Different risk factor profiles between silent brain infarction and symptomatic lacunar infarction.

Abstract:

BACKGROUND/AIMS:It is generally assumed that silent brain infarction (SBI) and symptomatic lacunar infarction (sLAC) share common vascular risk factors and their pathogeneses are known to be similar. However, few studies have conducted a risk factor profile analysis of the two diseases in a single study design. METHODS:This study included 64 subjects with SBI lesions, 140 patients with sLAC, and 342 controls by retrospective investigation of brain MRI. Topographic findings and vascular risk factor profiles were compared. RESULTS AND CONCLUSION:Compared to the controls, the SBI group was found to be associated with hypertension (p = 0.002) and elevated plasma total homocysteine level (p = 0.02). The sLAC group was found to be associated with hypertension (p = 0.001), diabetes (p = 0.004), smoking (p = 0.002), ischemic heart disease (p = 0.01) and hyperlipidemia (p = 0.04). In the present study, risk factor profiles of the SBI and sLAC were not exactly the same, indicating a different pathogenesis between the two diseases.

journal_name

Eur Neurol

journal_title

European neurology

authors

Kim MH,Moon JS,Park SY,An SA,Kim OJ,Kim NK,Oh SH

doi

10.1159/000324335

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

250-6

issue

5

eissn

0014-3022

issn

1421-9913

pii

000324335

journal_volume

65

pub_type

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