Genome-Wide, Integrative Analysis Implicates Exosome-Derived MicroRNA Dysregulation in Schizophrenia.

abstract：:The schizophrenia research community has shared a belief that the incidence of schizophrenia shows little variation. This belief is related to the dogma that schizophrenia affects all individuals equally, regardless of sex, race, or nationality. However, there is now robust evidence that the incidence of schizophrenia...

journal_title：Schizophrenia bulletin

authors： McGrath JJ

更新日期：2006-01-01 00:00:00

abstract：:Changed synapse density has been suggested to be involved in the altered brain connectivity underlying schizophrenia (SCZ) pathology. However, postmortem studies addressing this topic are heterogeneous and it is not known whether changes are restricted to specific brain regions. Using meta-analysis, we systematically ...

journal_title：Schizophrenia bulletin

authors： Berdenis van Berlekom A,Muflihah CH,Snijders GJLJ,MacGillavry HD,Middeldorp J,Hol EM,Kahn RS,de Witte LD

更新日期：2020-02-26 00:00:00

abstract：:This article focuses on the cross-modal reaction time paradigm, which has been used to study deviation patterns of shifting attention across stimulus modalities in schizophrenic patients. Cross-modal reaction time research involving pathological and nonpathological populations is reviewed. The influence of sex, stimul...

journal_title：Schizophrenia bulletin

authors： Mannuzza S

更新日期：1980-01-01 00:00:00

abstract：:Spatial working memory (WM) processing has 3 distinct phases: encoding, maintenance, and retrieval and its dysfunction is a core feature in schizophrenia. We examined phase-specific brain activations associated with spatial WM in first-degree relatives of schizophrenia (genetic high risk, GHR), ultra-high risk (UHR) s...

journal_title：Schizophrenia bulletin

authors： Choi JS,Park JY,Jung MH,Jang JH,Kang DH,Jung WH,Han JY,Choi CH,Hong KS,Kwon JS

更新日期：2012-11-01 00:00:00

abstract：:Many brain regions and circuits have been implicated in the neuropathology of schizophrenia. Drs. Bogerts and Jones have reviewed the evidence that links the disorder to temporal limbic structures and to frontal-thalamic circuits, respectively. Each article is an important update on what we know about the relevance of...

journal_title：Schizophrenia bulletin

authors： Weinberger DR

更新日期：1997-01-01 00:00:00

abstract：:We report a 25-year followup of a group of 50 children at genetic risk for schizophrenia (by virtue of having a parent with the disorder) and 50 matched controls. The children who eventually developed schizophrenia spectrum disorders, including schizophrenia, were identifiable by cognitive-psychophysiological, neuroin...

journal_title：Schizophrenia bulletin

authors： Mirsky AF,Kugelmass S,Ingraham LJ,Frenkel E,Nathan M

更新日期：1995-01-01 00:00:00

abstract：:The literature on schizophrenia has reported a trend toward higher concordance rates for females in both monozygotic and dizygotic same-sexed twins. The validity of this finding is open to question. Rosenthal (1961 and 1962) pointed out that females are more likely than males to become inhabitants of chronic wards. Mo...

journal_title：Schizophrenia bulletin

authors： Samuels L

更新日期：1978-01-01 00:00:00

abstract：:The present functional magnetic resonance imaging study investigated the neural correlates of practice-associated activation changes in patients with schizophrenia and their association with symptom severity. A group of patients (n = 24) were divided into more successful and less successful learners and were asked to ...

journal_title：Schizophrenia bulletin

authors： Koch K,Wagner G,Schachtzabel C,Schultz C,Sauer H,Schlösser RG

更新日期：2010-05-01 00:00:00

abstract：:Does the McFarlane et al study provide a model for practical trials? Unfortunately, not. The methodological problems are here reviewed and used as a springboard to set out methodological criteria that might define such a model. ...

journal_title：Schizophrenia bulletin

authors： Kraemer HC

更新日期：2015-01-01 00:00:00

abstract：:One neuropathological feature of schizophrenia is a diminished number of dendritic spines in the prefrontal cortex and hippocampus. The neuregulin 1 (Nrg1) system is involved in the plasticity of dendritic spines, and chronic stress decreases dendritic spine densities in the prefrontal cortex and hippocampus. Here, we...

journal_title：Schizophrenia bulletin

authors： Clarke DJ,Chohan TW,Kassem MS,Smith KL,Chesworth R,Karl T,Kuligowski MP,Fok SY,Bennett MR,Arnold JC

