Biological studies in schizophrenia.

abstract：:Migration is a major risk factor for schizophrenia but the neurochemical processes involved are unknown. One candidate mechanism is through elevations in striatal dopamine synthesis and release. The objective of this research was to determine whether striatal dopamine function is elevated in immigrants compared to non...

journal_title：Schizophrenia bulletin

authors： Egerton A,Howes OD,Houle S,McKenzie K,Valmaggia LR,Bagby MR,Tseng HH,Bloomfield MA,Kenk M,Bhattacharyya S,Suridjan I,Chaddock CA,Winton-Brown TT,Allen P,Rusjan P,Remington G,Meyer-Lindenberg A,McGuire PK,Mizrahi R

更新日期：2017-03-01 00:00:00

abstract：:Advances in treatment technologies and development of evidence-based standards of care demand better methods for routine assessment of outcomes for schizophrenia in systems of care. This article describes the development and psychometrics of a new instrument to assess outcomes of routine care for persons with schizoph...

journal_title：Schizophrenia bulletin

authors： Lehman AF,Fischer EP,Postrado L,Delahanty J,Johnstone BM,Russo PA,Crown WH

更新日期：2003-01-01 00:00:00

abstract：:Recent years have witnessed widespread interest in the early phase of schizophrenia and other psychotic disorders. Strategies have been introduced to attempt to identify individuals in the prepsychotic or prodromal phase. The most widely used of these approaches is the ultra-high risk (UHR) approach, which combines kn...

journal_title：Schizophrenia bulletin

authors： Nelson B,Yung AR,Bechdolf A,McGorry PD

更新日期：2008-03-01 00:00:00

abstract：:This study examined the course of illness and factors affecting it in schizophrenias with onset between the ages of 14 and 18. Noteworthy in comparison to findings from other followup studies is the higher proportion of chronic courses of illness, about 50 percent. In addition, the type of course of illness correspond...

journal_title：Schizophrenia bulletin

authors： Krausz M,Müller-Thomsen T

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Cannabis use has been identified as a potent predictor of the earlier onset of psychosis, but meta-analysis has not indicated that it has a clear effect in established psychosis. AIM:To assess the association between cannabis and outcomes, including whether change in cannabis use affects symptoms and functi...

journal_title：Schizophrenia bulletin

authors： Barrowclough C,Emsley R,Eisner E,Beardmore R,Wykes T

更新日期：2013-03-01 00:00:00

abstract：:This study compared the performance of 39 biological relatives of persons with schizophrenia to that of 30 normal adult controls on graphesthesia processing, a complex somatosensory processing task. The relatives performed significantly worse on the graphesthesia task compared to the healthy controls. The relatives an...

journal_title：Schizophrenia bulletin

authors： Chang BP,Lenzenweger MF

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Acute treatment with subanaesthetic doses of NMDA receptor antagonists, such as ketamine, provides a translational model with relevance to many of the symptoms of schizophrenia. Previous studies have focused specifically on the prefrontal cortex (PFC) because this region is implicated in many of the function...

journal_title：Schizophrenia bulletin

authors： Dawson N,Morris BJ,Pratt JA

更新日期：2013-03-01 00:00:00

abstract：:Endophenotypes represent intermediate phenotypes on the putative causal pathway from the genotype to the phenotype. They offer a potentially valuable strategy to examine the molecular etiopathology of complex behavioral phenotypes such as schizophrenia. Neurocognitive and neurophysiological impairments that suggest fu...

journal_title：Schizophrenia bulletin

authors： Prasad KM,Keshavan MS

更新日期：2008-07-01 00:00:00

abstract：:Cognitive deficits are a central and debilitating aspect of schizophrenia and other major mental illnesses. Although they are largely refractory to pharmacotherapy, multiple studies have now shown that large and lasting improvements in cognition can result from behavioral interventions. We will review our work over th...

journal_title：Schizophrenia bulletin

authors： Wexler BE,Bell MD

更新日期：2005-10-01 00:00:00

abstract：:Childhood trauma (CT) has been identified as a potential risk factor for the onset of psychotic disorders. However, to date, there is limited consensus with respect to which symptoms may ensue after exposure to trauma in early life, and whether specific pathways may account for these associations. The aim of the prese...

journal_title：Schizophrenia bulletin

authors： Isvoranu AM,van Borkulo CD,Boyette LL,Wigman JT,Vinkers CH,Borsboom D,Group Investigators.

