Abstract:
:Although multifocal motor neuropathy (MMN) is now recognized as a distinct, albeit rare, neurological condition, the path to its recognition was long and winding. This article provides an insight into the medical history of MMN "patient zero" and the first scientific publication that led to the recognition of MMN by the medical community. Multifocal motor neuropathy is nowadays recognized as a disease that produces asymmetric muscle weakness and cramping, with spontaneous motor unit activity (fasciculations and myokymia) but without sensory disorder. From an electrophysiological point of view, the neuropathy is characterized by persistent conduction blocks that usually initially affect the proximal upper extremity. The path to recognizing this rare entity was long and winding. In this article, we describe the first known patient suffering from this disease and the scientific context of its emergence, leading to the first publication on the subject, written by Gérard Roth (1923-2006) and his colleagues at the Neurology Department of Geneva University Hospital (Switzerland) [Eur Neurol. 1986;25(6):416-23].
journal_name
Eur Neuroljournal_title
European neurologyauthors
Ochsner F,Tatu Ldoi
10.1159/000511732subject
Has Abstractpub_date
2020-11-11 00:00:00pages
1-3eissn
0014-3022issn
1421-9913pii
000511732pub_type
杂志文章abstract:BACKGROUND:The association between edentulism and cerebral small vessel disease is controversial. We aimed to assess this relationship in community-dwelling older adults living in rural Ecuador. METHODS:MRI was performed in 311 (81%) of 385 individuals ≥60 years enrolled in the Atahualpa Project. Participants were cla...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000448839
更新日期:2016-01-01 00:00:00
abstract::Two cases are presented with a long clinical history of multiple sclerosis (MS) before the diagnosis of an intracranial brain tumor. In the subsequent brain autopsy, however, both cases presented a diffusely growing anaplastic astrocytoma, only, and no changes similar to MS were seen. Diffuse tumor growth was noted in...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116009
更新日期:1986-01-01 00:00:00
abstract::The binding of the dopamine uptake inhibitor [3H]GBR-12935 to postmortem putamen from a control group and patients with Alzheimer's disease/senile dementia of Alzheimer type (AD/SDAT) or vascular dementia (VD) was studied. The binding density (Bmax) in AD/SDAT was significantly reduced to 50% of control. A reduction o...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000117341
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:Tuberculous meningitis is the severest and commonest form of central nervous system tuberculosis causing high mortality and morbidity. We aim to study the clinical, biochemical, and radiological characteristics of tuberculous meningitis in adult patients in Qatar and to calculate the incidence. METHODS:A de...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000368894
更新日期:2015-01-01 00:00:00
abstract::The report deals with the changes of brain functions in the course of traumatic apallic syndrome (TAS) by means of the EEG examination, in the classical way, and by computer analysis as well. The development of EEG changes during individual stages of the TAS is studied. The EEG examination was performed repeatedly in ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116316
更新日期:1987-01-01 00:00:00
abstract::We performed serial neurophysiological tests in 22 patients with confirmed Guillain Barré syndrome (GBS) for 12 months following onset of the disease. Twenty-five age- and sex-matched healthy controls were also tested. Tests included nerve conduction and automated quantitative thermal threshold measurements. The commo...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116841
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:A marked proportion of multiple sclerosis (MS) relapses is followed by incomplete recovery. Our aim was to considerably increase the evidence of the clinical use of immunoadsorption (IA) as escalation therapy for patients with MS relapse. METHODS:A retrospective multicenter study was performed in MS patient...