更新日期：2019-03-07 00:00:00

abstract：:Although glutamate was first hypothesized to be involved in the pathophysiology of schizophrenia in the 1980s, it was the demonstration that N-methyl-D-aspartate (NMDA) receptor antagonists, the dissociative anesthetics, could replicate the full range of psychotic, negative, cognitive, and physiologic features of schi...

journal_title：Schizophrenia bulletin

authors： Coyle JT

更新日期：2012-09-01 00:00:00

abstract：:Empirically supported treatments for schizophrenia now include a variety of psychosocial interventions, such as social skills training, vocational rehabilitation, and psychotherapy. As awareness of the functional importance of neurocognitive impairments in schizophrenia has increased, interest in treatments to improve...

journal_title：Schizophrenia bulletin

authors： Twamley EW,Jeste DV,Bellack AS

更新日期：2003-01-01 00:00:00

abstract：:The role of gender in schizophrenia is explored, and literature on gender and schizophrenia is critically reviewed. The importance of investigating gender differences in schizophrenia is underscored by the lack of sufficient research in this area to date and the comparative neglect of sociocultural issues during the "...

journal_title：Schizophrenia bulletin

authors： Nasser EH,Walders N,Jenkins JH

更新日期：2002-01-01 00:00:00

abstract：:In contrast with issues of consent capacity, financial capacity has received surprisingly little clinical or ethical attention in the psychiatric literature. Issues of financial capacity emerge frequently regarding clients with serious mental illness (SMI), and their resolution has practical and ethical significance f...

journal_title：Schizophrenia bulletin

authors： Marson DC,Savage R,Phillips J

更新日期：2006-01-01 00:00:00

abstract：:As part of an open clinical trial currently underway at the Max Planck Institute of Psychiatry in Munich, the feasibility of behavioral family management (Falloon et al. 1984) for schizophrenia in combination with two different neuroleptic medication strategies was investigated. The treatment approaches were psychoedu...

journal_title：Schizophrenia bulletin

authors： Wiedemann G,Hahlweg K,Hank G,Feinstein E,Müller U,Dose M

更新日期：1994-01-01 00:00:00

abstract：Background:The diagnostic and prognostic significance of the DSM-5-defined Attenuated Psychosis Syndrome (DSM-5-APS) in individuals undergoing an ultra high risk (UHR) clinical assessment for suspicion of psychosis risk is unknown. Methods:Prospective cohort study including all consecutive help-seeking individuals und...

journal_title：Schizophrenia bulletin

authors： Fusar-Poli P,De Micheli A,Cappucciati M,Rutigliano G,Davies C,Ramella-Cravaro V,Oliver D,Bonoldi I,Rocchetti M,Gavaghan L,Patel R,McGuire P

更新日期：2018-02-15 00:00:00

abstract：:Previous studies have reported associations between childhood adversities, eg, loss of a parent, being raised in institutional care, sexual and other kinds of abuse by adults and bullying by peers, and psychosis in adulthood. However, the mechanisms by which these adversities lead to psychotic experiences are poorly u...

journal_title：Schizophrenia bulletin

authors： Bentall RP,Wickham S,Shevlin M,Varese F

更新日期：2012-06-01 00:00:00

abstract：:The nature and definition of schizotypy, as the latent liability for schizophrenia capable of generating various phenotypic and endophenotypic outcomes, is reviewed. The proceedings of the 2017 meeting of the International Consortium on Schizotypy Research are included in this Special Section and they are presented as...

journal_title：Schizophrenia bulletin

authors： Lenzenweger MF

更新日期：2018-10-15 00:00:00

abstract：:The clinical importance of subtypes based on enduring deficit or negative symptoms was examined in a group of schizophrenic patients who were assessed twice over a 1-year period. Subgroups of patients with high levels of enduring negative or deficit symptoms, based on the Scale for the Assessment of Negative Symptoms ...

journal_title：Schizophrenia bulletin

authors： Mueser KT,Douglas MS,Bellack AS,Morrison RL

更新日期：1991-01-01 00:00:00

abstract：:Endophenotypes represent intermediate phenotypes on the putative causal pathway from the genotype to the phenotype. They offer a potentially valuable strategy to examine the molecular etiopathology of complex behavioral phenotypes such as schizophrenia. Neurocognitive and neurophysiological impairments that suggest fu...

