Abstract:
:The management of early Parkinson's disease (PD) involves the treatment of motor symptoms and, increasingly, non-motor symptoms. Given the fast pace of clinical research in PD, clinicians are faced with the challenge of integrating the latest findings into the ongoing care of individual PD patients. Part 1 of this 2-part article reviews motor symptom efficacy data for the newest PD treatment options, as well as for established therapies. Safety and tolerability data are also reviewed. Part 2 of the article reviews key findings relevant to the assessment of potential neuroprotective therapies and the treatment of non-motor symptoms.
journal_name
Eur Neuroljournal_title
European neurologyauthors
Simuni T,Lyons KE,Pahwa R,Hauser RA,Comella C,Elmer L,Weintraub Ddoi
10.1159/000197103subject
Has Abstractpub_date
2009-01-01 00:00:00pages
193-205issue
4eissn
0014-3022issn
1421-9913pii
000197103journal_volume
61pub_type
杂志文章,评审abstract:BACKGROUND:The meningitides are rare but well-identified complications in patients with systemic lupus erythematosus (SLE). AIMS:To determine the clinical characteristics, risk factors, prevalence and outcomes of the meningitides (septic and aseptic) in patients with SLE. PATIENTS AND METHODS:From January 1988 to Dec...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000186504
更新日期:2009-01-01 00:00:00
abstract::Botulinum toxin type B (BT-B) therapy failure due to formation of botulinum toxin type B antibodies (BT-B-AB) has only been reported in patients with botulinum toxin type A antibodies (BT-A-AB). We are reporting BT-B-AB-induced therapy failure in 2 patients with no previous exposure to botulinum toxin. In patient 1 co...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000081463
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Most reports on thalamic infarcts have focused on clinicoanatomical correlations while the mechanisms of stroke have rarely been investigated. Moreover, most series have included mainly elderly stroke patients, whereas scarce information is available about the etiology of thalamic infarcts in the young. OBJ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000047944
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:One of the hallmarks of the α-synucleinopathies is the degeneration of the autonomic nervous system. SUMMARY:This review discusses the diagnosis and management of cardiovascular autonomic failure within the context of the α-synucleinopathies. In addition, it outlines the utility of various laboratory assess...
journal_title:European neurology
pub_type: 杂志文章,评审
doi:10.1159/000368828
更新日期:2015-01-01 00:00:00
abstract::The gradual intraneuronal accumulation of an insoluble fibrous material which partly consists of abnormally phosphorylated tau protein (neurofibrillary change) represents an important neuropathological hallmark of Alzheimer's disease. Neurofibrillary tangles and neuropil threads formed from this material develop in on...
journal_title:European neurology
pub_type: 杂志文章,评审
doi:10.1159/000116984
更新日期:1993-01-01 00:00:00
abstract:OBJECTIVE:To determine whether orbitofrontal cortex (OFC) function improves with blepharospasm (BSP) symptom remission using a verbal fluency task and near-infrared spectroscopy (NIRS). METHODS:Nineteen BSP patients and 9 healthy controls (HCs) matched by gender and education were examined using NIRS. The BSP patients...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000471850
更新日期:2017-01-01 00:00:00
abstract::Petit mal absences in childhood are often followed by grand mal seizures in adolescence and a coexistence of both types of seizures is not uncommon at all. It is noteworthy, however, that such a coexistence does not imply immediate transition from one type of seizure into the other one. Hence, a grand mal attack may b...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000114721
更新日期:1976-01-01 00:00:00
abstract:BACKGROUND/AIMS:Whereas insomnia is frequent in restless legs syndrome (RLS), little is known about daytime sleepiness. We studied a series of 27 consecutive patients with idiopathic RLS in order to identify the characteristics and evolution of excessive daytime sleepiness (EDS) under dopaminergic treatment. METHODS:P...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000228261
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:To examine the therapeutic effect of intravenous recombinant tissue plasminogen activator (rt-PA) therapy for stroke patients receiving maintenance hemodialysis (HD). methods: Of 600 stroke patients receiving intravenous rt-PA using 0.6 mg/kg alteplase who were enrolled in a multicenter observational study i...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000328792
更新日期:2011-01-01 00:00:00
abstract::A 9-year-old girl with huge, double arachnoid cysts at the cerebellopontine angle is reported. After a cyst-peritoneal shunt operation, she developed fine, high-frequency gaze nystagmus towards the lesion side combined with coarse, large amplitude nystagmus in the opposite direction, which is the reverse of the Bruns'...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116903
更新日期:1993-01-01 00:00:00
abstract:OBJECTIVES:To evaluate the diagnostic yield of nerve biopsy in patients with peripheral neuropathy of undetermined cause despite extensive diagnostic workup. METHODS:From November 2001 through January 2004, 38 patients underwent nerve biopsy because of unclassified neuropathy. RESULTS:The etiology of the neuropathies...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000098057
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:The association between edentulism and cerebral small vessel disease is controversial. We aimed to assess this relationship in community-dwelling older adults living in rural Ecuador. METHODS:MRI was performed in 311 (81%) of 385 individuals ≥60 years enrolled in the Atahualpa Project. Participants were cla...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000448839
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVES:To analyze the trajectory to diagnosis and information provided in a series of cluster headache (CH) patients from five headache clinics. METHODS:CH patients were asked to fill in an ad hoc questionnaire. RESULTS:Seventy-five patients (mean age 41.5 years, 67 males) completed the questionnaire. Patients ha...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000362517
更新日期:2014-01-01 00:00:00
abstract::In 128 patients with multiple sclerosis (MS) and 204 blood donors (control persons) the in vitro activation of 'Ficoll-purified' peripheral blood T lymphocytes was measured using the 3H-thymidine incorporation rate without (spontaneous proliferation) and with mitogen addition (concanavalin A, phytohemagglutinin). Mito...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116228