更新日期：2017-01-01 00:00:00

abstract：:North American outcome studies of schizophrenia conducted within the past quarter century are reviewed if their minimum average followup is 10 years and they meet at least some modern design criteria. Ten such investigations are described and summarized. Taken as a whole, they demonstrate that schizophrenia can be a c...

journal_title：Schizophrenia bulletin

authors： McGlashan TH

更新日期：1988-01-01 00:00:00

abstract：Background:Motor abnormalities (MAs) of severe mental disorders have been traditionally neglected both in clinical practice and research, although they are an increasing focus of attention because of their clinical and neurobiological relevance. For historical reasons, most of the literature on MAs has been focused to ...

journal_title：Schizophrenia bulletin

authors： Peralta V,Cuesta MJ

更新日期：2017-09-01 00:00:00

abstract：:Randomized controlled trials for antipsychotic drugs have a variety of design features suited to diverse purposes. Efficacy (or explanatory) trials seek to establish if a drug can reduce psychotic symptoms under ideal circumstances. To isolate drug effects, researchers enroll carefully selected patients. Specialized r...

journal_title：Schizophrenia bulletin

authors： Stroup TS,Geddes JR

更新日期：2008-03-01 00:00:00

abstract：:Mobile assessment techniques have been used for nearly 3 decades in mental health research, including in investigations of individuals with schizophrenia and other severe disorders. This article reviews the benefits of these data collection strategies relative to traditional self-report or clinician-administered measu...

journal_title：Schizophrenia bulletin

authors： Kimhy D,Myin-Germeys I,Palmier-Claus J,Swendsen J

更新日期：2012-05-01 00:00:00

abstract：:Schizophrenia (SCZ) is associated with differences in subcortical brain volumes and intracranial volume (ICV). However, little is known about the underlying etiology of these brain alterations. Here, we explored whether brain structure volumes and SCZ share genetic risk factors. Using conditional false discovery rate ...

journal_title：Schizophrenia bulletin

authors： Smeland OB,Wang Y,Frei O,Li W,Hibar DP,Franke B,Bettella F,Witoelar A,Djurovic S,Chen CH,Thompson PM,Dale AM,Andreassen OA

更新日期：2018-06-06 00:00:00

abstract：:The purpose of this study was to investigate the construct validity and the test-retest reliability of the willingness to pay (WTP) method for estimating health state preferences associated with side effects of antipsychotic medication. Ninety-six schizophrenia patients on antipsychotics were asked (1) how much they w...

journal_title：Schizophrenia bulletin

authors： Sevy S,Nathanson K,Schechter C,Fulop G

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Given the evidence that reasoning biases contribute to delusional persistence and change, several research groups have made systematic efforts to modify them. The current experiment tested the hypothesis that targeting reasoning biases would result in change in delusions. METHODS:One hundred and one partici...

journal_title：Schizophrenia bulletin

authors： Garety P,Waller H,Emsley R,Jolley S,Kuipers E,Bebbington P,Dunn G,Fowler D,Hardy A,Freeman D

更新日期：2015-03-01 00:00:00

abstract：:The European Psychiatric Services: Inputs Linked to Outcomes and Needs (EPSILON) study was a EU BIOMED-2-funded comparative, cross-national, cross-sectional study aimed (1) to produce standardized versions of five key research instruments in five languages, and (2) to compare the characteristics, needs, and life quali...

journal_title：Schizophrenia bulletin

authors： van Wijngaarden B,Schene A,Koeter M,Becker T,Knapp M,Knudsen HC,Tansella M,Thornicroft G,Vázquez-Barquero JL,Lasalvia A,Leese M,EPSILON Study Group.

更新日期：2003-01-01 00:00:00

abstract：:Genetic variants conferring risk for schizophrenia (SCZ) have been extensively studied, but the role of posttranscriptional mechanisms in SCZ is not well studied. Here we performed the first genome-wide microRNA (miRNA) expression profiling in serum-derived exosome from 49 first-episode, drug-free SCZ patients and 46 ...

journal_title：Schizophrenia bulletin

authors： Du Y,Yu Y,Hu Y,Li XW,Wei ZX,Pan RY,Li XS,Zheng GE,Qin XY,Liu QS,Cheng Y

更新日期：2019-10-24 00:00:00

abstract：BACKGROUND:There is evidence of a positive association between insight and depression among patients with schizophrenia. Self-stigma was shown to play a mediating role in this association. We attempted to broaden this concept by investigating insight as a potential moderator of the association between depressive sympto...

