Abstract:
BACKGROUND:Patients with multiple sclerosis (MS) report sleep disturbances (SD) and excessive daytime sleepiness (EDS) more frequently than the general population. Our objectives were to evaluate SD and EDS in MS patients and to test the reliability of subjective sleep questionnaires. METHODS:Demographic and clinical characteristics of unselected consecutive patients with MS were collected. Different questionnaires were used to assess quality of sleep, daytime sleepiness, fatigue, anxiety, depression and quality of life (QoL). Nocturnal polysomnography and Multiple Sleep Latency Test (MSLT) were performed in 25 selected MS patients with fatigue and with or without EDS. RESULTS:205 MS patients were enrolled. More than half of the MS patients were classified as 'poor sleepers'. In multivariate analysis, SD were correlated with disability, fatigue, depression, QoL, and pain, but not with EDS. Subjective sleepiness evaluated with the Epworth Sleepiness Scale and SD with the Pittsburgh Sleep Quality Index were not correlated with the results of the objective assessments of vigilance (MSLT) and sleep. CONCLUSIONS:SD and EDS are frequent among MS patients. Objective assessment of vigilance and sleep can be challenging but MS patients who are poor sleepers should receive immediate assessment and treatment in order to improve QoL.
journal_name
Eur Neuroljournal_title
European neurologyauthors
Neau JP,Paquereau J,Auche V,Mathis S,Godeneche G,Ciron J,Moinot N,Bouche Gdoi
10.1159/000335076subject
Has Abstractpub_date
2012-01-01 00:00:00pages
8-15issue
1eissn
0014-3022issn
1421-9913pii
000335076journal_volume
68pub_type
杂志文章abstract::A randomized, double-blind trial on the effects of GM1 ganglioside in cerebrovascular diseases was done on 40 patients; the treatment (40 mg/day i.m. injection) began after the acute phase and lasted 6 weeks. 18 cases took the drug and 16 the placebo. The evaluation of the cases was made by graduating the severity of ...
journal_title:European neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000115823
更新日期:1985-01-01 00:00:00
abstract::A 21-year-old male developed back pain, fever, and rapidly progressive quadriparesis. Lumbar tap yielded frank pus which was confirmed on magnetic resonance imaging (MRI) to be located mainly in the cervical epidural space. Conservative antibiotic remedy was partially effective for restoration of the neurological defi...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116855
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abstract::A catamnestic study of 50 patients with Wernicke's disease showed that nearly all patients retained residual symptoms and that the prognosis as to life expectancy and social functioning was poor, even after early institution of vitamin B-complex medication. It is advisable to give vitamin B-complex prophylactically in...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000114797
更新日期:1977-01-01 00:00:00
abstract::Our knowledge about pathophysiology of intracerebral hemorrhage (ICH) mainly originates from preclinical models of ICH. In this study, cerebral ultrastructure surrounding hematoma and its correlation with clinical severity were investigated in ICH patients. Thirty patients with basal ganglia hemorrhage and 6 control s...
journal_title:European neurology
pub_type: 杂志文章
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abstract::Botulinum toxin type B (BT-B) therapy failure due to formation of botulinum toxin type B antibodies (BT-B-AB) has only been reported in patients with botulinum toxin type A antibodies (BT-A-AB). We are reporting BT-B-AB-induced therapy failure in 2 patients with no previous exposure to botulinum toxin. In patient 1 co...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000081463
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abstract::The electrocardiogram was analyzed in 31 patients with motor neurone disease. ECG abnormalities were encountered in 27 of the patients. The dominating ECG changes consisted of ST-T wave changes and supraventricular arrhythmias. The underlying mechanisms are discussed in relation to the neurological symptomatology. ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000114770
更新日期:1976-01-01 00:00:00
abstract::This lecture is mainly concerned with questions about how hemodynamic conditions in atherosclerotic arteries affect arriving platelets that aggregate there and about the chemical agents responsible for making the platelets reactive. The effects of hemodynamic conditions and the agents are known mainly from in vitro ex...
journal_title:European neurology
pub_type: 杂志文章,评审
doi:10.1159/000115608
更新日期:1983-01-01 00:00:00
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journal_title:European neurology
pub_type: 杂志文章,多中心研究
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更新日期:2011-01-01 00:00:00
abstract::We report a short-term double-blind, crossover study of CoQ10 in 8 patients with mitochondrial encephalomyopathies. Four patients had myoclonus epilepsy with ragged-red fibers syndrome, 3 had mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes syndrome, and 1 had chronic progressive extern...