更新日期:1988-01-01 00:00:00
abstract::A 32-year-old patient with a lifelong history of epileptic attacks is described. A skull X-ray showed a round calcified nonhomogenous left frontotemporal mass. A CT scan confirmed its presence, as well as displacement of the left lateral and the third ventricles. At surgery a calcified inactive hydatid cyst was totall...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116120
更新日期:1987-01-01 00:00:00
abstract::During the first 5 days after an intracranial haemorrhage, the red blood cells slowly haemolyse. Most of the oxyhaemoglobin, released in the cerebrospinal fluid, is transformed into bilirubin by an enzyme-dependent process. After 5 days, the haemolysis increases without a corresponding enhancement in the formation of ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116339
更新日期:1987-01-01 00:00:00
abstract::A 48-year-old woman was referred from Zaire with suspected rabies encephalitis. Survival was 34 days after the onset of symptoms and the diagnosis of rabies was ultimately proven after brain autopsy. Serial neurophysiological investigations, including EEG and multimodality evoked potentials and radiological examinatio...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116939
更新日期:1993-01-01 00:00:00
abstract::Of 150 new cases of nasopharyngeal carcinoma diagnosed in Israel during a 9-year period (nationwide study 1960--1968), 74 patients developed neurological complications. In 92% of the cases, neurologic deficits were confined exclusively to cranial nerves. The majority of these patients presented general symptoms of dis...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000114938
更新日期:1978-01-01 00:00:00
abstract::MPTP, 1-methyl-4-phenyl-pyridinium ion (MPP+) and the structurally related compounds including N-methyltetrahydroisoquinilinium ion inhibited the tyrosine hydroxylase (TH) system in tissue slices of rat striatum at 10(-5) M. Mouse striatum is more susceptible to MPTP than rat striatum. A similar degree of inhibition b...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116350
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND:Several treatments are available to treat the immune-mediated chronic inflammatory demyelinating polyneuropathy (CIDP). Among these treatments, intravenous immunoglobulins, corticosteroids and plasma exchanges are validated and widely used. A few immunosuppressive drugs have been tried, but they had little e...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000381767
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:The diagnosis of Guillain-Barre syndrome (GBS) in the very early stage may be challenging. Our aim was to report the neurophysiological abnormalities in GBS within 4 days of clinical onset. We expected that GBS will be diagnosed by the assistance of neurophysiological study in the very early stage. METHODS:We ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000494261
更新日期:2018-01-01 00:00:00
abstract::The present report evaluates the suppression of antiepileptic drugs in a group of 608 epileptics. Conditions for the suppression of antiepileptic treatment included a previous seizure-free period of 5 years under medication, and a careful evaluation of individual social and work-related circumstances. The reduction of...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116141
更新日期:1987-01-01 00:00:00
abstract::Transient global amnesia (TGA) is a clinical syndrome of unknown etiology characterized by sudden onset anterograde amnesia, which was thought to resolve completely. However, some authors have also suggested permanent memory impairment. It is unclear whether these results reflect a true persistent damage or a simply t...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000104715
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:To study gender differences of coping with illness strategies in tension-type headaches. METHOD:We enrolled 89 subjects (50 women, 39 men) suffering from episodic (n = 37) and chronic (n = 52) tension-type headaches (TTH). Patients were required to answer a Freiburg Questionnaire of Coping with Illness (FQCI...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000072502
更新日期:2003-01-01 00:00:00
abstract::Two cases of malignant tumours of the nerve sheaths are reported. In the first patient, who had von Recklinghausen's disease, light- and electron-microscopic investigations showed an undifferentiated mesenchymal tumour of the radial nerve with the property of producing collagen fibres, an aspect characteristic of sarc...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000114873
更新日期:1977-01-01 00:00:00
abstract::Bilateral choroid plexus papillomas, or villous hypertrophy of the choroid plexus, is a very rare entity that presents serious therapeutical problems in the management of secondary oversecretive hydrocephalus. The authors report the cases of 2 infants affected by this condition, and cured with removal of the lateral v...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000117402
更新日期:1997-01-01 00:00:00
abstract::Changes in the maximal rate of some cerebral enzymatic activities related to 400ene transduction and neurotransmission (lactate dehydrogenase; citrate synthase and malate dehydrogenase; total NADH-cytochrome c reductase and cytochrome oxidase; glutamate dehydrogenase; acetylcholine esterase) were assayed both in the c...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115242
更新日期:1981-01-01 00:00:00
abstract::A case of Fisher's syndrome which recurred 10 years apart was reported. Laterality of cranial nerve findings in the initial episode was replicated in the recurrence. Some kind of localized immune sensitization is supposed to play a role in replicating such a laterality. Increased CD4/CD8 ratio and elevated IgE were no...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116688
更新日期:1991-01-01 00:00:00
abstract::This study investigates the remote effects of botulinum toxin injections by examining the motor unit architecture of noninjected distant muscles. In 21 dystonia patients treated with botulinum toxin (n = 11, mean cumulative dose = 815 mU; n = 10, mean cumulative dose = 7,207 mU) and 10 control individuals, a blinded s...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000008222
更新日期:2000-01-01 00:00:00
abstract::Two cases of lithium neurotoxic effects are reported. Both cases are expressed by choreoathetotic movements and in both of them intoxication was caused by combined drug therapy. In our opinion caution is advised when lithium is administered in combination with drugs, especially in elderly patients. ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116044
更新日期:1986-01-01 00:00:00