Clinical characteristics and outcome in the acute phase of ischemic locked-in syndrome: case series of twenty patients with ischemic LIS.

Abstract:

BACKGROUND:Locked-in syndrome (LIS) is a condition characterized by quadriplegia and anarthria. The most common cause is a ventral pontine lesion due to atherosclerotic basilar artery disease. METHODS:Cases with LIS were prospectively identified among the patients with acute ischemic stroke over 3 years, between 2009 and 2011. Clinical characteristics, topographic localization of lesions, and outcome were determined during the first 6 months from onset of LIS. RESULTS:Our case series consists of 20 patients (mean age 62 ± 10 years; range 46-82). Initially 16 patients had a reduced level of consciousness (mean 3 days; range 1-15). Respiratory disturbance, mainly as impairment of the breathing pattern, was noted in all cases. Five patients died within the first 10 days due to stroke progression or cardiac arrest. In the remaining cases the most frequent causes of death were pulmonary infections and sepsis. Overall mortality in the acute phase of LIS is 75%, and the median survival time is 42 days. There was a statistically significant association between the more extensive parenchymal brain stem lesions and observed mortality. CONCLUSIONS:Ischemic LIS is commonly caused by an acute complete occlusion of the basilar artery due to atherosclerotic lesions in intracranial vertebrobasilar vessels. Mortality remains high in the acute phase of the disease.

journal_name

Eur Neurol

journal_title

European neurology

authors

Nikić PM,Jovanović D,Paspalj D,Georgievski-Brkić B,Savić M

doi

10.1159/000345272

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

207-12

issue

4

eissn

0014-3022

issn

1421-9913

pii

000345272

journal_volume

69

pub_type

杂志文章
  • An Elevated High-Sensitivity C-Reactive Protein Level Is Associated with Unfavorable Functional Outcomes of Small-Artery Occlusion in Patients without Diabetes.

    abstract:BACKGROUND:High-sensitivity C-reactive protein (hs-CRP) is associated with a risk of causing diabetes mellitus and ischemic stroke. However, the association between hs-CRP levels and functional outcome after small-artery occlusion (SAO) is unknown. METHODS:Data for 836 patients diagnosed with SAO were collected from t...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000477929

    authors: Gao Y,Liu J,Wang W,Gao C,Yu C,Liu S,Wu J

    更新日期:2017-01-01 00:00:00

  • Scapulo-peroneal muscular atrophy. Full autopsy report. Unusual findings in the anterior horn of the spinal cord. Lipid storage in muscle.

    abstract::Morphological findings of 3 cases of Kaeser's scapulo-peroneal muscular atrophy are described. 1 of them is the first complete autopsy report on this disease. While the number of motor neurons in the spinal cord was grossly normal, the neuropil of the anterior horn exhibited axonal swellings, accumulations of possibly...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000114899

    authors: Probst A,Ulrich J,Kaeser HE,Heitz P

    更新日期:1977-01-01 00:00:00

  • Silent coronaropathy: usefulness of dobutamine stress echocardiography in ischemic stroke.

    abstract:BACKGROUND:Several testing options are available to detect asymptomatic coronary artery disease (CAD). Dobutamine stress echocardiography (DSE) has been reported to increase the sensitivity and specificity of stress testing to detect CAD. Most studies concerned patients with known or suspected CAD who have a high prete...

    journal_title:European neurology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000096488

    authors: Nighoghossian N,Cakmak S,Derex L,Barthelet M,Thibault H,Finet G,Ovize M,Derumeaux G,Nemoz C,Chapuis F,Rioufol G

    更新日期:2006-01-01 00:00:00

  • The Topography of Cortical Microinfarcts in Neurodegenerative Diseases and in Vascular Dementia: A Postmortem 7.0-Tesla Magnetic Resonance Imaging Study.

    abstract:BACKGROUND:Cortical microinfarcts (CoMIs) are considered as barely visible lesions in clinical-neuroradiological correlation studies. On postmortem 7.0-tesla MRI, however, CoMIs of different size are easily detected. SUMMARY:The present MRI study investigates 84 postmortem brains with different neurodegenerative disea...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000447297

    authors: De Reuck JL,Auger F,Durieux N,Cordonnier C,Deramecourt V,Pasquier F,Maurage CA,Leys D,Bordet R

    更新日期:2016-01-01 00:00:00

  • Myoglobin RIA in detecting carriers of Duchenne's muscular dystrophy.

    abstract::In a prospective study we evaluated myoglobin (MG) and serum creatine kinase (CK) levels in two groups of subjects different in age and carrier status. CK and MG values were significantly lower in the older group. Whereas both parameters fully coincided in the younger group, CK was detected in a higher number of carri...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116017

    authors: Sabria-Leal M,Gimeno-Leal JM,Paret-Masana A,Rey-Joly Barroso C

    更新日期:1986-01-01 00:00:00

  • Cranial percussion.

