NMDA receptor and schizophrenia: a brief history.

abstract：:Cognitive dysfunction is a core feature of schizophrenia. The subtyping of cognitive performance in schizophrenia may aid the refinement of disease heterogeneity. The literature on cognitive subtyping in schizophrenia, however, is limited by variable methodologies and neuropsychological tasks, lack of validation, and ...

journal_title：Schizophrenia bulletin

authors： Lim K,Smucny J,Barch DM,Lam M,Keefe RSE,Lee J

更新日期：2020-10-24 00:00:00

abstract：:Advances in treatment technologies and development of evidence-based standards of care demand better methods for routine assessment of outcomes for schizophrenia in systems of care. This article describes the development and psychometrics of a new instrument to assess outcomes of routine care for persons with schizoph...

journal_title：Schizophrenia bulletin

authors： Lehman AF,Fischer EP,Postrado L,Delahanty J,Johnstone BM,Russo PA,Crown WH

更新日期：2003-01-01 00:00:00

abstract：:Antistigma campaigns have been promoting a medical view of schizophrenia. Given the growing body of research finding negative associations between biogenetic (BG) causal attributions and stigmatizing attitudes, this approach must be reappraised. The present study investigates the impact of different psychoeducational ...

journal_title：Schizophrenia bulletin

authors： Lincoln TM,Arens E,Berger C,Rief W

更新日期：2008-09-01 00:00:00

abstract：:The dopamine hypothesis of schizophrenia is usually presented in a static, rather than dynamic fashion. We propose that increased dopaminergic activity may represent a stage of a dynamic schizophrenic process rather than its cause. Dopamine, as well as other neurotransmitters, responds in an adaptive fashion to stimul...

journal_title：Schizophrenia bulletin

authors： Csernansky JG,Holman CA,Hollister LE

更新日期：1983-01-01 00:00:00

abstract：:A selective review of the negative symptoms of schizophrenia is an appropriate article to result from the festschrift honoring William T. Carpenter Jr, as he has made substantial contributions in this area. This review assesses progress in 3 areas in which he has been an important investigator: the distinction between...

journal_title：Schizophrenia bulletin

authors： Kirkpatrick B

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Emotion dysregulation is crucial to both poor social functioning and psychotic symptom formation in patients with schizophrenia. The efficient use of emotion regulation strategies, such as cognitive reappraisal, has been less frequently observed in the early phases of psychotic disorder. It is unknown whethe...

journal_title：Schizophrenia bulletin

authors： Kim M,Hwang WJ,Park J,Kim T,Oh S,Kwon JS

更新日期：2021-01-23 00:00:00

abstract：BACKGROUND:Task-based functional neuroimaging studies of schizophrenia have not yet replicated the increased coordinated hyperactivity in speech-related brain regions that is reported with symptom-capture and resting-state studies of hallucinations. This may be due to suboptimal selection of cognitive tasks. METHODS:I...

journal_title：Schizophrenia bulletin

authors： Lavigne KM,Rapin LA,Metzak PD,Whitman JC,Jung K,Dohen M,Lœvenbruck H,Woodward TS

更新日期：2015-01-01 00:00:00

abstract：:Despite NIMH efforts to facilitate the study of women and minorities in federally funded schizophrenia research, there is a significant lack of information about race differences in brain morphology and neuropsychological function in schizophrenia. A review of three major psychiatric journals between 1994 and 1996 rev...

journal_title：Schizophrenia bulletin

authors： Lewine RR,Caudle J

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVE:Impaired cognition is an important dimension in psychosis and its at-risk states. Research on the value of impaired cognition for psychosis prediction in at-risk samples, however, mainly relies on study-specific sample means of neurocognitive tests, which unlike widely available general test norms are difficu...

journal_title：Schizophrenia bulletin

authors： Michel C,Ruhrmann S,Schimmelmann BG,Klosterkötter J,Schultze-Lutter F

更新日期：2014-11-01 00:00:00

abstract：:Persistent negative symptoms represent an alternative approach for assessing negative symptoms in the context of clinical trials. Persistent negative symptoms are designed to capture those symptoms that lead to functional impairment but are currently understudied and for which there are no currently available effectiv...

journal_title：Schizophrenia bulletin

authors： Buchanan RW

更新日期：2007-07-01 00:00:00

abstract：:Studies indicate a high prevalence of childhood trauma in patient cohorts with established psychotic disorder and in those at risk of developing psychosis. A causal link between childhood trauma and development of psychosis has been proposed. We aimed to examine the association between experience of childhood trauma a...

