Abstract:
BACKGROUND:Small fiber neuropathy (SFN) is a challenging subtype of peripheral neuropathies. Once the diagnosis has been established, there is an uncertainty how SFN may progress, whether larger fibers will become involved over time, whether quality of life may be compromised, or whether repeated diagnostic workup in patients with unknown underlying cause may increase the yield of treatable causes of SFN. METHODS:We evaluated 16 patients with documented long-time course of idiopathic SFN. RESULTS:Clinical and electrophysiological course remained stable in 75% of the patients, while 25% SFN-patients developed large fiber neuropathies. CONCLUSIONS:Our data suggest that SFN represents a benign disease course in the majority of patients without severely limiting the quality of life.
journal_name
Eur Neuroljournal_title
European neurologyauthors
Flossdorf P,Haupt WF,Brunn A,Deckert M,Fink GR,Lehmann HC,Wunderlich Gdoi
10.1159/000487717subject
Has Abstractpub_date
2018-01-01 00:00:00pages
161-165issue
3-4eissn
0014-3022issn
1421-9913pii
000487717journal_volume
79pub_type
杂志文章abstract:BACKGROUND:Several treatments are available to treat the immune-mediated chronic inflammatory demyelinating polyneuropathy (CIDP). Among these treatments, intravenous immunoglobulins, corticosteroids and plasma exchanges are validated and widely used. A few immunosuppressive drugs have been tried, but they had little e...
journal_title:European neurology
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更新日期:2015-01-01 00:00:00
abstract:BACKGROUND/AIMS:It is generally assumed that silent brain infarction (SBI) and symptomatic lacunar infarction (sLAC) share common vascular risk factors and their pathogeneses are known to be similar. However, few studies have conducted a risk factor profile analysis of the two diseases in a single study design. METHOD...
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abstract::About one third of patients with newly diagnosed epilepsy do not achieve seizure control despite medical therapy and should be assessed in detail to confirm the diagnosis, to determine the epilepsy syndrome and to plan treatment strategy. Refractory epilepsy is established when there is inadequate seizure control desp...
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更新日期:2009-01-01 00:00:00
abstract::The authors report a case of a giant aneurysm of the distal portion of the posterior inferior cerebellar artery presenting the classical picture of a tumor of the posterior fossa. CT scan of a giant aneurysm reveals the clear margin and high density area of aneurysm wall, and the homogeneous and high density area of t...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115108
更新日期:1979-01-01 00:00:00
abstract::Continuing the previously published clinical development of a case of adult metachromatic leukodystrophy (MLD), we now describe the terminal phase and death (at 46 years of age) of our patient. The final phase was characterized clinically by progression of generalized peripheral neuropathy, advanced extrapyramidal and...
journal_title:European neurology
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更新日期:1980-01-01 00:00:00
abstract::197 cases of patients with CVI, subjected to surgery by carotid endarterectomy, are examined. The results were nearly always good and hence the technique is recommended. Particular interest is attached to the risk connected with carotid clamping, through intraoperative study of CBF with 133Xe, such a risk is practical...
journal_title:European neurology
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doi:10.1159/000115010
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journal_title:European neurology
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更新日期:1988-01-01 00:00:00
abstract::In the fast moving field of muscular dystrophy, therapeutic matters are now high on the agenda. Despite little progress made in the understanding of the exact pathogenesis, hopes have been raised with the advent of molecular medicine applied to such disorders. A constellation of techniques or therapeutic solutions are...
journal_title:European neurology
pub_type: 杂志文章,评审
doi:10.1159/000008150
更新日期:2000-01-01 00:00:00
abstract::Concentrations of carbamazepine (CBZ) and its metabolite carbamazepine-10, 11-epoxide (CE) were determined in serum (free and total), brain tumors and paratumorous cortex from 37 epileptic patients. Tumor biopsies were available from 25 different gliomas, 5 hamartomas and 1 angioma. The free serum concentrations of CB...
