Motor disturbance and brain functional imaging in Parkinson's disease.

Abstract:

:18F-Dopa positron emission tomography (PET) provides a sensitive means of quantitating the loss of nigrostriatal dopaminergic fibres in Parkinson's disease and so can be used to diagnose its presence and to objectively follow the rate of disease progression. It can also be used, in principle, to determine the efficacy of putative neuroprotective agents and has already been extensively used to monitor the viability of striatal transplants of fetal mesencephalic tissue. Loss of dopaminergic projections produces significant changes in the patterns of both resting and activated cortical function. H2(15)O PET activation studies have suggested that the akinesia of Parkinson's disease is associated with failure to activate the supplementary motor and dorsal prefrontal areas, brain regions particularly involved in motor preparation and decision making. Activation of these cortical areas can be restored by administering dopaminergic medication, implanting the striatum with fetal mesencephalic tissue, and by pallidotomy. This article reviews the insight that PET studies have provided into the pathophysiology of Parkinson's disease.

journal_name

Eur Neurol

journal_title

European neurology

authors

Brooks DJ

doi

10.1159/000113473

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

26-32

eissn

0014-3022

issn

1421-9913

journal_volume

38 Suppl 2

pub_type

杂志文章,评审
  • Positive Predictive Value of French Hospitalization Discharge Codes for Stroke and Transient Ischemic Attack.

    abstract:BACKGROUND:We aimed at measuring the positive predictive value (PPV) of data in the French Hospital Medical Information Database (FHD). SUMMARY:This retrospective multicenter study included 31 hospitals from where 56 hospital stays were randomly selected among all hospitalizations for the years 2009 and 2010 with at l...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000438859

    authors: Giroud M,Hommel M,Benzenine E,Fauconnier J,Béjot Y,Quantin C,FRESCO Study.

    更新日期:2015-01-01 00:00:00

  • Marie-Jean-Pierre Flourens (1794-1867) and cortical localization.

    abstract::The child prodigy Marie-Jean-Pierre Flourens received his medical degree at Montpellier when aged 19. As a young promising physician Flourens was asked to investigate Gall's controversial views on cerebral localization. To test Gall's assertions, Flourens developed ablation as a procedure to explore the workings of th...

    journal_title:European neurology

    pub_type: 传,历史文章,杂志文章

    doi:10.1159/000206858

    authors: Pearce JM

    更新日期:2009-01-01 00:00:00

  • Superior orbital fissure syndrome. Review of 130 cases.

    abstract::Superior orbital fissure syndrome is a symptomatologic complex, consisting of retroorbital pain, paralysis of extraocular muscles, impairment of first trigeminal branches and frequent involvement of the optic nerve. From a review of 130 published cases including two personal observations, it appears that the clinical ...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000114876

    authors: Lenzi GL,Fieschi C

    更新日期:1977-01-01 00:00:00

  • Adult tuberculous meningitis in Qatar: a descriptive retrospective study from its referral center.

    abstract:BACKGROUND:Tuberculous meningitis is the severest and commonest form of central nervous system tuberculosis causing high mortality and morbidity. We aim to study the clinical, biochemical, and radiological characteristics of tuberculous meningitis in adult patients in Qatar and to calculate the incidence. METHODS:A de...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000368894

    authors: Imam YZ,Ahmedullah HS,Akhtar N,Chacko KC,Kamran S,Al Alousi F,Alsuwaidi Z,Almaslmani M,Al Khal AL,Deleu D

    更新日期:2015-01-01 00:00:00

  • Transient global amnesia and stroke.

    abstract::Four patients who experienced isolated transient global amnesia had computed tomographic evidence for a cerebral infarct (3 cases) or hemorrhage (1 case). The medial part of the temporal lobe was involved in 2 patients (left in 1, right in 1), the left lentiform nucleus in 1 patient, and the left thalamus in 1 left-ha...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116240

    authors: Bogousslavsky J,Regli F

    更新日期:1988-01-01 00:00:00

  • Three-dimensional computed tomography angiography and magnetic resonance angiography of carotid bifurcation stenosis.

    abstract:PURPOSE:To evaluate the role of computed tomography angiography (CTA) and magnetic resonance angiography (MRA) in the quantification of atherosclerotic stenosis of carotid artery bifurcation in comparison with digital substraction angiography (DSA) and Doppler sonography (DS). MATERIALS AND METHODS:Twenty-five patient...