journal_title：Schizophrenia bulletin

authors： Krupchanka D,Katliar M

更新日期：2016-05-01 00:00:00

abstract：:This research studied hypotheses that positive thought disorder in schizophrenia is influenced by patients' not taking in immediate target contextual material, thereby losing vital cues that guide thought processes. We assessed 164 acute inpatients (including 55 schizophrenia and 31 bipolar disorder patients), using s...

journal_title：Schizophrenia bulletin

authors： Harrow M,Green KE,Sands JR,Jobe TH,Goldberg JF,Kaplan KJ,Martin EM

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVE:Impaired cognition is an important dimension in psychosis and its at-risk states. Research on the value of impaired cognition for psychosis prediction in at-risk samples, however, mainly relies on study-specific sample means of neurocognitive tests, which unlike widely available general test norms are difficu...

journal_title：Schizophrenia bulletin

authors： Michel C,Ruhrmann S,Schimmelmann BG,Klosterkötter J,Schultze-Lutter F

更新日期：2014-11-01 00:00:00

abstract：:In this issue we have tried to bring together a series of reviews describing new developments in the pharmacologic management of schizophrenia. Important progress is being made not only in medication development, but also in furthering our ability to use available treatments and treatment combinations in the most effe...

journal_title：Schizophrenia bulletin

authors： Kane JM

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:The clinical high-risk state for psychosis (HRP) is associated with an enhanced probability of developing a psychotic episode over a relatively short period of time. However, the extent to which different diagnostic types of illness develop remains unclear. METHODS:A systematic review was performed to ident...

journal_title：Schizophrenia bulletin

authors： Fusar-Poli P,Bechdolf A,Taylor MJ,Bonoldi I,Carpenter WT,Yung AR,McGuire P

更新日期：2013-07-01 00:00:00

abstract：:Although weight gain is a serious but variable adverse effect of antipsychotics that has genetic underpinnings, a comprehensive meta-analysis of pharmacogenetics of antipsychotic-related weight gain is missing. In this review, random effects meta-analyses were conducted for dominant and recessive models on association...

journal_title：Schizophrenia bulletin

authors： Zhang JP,Lencz T,Zhang RX,Nitta M,Maayan L,John M,Robinson DG,Fleischhacker WW,Kahn RS,Ophoff RA,Kane JM,Malhotra AK,Correll CU

更新日期：2016-11-01 00:00:00

abstract：:This study compared smoking behavior and motivation to quit smoking, assessed with a "stages of change" questionnaire, in outpatients with schizophrenia or schizoaffective disorder and in a representative sample of the general population. We conducted a mail survey in a representative sample of the general population ...

journal_title：Schizophrenia bulletin

authors： Etter M,Mohr S,Garin C,Etter JF

更新日期：2004-01-01 00:00:00

abstract：:Development of schizophrenia relates to both genetic and environmental factors. Functional deficits in many cognitive domains, including the ability to communicate in social interactions and impaired recognition of facial expressions, are common for patients with schizophrenia and might also be present in individuals ...

journal_title：Schizophrenia bulletin

authors： Lieslehto J,Kiviniemi VJ,Nordström T,Barnett JH,Murray GK,Jones PB,Paus T,Veijola J

更新日期：2019-06-18 00:00:00

abstract：:The left superior temporal sulcus (STS) plays an important role in integrating audiovisual information and is functionally connected to disparate regions of the brain. For the integration of gesture information in an abstract sentence context (metaphoric gestures), intact connectivity between the left STS and the infe...

journal_title：Schizophrenia bulletin

authors： Straube B,Green A,Sass K,Kircher T

更新日期：2014-07-01 00:00:00

abstract：:The purpose of the study was to examine (1) to which negative symptoms schizophrenia patients attribute distress and (2) whether clinical variables can predict the levels of reported distress. With the help of a research assistant, 86 hospitalized patients completed a self-rating scale for negative symptoms. The 21 it...

journal_title：Schizophrenia bulletin

authors： Selten JP,Wiersma D,van den Bosch RJ

更新日期：2000-01-01 00:00:00

abstract：:Data provided by case managers in community support programs are used to analyze the problems of families providing shelter to mentally ill relatives. Factors affecting complaints in 345 family households are contrasted with factors leading to complaints in a subsample of 622 other residential alternatives. Behavioral...

journal_title：Schizophrenia bulletin

authors： Gubman GD,Tessler RC,Willis G

更新日期：1987-01-01 00:00:00