Motor fluctuations in levodopa treatment: clinical pharmacology.

abstract：:Three patients with unusual presentations of basilar artery ectasia are described: subarachnoid hemorrhage was manifest in one and autonomic dysfunction developed in the other two. Aneurysmal rupture was the cause in the first patient, while compression of the brainstem and/or of the baroreceptor afferences of the IXt...

journal_title：European neurology

authors： Nogues M,Casas Parera I,Starkstein S,Micheli F

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Effective management of multisymptomatic chronic diseases such as multiple sclerosis (MS) requires a multimodal, interdisciplinary approach. At MS clinics, numerous healthcare specialties are coordinated to provide patients with quality clinical care for all aspects of their disease. Settings and resource av...

journal_title：European neurology

authors： Gallien P,Gich J,Sánchez-Dalmau BF,Feneberg W

更新日期：2014-01-01 00:00:00

abstract：:The clinical severity of EAE is enhanced by pre-treatment with distemper, measles and BCG vaccine, measles vaccine gives a more severe onset of disease. Rubella vaccine and TAB leads to mild disease which recurs on re-treatment with the appropriate vaccine. These findings and their possible significance in MS are brie...

journal_title：European neurology

authors： Caspary EA

更新日期：1977-01-01 00:00:00

abstract：:To clarify the function of human atrial natriuretic peptide (hANP) in the cerebrospinal fluid (CSF), we examined hANP levels in the CSF of patients with various neurological diseases. The subjects were 16 controls without neurological disease and 45 patients with neurological disease. The 45 patients with neurological...

journal_title：European neurology

authors： Yamasaki H,Sugino M,Ohsawa N

更新日期：1997-01-01 00:00:00

abstract：:Dopamine uptake sites, labelled by 3 nM [3H]GBR 12935, were reduced by 28-34% in post-mortem Parkinson's diseased striata (n = 22) compared to control striata (n = 28). There was no significant difference between post-mortem striata from schizophrenics (n = 16) and controls. Both dopamine D1 and D2 receptors are consi...

journal_title：European neurology

authors： Pearce RK,Seeman P,Jellinger K,Tourtellotte WW

更新日期：1990-01-01 00:00:00

abstract：:Fifteen chronic alcoholic male patients with impotence have been investigated with the electrophysiological method of sympathetic skin potentials recorded from the genital skin and with the electrically induced bulbocavernosus reflex. Both electrophysiological tests did not differ from those of normal controls. It was...

journal_title：European neurology

authors： Ertekin C,Almis S,Ertekin N

更新日期：1990-01-01 00:00:00

abstract：:Trials of pharmacological intervention for acute stroke show several points of similarity with legal trials by jury. The relationships between sponsoring organisation and regulatory authorities and the roles of the many other participants are described. Only through a partnership can the common aim of developing impro...

journal_title：European neurology

authors： Lees KR

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Newly developed troponin assays have superior diagnostic and prognostic performance in acute coronary syndrome (ACS), when compared to conventional troponin assays; however, highly sensitive troponin has not been evaluated in patients with acute ischemic stroke. METHODS:Highly sensitive troponin T (hsTnT) w...

journal_title：European neurology

authors： Jensen JK,Ueland T,Aukrust P,Antonsen L,Kristensen SR,Januzzi JL,Ravkilde J

更新日期：2012-01-01 00:00:00

abstract：:The therapeutic efficacy of Madopar HBS was investigated in 5 patients with advanced parkinsonism. They were under treatment with standard Madopar and suffered from marked fluctuations, mainly end-of-dose akinesia. All patients were abruptly switched from standard Madopar to the HBS formulation. For the first few days...

journal_title：European neurology

authors： Fischer PA,Baas H

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVE:To determine whether orbitofrontal cortex (OFC) function improves with blepharospasm (BSP) symptom remission using a verbal fluency task and near-infrared spectroscopy (NIRS). METHODS:Nineteen BSP patients and 9 healthy controls (HCs) matched by gender and education were examined using NIRS. The BSP patients...

journal_title：European neurology

authors： Shen CY,Wang YJ,Liu XM,Zhang XQ,Ren XJ,Ma XY,Sun JJ,Feng K,Sun GX,Xu B,Liu PZ