journal_title：Schizophrenia bulletin

authors： Prasad KM,Keshavan MS

更新日期：2008-07-01 00:00:00

abstract：:Evidence suggests that dissociation is associated with psychotic experiences, particularly hallucinations, but also other symptoms. However, until now, symptom-specific relationships with dissociation have not been comprehensively synthesized. This is the first prospectively registered (CRD42017058214) meta-analysis t...

journal_title：Schizophrenia bulletin

authors： Longden E,Branitsky A,Moskowitz A,Berry K,Bucci S,Varese F

更新日期：2020-03-18 00:00:00

abstract：:While the role of childhood adversity in increasing the risk of psychosis has been extensively investigated, it is not clear what the impact of early adverse experiences is on the outcomes of psychotic disorders. Therefore, we investigated associations between childhood adversity and 1-year outcomes in 285 first-prese...

journal_title：Schizophrenia bulletin

authors： Trotta A,Murray RM,David AS,Kolliakou A,O'Connor J,Di Forti M,Dazzan P,Mondelli V,Morgan C,Fisher HL

更新日期：2016-03-01 00:00:00

abstract：:The aim of the study was to evaluate the latent structure of DSM-IV schizotypal personality disorder (SPD) diagnostic criteria. The sample consisted of 564 consecutively admitted inpatients and outpatients. Exploratory latent class analysis identified a four-class model as the best fitting model for DSM-IV SPD criteri...

journal_title：Schizophrenia bulletin

authors： Fossati A,Maffei C,Battaglia M,Bagnato M,Donati D,Donini M,Fiorilli M,Novella L

更新日期：2001-01-01 00:00:00

abstract：:The Seventh International Congress on Schizophrenia Research was held in Santa Fe, New Mexico, in April 1999. This was the largest Congress meeting to date, with almost 1,000 presentations that covered all aspects of schizophrenia research. This article provides an account of the Congress proceedings. Several research...

journal_title：Schizophrenia bulletin

authors： Buckley PF,Buchanan RW,Tamminga CA,Schulz SC

更新日期：2000-01-01 00:00:00

abstract：:Kraepelin said severe mental illness was due to 2 diseases subsequently characterized as disorders of thought vs disorders of mood, ie, the Kraepelinian dichotomy. Schizophrenia, traditionally considered the disorder of thought, has been defined by the presence of hallucinations, delusions, catatonia, and disorganizat...

journal_title：Schizophrenia bulletin

authors： Raymond Lake C

更新日期：2008-01-01 00:00:00

abstract：:Staff members from nine mental health agencies were trained in psychiatric rehabilitation technology. The trainers then received intensive followup to assist them in implementing the technology in their own agencies. Evaluation of the impact of the "training of trainers" strategy suggested that mental health workers w...

journal_title：Schizophrenia bulletin

authors： Rogers ES,Cohen BF,Danley KS,Hutchinson D,Anthony WA

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:Cigarette smoking was consistently found to be more prevalent in individuals with schizophrenia than in other psychiatric groups and the general population. These findings have been interpreted as evidence of a specific association between schizophrenia and smoking. However, the supporting data come primaril...

journal_title：Schizophrenia bulletin

authors： Kotov R,Guey LT,Bromet EJ,Schwartz JE

更新日期：2010-01-01 00:00:00

abstract：:Descriptions of various psychotic symptoms in children began to appear in the psychiatric literature at about the same time as descriptions of psychotic symptoms in adults. For example, Kraepelin estimated that at least 3.5 percent of his cases of dementia praecox had onsets before age 10. The construct of "childhood ...

journal_title：Schizophrenia bulletin

authors： Asarnow RF,Asarnow JR

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Schizophrenia leads to significant personal costs matched by high economic costs. Cognitive function is a strong predictor of disabilities in schizophrenia, which underpin these costs. This study of cognitive remediation therapy (CRT), which has been shown to improve cognition and reduce disability ...

journal_title：Schizophrenia bulletin

authors： Reeder C,Harris V,Pickles A,Patel A,Cella M,Wykes T

更新日期：2014-11-01 00:00:00

abstract：:Numerous studies have differentiated schizophrenic patients and normal controls in electroencephalography (EEG) spectral patterns recorded at rest. We replicated the resting EEG spectral differences between these groups and observed significant differences in periodic photic stimuli on the EEG spectra. Drug-free schiz...

journal_title：Schizophrenia bulletin

authors： Jin Y,Potkin SG,Rice D,Sramek J,Costa J,Isenhart R,Heh C,Sandman CA

更新日期：1990-01-01 00:00:00