Abstract:
BACKGROUND AND PURPOSE:Data on the association between renal dysfunction and outcome in patients with stroke are controversial and scarce. We investigated the predictors of renal dysfunction upon admission and the association between renal dysfunction and clinical outcome in patients with acute stroke in a hospitalized Chinese population. METHODS:1,758 acute stroke patients were consecutively enrolled into the study. The estimated glomerular filtration rate (eGFR) was calculated by the Modification of Diet in Renal Disease equation. Reduced estimate of the glomerular filtration rate was defined as eGFR <60 ml/min/1.73 m(2). Multivariate logistical regression was used to evaluate the predictors of renal dysfunction upon admission and to examine the association between renal dysfunction and outcomes. The main outcome measures were death and death/disability (disability defined as modified Rankin Scale score >2) at 12 months after stroke. RESULTS:Of the included 1,758 cases (ischemic stroke: n = 1,192; hemorrhagic stroke: n = 566), 463 cases had reduced eGFR, which accounted for 26.3% of the total number. The distribution of eGFR upon admission was normal and the mean was 75.87 +/- 38.31 ml/min/1.73 m(2) (ischemic stroke: 75.07 +/- 29.89 ml/min/1.73 m(2); hemorrhagic stroke: 77.57 +/- 51.73 ml/min/1.73 m(2)). There was no significant difference between the two groups (p = 0.285). The independent predictors of eGFR upon admission were age (OR = 1.039, 95% CI = 1.028-1.050), male gender (OR = 0.658, 95% CI = 0.504-0.859), hematocrit on admission (OR = 1.008, 95% CI = 1.003-1.013), history of hypertension (OR = 1.307, 95% CI = 1.034-1.653), history of diabetes (OR = 1.411, 95% CI = 1.012-1.967) and NIHSS scores upon admission (OR = 1.497, 95% CI = 1.286-1.743). After adjustment for confounders, the patients with renal dysfunction had a significantly higher risk of death/disability (OR = 1.864, 95% CI = 1.170-2.970) compared with patients whose eGFR was more than 90 ml/min/1.73 m(2) at the end of the 12th month. Further analysis on type of stroke showed that reduced eGFR was an independent predictor of death/disability at the end of the 12th month in patients with hemorrhagic stroke (OR = 2.353, 95% CI = 1.063-5.209), but not for ischemic stroke (OR = 1.625, 95% CI = 0.881-2.999). CONCLUSIONS:Our study indicated that more than 1/4 of all patients with acute stroke presented with renal dysfunction. Reduced eGFR on admission is a strong predictor of poor outcome for hemorrhagic stroke but not for ischemic stroke.
journal_name
Eur Neuroljournal_title
European neurologyauthors
Hao Z,Wu B,Lin S,Kong FY,Tao WD,Wang DR,Liu Mdoi
10.1159/000285165subject
Has Abstractpub_date
2010-01-01 00:00:00pages
237-42issue
4eissn
0014-3022issn
1421-9913pii
000285165journal_volume
63pub_type
杂志文章abstract:OBJECTIVES:To analyze the trajectory to diagnosis and information provided in a series of cluster headache (CH) patients from five headache clinics. METHODS:CH patients were asked to fill in an ad hoc questionnaire. RESULTS:Seventy-five patients (mean age 41.5 years, 67 males) completed the questionnaire. Patients ha...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000362517
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND/AIMS:We assessed the, hitherto unknown, impact of intravenous methylprednisolone (ivMP) pulses during relapses of multiple sclerosis (MS) on the kinetics of anti-interferon-beta neutralizing antibodies (Nabs) and binding antibodies (Babs). METHODS:Babs (ELISA) and Nabs (antiviral cytopathic effect assay) ti...
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更新日期:2016-01-01 00:00:00
abstract::To investigate the association between APOE-epsilon4 allele and memory phenotype in the preclinical stage of Alzheimer's disease (AD). We compared an extensive preclinical memory profile at the baseline evaluation of 2 AD genotype groups: APOE-epsilon4 allele carriers and patients with APOE-epsilon3 homozygosity. Base...
