Abstract:
:This lecture is mainly concerned with questions about how hemodynamic conditions in atherosclerotic arteries affect arriving platelets that aggregate there and about the chemical agents responsible for making the platelets reactive. The effects of hemodynamic conditions and the agents are known mainly from in vitro experiments in which aggregation can be quantitatively correlated with blood flow and biochemical effects by simple and reproducible methods; the relevance to the more complicated situations in hemostasis and thrombosis is uncertain. It is difficult to devise quantitative in vivo methods, mainly because of the rapidity with which platelets adhere and aggregate in diseased or damaged blood vessels. Hypotheses for explaining in vivo platelet aggregation in biochemical terms must take the hemodynamic situation into account.
journal_name
Eur Neuroljournal_title
European neurologyauthors
Born GVdoi
10.1159/000115608subject
Has Abstractpub_date
1983-01-01 00:00:00pages
30-4eissn
0014-3022issn
1421-9913journal_volume
22 Suppl 1pub_type
杂志文章,评审abstract::The clinical severity of EAE is enhanced by pre-treatment with distemper, measles and BCG vaccine, measles vaccine gives a more severe onset of disease. Rubella vaccine and TAB leads to mild disease which recurs on re-treatment with the appropriate vaccine. These findings and their possible significance in MS are brie...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000114898
更新日期:1977-01-01 00:00:00
abstract:BACKGROUND:High-sensitivity C-reactive protein (hs-CRP) is associated with a risk of causing diabetes mellitus and ischemic stroke. However, the association between hs-CRP levels and functional outcome after small-artery occlusion (SAO) is unknown. METHODS:Data for 836 patients diagnosed with SAO were collected from t...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000477929
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:To evaluate the role of computed tomography angiography (CTA) and magnetic resonance angiography (MRA) in the quantification of atherosclerotic stenosis of carotid artery bifurcation in comparison with digital substraction angiography (DSA) and Doppler sonography (DS). MATERIALS AND METHODS:Twenty-five patient...
journal_title:European neurology
pub_type: 临床试验,杂志文章
doi:10.1159/000050752
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Cerebral infarction (CI) occurring soon after intracerebral hemorrhage (ICH) has been rarely reported. The purpose of the present study was to characterize this condition and discuss the possible pathophysiology. METHOD:We retrospectively studied 6 patients who developed CI within 10 days after ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000098465
更新日期:2007-01-01 00:00:00
abstract::The aim of this study was to investigate whether there are clues for a correlation between tumor progression and serum anti-Hu antibody concentration in patients with anti-Hu-associated paraneoplastic neurological syndromes (PNS). 19 patients with anti-Hu-associated PNS were assigned to three groups according to the c...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000057897
更新日期:2002-01-01 00:00:00
abstract::In 167 patients with cerebrovascular disorders 323 carotid bifurcations were investigated by Duplex ultrasound. In 100 of these patients, additionally intravenous digital subtraction angiography (DSA) was performed and in 35 patients, also intra-arterial DSA was carried out. In 32 patients all three procedures were pe...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116233
更新日期:1988-01-01 00:00:00
abstract::The blink reflex and its equivalent glabella tap reflex are behavioural motor responses normally found in neonates and in the physiological startle reflex. Historically, it was described by Overend in 1896 and soon afterwards by McCarthy and by Bekhterev who disputed its origins. Kugelberg in 1952 recorded the early-l...
