Amyotrophic lateral sclerosis and frontal lobe dementia in Alzheimer's disease. Case report and review of the literature.

Abstract:

:Clinicopathological data of a woman with a 3-year course of concurrent amyotrophic lateral sclerosis and dementia are presented. Dementia had occurred at time of onset of motor disturbances and presented as typical frontal lobe dementia. Pathology confirmed motor neuron disease of amyotrophic lateral sclerosis and frontal lobe atrophy. Multiple senile plaques were distributed cortically and in the hippocampus, where diffuse spread of neurofibrillary tangles was seen. Hence, this Alzheimer's dementia in a patient with sporadic amyotrophic lateral raises the question of a possible association between the two conditions.

journal_name

Eur Neurol

journal_title

European neurology

authors

Müller M,Vieregge P,Reusche E,Ogomori K

doi

10.1159/000116962

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

320-4

issue

4

eissn

0014-3022

issn

1421-9913

journal_volume

33

pub_type

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