Abstract:
:Deficits in the cholinergic system are pronounced in dementia with Lewy bodies (DLB) and are more severe in patients with visual hallucinations (VHs). The aim is to identify the occipital glucose metabolism patterns by positron emission tomography (PET) and the changes following donepezil treatment. 13 DLB patients with VHs were enrolled in the study. After the first FDG-PET study, 5 mg/day donepezil was administered orally, and a second PET study was performed 3 months later. After donepezil administration, VHs disappeared completely in 6 patients, and the PET studies revealed significantly decreased glucose metabolism in the medial occipital cortex. These results suggest that VHs in DLB were associated with impaired glucose metabolism in the medial occipital cortex. Donepezil treatment may modify regional glucose metabolism.
journal_name
Eur Neuroljournal_title
European neurologyauthors
Satoh M,Ishikawa H,Meguro K,Kasuya M,Ishii H,Yamaguchi Sdoi
10.1159/000322121subject
Has Abstractpub_date
2010-01-01 00:00:00pages
337-44issue
6eissn
0014-3022issn
1421-9913pii
000322121journal_volume
64pub_type
临床试验,杂志文章abstract::Camptocormia (bent spine syndrome, cyphose hystérique) is an abnormality characterized by severe forward flexion of the thoracolumbar spine which typically increases during walking or standing and completely disappears in supine position. Camptocormia can be due to central nervous system diseases, such as Parkinson's ...
journal_title:European neurology
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journal_title:European neurology
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journal_title:European neurology
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journal_title:European neurology
pub_type: 杂志文章
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journal_title:European neurology
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journal_title:European neurology
pub_type: 杂志文章
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journal_title:European neurology
pub_type: 临床试验,杂志文章
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journal_title:European neurology
pub_type: 杂志文章,评审
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journal_title:European neurology
pub_type: 历史文章,杂志文章,评审
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更新日期:2008-01-01 00:00:00
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journal_title:European neurology
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journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115736
更新日期:1984-01-01 00:00:00