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更新日期:2004-01-01 00:00:00
abstract::A method is described to relate brain morphology and neuropsychological disturbances such as aphasia. By mapping lesions with computerized tomography onto a grid model of five brain slices, it is possible to compare aphasiological information and lesion site by data processing, allowing the quantitative and qualitativ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115210
更新日期:1981-01-01 00:00:00
abstract::Four patients who experienced isolated transient global amnesia had computed tomographic evidence for a cerebral infarct (3 cases) or hemorrhage (1 case). The medial part of the temporal lobe was involved in 2 patients (left in 1, right in 1), the left lentiform nucleus in 1 patient, and the left thalamus in 1 left-ha...
journal_title:European neurology
pub_type: 杂志文章
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更新日期:1988-01-01 00:00:00
abstract:BACKGROUND/AIM:In this case-control study, our aim was to check for a possible independent role of hypertension in increasing the risk of developing Bell's palsy. METHODS:All patients diagnosed as having Bell's palsy referred to a neurology clinic were enrolled as cases. Controls were selected among other patients ref...
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journal_title:European neurology
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更新日期:1979-01-01 00:00:00
abstract::A Norwegian family with asymmetrical scapuloperoneal atrophy is described. Chronic, aching shoulder pain, slight proximal and distal sensory dysfunction, and atrophy of the extensor digitorum brevis muscle occurred in some individuals. The proband had slightly impaired sensory conduction velocity, and his father exhib...
journal_title:European neurology
pub_type: 杂志文章
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abstract::Nocturnal sleep patterns were registered from 6 parkinsonian patients treated with bromocryptine, ("-Br-L-ergocryptine, C.B.-154) a dopamine-like agonist. No significant differences in their sleep patterns were found in comparison with patients treated with L-dopa. Since bromocryptine acts direct on the dopaminergic r...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000114973
更新日期:1978-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2002-01-01 00:00:00
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journal_title:European neurology
pub_type: 杂志文章
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更新日期:1988-01-01 00:00:00
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更新日期:2018-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1159/000341340
更新日期:2012-01-01 00:00:00
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journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000324152
更新日期:2011-01-01 00:00:00
abstract::The consequences of cerebral infarcts involving the left hemisphere differ from those of the right homologue areas. Data of 337 consecutive, unselected patients with acute ischaemic stroke in the territory of the right or left middle cerebral artery were analysed. Furthermore, lesion locations of 77 stroke patients wi...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000065515
更新日期:2002-01-01 00:00:00
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journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000008051
更新日期:1999-01-01 00:00:00
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journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000101287
更新日期:2007-01-01 00:00:00
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journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000336299
更新日期:2012-01-01 00:00:00
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journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116893
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doi:10.1159/000117402
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pub_type: 杂志文章,评审
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更新日期:1997-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1159/000115123
更新日期:1980-01-01 00:00:00
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journal_title:European neurology
pub_type: 杂志文章
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更新日期:1993-01-01 00:00:00
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journal_title:European neurology
pub_type: 杂志文章
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更新日期:2011-01-01 00:00:00
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journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000114887
更新日期:1977-01-01 00:00:00
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journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000367620
更新日期:2014-01-01 00:00:00
abstract::In 128 patients with multiple sclerosis (MS) and 204 blood donors (control persons) the in vitro activation of 'Ficoll-purified' peripheral blood T lymphocytes was measured using the 3H-thymidine incorporation rate without (spontaneous proliferation) and with mitogen addition (concanavalin A, phytohemagglutinin). Mito...
journal_title:European neurology
pub_type: 杂志文章
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更新日期:1988-01-01 00:00:00
abstract::This study aimed at examining correlations between quantitative REM sleep EEG, regional cerebral blood flow measured by single photon emission computerized tomography (SPECT) and global cognitive functioning in nine patients with mild to moderate Alzheimer's disease. REM sleep EEG was not correlated with SPECT measure...
journal_title:European neurology
pub_type: 临床试验,杂志文章
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更新日期:1996-01-01 00:00:00
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journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000047971
更新日期:2002-01-01 00:00:00