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pub_type: 杂志文章
doi:10.1159/000117041
更新日期:1994-01-01 00:00:00
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doi:10.1159/000116627
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND/AIMS:Newer Scandinavian data on intracerebral hemorrhage (ICH) are scarce. We aimed at providing updated community-based data on the incidence, characteristics and outcome of ICH leading to hospitalization in the southernmost region in Norway. METHODS:We analyzed data from all consecutive patients hospitali...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000336299
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND/AIMS:This study aimed at assessing the feasibility of diffusion tensor imaging (DTI) in multilevel cervical spondylotic myelopathy (MCSM) and quantifying the association between DTI parameters and neuronal status as a whole. METHODS:Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were ob...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000443270
更新日期:2016-01-01 00:00:00
abstract::Automatic analysis of EMG (T/A analysis) and invasive muscle fiber conduction velocity in situ (MFCV) were performed in 15 patients after traumatic lesions of the knee and immobilization with quadriceps atrophy. T/A analysis showed transient reduced number of turns, consistent with inhibition of quadriceps motoneurons...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000008145
更新日期:2000-01-01 00:00:00
abstract::We report a 60-year-old right-handed Japanese man who showed an isolated persistent typing impairment without aphasia, agraphia, apraxia or any other neuropsychological deficit. We coined the term 'dystypia' for this peculiar neuropsychological manifestation. The symptom was caused by an infarction in the left frontal...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000047971
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Cardiac myxomas may present clinically with many different features. Since highly effective treatments exist, it is important that they are diagnosed quickly in order to avoid further complications. Our aim was to determine the influence of neurological presentation in diagnosis and prognosis of car...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000052116
更新日期:2001-01-01 00:00:00
abstract::Seventy-eight asymptomatic HIV-seropositive (aHIV) subjects were examined by means of an extensive neuropsychological test battery in comparison with 32 HIV-seronegative controls. They were also tested with regard to CD4+ and serum p24 antigen. Fifty-six of them completed a clinical follow-up of 12 up to 36 months and...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000117228
更新日期:1996-01-01 00:00:00
abstract:AIM:To determine the association between interleukin-6 (IL-6) and soluble E-selectin (sE-selectin) levels with the electrodiagnostic abnormalities in patients with impaired fasting glucose (IFG) and impaired glucose tolerance (IGT). METHODS:Serum HbA1c, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), f...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000444661
更新日期:2016-01-01 00:00:00
abstract::A case of Fisher's syndrome associated with trigeminal herpes zoster is reported for the first time. Retrograde propagation of the virus to the brainstem through the trigeminal root was thought to be the most probable pathogenic mechanism. We provide additional evidence suggesting that the focus of Fisher's syndrome i...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115817
更新日期:1985-01-01 00:00:00
abstract::To investigate the association between APOE-epsilon4 allele and memory phenotype in the preclinical stage of Alzheimer's disease (AD). We compared an extensive preclinical memory profile at the baseline evaluation of 2 AD genotype groups: APOE-epsilon4 allele carriers and patients with APOE-epsilon3 homozygosity. Base...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000078486
更新日期:2004-01-01 00:00:00
abstract::This paper records a patient of Osler's, who showed many features compatible with the Churg-Strauss syndrome of allergic granulomatous angiitis to be described 50 years later. ...
journal_title:European neurology
pub_type: 历史文章,杂志文章
doi:10.1159/000098474
更新日期:2007-01-01 00:00:00
abstract::Here we review a total of 17 patients, including 4 of our own, with young-adult-onset arteriosclerotic leukoencephalopathy, alopecia and lumbago without hypertension. All were Japanese and the illness seemed to be transmitted in an autosomal recessive fashion. The male to female ratio was 7.5:1. The age of onset usual...
journal_title:European neurology
pub_type: 杂志文章,评审
doi:10.1159/000117096
更新日期:1995-01-01 00:00:00
abstract::Blood samples from 45 cases of subacute sclerosing panencephalitis in Israel were tested for the presence of antibodies to Epstein-Barr virus capsid antigen and early antigen by the indirect immunofluorescence method. Significantly higher titers were found in patients as compared to healthy controls with higher titers...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000114697
更新日期:1975-01-01 00:00:00
abstract::Leonardo da Vinci clearly observed and described capillaries. Using the microscope, Marcello Malpighi examined the brain and major organs to demonstrate their finer anatomical features. This led to his discovery in 1661, of capillaries that proved fundamental to our understanding of the vascular system in the brain an...
journal_title:European neurology
pub_type: 传,历史文章,杂志文章
doi:10.1159/000107974
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:To assess the Multiple Sclerosis Neuropsychological Questionnaire (MSNQ) in patients with clinically isolated syndrome (CIS). METHODS:130 European CIS patients and 60 relatives completed the MSNQ. RESULTS:The mean (SD) MSNQ score for CIS patients was 15.5 (10.8) and for their informants 11.3 (9.6). Neither ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000345698
更新日期:2013-01-01 00:00:00
abstract::We have recently observed a diffuse slowing of brain waves using serial quantitative electroencephalographic (qEEG) examinations in interferon (IFN)-alpha-treated chronic hepatitis C patients. However, it remains unclear how this alteration could be assessed. We evaluated the correlation between the qEEG changes and t...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000062997
更新日期:2002-01-01 00:00:00
abstract::Embolism from the aneurysmal sac is a rare but possible manifestation of intracranial aneurysm; thrombus formation is probably related to the combined action of turbulent flow and a 'stagnant zone'. Three cases are presented: 2 with giant aneurysms (1 internal carotid and 1 sylvian) and 1 with a large aneurysm of the ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116824
更新日期:1992-01-01 00:00:00
abstract::To examine the possible influence of the blood-CSF barrier function on mathematical formulas for estimating intrathecal IgG production (IgG index, Tourtellotte's formula [TOURT], Schuller and Sagar's formula [Schull], and Reiber and Felgenhauer's formula [IgG(loc)]), we analysed serum and CSF samples from 105 healthy ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116920
更新日期:1993-01-01 00:00:00
abstract::The IgG oligoclonal bands in CSF can be found in high percentage of MS patients but the existence of a limited number of cases with CSF normal IgG profile is known as well. In the present study 63 out of 70 patients with definite MS and 24 out of 35 with probable MS had oligoclonal bands in the CSF at the isoelectric ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115534
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND:High-sensitivity C-reactive protein (hs-CRP) is associated with a risk of causing diabetes mellitus and ischemic stroke. However, the association between hs-CRP levels and functional outcome after small-artery occlusion (SAO) is unknown. METHODS:Data for 836 patients diagnosed with SAO were collected from t...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000477929
更新日期:2017-01-01 00:00:00