Abstract:
BACKGROUND:The association between edentulism and cerebral small vessel disease is controversial. We aimed to assess this relationship in community-dwelling older adults living in rural Ecuador. METHODS:MRI was performed in 311 (81%) of 385 individuals ≥60 years enrolled in the Atahualpa Project. Participants were classified in 2 groups according to whether they have severe edentulism (<10 remaining teeth) or not. Using multivariate logistic regression and exposure effect models, we assessed whether edentulism correlated with severity of white matter hyperintensities (WMHs), after adjusting for relevant confounders. RESULTS:Mean age of participants was 70 ± 8 years (57% women). Severe edentulism was noticed in 152 (49%) individuals and moderate-to-severe WMHs in 81 (26%). In univariate analyses, moderate-to-severe WMHs were more common among edentulous individuals (OR 1.88, 95% CI 1.13-3.16, p = 0.015). Such difference became non-significant in the logistic regression model (OR 1.65, 95% CI 0.91-2.99, p = 0.098); in this model, the single relevant covariate was age. A weighted exposure effect model revealed no association of severe edentulism with moderate-to-severe WMH (average exposure effect: 0.73, 95% CI -0.01 to 0.16, p = 0.10). CONCLUSION:The relationship between edentulism and diffuse subcortical damage of vascular might be explained by the high prevalence of both variables in older adults.
journal_name
Eur Neuroljournal_title
European neurologyauthors
Del Brutto OH,Mera RM,Zambrano Mdoi
10.1159/000448839subject
Has Abstractpub_date
2016-01-01 00:00:00pages
112-116issue
3-4eissn
0014-3022issn
1421-9913pii
000448839journal_volume
76pub_type
杂志文章abstract::A case of Fisher's syndrome associated with trigeminal herpes zoster is reported for the first time. Retrograde propagation of the virus to the brainstem through the trigeminal root was thought to be the most probable pathogenic mechanism. We provide additional evidence suggesting that the focus of Fisher's syndrome i...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115817
更新日期:1985-01-01 00:00:00
abstract:UNLABELLED:Intracranial angioplasty stenting may be an efficient therapy in patients with intracranial atherosclerotic symptomatic vertebrobasilar artery stenosis unresponsive to optimal medical therapy. We present our experience in this setting. RESULTS:The study included 12 cases (8 men, 4 women), with an age range ...
journal_title:European neurology
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更新日期:2013-01-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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