Preclinical memory profile in Alzheimer patients with and without allele APOE-epsilon4.

Abstract:

:To investigate the association between APOE-epsilon4 allele and memory phenotype in the preclinical stage of Alzheimer's disease (AD). We compared an extensive preclinical memory profile at the baseline evaluation of 2 AD genotype groups: APOE-epsilon4 allele carriers and patients with APOE-epsilon3 homozygosity. Baseline memory performance was carried out at least 2 years (interval of 27.7 +/- 4 months) before AD diagnosis was established, and analysis included different modalities of working memory (visuoperceptive, visuospatial, digit span and processing speed), of declarative memory (recent, verbal learning, prospective and semantic) and of nondeclarative memory (procedural, incidental and priming). We found no significant differences: memory performance was similar in both genotype groups. The presence of the APOE-epsilon4 allele does not seem to be sufficient to cause a distinctive preclinical memory phenotype in AD patients.

journal_name

Eur Neurol

journal_title

European neurology

authors

Estévez-González A,García-Sánchez C,Boltes A,Otermín P,Baiget M,Escartín A,del Rio E,Gironell A,Kulisevsky J

doi

10.1159/000078486

keywords:

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

199-205

issue

4

eissn

0014-3022

issn

1421-9913

pii

78486

journal_volume

51

pub_type

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