Downregulation of striatal dopamine D2 receptors in advanced Parkinson's disease contributes to the development of motor fluctuation.

abstract：AIMS:This study was designed to investigate if folate treatment is able to reverse the phenytoin-induced deficiency of salivary immunoglobulin A (IgA). METHODS AND MATERIAL:Twenty-five epileptic patients who had been under phenytoin therapy for at least the last 6 months were randomly selected and subjected to folic a...

journal_title：European neurology

authors： Zare M,Ghazvini MR,Yazdi HR,Nezhad VS,Chitsaz A

更新日期：2008-01-01 00:00:00

abstract：:Percussion of the skull dates from a time when there were virtually no radiological methods for examining the skull and brain. Three apparently independent contributions appeared within the years 1893-1895. The sound elicited, tenderness, and auscultatory percussion have each been employed for diagnostic purposes, but...

journal_title：European neurology

authors： Pearce JM

更新日期：2008-01-01 00:00:00

abstract：:We present a long-term follow-up examination concerning patients with isolated extra-ocular muscle involvement in thyroid-related orbitopathy. Within the previous 13 years we observed 7 patients with endocrine orbitopathy and marked myopathy of the extra-ocular muscles. Five of these patients had no detectable proptos...

journal_title：European neurology

authors： Gerlach M,Ferbert A

更新日期：2008-01-01 00:00:00

abstract：:Although repetitive transcranial magnetic stimulation (rTMS) for hemiparesis is beneficial, so far no study has examined the usefulness of rTMS for apathy. Thirteen patients with chronic stroke were assigned randomly to 2 groups: rTMS group (n = 7) and sham stimulation group (n = 6). The patients received 5 sessions o...

journal_title：European neurology

authors： Sasaki N,Hara T,Yamada N,Niimi M,Kakuda W,Abo M

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:High-sensitivity C-reactive protein (hs-CRP) is associated with a risk of causing diabetes mellitus and ischemic stroke. However, the association between hs-CRP levels and functional outcome after small-artery occlusion (SAO) is unknown. METHODS:Data for 836 patients diagnosed with SAO were collected from t...

journal_title：European neurology

authors： Gao Y,Liu J,Wang W,Gao C,Yu C,Liu S,Wu J

更新日期：2017-01-01 00:00:00

abstract：:The association of anaemia and gastro-intestinal abnormalities with disorders of the brain, spinal cord, and peripheral nerves has been recognized since the mid 19th century. In early reports interpretable as subacute combined degeneration, anaemia was overlooked, and conversely in Addison's and other early reports of...

journal_title：European neurology

authors： Pearce JM

更新日期：2008-01-01 00:00:00

abstract：:40 patients with multiple sclerosis were investigated by magnetic resonance imaging (MRI) and computer tomography (CT). Additionally, cerebrospinal fluid (CSF) findings and evoked potentials (EPs; visual, brainstem) were evaluated. MRI findings were abnormal in 85% of the patients, whilst CT scan showed pathological c...

journal_title：European neurology

authors： Boné G,Ladurner G,Artmann W,Bsteh C

更新日期：1988-01-01 00:00:00

abstract：:Fluctuations in motor performance and dyskinesias are a common problem in the long-term management of Parkinson's disease. The pharmacokinetics and the pharmacodynamics of levodopa, loss of presynaptic dopamine terminals, alterations in postsynaptic dopamine receptor sensitivity, or changes in the modulatory influence...

journal_title：European neurology

authors： Stocchi F,Bonamartini A,Vacca L,Ruggieri S

更新日期：1996-01-01 00:00:00

abstract：:Anticonvulsant therapy was stopped in 191 epileptic children (109 males and 82 females) after a seizure-free period of at least 2 years, independent of EEG findings, followed up for a minimum of 2 years after withdrawal. Overall, 43 (22.5%) had recurrence of seizures; of these, 79% relapsed within the 1st year after d...

journal_title：European neurology

authors： Mastropaolo C,Tondi M,Carboni F,Manca S,Zoroddu F

更新日期：1992-01-01 00:00:00

abstract：:Leonardo da Vinci clearly observed and described capillaries. Using the microscope, Marcello Malpighi examined the brain and major organs to demonstrate their finer anatomical features. This led to his discovery in 1661, of capillaries that proved fundamental to our understanding of the vascular system in the brain an...