journal_title:European neurology
pub_type: 杂志文章,多中心研究
doi:10.1159/000447059
更新日期:2016-01-01 00:00:00
abstract:INTRODUCTION:We investigated the predictive value of standard neurological evaluation, a commercially available biomarker assay and neuroimaging in the subacute phase for outcome after thrombolytic therapy in ischemic stroke. METHODS:Thirty-four consecutive ischemic stroke patients were evaluated by means of the NIH S...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000215876
更新日期:2009-01-01 00:00:00
abstract::We describe a case presenting continuous muscle fiber activity syndrome, which was slightly reduced by the blocking of nerve conduction and abolished by ischemia. Clinical, electromyographical and bioptical evidence of marked abnormalities of peripheral motoneurons were observed. Association with central motoneuron le...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115508
更新日期:1982-01-01 00:00:00
abstract::The blink reflex and its equivalent glabella tap reflex are behavioural motor responses normally found in neonates and in the physiological startle reflex. Historically, it was described by Overend in 1896 and soon afterwards by McCarthy and by Bekhterev who disputed its origins. Kugelberg in 1952 recorded the early-l...
journal_title:European neurology
pub_type: 历史文章,杂志文章,评审
doi:10.1159/000114053
更新日期:2008-01-01 00:00:00
abstract::3 out of 24 patients with mitral valve prolapse (MVP), mean age 25.7 +/- 3.1 displayed markedly thickened redundant and shaggy mitral leaflets in the two-dimensional echocardiogram. The anterior leaflet appeared in the parasternal long axis plane club-shaped in diastole. These three female patients had a history of is...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115766
更新日期:1985-01-01 00:00:00
abstract::The importance of patent foramen ovale (PFO) has long been discussed in the literature in relation to different coexisting medical conditions. Many researchers focused on the occurrence of PFO in ischemic stroke patients, especially in the subgroup of young patients with a recurrent event. Unfortunately, before establ...
journal_title:European neurology
pub_type: 杂志文章,评审
doi:10.1159/000342900
更新日期:2013-01-01 00:00:00
abstract::26 adult epileptic patients with diffuse slow spikes and waves and start of seizures after the age of 6 years were analyzed. The seizure spectrum encompasses generalized and focal seizures. The occurrence of several types of seizures is the rule. Epileptic drop attacks are most characteristic. Atonic, tonic and myoclo...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115581
更新日期:1983-01-01 00:00:00
abstract::In order to consider the prognostic value of hyperdensity of the middle cerebral artery (MCA), we studied retrospectively the medical records of 80 consecutive patients with the diagnosis of ischemic stroke who underwent a non-enhanced computed tomography no longer than 24 h after the onset of the symptoms. To determi...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116949
更新日期:1993-01-01 00:00:00
abstract::In recent years, the involvement of the immune system in acquired forms of cerebellar ataxia has been frequently demonstrated. In this study, we describe 6 out of 49 patients with subacute or chronic progressive cerebellar ataxia in whom antibodies against neuronal and non-neuronal antigens were identified. Two women ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000242010
更新日期:2009-01-01 00:00:00
abstract::Clinical evaluation, quantitative analysis of the EMG, and motor unit fiber density were carried out on 34 selected patients that suffered paralytic poliomyelitis. 50% of the subjects developed a late and slowly progressive weakness. Automatic analysis of the electromyogram showed a great increase in mean amplitude in...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115578
更新日期:1983-01-01 00:00:00
abstract::Dopamine uptake sites, labelled by 3 nM [3H]GBR 12935, were reduced by 28-34% in post-mortem Parkinson's diseased striata (n = 22) compared to control striata (n = 28). There was no significant difference between post-mortem striata from schizophrenics (n = 16) and controls. Both dopamine D1 and D2 receptors are consi...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000117168
更新日期:1990-01-01 00:00:00
abstract::Median nerve somatosensory evoked potentials (SEPs) and jerk-locked EEG back-averaging (JLA) were performed in 2 patients with left-hand myoclonus. Both SEPs were characterized by a normal parietal N20 and an enhanced N27-P27 fronto-parietal complex, but the giant central N40 described by most authors was only observe...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000119509
更新日期:1994-01-01 00:00:00