journal_title：Schizophrenia bulletin

authors： Thompson AD,Nelson B,Yuen HP,Lin A,Amminger GP,McGorry PD,Wood SJ,Yung AR

更新日期：2014-05-01 00:00:00

abstract：:It is increasingly evident that the brain is not truly an immune privileged site and that cells of the central nervous system are sensitive to the inflammation generated when the brain is fighting off infection. Among the many microorganisms that have access to the brain, the apicomplexan protozoan Toxoplasma gondii h...

journal_title：Schizophrenia bulletin

authors： Xiao J,Prandovszky E,Kannan G,Pletnikov MV,Dickerson F,Severance EG,Yolken RH

更新日期：2018-08-20 00:00:00

abstract：INTRODUCTION:ABT-288 is a highly potent histamine-3 receptor antagonist that has demonstrated pro-cognitive effects in preclinical models relevant to schizophrenia. This study evaluated the efficacy and safety of two doses of ABT-288 in the treatment of cognitive impairment associated with schizophrenia. METHODS:A ran...

journal_title：Schizophrenia bulletin

authors： Haig GM,Bain E,Robieson W,Othman AA,Baker J,Lenz RA

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:Previous studies of nonclinical samples exhibiting schizotypal traits have provided support for the existence of a continuous distribution of psychotic symptoms in the general population. Few studies, however, have examined the neural correlates of psychometric schizotypy using structural and diffusion tenso...

journal_title：Schizophrenia bulletin

authors： DeRosse P,Nitzburg GC,Ikuta T,Peters BD,Malhotra AK,Szeszko PR

更新日期：2015-01-01 00:00:00

abstract：:The European Psychiatric Services: Inputs Linked to Outcomes and Needs (EPSILON) study was a EU BIOMED-2-funded comparative, cross-national, cross-sectional study aimed (1) to produce standardized versions of five key research instruments in five languages, and (2) to compare the characteristics, needs, and life quali...

journal_title：Schizophrenia bulletin

authors： van Wijngaarden B,Schene A,Koeter M,Becker T,Knapp M,Knudsen HC,Tansella M,Thornicroft G,Vázquez-Barquero JL,Lasalvia A,Leese M,EPSILON Study Group.

更新日期：2003-01-01 00:00:00

abstract：:Pharmacologic agents currently used or being studied for the treatment of schizophrenia are reviewed. Neuroleptic medications are still the mainstay of treatment, but recent studies suggest new approaches to dosage and to the treatment of acute psychosis. Lithium is beneficial in psychotic illnesses with acute onset a...

journal_title：Schizophrenia bulletin

authors： Donaldson SR,Gelenberg AJ,Baldessarini RJ

更新日期：1983-01-01 00:00:00

abstract：:Family interventions for first-episode psychosis (FEP) are an integral component of treatment, with positive effects mainly on patients' mental state and relapse rate. However, comparatively little attention has been paid to the effects of family interventions on caregivers' stress coping and well-being, especially in...

journal_title：Schizophrenia bulletin

authors： Chien WT,Thompson DR,Lubman DI,McCann TV

更新日期：2016-11-01 00:00:00

abstract：:Little is known about the neurobiological factors that determine functional outcome in people at high risk for psychosis. We use multimodal neuroimaging to investigate whether cortical responses during a cognitive task and thalamic glutamate levels were associated with subsequent functional outcome. Sixty subjects par...

journal_title：Schizophrenia bulletin

authors： Allen P,Chaddock CA,Egerton A,Howes OD,Barker G,Bonoldi I,Fusar-Poli P,Murray R,McGuire P

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Adult patients having schizophrenia (SZ) or bipolar disorder (BP) may have in common neurocognitive deficits. Former evidence suggests impairments in several neuropsychological functions in young offspring at genetic risk for SZ or BP. Moreover, a dose-response relation may exist between the degree of famili...

journal_title：Schizophrenia bulletin

authors： Maziade M,Rouleau N,Gingras N,Boutin P,Paradis ME,Jomphe V,Boutin J,Létourneau K,Gilbert E,Lefebvre AA,Doré MC,Marino C,Battaglia M,Mérette C,Roy MA

更新日期：2009-09-01 00:00:00

abstract：OBJECTIVE:Schizophrenia is associated with excess physical comorbidity. Yet, to our knowledge, large studies are lacking on the associations with somatic diseases before the onset of schizophrenia. The authors conducted a nationwide study of the full spectrum of treated somatic diseases before the first diagnosis of sc...