journal_title：European neurology

authors： Pearce JM

更新日期：2007-01-01 00:00:00

abstract：:A 24-year-old man presented with dystonia, dementia, amyotrophy, choreoathetosis, and ataxia. Partial hexosaminidase A deficiency was documented in serum and leukocytes and confirmed by rectal biopsy with ganglion cells containing membranous cytoplasmic bodies. A brief review of the literature reveals that tremor, dys...

journal_title：European neurology

authors： Oates CE,Bosch EP,Hart MN

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:Cerebral cavernous malformations (CCMs) are intracranial vascular malformations that can exist as a single lesion or mixed vascular lesions. The most common mixed form is the coexistence of CCM with an associated developmental venous anomaly (DVA). In this paper, we aim to give a comprehensive review of CCM,...

journal_title：European neurology

authors： Idiculla PS,Gurala D,Philipose J,Rajdev K,Patibandla P

更新日期：2020-01-01 00:00:00

abstract：:Diplopia, blurred vision and colour disturbances are well-known side effects associated with anti-epileptic drugs (AEDs). Farnsworth-Munsell 100-hue colour test (F-100) is an accepted and sensitive tool to detect changes in colour perception. To determine the impact of AEDs upon colour vision, we evaluated 37 consecut...

journal_title：European neurology

authors： López L,Thomson A,Rabinowicz AL

更新日期：1999-01-01 00:00:00

abstract：:The role of genetics in Parkinson's disease (PD), previously controversial, is now documented by several studies. A major breakthrough has been the discovery of two single-gene defects in familial PD. A single base pair change at position 209 from G to A (G209A) in the fourth exon of the alpha-synuclein gene has been ...

journal_title：European neurology

authors： Hu CJ,Sung SM,Liu HC,Lee CC,Tsai CH,Chang JG

更新日期：2000-01-01 00:00:00

abstract：:The biochemical process underlying Parkinson's disease is dopamine cell death of the nigrostriatal system. The age-dependent cell death is now proposed to be elicited by the formation of free hydroxy radicals which are formed from hydrogen peroxide, a product of oxidation of dopamine by monoamine oxidase, especially t...

journal_title：European neurology

authors： Naoi M,Maruyama W

更新日期：1993-01-01 00:00:00

abstract：OBJECTIVE:Evaluation for surgical treatment is offered to patients who do not respond to antiepileptic drugs. Pseudo-pharmacoresistance (PPR) has been described in the context of impaired compliance, incorrect diagnosis of epilepsy or pharmacological interference resulting in too low blood levels. We were interested to...

journal_title：European neurology

authors： Constantinescu I,Korff CM,Vulliemoz S,Picard F,Seeck M

更新日期：2017-01-01 00:00:00

abstract：:The effect of thoracic duct lymph drainage (5-34 days) in 12 patients with myasthenia gravis on muscular function has been followed for 5-43 months. Among the results obtained were: (1) During the drainage the myasthenic symptoms decreased markedly after 1-4 days and remained so during the drainage. (2) The doses of c...

journal_title：European neurology

authors： Bergström K,Franksson C,Matell G,Nilsson BY,Persson A,von Reis G,Stensman R

更新日期：1975-01-01 00:00:00

abstract：BACKGROUND:The meningitides are rare but well-identified complications in patients with systemic lupus erythematosus (SLE). AIMS:To determine the clinical characteristics, risk factors, prevalence and outcomes of the meningitides (septic and aseptic) in patients with SLE. PATIENTS AND METHODS:From January 1988 to Dec...

journal_title：European neurology

authors： Baizabal-Carvallo JF,Delgadillo-Márquez G,Estañol B,García-Ramos G

更新日期：2009-01-01 00:00:00

abstract：:Patients suffering from migraine, tension-type headache (TTH), or combined headache (CH) are at risk of developing drug-induced headache (DIH) due to regular use of analgesics, ergot alkaloids, and triptans. The aim of our study was to determine (1) the clinical features of DIH, (2) the outcome of withdrawal therapy u...

journal_title：European neurology

authors： Fritsche G,Eberl A,Katsarava Z,Limmroth V,Diener HC

更新日期：2001-01-01 00:00:00

abstract：:This study investigates the remote effects of botulinum toxin injections by examining the motor unit architecture of noninjected distant muscles. In 21 dystonia patients treated with botulinum toxin (n = 11, mean cumulative dose = 815 mU; n = 10, mean cumulative dose = 7,207 mU) and 10 control individuals, a blinded s...

