Risk factors for central pontine and extrapontine myelinolysis following orthotopic liver transplantation.

Abstract:

BACKGROUND:Central pontine myelinolysis (CPM)/extrapontine myelinolysis (EPM) is one of the most serious neurological complications that can occur after orthotopic liver transplantation (OLT). We analyzed the risk factors for CPM/EPM in OLT patients. METHODS:We retrospectively reviewed the records of 1,247 patients who underwent OLT between 1992 and 2005. We compared demographic, clinical and biological parameters of patients with CPM/EPM with those of age-, sex- and operation date-matched patients without CPM/EPM (controls). RESULTS:Of 1,247 patients, 11 (0.88%) were diagnosed with CPM/EPM based on neuroimaging findings. A higher Model for End-Stage Liver Disease-Na score, preoperative hyponatremia and hypocholesterolemia, as well as greater changes in electrolytes, especially sodium, during surgery, were observed in the CPM/EPM group (p < 0.05). CONCLUSION:CPM/EPM after OLT is more likely to occur in patients with more severe preoperative liver dysfunction and greater changes in electrolyte imbalance, especially sodium, during surgery.

journal_name

Eur Neurol

journal_title

European neurology

authors

Lee EM,Kang JK,Yun SC,Kim KH,Kim SJ,Hwang KS,Lee SG

doi

10.1159/000242426

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

362-8

issue

6

eissn

0014-3022

issn

1421-9913

pii

000242426

journal_volume

62

pub_type

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