    journal_title:European neurology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000050752

    authors: Binaghi S,Maeder P,Uské A,Meuwly JY,Devuyst G,Meuli RA

    更新日期:2001-01-01 00:00:00

  • Contribution of PET studies in diagnosis of corticobasal degeneration.

    abstract::Five patients with clinical features of corticobasal degeneration (CBD) were studied with PET imaging. The main clinical findings included a unilateral extrapyramidal motor disorder, without significant response to levodopa, as well as clumsiness, dysarthria, apraxia and a clear asymmetry of neurological signs. PET st...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000008187

    authors: Lutte I,Laterre C,Bodart JM,De Volder A

    更新日期:2000-01-01 00:00:00

  • Nocturnal complex partial seizures precipitated by REM sleep. A case report.

    abstract::A 16-year-old patient presenting with complex partial seizures occurring in the transition from a REM period to wakefulness is described. His baseline EEG showed generalized and symmetrical slow spike and wave complexes, on a normal background activity, activated by NREM sleep. Polygraphic and videotape recordings, ca...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116383

    authors: Silvestri R,De Domenico P,Musolino R,Mento G,Marabello L,Longo M,Di Perri R

    更新日期:1989-01-01 00:00:00

  • Can oral 311C90, a novel 5-HT1D agonist, prevent migraine headache when taken during an aura?

    abstract::The purpose of this pilot study was to determine whether 20 mg oral 311C90 can prevent the development of migraine headache when taken during the aura phase of a migraine attack. The study also aimed to provide an initial safety profile for 311C90 when taken during the aura. Forty patients (31 females, 9 males) were e...

    journal_title:European neurology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1159/000119101

    authors: Dowson A

    更新日期:1996-01-01 00:00:00

  • European Association of Young Neurologists and Trainees: position paper on teaching courses for Generation Y.

    abstract::The European Association of Young Neurologists and Trainees (EAYNT) is a non-profit organization which acts on behalf of young neurologists in Europe and concertedly exerts influence on the formation of a new generation of neurologists [Struhal et al.: Eur J Neurol 2009;16:e146-e148]. This concerns particularly the Ge...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000327696

    authors: Struhal W,Falup-Pecurariu C,Sztriha LK,Grisold W,Sellner J

    更新日期:2011-01-01 00:00:00

  • Alfred Vulpian and Jean-Martin Charcot in each other's shadow? From Castor and Pollux at La Salpêtrière to neurology forever.

    abstract::While Alfred Vulpian (1826-1887) is not completely forgotten, he cannot match the uninterrupted celebrity which Jean-Martin Charcot (1825-1893) still enjoys today. After becoming interne (residents) at the same institute in 1848, both were involved in shaping the cradle of what would become modern neurology. Both star...

    journal_title:European neurology

    pub_type: 传,历史文章,杂志文章

    doi:10.1159/000325733

    authors: Bogousslavsky J,Walusinski O,Moulin T

    更新日期:2011-01-01 00:00:00

  • Prevalence rate of cerebrovascular disease in the rural population of northwest Peloponnese, Greece. A direct epidemiological study.

    abstract::In a direct (door-to-door) epidemiological study, the prevalence rate of cerebrovascular disease in the rural population of northwest Peloponnese, Greece, was found to be 995 strokes per 100,000 inhabitants over 20 years of age. This number is considerably lower than the prevalence rate (1,417 strokes per 100,000 inha...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116408

    authors: Paschalis C,Polychronopoulos P,Makris N,Kondakis X,Papapetropoulos T

    更新日期:1989-01-01 00:00:00

  • Styrene-induced peripheral neuropathy. A case report.

    abstract::A case of peripheral neuropathy due to styrene is described. The diagnosis of peripheral neuropathy was confirmed by a motor-nerve conduction study and sural nerve biopsy. ...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116046

    authors: Behari M,Choudhary C,Roy S,Maheshwari MC

    更新日期:1986-01-01 00:00:00

  • Increased density in the middle cerebral artery by nonenhanced computed tomography. Prognostic value in acute cerebral infarction.

    abstract::In order to consider the prognostic value of hyperdensity of the middle cerebral artery (MCA), we studied retrospectively the medical records of 80 consecutive patients with the diagnosis of ischemic stroke who underwent a non-enhanced computed tomography no longer than 24 h after the onset of the symptoms. To determi...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116949

    authors: Zorzon M,Masè G,Pozzi-Mucelli F,Biasutti E,Antonutti L,Iona L,Cazzato G

    更新日期:1993-01-01 00:00:00

  • Neurofibrillary tangles and Alzheimer's disease.