    abstract::Percussion of the skull dates from a time when there were virtually no radiological methods for examining the skull and brain. Three apparently independent contributions appeared within the years 1893-1895. The sound elicited, tenderness, and auscultatory percussion have each been employed for diagnostic purposes, but...

    journal_title:European neurology

    pub_type: 历史文章,杂志文章

    doi:10.1159/000115645

    authors: Pearce JM

    更新日期:2008-01-01 00:00:00

  • Chronic relapsing neuropathy associated with Castleman's disease (angiofollicular lymph node hyperplasia).

    abstract::We report a 17-year-old patient who presented a chronic relapsing sensorimotor demyelinating neuropathy with 6 relapses over a 7-year period, preceding by 4 years the diagnosis of a multicentric angiofollicular lymph node hyperplasia. A role for Epstein-Barr virus (EBV) as a trigger of the neuropathy may be suggested ...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000117156

    authors: Vingerhoets F,Kuntzer T,Delacrétaz,Steck AJ,Knecht H,Bogousslavsky J,Meier C,Regli F

    更新日期:1995-01-01 00:00:00

  • Cerebral Cavernous Malformations, Developmental Venous Anomaly, and Its Coexistence: A Review.

    abstract:BACKGROUND:Cerebral cavernous malformations (CCMs) are intracranial vascular malformations that can exist as a single lesion or mixed vascular lesions. The most common mixed form is the coexistence of CCM with an associated developmental venous anomaly (DVA). In this paper, we aim to give a comprehensive review of CCM,...

    journal_title:European neurology

    pub_type: 杂志文章,评审

    doi:10.1159/000508748

    authors: Idiculla PS,Gurala D,Philipose J,Rajdev K,Patibandla P

    更新日期:2020-01-01 00:00:00

  • Pharmacological approaches in the treatment of senile dementia.

    abstract::The pathogenesis of primary degenerative dementia is still unknown and current therapeutic approaches can aim only at ameliorating some of the symptoms associated with this brain disease. At present, most approaches, attempt to correct a cholinergic deficit. Although the therapeutic benefits obtained so far with curre...

    journal_title:European neurology

    pub_type: 杂志文章,评审

    doi:10.1159/000116479

    authors: Markstein R

    更新日期:1989-01-01 00:00:00

  • Electrocardiographic findings in motor neurone disease.

    abstract::The electrocardiogram was analyzed in 31 patients with motor neurone disease. ECG abnormalities were encountered in 27 of the patients. The dominating ECG changes consisted of ST-T wave changes and supraventricular arrhythmias. The underlying mechanisms are discussed in relation to the neurological symptomatology. ...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000114770

    authors: Hindfelt B

    更新日期:1976-01-01 00:00:00

  • Chorea and polycythaemia.

    abstract::An analysis is presented of 35 cases of chorea as a symptom of polycythaemia. This analysis reveals: (a) whereas polycythaemia occurs predominantly in males (3:2), polycythaemic chorea (PC) occurs predominantly in females (5:2), at a real ratio of female:male = 4:1, the prevalence being 1-2.5% of polycythaemic patient...

    journal_title:European neurology

    pub_type: 杂志文章,评审

    doi:10.1159/000115674

    authors: Bruyn GW,Padberg G

    更新日期:1984-01-01 00:00:00

  • Dopamine uptake sites and dopamine receptors in Parkinson's disease and schizophrenia.

    abstract::Dopamine uptake sites, labelled by 3 nM [3H]GBR 12935, were reduced by 28-34% in post-mortem Parkinson's diseased striata (n = 22) compared to control striata (n = 28). There was no significant difference between post-mortem striata from schizophrenics (n = 16) and controls. Both dopamine D1 and D2 receptors are consi...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000117168

    authors: Pearce RK,Seeman P,Jellinger K,Tourtellotte WW

    更新日期:1990-01-01 00:00:00

  • Homonymous defect of macular vision in ischemic stroke.

    abstract::It is generally believed that a homonymous defect of macular vision (HMV) is caused by a small lesion restricted to the occipital lobe tip and rarely results from ischemic stroke. The incidence of HMV was studied retrospectively in 54 patients with infarction of the posterior cerebral artery territory who underwent Go...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000050785

    authors: Isa K,Miyashita K,Yanagimoto S,Nagatsuka K,Naritomi H

    更新日期:2001-01-01 00:00:00

  • Appraising the plasticity of the circle of Willis: a model of hemodynamic modulation in cerebral arteriovenous malformations.