journal_title：European neurology

authors： Fertl E,Schnider P,Schneider B,Auff E

更新日期：2000-01-01 00:00:00

abstract：:A 47-year-old woman presented with paralysis of upward gaze associated with Addison's pernicious anaemia. Administration of cyanocobalamin resulted in significant improvement of eye movements and haematological parameters. Isolated paralysis of upward gaze may be a feature of vitamin B12 deficiency. ...

journal_title：European neurology

authors： Sandyk R

更新日期：1984-01-01 00:00:00

abstract：:Botulinum toxin type B (BT-B) therapy failure due to formation of botulinum toxin type B antibodies (BT-B-AB) has only been reported in patients with botulinum toxin type A antibodies (BT-A-AB). We are reporting BT-B-AB-induced therapy failure in 2 patients with no previous exposure to botulinum toxin. In patient 1 co...

journal_title：European neurology

authors： Dressler D,Bigalke H

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:ANO10 mutations have recently been reported in autosomal recessive cerebellar ataxia type 3 (ARCA3). The objective of this study was to describe the phenotype of 2 siblings with compound heterozygous ANO10 mutations and progressive cerebellar ataxia, epilepsy, and cognitive impairment. A porencephalic cyst w...

journal_title：European neurology

authors： Chamard L,Sylvestre G,Koenig M,Magnin E

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:The association between edentulism and cerebral small vessel disease is controversial. We aimed to assess this relationship in community-dwelling older adults living in rural Ecuador. METHODS:MRI was performed in 311 (81%) of 385 individuals ≥60 years enrolled in the Atahualpa Project. Participants were cla...

journal_title：European neurology

authors： Del Brutto OH,Mera RM,Zambrano M

更新日期：2016-01-01 00:00:00

abstract：:This lecture is mainly concerned with questions about how hemodynamic conditions in atherosclerotic arteries affect arriving platelets that aggregate there and about the chemical agents responsible for making the platelets reactive. The effects of hemodynamic conditions and the agents are known mainly from in vitro ex...

journal_title：European neurology

authors： Born GV

更新日期：1983-01-01 00:00:00

abstract：:A case of thoracic hematomyelia secondary to anticoagulant therapy is presented. Clinical features, similar to 2 other previously reported cases, are discussed. A high index of suspicion may lead to a quick diagnostic procedure and successful decompressive surgery. ...

journal_title：European neurology

authors： Constantini S,Ashkenazi E,Shoshan Y,Israel Z,Umansky F

更新日期：1992-01-01 00:00:00

abstract：:QTc intervals were measured in 30 patients with Parkinson's disease and 30 healthy control subjects. The mean value of QTc intervals in patients with Parkinson's disease significantly exceeded that of healthy controls (418 +/- 14 ms vs. 403 +/- 18 ms). Prolongation of the QTc interval was unrelated to the administrati...

journal_title：European neurology

authors： Oka H,Mochio S,Sato H,Katayama K

更新日期：1997-01-01 00:00:00

abstract：:Two cases of lithium neurotoxic effects are reported. Both cases are expressed by choreoathetotic movements and in both of them intoxication was caused by combined drug therapy. In our opinion caution is advised when lithium is administered in combination with drugs, especially in elderly patients. ...

journal_title：European neurology

authors： Walevski A,Radwan M

更新日期：1986-01-01 00:00:00

abstract：:In order to examine the plasminogen activator (PA) induction involved in the pathogenesis of acute disseminated encephalomyelitis (ADEM) and multiple sclerosis (MS), PA activity in peripheral blood lymphocytes derived from 5 ADEM and 3 MS patients was investigated. There was no PA induction in any ADEM, MS or control ...

journal_title：European neurology

authors： Sugita K,Suzuki N,Shimizu N,Takanashi J,Ishii M,Niimi N

更新日期：1993-01-01 00:00:00

abstract：UNLABELLED:Intracranial angioplasty stenting may be an efficient therapy in patients with intracranial atherosclerotic symptomatic vertebrobasilar artery stenosis unresponsive to optimal medical therapy. We present our experience in this setting. RESULTS:The study included 12 cases (8 men, 4 women), with an age range ...

journal_title：European neurology

authors： Ralea IC,Nighoghossian N,Tahon F,Derex L,Cakmak S,Trouillas P,Turjman F

更新日期：2008-01-01 00:00:00