Prevalence and severity of multiple-sclerosis-associated fatigue in treated and untreated patients.

Abstract:

:Fatigue is one of the most frequent and most disabling symptoms in multiple sclerosis (MS). We investigated the possible association of the MS-related fatigue syndrome with the available disease-modifying therapies and the main disease characteristics in a cross-sectional study on 320 consecutive patients. The prevalence of severe fatigue (Fatigue Severity Scale score > or =5) was 50%. In a multivariate regression model controlling for age, disease subtype, duration and disability we did not find a significant association between the use of immunosuppressive or immunomodulatory drugs compared to no treatment (OR = 1.34, p = 0.38 for immunosuppressants; OR = 0.95, p = 0.85 for immune-modulating agents). Although all used disease-modifying agents successfully reduce disease activity and inflammation, they do not appear to exhibit a significant effect on MS-related fatigue.

journal_name

Eur Neurol

journal_title

European neurology

authors

Putzki N,Katsarava Z,Vago S,Diener HC,Limmroth V

doi

10.1159/000111876

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

136-42

issue

3-4

eissn

0014-3022

issn

1421-9913

pii

000111876

journal_volume

59

pub_type

杂志文章
  • Rate of cerebral embolic events in relation to antibiotic and anticoagulant therapy in patients with bacterial endocarditis.

    abstract::To quantitate embolic risk we studied a retrospective series of 61 patients with strictly defined bacterial endocarditis. Eighteen patients had neurological complications attributable to cerebral embolism. Seventeen embolic episodes occurred prior to antibiotic treatment and 8 episodes after its commencement. The rate...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000117317

    authors: Paschalis C,Pugsley W,John R,Harrison MJ

    更新日期:1990-01-01 00:00:00

  • Clinical and radiological characteristics in multiple sclerosis patients with large cavitary lesions.

    abstract:BACKGROUND:Large cavitary lesions are not typical for multiple sclerosis (MS). Cavitary white matter changes may be seen in megalencephalic leukoencephalopathy with subcortical cysts, Alexander disease, mitochondrial leukoencephalopathies, vanishing white matter disease, leukoencephalopathy with calcifications and cyst...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000338476

    authors: Renard D,Brochet B,Vukusic S,Edan G,Deburghgraeve V,Goizet C,Dupuy D,Touze E,Deschamps R,Zephyr H,Creange A,Castelnovo G,Boespflug-Tanguy O,Labauge P

    更新日期:2012-01-01 00:00:00

  • Cognitive impairment in asymptomatic stages of HIV infection. A longitudinal study.

    abstract::Seventy-eight asymptomatic HIV-seropositive (aHIV) subjects were examined by means of an extensive neuropsychological test battery in comparison with 32 HIV-seronegative controls. They were also tested with regard to CD4+ and serum p24 antigen. Fifty-six of them completed a clinical follow-up of 12 up to 36 months and...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000117228

    authors: Villa G,Solida A,Moro E,Tavolozza M,Antinori A,De Luca A,Murri R,Tamburrini E

    更新日期:1996-01-01 00:00:00

  • No mutation of G209A in the alpha-synuclein gene in sporadic Parkinson's disease among Taiwan Chinese.

    abstract::The role of genetics in Parkinson's disease (PD), previously controversial, is now supported by several studies. A major breakthrough has been the discovery of a single gene defect in familial Parkinson's disease. A single base pair change at position 209 from G to A (G209A) in the fourth exon of the alpha-synuclein g...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000008008

    authors: Hu CJ,Sung SM,Liu H,Chang JG

    更新日期:1999-01-01 00:00:00

  • Independent role of hypertension in Bell's palsy: a case-control study.

    abstract:BACKGROUND/AIM:In this case-control study, our aim was to check for a possible independent role of hypertension in increasing the risk of developing Bell's palsy. METHODS:All patients diagnosed as having Bell's palsy referred to a neurology clinic were enrolled as cases. Controls were selected among other patients ref...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000151701

    authors: Savadi-Oskouei D,Abedi A,Sadeghi-Bazargani H

    更新日期:2008-01-01 00:00:00

  • Contribution of nerve biopsy to unclassified neuropathy.

    abstract:OBJECTIVES:To evaluate the diagnostic yield of nerve biopsy in patients with peripheral neuropathy of undetermined cause despite extensive diagnostic workup. METHODS:From November 2001 through January 2004, 38 patients underwent nerve biopsy because of unclassified neuropathy. RESULTS:The etiology of the neuropathies...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000098057

    authors: Schweikert K,Fuhr P,Probst A,Tolnay M,Renaud S,Steck AJ

    更新日期:2007-01-01 00:00:00

  • Preliminary experience with Madopar HBS: clinical observations and plasma levodopa concentrations.