    abstract:OBJECTIVES:Cerebral arteriovenous malformations (AVMs) harbor a network of abnormal vasculatures, namely the nidus between arterial and venous components. The pressure gradient between these two components results in abnormal high-velocity arteriovenous shunts flowing through the nidus and alternate intracranial hemody...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000292431

    authors: Chuang YM,Guo W,Lin CP

    更新日期:2010-01-01 00:00:00

  • Writing error may be a predictive sign for impending brain atrophy progression in amyotrophic lateral sclerosis: a preliminary study using X-ray computed tomography.

    abstract:AIM:To investigate whether writing errors are predictive of longitudinal brain atrophy progression in patients with amyotrophic lateral sclerosis (ALS). METHODS:The frequency of writing errors in 6 ALS patients without dementia was compared with longitudinal changes in lateral ventricular areas of the bilateral anteri...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000328216

    authors: Ichikawa H,Ohno H,Murakami H,Ohnaka Y,Kawamura M

    更新日期:2011-01-01 00:00:00

  • Self-treatment of acute migraine with subcutaneous sumatriptan using an auto-injector device. The Sumatriptan Auto-Injector Study Group.

    abstract::The efficacy and safety of sumatriptan, a selective 5-HT1-like receptor agonist, were studied in a randomized, double-blind, placebo-controlled, parallel-group, multicentre, multinational clinical trial of 235 patients suffering a moderate to severe migraine attack. Patients were randomized to treat a single migraine ...

    journal_title:European neurology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1159/000116760

    authors:

    更新日期:1991-01-01 00:00:00

  • Choreoathetosis as toxic effect of lithium treatment.

    abstract::Two cases of lithium neurotoxic effects are reported. Both cases are expressed by choreoathetotic movements and in both of them intoxication was caused by combined drug therapy. In our opinion caution is advised when lithium is administered in combination with drugs, especially in elderly patients. ...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116044

    authors: Walevski A,Radwan M

    更新日期:1986-01-01 00:00:00

  • Transcriptome-wide characterization of gene expression associated with unruptured intracranial aneurysms.

    abstract:BACKGROUND:The biological mechanisms by which cerebral aneurysms emerge, enlarge and rupture are not totally understood. In the present study, we analyzed the genome-wide gene expression profile in human intracranial aneurysms using cDNA microarrays. METHODS:Affymetrix HU133 Plus 2.0 microarrays were used to compare g...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000236911

    authors: Li L,Yang X,Jiang F,Dusting GJ,Wu Z

    更新日期:2009-01-01 00:00:00

  • Stroke prediction after transient ischemic attacks in patients admitted to a stroke unit.

    abstract:BACKGROUND:Transient ischemic attacks (TIAs) bear a presumed high risk of early recurrence of stroke. Data in the literature, however, are inconsistent, as recurrence rates range from 9.5 to 20%, at 90 days. AIMS:The study was designed to determine the risk of stroke after TIA. METHODS:94 consecutive patients referre...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000332999

    authors: Tari Capone F,Cavallari M,Casolla B,Caselli G,Pieroni A,Di Lazzaro V,Napolitano S,Stanzione P,Puca E,Toni D,Rasura M,Orzi F

    更新日期:2012-01-01 00:00:00

  • Is cerebrospinal fluid spectrophotometry useful in CT scan-negative suspected subarachnoid haemorrage?

    abstract::Missed cerebral aneurysms in CT-negative patients can have serious implications. We set out to determine the usefulness of cerebrospinal fluid (CSF) spectrophotometry and the individual significance of CSF oxyhaemoglobin, bilirubin and methaemoglobin in 463 CT scan-negative patients with suspected subarachnoid haemorr...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000082162

    authors: Gunawardena H,Beetham R,Scolding N,Lhatoo SD

    更新日期:2004-01-01 00:00:00

  • Multidisciplinary management of multiple sclerosis symptoms.

    abstract:BACKGROUND:Effective management of multisymptomatic chronic diseases such as multiple sclerosis (MS) requires a multimodal, interdisciplinary approach. At MS clinics, numerous healthcare specialties are coordinated to provide patients with quality clinical care for all aspects of their disease. Settings and resource av...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000367620

    authors: Gallien P,Gich J,Sánchez-Dalmau BF,Feneberg W

    更新日期:2014-01-01 00:00:00

  • S-100B concentration is not related to neurocognitive performance in the first month after mild traumatic brain injury.

    abstract::The serum concentration of S-100B is reported to reflect the severity of brain damage. The purpose of this study was to determine whether elevated serum S-100B concentrations were related to neuropsychological test performance of patients in the subacute phase of recovery from mild traumatic brain injury (TBI). S-100B...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000083678

    authors: Stapert S,de Kruijk J,Houx P,Menheere P,Twijnstra A,Jolles J

    更新日期:2005-01-01 00:00:00

  • Unaltered respiratory chain enzyme activity and mitochondrial DNA in skeletal muscle from patients with idiopathic Parkinson's syndrome.

