Abstract:
:Oxidative stress and generation of reactive oxygen species are believed to be implicated in Parkinson's disease (PD). Erythrocyte activity of superoxide dismutase (SOD) and catalase, the blood glutathione system, and plasma levels of thiobarbituric-acid-reactive substances (TBARS) were measured in 80 PD patients. These biochemical parameters were also measured in 29 age-matched controls. Patients with PD had significantly higher red blood corpuscle (RBC) activity of SOD. The mean RBC activity of catalase in PD patients did not differ significantly from those of controls. RBC catalase activity was significantly lower in advanced cases of PD compared to early cases. Oxidized glutathione was significantly higher in RBCs of PD patients, although there were no changes in total glutathione and reduced glutathione compared to controls. TBARS content was increased in patients with PD. Levodopa therapy, age and duration of illness did not significantly influence the measured parameters. Our study supports the previous hypothesis that oxidative stress is implicated in the pathogenesis of PD. Perspectives for treatment of PD in the future could include antioxidant therapy.
journal_name
Eur Neuroljournal_title
European neurologyauthors
Younes-Mhenni S,Frih-Ayed M,Kerkeni A,Bost M,Chazot Gdoi
10.1159/000103641subject
Has Abstractpub_date
2007-01-01 00:00:00pages
78-83issue
2eissn
0014-3022issn
1421-9913pii
000103641journal_volume
58pub_type
杂志文章abstract::Camptocormia (bent spine syndrome, cyphose hystérique) is an abnormality characterized by severe forward flexion of the thoracolumbar spine which typically increases during walking or standing and completely disappears in supine position. Camptocormia can be due to central nervous system diseases, such as Parkinson's ...
journal_title:European neurology
pub_type: 杂志文章,评审
doi:10.1159/000314897
更新日期:2010-01-01 00:00:00
abstract::We report a laser microprobe mass analysis of aluminum and iron content in the hippocampus and in the inferior temporal cortex in 2 cases of dementia pugilistica (DP), 4 cases of Alzheimer's disease (AD), and 3 controls. There was a predominant accumulation of Al and Fe within neurofibrillary tangles (NFT) in both DP ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000112903
更新日期:1997-01-01 00:00:00
abstract::We wish to retract the paper entitled "Hypovitaminosis D and Decreased Bone Mineral Density in Amyotrophic Lateral Sclerosis" [Eur Neurol 1997; 37: 225-229] by Y. Sato, Y. Honda, T. Asoh, M. Kikuyama, K. Oizumi as a -result of concerns about data integrity and scientific misconduct which have been brought to our atten...
journal_title:European neurology
pub_type: 杂志文章,撤回出版物
doi:10.1159/000488922
更新日期:2018-01-01 00:00:00
abstract::T lymphocytes were determined according to their ability to form rosettes with sheep erythrocytes, in cerebrospinal fluid (CSF) from 120 patients, and in peripheral blood from 59 patients. Normal CSF contained 74.9 +/- 9.6% T lymphocytes. Increased T lymphocyte percentage was found in CSF from patients with active mul...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115074
更新日期:1979-01-01 00:00:00
abstract::In 128 patients with multiple sclerosis (MS) and 204 blood donors (control persons) the in vitro activation of 'Ficoll-purified' peripheral blood T lymphocytes was measured using the 3H-thymidine incorporation rate without (spontaneous proliferation) and with mitogen addition (concanavalin A, phytohemagglutinin). Mito...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116228
更新日期:1988-01-01 00:00:00
abstract:AIM:The aim of this study was to investigate the association of autonomic nervous system abnormalities on head-up tilt table test (HUTT) with generalized joint hypermobility, expressed by Beighton score (BS). METHODS:This was a prospective study that included 115 consecutive patients (91 females; mean age 34.35 ± 14.1...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000490628
更新日期:2018-01-01 00:00:00
abstract::Fifteen chronic alcoholic male patients with impotence have been investigated with the electrophysiological method of sympathetic skin potentials recorded from the genital skin and with the electrically induced bulbocavernosus reflex. Both electrophysiological tests did not differ from those of normal controls. It was...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000117367
更新日期:1990-01-01 00:00:00
abstract::SJL/J mice have been studied as the model animals for autoimmunological diseases. Recently it was clarified that SJL/J mice have a defect of dysferlin. Human limb girdle muscular dystrophy 2B and Miyoshi myopathy also have a defect of dysferlin. In this study we present the histological and immunohistological changes ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000097005
更新日期:2007-01-01 00:00:00