journal_title:European neurology
pub_type: 历史文章,杂志文章,评审
doi:10.1159/000114053
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:We investigated the predictive value of standard neurological evaluation, a commercially available biomarker assay and neuroimaging in the subacute phase for outcome after thrombolytic therapy in ischemic stroke. METHODS:Thirty-four consecutive ischemic stroke patients were evaluated by means of the NIH S...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000215876
更新日期:2009-01-01 00:00:00
abstract::Direct evidence of the anatomical localization of brain function is provided by functional neurological changes during awake surgery combined with data from preoperative functional magnetic resonance imaging and diffusion tensor imaging studies. The goal of the present study was to analyze the etiology and mechanism o...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000258636
更新日期:2010-01-01 00:00:00
abstract::MPTP, 1-methyl-4-phenyl-pyridinium ion (MPP+) and the structurally related compounds including N-methyltetrahydroisoquinilinium ion inhibited the tyrosine hydroxylase (TH) system in tissue slices of rat striatum at 10(-5) M. Mouse striatum is more susceptible to MPTP than rat striatum. A similar degree of inhibition b...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116350
更新日期:1987-01-01 00:00:00
abstract::Clinical evaluation, quantitative analysis of the EMG, and motor unit fiber density were carried out on 34 selected patients that suffered paralytic poliomyelitis. 50% of the subjects developed a late and slowly progressive weakness. Automatic analysis of the electromyogram showed a great increase in mean amplitude in...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115578
更新日期:1983-01-01 00:00:00
abstract::A case of peripheral neuropathy due to styrene is described. The diagnosis of peripheral neuropathy was confirmed by a motor-nerve conduction study and sural nerve biopsy. ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116046
更新日期:1986-01-01 00:00:00
abstract::Two cases are presented with a long clinical history of multiple sclerosis (MS) before the diagnosis of an intracranial brain tumor. In the subsequent brain autopsy, however, both cases presented a diffusely growing anaplastic astrocytoma, only, and no changes similar to MS were seen. Diffuse tumor growth was noted in...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116009
更新日期:1986-01-01 00:00:00
abstract::Marcel Proust is one of the most important French writers of the 20th century. His relationship with medicine and with neurology is possibly linked to the fact that his asthma was considered to be a psychosomatic disease classified as neurasthenia. Stendhal's syndrome is a rare psychiatric syndrome characterized by an...
journal_title:European neurology
pub_type: 传,历史文章,杂志文章
doi:10.1159/000357562
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Several testing options are available to detect asymptomatic coronary artery disease (CAD). Dobutamine stress echocardiography (DSE) has been reported to increase the sensitivity and specificity of stress testing to detect CAD. Most studies concerned patients with known or suspected CAD who have a high prete...
journal_title:European neurology
pub_type: 临床试验,杂志文章
doi:10.1159/000096488
更新日期:2006-01-01 00:00:00
abstract::Five patients with monomelic spinal muscular atrophy are described. Clinical features included insidious onset of wasting and weakness of one limb, lack of involvement of the cranial nerves, brain stem, pyramidal tracts and sensory system, and a stable condition over a period of 4-20 years. Clinical findings, electrom...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116249
更新日期:1988-01-01 00:00:00
abstract::Superior orbital fissure syndrome is a symptomatologic complex, consisting of retroorbital pain, paralysis of extraocular muscles, impairment of first trigeminal branches and frequent involvement of the optic nerve. From a review of 130 published cases including two personal observations, it appears that the clinical ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000114876
更新日期:1977-01-01 00:00:00
abstract::The report deals with the changes of brain functions in the course of traumatic apallic syndrome (TAS) by means of the EEG examination, in the classical way, and by computer analysis as well. The development of EEG changes during individual stages of the TAS is studied. The EEG examination was performed repeatedly in ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116316
更新日期:1987-01-01 00:00:00
abstract::The etiology of multiple sclerosis (MS) is still largely unknown and it has been proposed that an impaired venous drainage from the central nervous system, defined as chronic cerebrospinal venous insufficiency (CCSVI), may play a role in this. We investigated the prevalence of extracranial venous drainage pattern alte...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000445540
更新日期:2016-01-01 00:00:00
abstract::The aim of this study was to investigate whether the side and location of single small infarcts (< or = 3 cm) in the corona radiata (28 patients) and pontine base (36 patients) influence the incidence of contralateral upper or lower limb paresis and dysarthria. While the severity of contralateral limb paresis was not ...