    abstract::There is good evidence that patients with Parkinson's disease have respiratory chain dysfunction in their substantia nigra. Since mitochondrial cytopathies due to enzyme defects in the respiratory chain are predominantly manifested in tissues with a high oxidative metabolism we analyzed oxidative energy metabolism in ...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000117053

    authors: Reichmann H,Janetzky B,Bischof F,Seibel P,Schöls L,Kuhn W,Przuntek H

    更新日期:1994-01-01 00:00:00

  • Tetrahydrocannabinol:Cannabidiol Oromucosal Spray for Multiple Sclerosis-Related Resistant Spasticity in Daily Practice.

    abstract:BACKGROUND:Tetrahydrocannabinol:cannabidiol (THC:CBD) oromucosal spray (Sativex®) is an add-on therapy for moderate-to-severe multiple sclerosis (MS)-related drug-resistant spasticity (MSS). AIM:The MOVE-2 EU study collected data from everyday clinical practice concerning the effectiveness and tolerability of THC:CBD....

    journal_title:European neurology

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000449413

    authors: Vermersch P,Trojano M

    更新日期:2016-01-01 00:00:00

  • Antioxidant status in acute stroke patients and patients at stroke risk.

    abstract:BACKGROUND AND PURPOSE:Antioxidant enzymes like copper/zinc superoxide dismutase (SOD), catalase and gluthatione peroxidase (GSHPx) are part of intracellular protection mechanisms to overcome oxidative stress and are known to be activated in vascular diseases and acute stroke. We investigated the differences of antioxi...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000077662

    authors: Zimmermann C,Winnefeld K,Streck S,Roskos M,Haberl RL

    更新日期:2004-01-01 00:00:00

  • Transient global amnesia and stroke.

    abstract::Four patients who experienced isolated transient global amnesia had computed tomographic evidence for a cerebral infarct (3 cases) or hemorrhage (1 case). The medial part of the temporal lobe was involved in 2 patients (left in 1, right in 1), the left lentiform nucleus in 1 patient, and the left thalamus in 1 left-ha...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116240

    authors: Bogousslavsky J,Regli F

    更新日期:1988-01-01 00:00:00

  • Conduction of electrically elicited impulses in peripheral nerves of diabetic patients.

    abstract::Nerve conduction of single impulses and the ability to transmit frequent trains of stimuli were studied in sensory median and in sural nerves of controls and patients with diabetes mellitus. Decrease of relative amplitudes and increase of relative latencies were more marked in the diabetics as compared with normal con...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000115123

    authors: Tackmann W,Lehmann HJ

    更新日期:1980-01-01 00:00:00

  • Executive and Attentional Disorders, Epilepsy and Porencephalic Cyst in Autosomal Recessive Cerebellar Ataxia Type 3 Due to ANO10 Mutation.

    abstract:BACKGROUND:ANO10 mutations have recently been reported in autosomal recessive cerebellar ataxia type 3 (ARCA3). The objective of this study was to describe the phenotype of 2 siblings with compound heterozygous ANO10 mutations and progressive cerebellar ataxia, epilepsy, and cognitive impairment. A porencephalic cyst w...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000445109

    authors: Chamard L,Sylvestre G,Koenig M,Magnin E

    更新日期:2016-01-01 00:00:00

  • Prospective analysis of falls in dominant ataxias.

    abstract::In a previous retrospective study, we demonstrated that falls are common and often injurious in dominant spinocerebellar ataxias (SCAs) and that nonataxia features play an important role in these falls. Retrospective surveys are plagued by recall bias for the presence and details of prior falls. We therefore sought to...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000342907

    authors: Fonteyn EM,Schmitz-Hübsch T,Verstappen CC,Baliko L,Bloem BR,Boesch S,Bunn L,Giunti P,Globas C,Klockgether T,Melegh B,Pandolfo M,Schöls L,Timmann D,van de Warrenburg BP

    更新日期:2013-01-01 00:00:00

  • Sporadic distal myopathy with early adult onset: study of muscle biopsies and muscle cell cultures.

    abstract::A 28-year-old man with negative family history for neuromuscular diseases showed a distal myopathy. Creatine kinase was slightly increased. Two muscle biopsies were performed. The first showed myopathic features, rimmed vacuoles in a limited area and increase of free glycogen; the second showed only nonspecific pathol...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116430

    authors: Mongini T,Doriguzzi C,Palmucci L,Pollo B,Arnaudo E,Bresolin N

    更新日期:1989-01-01 00:00:00