abstract::Calcium ions play a major role in the regulation of cell functions. Minor alterations of the cellular calcium ion homeostasis lead to major functional aberrations. Alterations of the calcium homeostasis occur under conditions of hypoxia, the major cause being an extracellular increase of potassium ions which gate volt...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116059
更新日期:1986-01-01 00:00:00
abstract::Blood samples from 45 cases of subacute sclerosing panencephalitis in Israel were tested for the presence of antibodies to Epstein-Barr virus capsid antigen and early antigen by the indirect immunofluorescence method. Significantly higher titers were found in patients as compared to healthy controls with higher titers...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000114697
更新日期:1975-01-01 00:00:00
abstract::Transient global amnesia (TGA) is a clinical syndrome of unknown etiology characterized by sudden onset anterograde amnesia, which was thought to resolve completely. However, some authors have also suggested permanent memory impairment. It is unclear whether these results reflect a true persistent damage or a simply t...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000104715
更新日期:2007-01-01 00:00:00
abstract::A 49-year-old alcoholic woman was admitted for convulsions. She died after a 4-week clinical course characterized by a persistent coma with diffuse muscular hypertonia. Post-mortem examination of the brain demonstrated a spongy degeneration and gliosis of the cerebral cortex, limited to the 3rd and the 4th layers. No ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000114939
更新日期:1978-01-01 00:00:00
abstract:INTRODUCTION:Recently, neurosyphilis was found to be associated with diabetes mellitus (DM). Whether the association was specific to neurosyphilis among central nervous system (CNS) infections, and whether neurosyphilis is associated with other prevalent metabolic disorders deserves further study. METHODS:An in-depth ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000503626
更新日期:2019-01-01 00:00:00
abstract::The case of an 8-year-old boy presenting diffuse, prevalently right-sided nevus flammeus, venous angioma of the right cerebral hemisphere, right-sided facial hyperplasia, lef-handedness and recurring strokes is reported together with the clinical, angiographic and CT features. ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115201
更新日期:1981-01-01 00:00:00
abstract::2 patients with hypoparathyroidism, one idiopathic and the other pseudoform, were studied by overnight polygraphic recording of the sleep EEG and related activities before and after start of treatment to investigate their sleep EEG patterns and states, with the results as follows. (1) Conspicuous abnormalities were no...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115052
更新日期:1979-01-01 00:00:00
abstract::A Norwegian family with asymmetrical scapuloperoneal atrophy is described. Chronic, aching shoulder pain, slight proximal and distal sensory dysfunction, and atrophy of the extensor digitorum brevis muscle occurred in some individuals. The proband had slightly impaired sensory conduction velocity, and his father exhib...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115834
更新日期:1985-01-01 00:00:00
abstract::In a 14-year follow-up the improvement of language functions and the decrease of EEG abnormalities are described in a girl with the Landau-Kleffner syndrome. In this case, the results of subsequent EEG recordings do not permit conclusions about the course of the aphasia. Disappearance of focal spike and waves, bilater...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116390
更新日期:1989-01-01 00:00:00
abstract::A 28-year-old man with negative family history for neuromuscular diseases showed a distal myopathy. Creatine kinase was slightly increased. Two muscle biopsies were performed. The first showed myopathic features, rimmed vacuoles in a limited area and increase of free glycogen; the second showed only nonspecific pathol...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116430
更新日期:1989-01-01 00:00:00
abstract:AIM:To investigate whether writing errors are predictive of longitudinal brain atrophy progression in patients with amyotrophic lateral sclerosis (ALS). METHODS:The frequency of writing errors in 6 ALS patients without dementia was compared with longitudinal changes in lateral ventricular areas of the bilateral anteri...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000328216
更新日期:2011-01-01 00:00:00
abstract::The purpose of this pilot study was to determine whether 20 mg oral 311C90 can prevent the development of migraine headache when taken during the aura phase of a migraine attack. The study also aimed to provide an initial safety profile for 311C90 when taken during the aura. Forty patients (31 females, 9 males) were e...