journal_title:European neurology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1997-01-01 00:00:00
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journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116076
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journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116240
更新日期:1988-01-01 00:00:00
abstract::SJL/J mice have been studied as the model animals for autoimmunological diseases. Recently it was clarified that SJL/J mice have a defect of dysferlin. Human limb girdle muscular dystrophy 2B and Miyoshi myopathy also have a defect of dysferlin. In this study we present the histological and immunohistological changes ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000097005
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:The profile and degree of cognitive impairment in Multiple System Atrophy (MSA) and the impact of sleep disorders, REM sleep behavior disorder (RBD) in particular, in parkinsonism-related cognitive deficits are currently being debated. SUMMARY:We reviewed the cognitive, affective and sleep findings in MSA a...
journal_title:European neurology
pub_type: 杂志文章,评审
doi:10.1159/000364903
更新日期:2014-01-01 00:00:00
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journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000073055
更新日期:2003-01-01 00:00:00
abstract::The blink reflex and its equivalent glabella tap reflex are behavioural motor responses normally found in neonates and in the physiological startle reflex. Historically, it was described by Overend in 1896 and soon afterwards by McCarthy and by Bekhterev who disputed its origins. Kugelberg in 1952 recorded the early-l...
journal_title:European neurology
pub_type: 历史文章,杂志文章,评审
doi:10.1159/000114053
更新日期:2008-01-01 00:00:00
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journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000329578
更新日期:2011-01-01 00:00:00
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journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115081
更新日期:1979-01-01 00:00:00
abstract:BACKGROUND:Transient ischemic attacks (TIAs) bear a presumed high risk of early recurrence of stroke. Data in the literature, however, are inconsistent, as recurrence rates range from 9.5 to 20%, at 90 days. AIMS:The study was designed to determine the risk of stroke after TIA. METHODS:94 consecutive patients referre...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000332999
更新日期:2012-01-01 00:00:00
abstract::The efficacy and safety of sumatriptan, a selective 5-HT1-like receptor agonist, were studied in a randomized, double-blind, placebo-controlled, parallel-group, multicentre, multinational clinical trial of 235 patients suffering a moderate to severe migraine attack. Patients were randomized to treat a single migraine ...
journal_title:European neurology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1159/000116760
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Half of Parkinson's disease (PD) patients with mild cognitive impairment (MCI) develop dementia. We studied topographic distribution of cerebral hypometabolism in PD with different types of MCI. METHODS:This study included 61 nondemented PD patients and 14 age-matched controls. PD patients were grouped into...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000315036
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journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000102161
更新日期:2007-01-01 00:00:00
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journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000114898
更新日期:1977-01-01 00:00:00
abstract::The role of genetics in Parkinson's disease (PD), previously controversial, is now documented by several studies. A major breakthrough has been the discovery of two single-gene defects in familial PD. A single base pair change at position 209 from G to A (G209A) in the fourth exon of the alpha-synuclein gene has been ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000008203
更新日期:2000-01-01 00:00:00
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journal_title:European neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000117129
更新日期:1995-01-01 00:00:00
abstract::In 167 patients with cerebrovascular disorders 323 carotid bifurcations were investigated by Duplex ultrasound. In 100 of these patients, additionally intravenous digital subtraction angiography (DSA) was performed and in 35 patients, also intra-arterial DSA was carried out. In 32 patients all three procedures were pe...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116233
更新日期:1988-01-01 00:00:00
abstract::Regressive painless left third nerve paralysis with pupillary involvement was followed 6 months later by a right painful complete ophthalmoplegia. The two attacks resolved without treatment. The patient, 22 years old, was recognized diabetic and no other cause was found. It is suggested that this clinical pattern is c...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115554
更新日期:1983-01-01 00:00:00
abstract::A critical analysis of cases of systemic lupus erythematosus (SLE) and chorea is presented. Choreatic movements occurred early in the course of the disease in most cases; the duration varied from several days to 3 years. No sex predominance was found and no relationship could be demonstrated between chorea and other n...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115743
更新日期:1984-01-01 00:00:00
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journal_title:European neurology
pub_type: 杂志文章
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更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:Effective management of multisymptomatic chronic diseases such as multiple sclerosis (MS) requires a multimodal, interdisciplinary approach. At MS clinics, numerous healthcare specialties are coordinated to provide patients with quality clinical care for all aspects of their disease. Settings and resource av...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000367620
更新日期:2014-01-01 00:00:00