    abstract::The neuropathological diagnosis of Alzheimer's disease relies on the presence of both neurofibrillary tangles and senile plaques. The number of neurofibrillary tangles is tightly linked to the degree of dementia, suggesting that the formation of neurofibrillary tangles more directly correlates with neuronal dysfunctio...

    journal_title:European neurology

    pub_type: 杂志文章,评审

    doi:10.1159/000007969

    authors: Brion JP

    更新日期:1998-10-01 00:00:00

  • Executive and Attentional Disorders, Epilepsy and Porencephalic Cyst in Autosomal Recessive Cerebellar Ataxia Type 3 Due to ANO10 Mutation.

    abstract:BACKGROUND:ANO10 mutations have recently been reported in autosomal recessive cerebellar ataxia type 3 (ARCA3). The objective of this study was to describe the phenotype of 2 siblings with compound heterozygous ANO10 mutations and progressive cerebellar ataxia, epilepsy, and cognitive impairment. A porencephalic cyst w...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000445109

    authors: Chamard L,Sylvestre G,Koenig M,Magnin E

    更新日期:2016-01-01 00:00:00

  • Cognitive and demographic determinants of dementia in depressed patients with subjective memory complaints.

    abstract:BACKGROUND:Previous studies showed that late-life depression with subjective memory complaints (SMC) may be associated with an increased risk of developing dementia. However, not all such patients have cognitive decline. The aim of this longitudinal study was to identify possible clinical determinants of progressive de...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000090104

    authors: von Gunten A,Giannakopoulos P,Duc R

    更新日期:2005-01-01 00:00:00

  • Very Early Neurophysiological Study in Guillain-Barre Syndrome.

    abstract:PURPOSE:The diagnosis of Guillain-Barre syndrome (GBS) in the very early stage may be challenging. Our aim was to report the neurophysiological abnormalities in GBS within 4 days of clinical onset. We expected that GBS will be diagnosed by the assistance of neurophysiological study in the very early stage. METHODS:We ...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000494261

    authors: Jin J,Hu F,Qin X,Liu X,Li M,Dang Y,Dang J

    更新日期:2018-01-01 00:00:00

  • Clinical, biochemical and neuroimaging parameters after thrombolytic therapy predict long-term stroke outcome.

    abstract:INTRODUCTION:We investigated the predictive value of standard neurological evaluation, a commercially available biomarker assay and neuroimaging in the subacute phase for outcome after thrombolytic therapy in ischemic stroke. METHODS:Thirty-four consecutive ischemic stroke patients were evaluated by means of the NIH S...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000215876

    authors: Brouns R,Sheorajpanday R,Kunnen J,De Surgeloose D,De Deyn PP

    更新日期:2009-01-01 00:00:00

  • Tumor progression and serum anti-HuD antibody concentration in patients with paraneoplastic neurological syndromes.

    abstract::The aim of this study was to investigate whether there are clues for a correlation between tumor progression and serum anti-Hu antibody concentration in patients with anti-Hu-associated paraneoplastic neurological syndromes (PNS). 19 patients with anti-Hu-associated PNS were assigned to three groups according to the c...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000057897

    authors: Rauer S,Andreou I

    更新日期:2002-01-01 00:00:00

  • Brainstem involvement in hypertensive encephalopathy: a report of two cases and literature review.

    abstract::The cerebral hemispheres show prominent involvement in hypertensive encephalopathy far more frequently than the brainstem. Two patients with severe paroxysmally accelerated hypertension associated with brainstem hyperintensity in T2-weighted magnetic resonance images are presented. Both present hyperintense lesions im...

    journal_title:European neurology

    pub_type: 杂志文章,评审

    doi:10.1159/000100015

    authors: Uchino M,Haga D,Nomoto J,Mito T,Kuramitsu T

    更新日期:2007-01-01 00:00:00

  • Sympathetic skin potentials and bulbocavernosus reflex in patients with chronic alcoholism and impotence.

    abstract::Fifteen chronic alcoholic male patients with impotence have been investigated with the electrophysiological method of sympathetic skin potentials recorded from the genital skin and with the electrically induced bulbocavernosus reflex. Both electrophysiological tests did not differ from those of normal controls. It was...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000117367

    authors: Ertekin C,Almis S,Ertekin N

    更新日期:1990-01-01 00:00:00

  • Continuous muscle fiber activity associated with denervation atrophy. Clinical presentation, electrophysiological and pharmacological investigations, histological and histochemical examinations of muscle biopsy.