    abstract::The therapeutic efficacy of Madopar HBS was investigated in 5 patients with advanced parkinsonism. They were under treatment with standard Madopar and suffered from marked fluctuations, mainly end-of-dose akinesia. All patients were abruptly switched from standard Madopar to the HBS formulation. For the first few days...

    journal_title:European neurology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000116198

    authors: Fischer PA,Baas H

    更新日期:1987-01-01 00:00:00

  • Characteristics and outcomes of patients with seizures according to the time of onset in relation to stroke.

    abstract:BACKGROUND/AIM:Although most late-onset seizures (LS) appear within 2 years after stroke, some of them occur later and their characteristics are unknown. The aim of this study was to compare the characteristics of patients with very-late-onset seizures (VLS) to those with early-onset seizures (ES) and those with LS. P...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000115635

    authors: De Reuck J,Sieben A,Van Maele G

    更新日期:2008-01-01 00:00:00

  • Adult metachromatic leukodystrophy. I. Clinical manifestation in a female aged 44 years, previously diagnosed in the preclinical state.

    abstract::In a 5-year follow-up of a case of adult metachromatic leukodystrophy, already diagnosed in the preclinical stage, the development of the symptoms of this disease could be studied in detail: initially, lack of drive, emotional lability and depressive mood. At the same time, pain in the arms and beginning gait disturba...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000114818

    authors: Pilz H,Duensing I,Heipertz R,Seidel D,Lowitzsch K,Hopf HC,Goebel HH

    更新日期:1977-01-01 00:00:00

  • Downregulation of striatal dopamine D2 receptors in advanced Parkinson's disease contributes to the development of motor fluctuation.

    abstract::The purpose of this study was to evaluate the contribution of the postsynaptic mechanism to the development of motor fluctuation in advanced Parkinson's disease (PD). We used 123I-iodobenzamide single-photon emission computed tomography to measure the striatal dopamine D2 receptor densities in early levodopa-naïve PD,...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000047962

    authors: Hwang WJ,Yao WJ,Wey SP,Shen LH,Ting G

    更新日期:2002-01-01 00:00:00

  • Increment of the platelet count in temporal arteritis: response to therapy and ischemic complications.

    abstract::Temporal arteritis (TA) is a vasculitis involving mainly cranial branches of the aorta that can lead to ischemic complications such as amaurosis or ischemic stroke. Increment in the platelet count has been described in the acute period of the disease. We studied retrospectively the platelet count in patients with TA, ...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000052088

    authors: Gonzalez-Alegre P,Ruiz-Lopez AD,Abarca-Costalago M,Gonzalez-Santos P

    更新日期:2001-01-01 00:00:00

  • Reports of patients and relatives from the CogniCIS study about cognition in clinically isolated syndrome: what are our patients telling us?

    abstract:OBJECTIVE:To assess the Multiple Sclerosis Neuropsychological Questionnaire (MSNQ) in patients with clinically isolated syndrome (CIS). METHODS:130 European CIS patients and 60 relatives completed the MSNQ. RESULTS:The mean (SD) MSNQ score for CIS patients was 15.5 (10.8) and for their informants 11.3 (9.6). Neither ...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000345698

    authors: Langdon DW,Benedict RH,Wicklein EM,Beckmann K,Fredrikson S

    更新日期:2013-01-01 00:00:00

  • Henry Duret (1849-1921): a surgeon and forgotten neurologist.

    abstract::Henri Duret (1849-1921) was a surgeon whose training started in the laboratory of Jean-Martin Charcot and Alfred Vulpian at La Salpêtrière in 1874. Using injections of colored gelatine, Duret was the first to describe the distribution of supply arteries in the brainstem and then in the cortex. His descriptions correla...

    journal_title:European neurology

    pub_type: 传,历史文章,杂志文章

    doi:10.1159/000361046

    authors: Walusinski O,Courrivaud P

    更新日期:2014-01-01 00:00:00

  • Pure eye muscle involvement in endocrine orbitopathy.

