Abstract:
:Neuropathological changes such as dystrophic neurites and the presence of abnormal tau protein in the olfactory system, including primary sensory cells and nerve fibres have previously been demonstrated in nasal mucosa tissue of patients with Alzheimer's disease (AD). These changes were detected in autopsy-derived material from histopathologically confirmed AD cases as well as in biopsy tissue from clinical severely ill AD patients. To investigate the potential usefulness for the early diagnosis of AD, we obtained biopsy tissue from olfactory mucosa from 5 clinically mild to moderate AD patients and stained for the presence of tau or beta-amyloid by immunocytochemistry using a panel of specific antibodies. No positive staining was found in any of the cases. For comparison, post-mortem olfactory tissue from AD patients with severe neuropathological changes (widespread neurofibrillary tangles and amyloid in the brain) was investigated. In these severe cases, tau immunoreactivity was found in fine nerve fibres in the lamina propria and in a few olfactory epithelial cells. These results are consistent with other reports showing that cytoskeletal changes and tau pathology in the olfactory epithelium are not primary (or specific) features of AD and may occur predominantly in late stages of the disease.
journal_name
Eur Neuroljournal_title
European neurologyauthors
Hock C,Golombowski S,Müller-Spahn F,Peschel O,Riederer A,Probst A,Mandelkow E,Unger Jdoi
10.1159/000007953subject
Has Abstractpub_date
1998-07-01 00:00:00pages
31-6issue
1eissn
0014-3022issn
1421-9913pii
ene40031journal_volume
40pub_type
杂志文章abstract::26 adult epileptic patients with diffuse slow spikes and waves and start of seizures after the age of 6 years were analyzed. The seizure spectrum encompasses generalized and focal seizures. The occurrence of several types of seizures is the rule. Epileptic drop attacks are most characteristic. Atonic, tonic and myoclo...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115581
更新日期:1983-01-01 00:00:00
abstract::Continuing the previously published clinical development of a case of adult metachromatic leukodystrophy (MLD), we now describe the terminal phase and death (at 46 years of age) of our patient. The final phase was characterized clinically by progression of generalized peripheral neuropathy, advanced extrapyramidal and...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115164
更新日期:1980-01-01 00:00:00
abstract::The present paper is a study of a microcystic intraspinal tumour that developed in a 4-year-old child. The histologic examination showed the presence of neuroblastic elements developing next to smooth muscle fibers. The tumour had diffusely invaded the meninges, presenting a marked collagen reaction. Ultrastructurally...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000114682
更新日期:1975-01-01 00:00:00
abstract::An analysis is presented of 35 cases of chorea as a symptom of polycythaemia. This analysis reveals: (a) whereas polycythaemia occurs predominantly in males (3:2), polycythaemic chorea (PC) occurs predominantly in females (5:2), at a real ratio of female:male = 4:1, the prevalence being 1-2.5% of polycythaemic patient...