更新日期：2017-01-01 00:00:00

abstract：:A method is described to relate brain morphology and neuropsychological disturbances such as aphasia. By mapping lesions with computerized tomography onto a grid model of five brain slices, it is possible to compare aphasiological information and lesion site by data processing, allowing the quantitative and qualitativ...

journal_title：European neurology

authors： Blunk R,De Bleser R,Willmes K,Zeumer H

更新日期：1981-01-01 00:00:00

abstract：:Two prospective projects were started in May 1985 to evaluate the long-term effects of bromocriptine in patients with Parkinson's disease. One of the projects is to see if combination therapy with levodopa and bromocriptine is superior to levodopa alone with regard to the prevention of late side effects of levodopa th...

journal_title：European neurology

authors： Nakanishi T,Mizuno Y,Goto I,Iwata M,Kanazawa I,Kowa H,Mannen T,Nishitani H,Ogawa N,Takahashi A

更新日期：1988-01-01 00:00:00

abstract：:Estrogen receptor (ER) analysis was performed with an enzyme immunoassay using monoclonal antibodies against human ER protein (estrophilin) in 70 meningiomas. [3H]methyltrienolone, a synthetic androgen, was used for concurrent determination of the androgen receptor (AR)-binding activity. Low levels of ER immunoreactiv...

journal_title：European neurology

authors： Lesch KP,Schott W,Engl HG,Gross S

更新日期：1987-01-01 00:00:00

abstract：:The pathogenesis of primary degenerative dementia is still unknown and current therapeutic approaches can aim only at ameliorating some of the symptoms associated with this brain disease. At present, most approaches, attempt to correct a cholinergic deficit. Although the therapeutic benefits obtained so far with curre...

journal_title：European neurology

authors： Markstein R

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:Mood disorder is a frequent complication of stroke. Comorbid depressive and anxiety disorders are very common, indicating that it is advisable to assess both disorders at the same time. The aim of the present study was to examine the prevalence of post-stroke depression (PSD) and poststroke anxiety (PSA) at ...

journal_title：European neurology

authors： Kim JT,Park MS,Yoon GJ,Jung HJ,Choi KH,Nam TS,Lee SH,Choi SM,Kim BC,Kim MK,Cho KH

更新日期：2011-01-01 00:00:00

abstract：:We describe a case presenting continuous muscle fiber activity syndrome, which was slightly reduced by the blocking of nerve conduction and abolished by ischemia. Clinical, electromyographical and bioptical evidence of marked abnormalities of peripheral motoneurons were observed. Association with central motoneuron le...

journal_title：European neurology

authors： Cotrufo R,Di Iorio G,Ammendola A,Bravaccio F

更新日期：1982-01-01 00:00:00

abstract：:There is good evidence that patients with Parkinson's disease have respiratory chain dysfunction in their substantia nigra. Since mitochondrial cytopathies due to enzyme defects in the respiratory chain are predominantly manifested in tissues with a high oxidative metabolism we analyzed oxidative energy metabolism in ...

journal_title：European neurology

authors： Reichmann H,Janetzky B,Bischof F,Seibel P,Schöls L,Kuhn W,Przuntek H

更新日期：1994-01-01 00:00:00

abstract：:A Norwegian family with asymmetrical scapuloperoneal atrophy is described. Chronic, aching shoulder pain, slight proximal and distal sensory dysfunction, and atrophy of the extensor digitorum brevis muscle occurred in some individuals. The proband had slightly impaired sensory conduction velocity, and his father exhib...

journal_title：European neurology

authors： Sand T,Hestnes A

更新日期：1985-01-01 00:00:00

abstract：:13 patients with spinal dural arteriovenous fistulas (DAVF) diagnosed in our Institution have been the object of this study. The necessity to include the disease in the differential diagnosis with other pathologies affecting the lower thoracic cord, particularly in middle-aged and old males, is emphasized. Involvement...

journal_title：European neurology

authors： Bradac GB,Daniele D,Riva A,Bracchi M,Stura G,Riccio A,Pagni CA

更新日期：1994-01-01 00:00:00

abstract：AIMS:This study was designed to investigate if folate treatment is able to reverse the phenytoin-induced deficiency of salivary immunoglobulin A (IgA). METHODS AND MATERIAL:Twenty-five epileptic patients who had been under phenytoin therapy for at least the last 6 months were randomly selected and subjected to folic a...