journal_title：Schizophrenia bulletin

authors： Sørensen HJ,Nielsen PR,Benros ME,Pedersen CB,Mortensen PB

更新日期：2015-03-01 00:00:00

abstract：:This study compared smoking behavior and motivation to quit smoking, assessed with a "stages of change" questionnaire, in outpatients with schizophrenia or schizoaffective disorder and in a representative sample of the general population. We conducted a mail survey in a representative sample of the general population ...

journal_title：Schizophrenia bulletin

authors： Etter M,Mohr S,Garin C,Etter JF

更新日期：2004-01-01 00:00:00

abstract：:A pilot study of the effects of metacognition-oriented social skills training (MOSST) on social functioning in patients with schizophrenia spectrum disorders (SSDs) reported promising results. The main purpose of the current trial was to compare the effectiveness and potential benefits of MOSST vs conventional social ...

journal_title：Schizophrenia bulletin

authors： Inchausti F,García-Poveda NV,Ballesteros-Prados A,Ortuño-Sierra J,Sánchez-Reales S,Prado-Abril J,Aldaz-Armendáriz JA,Mole J,Dimaggio G,Ottavi P,Fonseca-Pedrero E

更新日期：2018-10-17 00:00:00

abstract：:Research on emotional processing in schizophrenia suggests relatively intact subjective responses to affective stimuli "in the moment." However, neuroimaging evidence suggests diminished activation in brain regions associated with emotional processing in schizophrenia. We asked whether given a more vulnerable cognitiv...

journal_title：Schizophrenia bulletin

authors： Becerril K,Barch D

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Executive control of attention in schizophrenia has recently been assessed by means of the Attention Network Test (ANT). In the past, for tasks assessing executive attention, findings in schizophrenia have been contradictory, among others suggesting a lack of increased stimulus interference effects. Attentio...

journal_title：Schizophrenia bulletin

authors： Opgen-Rhein C,Neuhaus AH,Urbanek C,Hahn E,Sander T,Dettling M

更新日期：2008-11-01 00:00:00

abstract：:Disrupted thalamo-cortical connectivity is regarded as a core psychopathology in patients diagnosed with schizophrenia. However, whether the thalamo-cortical white matter connectivity is disrupted before the onset of psychosis is still unknown. To determine this gap in knowledge, the strength of thalamo-cortical white...

journal_title：Schizophrenia bulletin

authors： Cho KI,Shenton ME,Kubicki M,Jung WH,Lee TY,Yun JY,Kim SN,Kwon JS

更新日期：2016-05-01 00:00:00

abstract：:Designs of clinical trials that will permit evaluation of independent, additive, and interactive effects of drugs and psychosocial treatments are described. The central feature of such designs is that they incorporate control conditions for both classes of treatment. Data from the articles in this issue are drawn upon...

journal_title：Schizophrenia bulletin

authors： Schooler NR

更新日期：1980-01-01 00:00:00

abstract：:To understand the biological significance of a decreased platelet MAO activity in schizophrenia, it is important to answer many questions about the basic molecular properties of the enzyme. The past decade has witnessed a huge expansion of research in this area which has provided some of these answers. A wide variety ...

journal_title：Schizophrenia bulletin

authors： Edwards DJ

更新日期：1980-01-01 00:00:00

abstract：:Catatonia is a central aspect of schizophrenia spectrum disorders (SSD) and most likely associated with abnormalities in affective, motor, and sensorimotor brain regions. However, contributions of different cortical features to the pathophysiology of catatonia in SSD are poorly understood. Here, T1-weighted structural...

journal_title：Schizophrenia bulletin

authors： Hirjak D,Kubera KM,Northoff G,Fritze S,Bertolino AL,Topor CE,Schmitgen MM,Wolf RC

更新日期：2019-10-24 00:00:00

abstract：:Clozapine can cause severe adverse effects yet it is associated with reduced mortality risk. We test the hypothesis this association is due to increased clinical monitoring and investigate risk of premature mortality from natural causes. We identified 14 754 individuals (879 deaths) with serious mental illness (SMI) i...

journal_title：Schizophrenia bulletin

authors： Hayes RD,Downs J,Chang CK,Jackson RG,Shetty H,Broadbent M,Hotopf M,Stewart R

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND AND AIMS:Schizophrenia leads to significant personal costs matched by high economic costs. Cognitive function is a strong predictor of disabilities in schizophrenia, which underpin these costs. This study of cognitive remediation therapy (CRT), which has been shown to improve cognition and reduce disability ...

journal_title：Schizophrenia bulletin

authors： Reeder C,Harris V,Pickles A,Patel A,Cella M,Wykes T

更新日期：2014-11-01 00:00:00