    abstract::We present a long-term follow-up examination concerning patients with isolated extra-ocular muscle involvement in thyroid-related orbitopathy. Within the previous 13 years we observed 7 patients with endocrine orbitopathy and marked myopathy of the extra-ocular muscles. Five of these patients had no detectable proptos...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000131894

    authors: Gerlach M,Ferbert A

    更新日期:2008-01-01 00:00:00

  • Association between the Levels of IL-6, sE-Selectin and Distal Sensory Nerve Conduction Studies in Patients with Prediabetes.

    abstract:AIM:To determine the association between interleukin-6 (IL-6) and soluble E-selectin (sE-selectin) levels with the electrodiagnostic abnormalities in patients with impaired fasting glucose (IFG) and impaired glucose tolerance (IGT). METHODS:Serum HbA1c, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), f...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000444661

    authors: Tiftikcioglu BI,Duksal T,Bilgin S,Kose S,Zorlu Y

    更新日期:2016-01-01 00:00:00

  • Highly sensitive troponin T in patients with acute ischemic stroke.

    abstract:BACKGROUND:Newly developed troponin assays have superior diagnostic and prognostic performance in acute coronary syndrome (ACS), when compared to conventional troponin assays; however, highly sensitive troponin has not been evaluated in patients with acute ischemic stroke. METHODS:Highly sensitive troponin T (hsTnT) w...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000341340

    authors: Jensen JK,Ueland T,Aukrust P,Antonsen L,Kristensen SR,Januzzi JL,Ravkilde J

    更新日期:2012-01-01 00:00:00

  • Utilization behavior after right thalamic infarction.

    abstract::We report a patient who showed exaggerated responses to external cues (utilization behavior), motor impersistence, and a right-hand-predominant instinctive grasp reaction after right thalamic infarction. High-resolution computed tomography with stereotaxic lesion localization revealed almost complete destruction of th...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000117092

    authors: Hashimoto R,Yoshida M,Tanaka Y

    更新日期:1995-01-01 00:00:00

  • Metabolic Disorders in Patients with Central Nervous System Infections: Associations with Neurosyphilis.

    abstract:INTRODUCTION:Recently, neurosyphilis was found to be associated with diabetes mellitus (DM). Whether the association was specific to neurosyphilis among central nervous system (CNS) infections, and whether neurosyphilis is associated with other prevalent metabolic disorders deserves further study. METHODS:An in-depth ...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000503626

    authors: Xiao Y,Chen MJ,Shen X,Lin LR,Liu LL,Yang TC,Niu JJ

    更新日期:2019-01-01 00:00:00

  • Is cerebrospinal fluid spectrophotometry useful in CT scan-negative suspected subarachnoid haemorrage?

    abstract::Missed cerebral aneurysms in CT-negative patients can have serious implications. We set out to determine the usefulness of cerebrospinal fluid (CSF) spectrophotometry and the individual significance of CSF oxyhaemoglobin, bilirubin and methaemoglobin in 463 CT scan-negative patients with suspected subarachnoid haemorr...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000082162

    authors: Gunawardena H,Beetham R,Scolding N,Lhatoo SD

    更新日期:2004-01-01 00:00:00

  • Sleep disorders and multiple sclerosis: a clinical and polysomnography study.

    abstract:BACKGROUND:Patients with multiple sclerosis (MS) report sleep disturbances (SD) and excessive daytime sleepiness (EDS) more frequently than the general population. Our objectives were to evaluate SD and EDS in MS patients and to test the reliability of subjective sleep questionnaires. METHODS:Demographic and clinical ...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000335076

    authors: Neau JP,Paquereau J,Auche V,Mathis S,Godeneche G,Ciron J,Moinot N,Bouche G

    更新日期:2012-01-01 00:00:00

  • Landau-Kleffner syndrome: a case study with a fourteen-year follow-up.

    abstract::In a 14-year follow-up the improvement of language functions and the decrease of EEG abnormalities are described in a girl with the Landau-Kleffner syndrome. In this case, the results of subsequent EEG recordings do not permit conclusions about the course of the aphasia. Disappearance of focal spike and waves, bilater...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116390

    authors: van Dongen HR,Meulstee J,Blauw-van Mourik M,van Harskamp F

    更新日期:1989-01-01 00:00:00

  • Loss of dopamine uptake sites labeled with [3H]GBR-12935 in Alzheimer's disease.

    abstract::The binding of the dopamine uptake inhibitor [3H]GBR-12935 to postmortem putamen from a control group and patients with Alzheimer's disease/senile dementia of Alzheimer type (AD/SDAT) or vascular dementia (VD) was studied. The binding density (Bmax) in AD/SDAT was significantly reduced to 50% of control. A reduction o...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000117341

    authors: Allard P,Alafuzoff I,Carlsson A,Eriksson K,Ericson E,Gottfries CG,Marcusson JO