journal_title:European neurology
pub_type: 杂志文章,评审
doi:10.1159/000115674
更新日期:1984-01-01 00:00:00
abstract::Acute ischemia of the brain induces a cascade of biochemical and physiological events. The final consequences depend on the fact whether ischemia is of transient or permanent, total or partial nature. Alteration of extracellular potassium concentration, intracellular calcium and potassium concentration, development of...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116058
更新日期:1986-01-01 00:00:00
abstract:AIM:To determine the frequency of epilepsies in the family members of epileptic patients. METHODS:The records of 4,851 patients with epilepsy were reviewed. The frequency and patterns of different epilepsies and epileptic syndromes in the patients, number of affected relatives and consanguinity were studied. RESULTS:...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000322125
更新日期:2011-01-01 00:00:00
abstract::In 128 patients with multiple sclerosis (MS) and 204 blood donors (control persons) the in vitro activation of 'Ficoll-purified' peripheral blood T lymphocytes was measured using the 3H-thymidine incorporation rate without (spontaneous proliferation) and with mitogen addition (concanavalin A, phytohemagglutinin). Mito...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116228
更新日期:1988-01-01 00:00:00
abstract::It is generally believed that a homonymous defect of macular vision (HMV) is caused by a small lesion restricted to the occipital lobe tip and rarely results from ischemic stroke. The incidence of HMV was studied retrospectively in 54 patients with infarction of the posterior cerebral artery territory who underwent Go...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000050785
更新日期:2001-01-01 00:00:00
abstract::Transient global amnesia (TGA) is a clinical syndrome of unknown etiology characterized by sudden onset anterograde amnesia, which was thought to resolve completely. However, some authors have also suggested permanent memory impairment. It is unclear whether these results reflect a true persistent damage or a simply t...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000104715
更新日期:2007-01-01 00:00:00
abstract::Trials of pharmacological intervention for acute stroke show several points of similarity with legal trials by jury. The relationships between sponsoring organisation and regulatory authorities and the roles of the many other participants are described. Only through a partnership can the common aim of developing impro...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000068509
更新日期:2003-01-01 00:00:00
abstract::We have recently observed a diffuse slowing of brain waves using serial quantitative electroencephalographic (qEEG) examinations in interferon (IFN)-alpha-treated chronic hepatitis C patients. However, it remains unclear how this alteration could be assessed. We evaluated the correlation between the qEEG changes and t...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000062997
更新日期:2002-01-01 00:00:00
abstract::Four patients who experienced isolated transient global amnesia had computed tomographic evidence for a cerebral infarct (3 cases) or hemorrhage (1 case). The medial part of the temporal lobe was involved in 2 patients (left in 1, right in 1), the left lentiform nucleus in 1 patient, and the left thalamus in 1 left-ha...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116240
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:Seizures and epilepsy are harmful and worsen the disability of stroke patients. There are currently no good clinical predictors of late-onset seizures and epilepsy in patients with cerebrovascular disease (CVD). PATIENTS AND METHODS:110 patients with delayed seizures after an ischaemic or a haemorrhagic str...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000087715
更新日期:2005-01-01 00:00:00
abstract::The production of novel, motivated or useful material defines creativity, which appears to be one of the higher, specific, human brain functions. While creativity can express itself in virtually any domain, art might particularly well illustrate how creativity may be modulated by the normal or pathological brain. Evid...
journal_title:European neurology
pub_type: 历史文章,杂志文章
doi:10.1159/000088645
更新日期:2005-01-01 00:00:00
abstract::In the last 2 years we have systematically treated 31 sleep apnea patients with 25-50 mg imipramine HCl given 30 min before bedtime. Imipramine treatment was attempted for nonoverweight patients with negative ear, nose and throat (ENT) findings and for patients who had not responded to weight reduction or ENT surgery ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115991
更新日期:1986-01-01 00:00:00
abstract::Electrophysiological findings in 10 patients with polyneuropathy and nonmalignant IgMk plasma cell dyscrasia are reported. The amplitude of sensory action potentials and maximum conduction velocity along the sural and median nerves are related to the structural changes found at the biopsy and to the immunologic result...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115979
更新日期:1986-01-01 00:00:00
abstract::The purpose of this pilot study was to determine whether 20 mg oral 311C90 can prevent the development of migraine headache when taken during the aura phase of a migraine attack. The study also aimed to provide an initial safety profile for 311C90 when taken during the aura. Forty patients (31 females, 9 males) were e...