abstract::Local cerebral glucose utilization (LCGU) was determined in 2- to 8-day-old beagle dogs by the quantitative 14C-deoxyglucose autoradiographic method. In physiologically controlled puppies (BP 66 +/- 3 mm Hg; paO2 71 +/- 2 mm Hg; paCO2 35 mm Hg, pH 7.39 +/- 0.04; hematocrit 39 +/- 2%), the 2-deoxyglucose (2-DG) autorad...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115226
更新日期:1981-01-01 00:00:00
abstract::Anticonvulsant therapy was stopped in 191 epileptic children (109 males and 82 females) after a seizure-free period of at least 2 years, independent of EEG findings, followed up for a minimum of 2 years after withdrawal. Overall, 43 (22.5%) had recurrence of seizures; of these, 79% relapsed within the 1st year after d...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116811
更新日期:1992-01-01 00:00:00
abstract::The clinical and biochemical data on 13 patients with Batten's syndrome are described. Clinically the disease was characterized by progressive maental and somatic deterioration. Initially, vision loss was found between the ages 4 and 8 years. This was associated with 1 or 2 years of normal school attendance followed b...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000114834
更新日期:1977-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to investigate the influence of psychosocial variables on patients with multiple sclerosis (MS) and the relationship between these variables and the onset of MS. BACKGROUND:The current evidence indicates that many types of psychosocial factors are involved in the development and rel...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000226428
更新日期:2009-01-01 00:00:00
abstract::Henri Duret (1849-1921) was a surgeon whose training started in the laboratory of Jean-Martin Charcot and Alfred Vulpian at La Salpêtrière in 1874. Using injections of colored gelatine, Duret was the first to describe the distribution of supply arteries in the brainstem and then in the cortex. His descriptions correla...
journal_title:European neurology
pub_type: 传,历史文章,杂志文章
doi:10.1159/000361046
更新日期:2014-01-01 00:00:00
abstract::Bilateral choroid plexus papillomas, or villous hypertrophy of the choroid plexus, is a very rare entity that presents serious therapeutical problems in the management of secondary oversecretive hydrocephalus. The authors report the cases of 2 infants affected by this condition, and cured with removal of the lateral v...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000117402
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Most of the previously described pathogenic mutations in desmin are located in highly conserved α-helical domains that play an important role in intermediate filament assembly. The role of the C-terminus non-α-helical 'tail' domain is much less investigated and until recently mutations in this domain have be...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000341617
更新日期:2012-01-01 00:00:00
abstract::The aim of this study was to investigate whether there are clues for a correlation between tumor progression and serum anti-Hu antibody concentration in patients with anti-Hu-associated paraneoplastic neurological syndromes (PNS). 19 patients with anti-Hu-associated PNS were assigned to three groups according to the c...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000057897
更新日期:2002-01-01 00:00:00
abstract::Five patients with clinical features of corticobasal degeneration (CBD) were studied with PET imaging. The main clinical findings included a unilateral extrapyramidal motor disorder, without significant response to levodopa, as well as clumsiness, dysarthria, apraxia and a clear asymmetry of neurological signs. PET st...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000008187
更新日期:2000-01-01 00:00:00
abstract::Dementia is one of the most common organic mental syndromes, usually caused by Alzheimer's disease (AD) or vascular dementia (VD) or both. Regarding AD we review the state or the art of the cholinergic approach and discuss some future options regarding preventive and nonsymptomatic strategies. Therapy for VD will cons...
journal_title:European neurology
pub_type: 杂志文章,评审
doi:10.1159/000113372
更新日期:1997-01-01 00:00:00
abstract::Transient ischemic attacks (TIAs) are warning episodes predicting that such patients are at high risk for stroke which potentially could be life-threatening or leave an individual with substantial disability. TIAs result from large or small vessel disease, cardiogenic embolic events and hematological abnormalities. Th...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000052065
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Cerebral infarction (CI) occurring soon after intracerebral hemorrhage (ICH) has been rarely reported. The purpose of the present study was to characterize this condition and discuss the possible pathophysiology. METHOD:We retrospectively studied 6 patients who developed CI within 10 days after ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000098465
更新日期:2007-01-01 00:00:00