    abstract::We describe a case presenting continuous muscle fiber activity syndrome, which was slightly reduced by the blocking of nerve conduction and abolished by ischemia. Clinical, electromyographical and bioptical evidence of marked abnormalities of peripheral motoneurons were observed. Association with central motoneuron le...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000115508

    authors: Cotrufo R,Di Iorio G,Ammendola A,Bravaccio F

    更新日期:1982-01-01 00:00:00

  • Electrocardiographic findings in motor neurone disease.

    abstract::The electrocardiogram was analyzed in 31 patients with motor neurone disease. ECG abnormalities were encountered in 27 of the patients. The dominating ECG changes consisted of ST-T wave changes and supraventricular arrhythmias. The underlying mechanisms are discussed in relation to the neurological symptomatology. ...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000114770

    authors: Hindfelt B

    更新日期:1976-01-01 00:00:00

  • Extracranial Venous Drainage Pattern in Multiple Sclerosis and Healthy Controls: Application of the 2011 Diagnostic Criteria for Chronic Cerebrospinal Venous Insufficiency.

    abstract::The etiology of multiple sclerosis (MS) is still largely unknown and it has been proposed that an impaired venous drainage from the central nervous system, defined as chronic cerebrospinal venous insufficiency (CCSVI), may play a role in this. We investigated the prevalence of extracranial venous drainage pattern alte...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000445540

    authors: Cardaioli G,Di Filippo M,Bianchi A,Eusebi P,Di Gregorio M,Gaetani L,Gallina A,Calabresi P,Sarchielli P

    更新日期:2016-01-01 00:00:00

  • Effects of acyclovir on sensory axonal neuropathy, segmental motor paresis and postherpetic neuralgia in herpes zoster patients.

    abstract::The effect of oral treatment with acyclovir (ACV) on sensory axonal neuropathy, segmental motor paresis and postherpetic neuralgia (PHN) was studied in 105 patients with herpes zoster. Forty-seven patients were treated with ACV at a dose of 4 g/day in 5 doses for at least a week; the others did not undergo any kind of...

    journal_title:European neurology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000117274

    authors: Mondelli M,Romano C,Passero S,Porta PD,Rossi A

    更新日期:1996-01-01 00:00:00

  • Diagnosis of Vertigo and Dizziness Syndromes in a Neurological Outpatient Clinic.

    abstract:BACKGROUND:Dizziness and vertigo are frequent complaints of outpatients in the neurological department. Our objective was to explore the epidemiological category and clinical features of patients with dizziness or vertigo in the neurological outpatient department of a tertiary hospital. METHODS:We consecutively recrui...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000489639

    authors: Pan Q,Zhang Y,Long T,He W,Zhang S,Fan Y,Zhou J

    更新日期:2018-01-01 00:00:00

  • Writing error may be a predictive sign for impending brain atrophy progression in amyotrophic lateral sclerosis: a preliminary study using X-ray computed tomography.

    abstract:AIM:To investigate whether writing errors are predictive of longitudinal brain atrophy progression in patients with amyotrophic lateral sclerosis (ALS). METHODS:The frequency of writing errors in 6 ALS patients without dementia was compared with longitudinal changes in lateral ventricular areas of the bilateral anteri...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000328216

    authors: Ichikawa H,Ohno H,Murakami H,Ohnaka Y,Kawamura M

    更新日期:2011-01-01 00:00:00

  • Relationship between psychosocial factors and onset of multiple sclerosis.

    abstract:OBJECTIVE:The aim of this study was to investigate the influence of psychosocial variables on patients with multiple sclerosis (MS) and the relationship between these variables and the onset of MS. BACKGROUND:The current evidence indicates that many types of psychosocial factors are involved in the development and rel...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000226428

    authors: Liu XJ,Ye HX,Li WP,Dai R,Chen D,Jin M

    更新日期:2009-01-01 00:00:00

  • Primary intracerebral hemorrhages in the Besançon stroke registry. Initial clinical and CT findings, early course and 30-day outcome in 350 patients.

    abstract::The purpose of this study was to estimate the risk factors, early course, outcome and neuroimaging patterns in primary intracerebral hemorrhages (PIH). Using the Besançon Stroke Registry, 350 patients with first PIH documented by computed tomography (CT) between 1987 and 1993 were included in the present study. Patien...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000008177

    authors: Tatu L,Moulin T,El Mohamad R,Vuillier F,Rumbach L,Czorny A

    更新日期:2000-01-01 00:00:00