontine myelinolysis (CPM)/extrapontine myelinolysis (EPM) is one of the most serious neurological complications that can occur after orthotopic liver transplantation (OLT). We analyzed the risk factors for CPM/EPM in OLT patients. METHODS:We retrospectively reviewed the records of 1,247 patients wh...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000242426

    authors: Lee EM,Kang JK,Yun SC,Kim KH,Kim SJ,Hwang KS,Lee SG

    更新日期:2009-01-01 00:00:00

  • Polycystic ovary syndrome and migraine headache, is there any correlation?

    abstract:BACKGROUND:To evaluate the role of some sex hormones in migraine headaches, the aim of this study was to assess the prevalence and characteristics of headache, especially migraine, in patients with polycystic ovary syndrome (PCO) compared with women without this disease. METHODS:One hundred and thirty-three women with...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000165349

    authors: Pourabolghasem S,Najmi S,Arami MA

    更新日期:2009-01-01 00:00:00

  • Adult metachromatic leukodystrophy. III. Clinical course, final stages and first biochemical results.

    abstract::Continuing the previously published clinical development of a case of adult metachromatic leukodystrophy (MLD), we now describe the terminal phase and death (at 46 years of age) of our patient. The final phase was characterized clinically by progression of generalized peripheral neuropathy, advanced extrapyramidal and...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000115164

    authors: Seidel D,Heipertz R,Goebel HH,Duensing I,Pilz H

    更新日期:1980-01-01 00:00:00

  • Hypertrophy of the inferior olivary nucleus in patients with progressive supranuclear palsy.

    abstract::Hypertrophic changes in the inferior olivary nuclei have been occasionally described in patients with progressive supranuclear palsy (PSP). To elucidate the incidence of olivary hypertrophy, we investigated morphologically the olives and their associated pathways in 20 autopsied cases: 11 cases of PSP, 3 cases of Mach...

    journal_title:European neurology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000007915

    authors: Hanihara T,Amano N,Takahashi T,Itoh Y,Yagishita S

    更新日期:1998-01-01 00:00:00

  • Three-dimensional computed tomography angiography and magnetic resonance angiography of carotid bifurcation stenosis.

    abstract:PURPOSE:To evaluate the role of computed tomography angiography (CTA) and magnetic resonance angiography (MRA) in the quantification of atherosclerotic stenosis of carotid artery bifurcation in comparison with digital substraction angiography (DSA) and Doppler sonography (DS). MATERIALS AND METHODS:Twenty-five patient...

    journal_title:European neurology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000050752

    authors: Binaghi S,Maeder P,Uské A,Meuwly JY,Devuyst G,Meuli RA

    更新日期:2001-01-01 00:00:00

  • William Halse Rivers Rivers (1864-1922) and the sensory nervous system.

    abstract::The polymath William Rivers played an important role in his work with Henry Head in demonstrating the varied, evolving patterns of sensory loss, and epicritic and protopathic sensation, after the section of the superficial ramus of Head's left radial nerve. After a mixed and frustrated army career Rivers devoted his a...

    journal_title:European neurology

    pub_type: 传,历史文章,杂志文章

    doi:10.1159/000148693

    authors: Pearce JM

    更新日期:2008-01-01 00:00:00

  • Phenotypic variation of autosomal-dominant corticobasal degeneration.

    abstract::Neurodegenerative tauopathies may be inherited as autosomal-dominant disorders with variable clinicopathological phenotypes, and causative mutations in the microtubule-associated protein tau (MAPT) gene are not regularly seen. Herein, we describe a patient with clinically typical and autopsy-proven corticobasal degene...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000334731

    authors: Jung HH,Bremer J,Streffer J,Virdee K,Spillantini MG,Crowther RA,Brugger P,Van Broeckhoven C,Aguzzi A,Tolnay M

    更新日期:2012-01-01 00:00:00

  • HTLV-I-associated myelopathy and adult T-cell leukemia cases in a family.

    abstract::Familial cases of HTLV-I-associated myelopathy (HAM) and adult T-cell leukemia (ATL), developing in a daughter and father, respectively, are reported. The coexistence of both diseases in a family has not been reported before. This supports the recent findings that ATL and HAM may be brought about by an identical virus...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116373

    authors: Shoji H,Kuwasaki N,Natori H,Kaji M,Miyamoto Y,Usuku K,Sonoda S,Osame M

    更新日期:1989-01-01 00:00:00

  • Wernicke's disease. A catamnestic study of 50 patients.

    abstract::A catamnestic study of 50 patients with Wernicke's disease showed that nearly all patients retained residual symptoms and that the prognosis as to life expectancy and social functioning was poor, even after early institution of vitamin B-complex medication. It is advisable to give vitamin B-complex prophylactically in...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000114797

    authors: Groen RH,Hoff HC

    更新日期:1977-01-01 00:00:00

  • Osler and the Churg-Strauss syndrome.

    abstract::This paper records a patient of Osler's, who showed many features compatible with the Churg-Strauss syndrome of allergic granulomatous angiitis to be described 50 years later. ...

    journal_title:European neurology

    pub_type: 历史文章,杂志文章

    doi:10.1159/000098474

    authors: Pearce JM

    更新日期:2007-01-01 00:00:00

  • Focal neurological deficit with sudden onset as the first manifestation of sarcoidosis: a case report with MRI follow-up.

    abstract::Stroke as a presenting manifestation of sarcoidosis has rarely been reported. This contrasts with the frequent anatomopathological findings of cerebrovascular involvement in neurosarcoidosis. We present a patient who developed acutely a right brachiofacial weakness and dysarthria. Pulmonary sarcoidosis was found. A br...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116697

    authors: Michotte A,Dequenne P,Jacobovitz D,Hildebrand J

    更新日期:1991-01-01 00:00:00