journal_title:European neurology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1159/000119101
更新日期:1996-01-01 00:00:00
abstract::The pathogenesis of Parkinson's disease (PD) has been linked to oxidative-mediated events including increased monoamine oxidase (MAO) and free-radical generation. We are investigating the ability of the MAO inhibitor, selegiline (deprenyl), and of the free-radical scavenger, tocopherol, to delay the onset of disabilit...
journal_title:European neurology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1159/000116869
更新日期:1992-01-01 00:00:00
abstract::The effect of dosage schedules on plasma drug levels was evaluated in two groups of ambulant epileptic patients, whose treatment with diphenylhydantoin (DPH) or phenobarbital (PB) had been simplified by reducing the daily frequency of the dosage regimens. Although the patients received the same milligram per kilogram ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115099
更新日期:1979-01-01 00:00:00
abstract::The serum concentration of S-100B is reported to reflect the severity of brain damage. The purpose of this study was to determine whether elevated serum S-100B concentrations were related to neuropsychological test performance of patients in the subacute phase of recovery from mild traumatic brain injury (TBI). S-100B...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000083678
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Intravenous thrombolysis (IVT) with urokinase is the standard reperfusion therapy for acute cerebral infarction (ACI) in China. Only about 30% patients who use urokinase for IVT can recanalize. Therefore, this study aimed to analyze the influencing factors of recanalization after IVT using urokinase in ACI p...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000507288
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND/AIMS:This study aimed at assessing the feasibility of diffusion tensor imaging (DTI) in multilevel cervical spondylotic myelopathy (MCSM) and quantifying the association between DTI parameters and neuronal status as a whole. METHODS:Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were ob...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000443270
更新日期:2016-01-01 00:00:00
abstract::A 47-year-old woman presented with paralysis of upward gaze associated with Addison's pernicious anaemia. Administration of cyanocobalamin resulted in significant improvement of eye movements and haematological parameters. Isolated paralysis of upward gaze may be a feature of vitamin B12 deficiency. ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115702
更新日期:1984-01-01 00:00:00
abstract::Of 150 new cases of nasopharyngeal carcinoma diagnosed in Israel during a 9-year period (nationwide study 1960--1968), 74 patients developed neurological complications. In 92% of the cases, neurologic deficits were confined exclusively to cranial nerves. The majority of these patients presented general symptoms of dis...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000114938
更新日期:1978-01-01 00:00:00
abstract::Ten patients with left-sided visuospatial neglect due to cerebrovascular accident were monitored using the Behavioural Inattention Test (BIT) at weekly intervals, on a long-term basis. The novel finding was that some patients showed occasional but transitory marked improvement in their visuospatial neglect at times pr...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000117028
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:Most of the previously described pathogenic mutations in desmin are located in highly conserved α-helical domains that play an important role in intermediate filament assembly. The role of the C-terminus non-α-helical 'tail' domain is much less investigated and until recently mutations in this domain have be...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000341617
更新日期:2012-01-01 00:00:00
abstract::The aim of this study was to investigate whether the side and location of single small infarcts (< or = 3 cm) in the corona radiata (28 patients) and pontine base (36 patients) influence the incidence of contralateral upper or lower limb paresis and dysarthria. While the severity of contralateral limb paresis was not ...
journal_title:European neurology
pub_type: 临床试验,杂志文章
doi:10.1159/000117290
更新日期:1996-01-01 00:00:00