Effect of multiple sclerosis serum on ventral root responses in isolated frog spinal cord.

Abstract:

:Serum from patients with multiple sclerosis (MS) and other diseases was added to the medium perfusing isolated hemisected frog spinal cord, and the effect on ventral root responses (VRR) tested. As control, a standardized commercial human serum (Moni-trol I) was used. In 25 out of 40 spinal cord preparations Moni-trol gave inhibition of VRR ranging from 2.8 to 23.1%. 76% of the tests with confirmed MS sera showed inhibition of VRR, after deduction of the control serum effect, while 53% of the tests with sera from other diseases were inhibitory. Sera from cases of suspected but clinically unconfirmed MS gave strong inhibition (above 20%).

journal_name

Eur Neurol

journal_title

European neurology

authors

Schmutz M,von Hahn HP,Honegger CG

doi

10.1159/000114824

subject

Has Abstract

pub_date

1977-01-01 00:00:00

pages

345-51

issue

6

eissn

0014-3022

issn

1421-9913

journal_volume

15

pub_type

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