journal_title:European neurology
pub_type: 临床试验,杂志文章
doi:10.1159/000117290
更新日期:1996-01-01 00:00:00
abstract::Hypertrophic changes in the inferior olivary nuclei have been occasionally described in patients with progressive supranuclear palsy (PSP). To elucidate the incidence of olivary hypertrophy, we investigated morphologically the olives and their associated pathways in 20 autopsied cases: 11 cases of PSP, 3 cases of Mach...
journal_title:European neurology
pub_type: 临床试验,杂志文章
doi:10.1159/000007915
更新日期:1998-01-01 00:00:00
abstract::In the fast moving field of muscular dystrophy, therapeutic matters are now high on the agenda. Despite little progress made in the understanding of the exact pathogenesis, hopes have been raised with the advent of molecular medicine applied to such disorders. A constellation of techniques or therapeutic solutions are...
journal_title:European neurology
pub_type: 杂志文章,评审
doi:10.1159/000008150
更新日期:2000-01-01 00:00:00
abstract::In a 14-year follow-up the improvement of language functions and the decrease of EEG abnormalities are described in a girl with the Landau-Kleffner syndrome. In this case, the results of subsequent EEG recordings do not permit conclusions about the course of the aphasia. Disappearance of focal spike and waves, bilater...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116390
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Assessing collateral status is important in acute ischemic stroke. The purpose of this study was to compare multiphasic perfusion computed tomography (MPCT) with digital subtraction angiography (DSA) in predicting leptomeningeal collateral flow in acute middle cerebral artery (MCA) infarction. METHODS:Conse...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000334867
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:To assess the Multiple Sclerosis Neuropsychological Questionnaire (MSNQ) in patients with clinically isolated syndrome (CIS). METHODS:130 European CIS patients and 60 relatives completed the MSNQ. RESULTS:The mean (SD) MSNQ score for CIS patients was 15.5 (10.8) and for their informants 11.3 (9.6). Neither ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000345698
更新日期:2013-01-01 00:00:00
abstract:INTRODUCTION:Recently, neurosyphilis was found to be associated with diabetes mellitus (DM). Whether the association was specific to neurosyphilis among central nervous system (CNS) infections, and whether neurosyphilis is associated with other prevalent metabolic disorders deserves further study. METHODS:An in-depth ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000503626
更新日期:2019-01-01 00:00:00
abstract::13 patients with spinal dural arteriovenous fistulas (DAVF) diagnosed in our Institution have been the object of this study. The necessity to include the disease in the differential diagnosis with other pathologies affecting the lower thoracic cord, particularly in middle-aged and old males, is emphasized. Involvement...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000117015
更新日期:1994-01-01 00:00:00
abstract::Previous findings regarding the role of TNF-alpha-308 gene polymorphism in multiple sclerosis (MS) are contradictory. The aim of this study was to investigate the possible influence of TNF-alpha-308 polymorphism on MS susceptibility and the MS disease process in a Croatian and Slovenian population. Genotyping was perf...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000099159
更新日期:2007-01-01 00:00:00
abstract::A case of Fisher's syndrome associated with trigeminal herpes zoster is reported for the first time. Retrograde propagation of the virus to the brainstem through the trigeminal root was thought to be the most probable pathogenic mechanism. We provide additional evidence suggesting that the focus of Fisher's syndrome i...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115817
更新日期:1985-01-01 00:00:00
abstract::A double-blind controlled trial was performed on 6 patients affected with Steinert's disease in order to evaluate the efficacy of two different dosages of diphenylhydantoin (PHT, 200 and 300 mg/day) and carbamazepine (CBZ, 600 and 800 mg/day) on the myotonic afterdischarge. Both dosages of PHT and CBZ induced a signif...
journal_title:European neurology
pub_type: 临床试验,杂志文章
doi:10.1159/000115546
更新日期:1983-01-01 00:00:00