journal_title：European neurology

authors： Zare M,Ghazvini MR,Yazdi HR,Nezhad VS,Chitsaz A

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:To evaluate the role of some sex hormones in migraine headaches, the aim of this study was to assess the prevalence and characteristics of headache, especially migraine, in patients with polycystic ovary syndrome (PCO) compared with women without this disease. METHODS:One hundred and thirty-three women with...

journal_title：European neurology

authors： Pourabolghasem S,Najmi S,Arami MA

更新日期：2009-01-01 00:00:00

abstract：:The possibility that epileptic seizures and classic migraine episodes may occur in the same patient is discussed. The probable relationship between the neurophysiological mechanisms which underlie both types of attacks has not yet been agreed upon. The case of a young man who suffered from classic migraine and who pre...

journal_title：European neurology

authors： Manzoni GC,Terzano MG,Mancia D

更新日期：1979-01-01 00:00:00

abstract：:Patients suffering from migraine, tension-type headache (TTH), or combined headache (CH) are at risk of developing drug-induced headache (DIH) due to regular use of analgesics, ergot alkaloids, and triptans. The aim of our study was to determine (1) the clinical features of DIH, (2) the outcome of withdrawal therapy u...

journal_title：European neurology

authors： Fritsche G,Eberl A,Katsarava Z,Limmroth V,Diener HC

更新日期：2001-01-01 00:00:00

abstract：:We examined a 29-year-old woman who had language disturbances and memory impairment after a left thalamic infarction. MRI showed injury that was limited to the tuberothalamic artery territory. Beside reduced voice volume and verbal memory trouble, she presented with aspontaneity, loss of psychic self-activation and af...

journal_title：European neurology

authors： Lisovoski F,Koskas P,Dubard T,Dessarts I,Dehen H,Cambier J

更新日期：1993-01-01 00:00:00

abstract：:In the fast moving field of muscular dystrophy, therapeutic matters are now high on the agenda. Despite little progress made in the understanding of the exact pathogenesis, hopes have been raised with the advent of molecular medicine applied to such disorders. A constellation of techniques or therapeutic solutions are...

journal_title：European neurology

authors： Urtizberea JA

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Spinal cord injury (SCI) is a constant challenge in medical research and a global therapeutic problem. Treatment of this condition remains difficult in clinical practice. Hence, prevention, treatment, and rehabilitation of SCI have become imminent tasks in the medical field. SUMMARY:Recent evidence suggest ...

journal_title：European neurology

authors： Gao K,Zhang T,Wang F,Lv C

更新日期：2019-01-01 00:00:00

abstract：:Acute ischemia of the brain induces a cascade of biochemical and physiological events. The final consequences depend on the fact whether ischemia is of transient or permanent, total or partial nature. Alteration of extracellular potassium concentration, intracellular calcium and potassium concentration, development of...

journal_title：European neurology

authors： Hartmann A

更新日期：1986-01-01 00:00:00

abstract：:Mitochondrial abnormalities and effectiveness of replacement therapy were examined in a murine model of systemic carnitine deficiency, namely the juvenile visceral steatosis (JVS) mouse. Homozygous JVS mice revealed severe lipid deposition and abnormal mitochondria in liver, heart, skeletal muscle, and kidney, but the...

journal_title：European neurology

authors： Kaido M,Fujimura H,Ono A,Toyooka K,Yoshikawa H,Nishimura T,Ozaki K,Narama I,Kuwajima M

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Statins inhibit the production of 2,3-dimethoxy,5-methyl,6-polyisoprene parabenzoquinone also known as ubiquinone or coenzyme Q10 (CoQ10), which is required for mitochondrial electron transport. Idiopathic or primary CoQ10 deficiencies have been known to cause mitochondrial encephalomyopathy. METHODS:We pre...

journal_title：European neurology

authors： Thomas JE,Lee N,Thompson PD

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND AND STUDY PURPOSE:Autonomic nervous system dysfunction is a common complication of acute cerebrovascular disorders. The aim of this study was to investigate a possible location-dependent difference in cardio-autonomic function in patients with ischaemic stroke. PATIENTS AND METHODS:Sympathetic function was ...

journal_title：European neurology

authors： Strittmatter M,Meyer S,Fischer C,Georg T,Schmitz B

更新日期：2003-01-01 00:00:00