journal_title:European neurology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1159/000119101
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:Tuberculous meningitis is the severest and commonest form of central nervous system tuberculosis causing high mortality and morbidity. We aim to study the clinical, biochemical, and radiological characteristics of tuberculous meningitis in adult patients in Qatar and to calculate the incidence. METHODS:A de...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000368894
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:The pathogenesis of card game-induced reflex epilepsy has not been determined so far. The aim of this study was to evaluate structural abnormalities using voxel-based morphometry (VBM) analysis, which may give some clue about the pathogenesis in card game-induced reflex epilepsy. METHODS:The 3 subjects were...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000447537
更新日期:2016-01-01 00:00:00
abstract::The possibility that epileptic seizures and classic migraine episodes may occur in the same patient is discussed. The probable relationship between the neurophysiological mechanisms which underlie both types of attacks has not yet been agreed upon. The case of a young man who suffered from classic migraine and who pre...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115066
更新日期:1979-01-01 00:00:00
abstract:BACKGROUND:The coincidence of coronary artery disease (CAD) and carotid artery stenosis (CAS) was observed. However, the association between pre-existing CAD and ischemic stroke (IS) outcome in patients with high-grade CAS remains unclear. We aimed to investigate the association between pre-existing CAD and outcomes of...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000512407
更新日期:2020-12-23 00:00:00
abstract::The urinary clearance of pyridostigmine was studied in six patients with myasthenia gravis. In three patients on pyridostigmine alone, renal clearance ranged from 349 to 481 ml/min, corresponding to a pyridostigmine:creatinine clearance ratio of 2.64 to 3.46. In a patient on bendrofluazide as well as pyridostigmine, a...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000114882
更新日期:1977-01-01 00:00:00
abstract::A woman who had spontaneous pain, hyperpathia and wasting of her left hand due to a subcortical lesion in the right parietal lobe is reported. The presentation and evaluation of this most unusual case are discussed. ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115753
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND:Previous studies showed that late-life depression with subjective memory complaints (SMC) may be associated with an increased risk of developing dementia. However, not all such patients have cognitive decline. The aim of this longitudinal study was to identify possible clinical determinants of progressive de...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000090104
更新日期:2005-01-01 00:00:00
abstract::Seventy-eight asymptomatic HIV-seropositive (aHIV) subjects were examined by means of an extensive neuropsychological test battery in comparison with 32 HIV-seronegative controls. They were also tested with regard to CD4+ and serum p24 antigen. Fifty-six of them completed a clinical follow-up of 12 up to 36 months and...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000117228
更新日期:1996-01-01 00:00:00
abstract:AIMS:We conducted this study to investigate the independent association of medial temporal atrophy (MTA) and white matter hyperintensities (WMH) with cognitive impairments of Alzheimer's disease (AD) patients and the interaction between MTA and WMH. METHODS:From 13 centers, a total of 216 AD patients were consecutivel...
journal_title:European neurology
pub_type: 杂志文章,多中心研究
doi:10.1159/000329277
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:A marked proportion of multiple sclerosis (MS) relapses is followed by incomplete recovery. Our aim was to considerably increase the evidence of the clinical use of immunoadsorption (IA) as escalation therapy for patients with MS relapse. METHODS:A retrospective multicenter study was performed in MS patient...
journal_title:European neurology
pub_type: 杂志文章,多中心研究
doi:10.1159/000447059
更新日期:2016-01-01 00:00:00
abstract::The authors themselves studied 26 patients. The EEGs were classified in terms of increasing severity in 5 categories. Incorporating over 400 cases from the literature, the authors correlated the initial EEG findings with the clinical outcome following cardiac arrest. Grade I EEG findings (normal alpha with theta-delta...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116329
更新日期:1987-01-01 00:00:00
abstract::Acid phosphatase staining is performed on cerebrospinal fluid cells of 365 samples from 105 patients with various types of meningitis. This enzyme activity is strongly positive in the early samples of bacterial meningitis, as far as the patients had not received a pretreatment with antibiotics for more than 24 h. It a...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116035
更新日期:1986-01-01 00:00:00
abstract::Current treatment options for restless legs syndrome (RLS), based on the American Academy of Sleep Medicine practice parameters, favor dopaminergic agents. The drug of first choice is levodopa, which is now licensed for RLS in two European countries. However, the short duration of action and augmentation of symptoms u...
journal_title:European neurology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1159/000058050
更新日期:2001-01-01 00:00:00