    更新日期:1990-01-01 00:00:00

  • EEG sleep study in parkinsonian patients under bromocryptine treatment.

    abstract::Nocturnal sleep patterns were registered from 6 parkinsonian patients treated with bromocryptine, ("-Br-L-ergocryptine, C.B.-154) a dopamine-like agonist. No significant differences in their sleep patterns were found in comparison with patients treated with L-dopa. Since bromocryptine acts direct on the dopaminergic r...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000114973

    authors: Rabey J,Vardi J,Glaubman H,Streifler M

    更新日期:1978-01-01 00:00:00

  • Appraising the plasticity of the circle of Willis: a model of hemodynamic modulation in cerebral arteriovenous malformations.

    abstract:OBJECTIVES:Cerebral arteriovenous malformations (AVMs) harbor a network of abnormal vasculatures, namely the nidus between arterial and venous components. The pressure gradient between these two components results in abnormal high-velocity arteriovenous shunts flowing through the nidus and alternate intracranial hemody...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000292431

    authors: Chuang YM,Guo W,Lin CP

    更新日期:2010-01-01 00:00:00

  • Impact of cognitive dysfunction on drooling in Parkinson's disease.

    abstract:BACKGROUND:Parkinson's disease (PD) is commonly characterized by its motor symptoms such as resting tremor, rigidity, bradykinesia and postural instability; however, some of the most debilitating symptoms of this disease are non-motor ones such as dementia and sialorrhea (drooling). Drooling is caused by impaired swall...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000348571

    authors: Rana AQ,Khondker S,Kabir A,Owalia A,Khondker S,Emre M

    更新日期:2013-01-01 00:00:00

  • Correlations between clinical and magnetic resonance imaging findings in multiple sclerosis.

    abstract::40 patients with multiple sclerosis were investigated by magnetic resonance imaging (MRI) and computer tomography (CT). Additionally, cerebrospinal fluid (CSF) findings and evoked potentials (EPs; visual, brainstem) were evaluated. MRI findings were abnormal in 85% of the patients, whilst CT scan showed pathological c...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116269

    authors: Boné G,Ladurner G,Artmann W,Bsteh C

    更新日期:1988-01-01 00:00:00

  • Normal functional capacity of blood lymphocytes in multiple sclerosis measured by stimulation with mitogens.

    abstract::The effect of phytohemagglutinin (PHA) and pokeweed mitogen (PWM) on blood lymphocytes was studied in multiple sclerosis, patients with acute CNS infections, and healthy controls. No significant differences in lymphocyte proliferation were registered between the group of MS patients and the two other groups, irrespect...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000115075

    authors: Kinnman J,Link H,Frydén A

    更新日期:1979-01-01 00:00:00

  • Spontaneous pain, hyperpathia and wasting of the hand due to parietal lobe haemorrhage.

    abstract::A woman who had spontaneous pain, hyperpathia and wasting of her left hand due to a subcortical lesion in the right parietal lobe is reported. The presentation and evaluation of this most unusual case are discussed. ...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000115753

    authors: Sandyk R

    更新日期:1985-01-01 00:00:00

  • Spinal dural arteriovenous fistulas: an underestimated cause of myelopathy.

    abstract::13 patients with spinal dural arteriovenous fistulas (DAVF) diagnosed in our Institution have been the object of this study. The necessity to include the disease in the differential diagnosis with other pathologies affecting the lower thoracic cord, particularly in middle-aged and old males, is emphasized. Involvement...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000117015

    authors: Bradac GB,Daniele D,Riva A,Bracchi M,Stura G,Riccio A,Pagni CA

    更新日期:1994-01-01 00:00:00

  • Prevalence rate of cerebrovascular disease in the rural population of northwest Peloponnese, Greece. A direct epidemiological study.

    abstract::In a direct (door-to-door) epidemiological study, the prevalence rate of cerebrovascular disease in the rural population of northwest Peloponnese, Greece, was found to be 995 strokes per 100,000 inhabitants over 20 years of age. This number is considerably lower than the prevalence rate (1,417 strokes per 100,000 inha...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116408

    authors: Paschalis C,Polychronopoulos P,Makris N,Kondakis X,Papapetropoulos T

    更新日期:1989-01-01 00:00:00