Schizophrenia research: a progress report, summarizing proceedings of the 1999 International Congress on Schizophrenia Research.

abstract：:The author reviews a number of studies which have shown that the overall mortality among patients with schizophrenia is about twice that in the general population. The highest excess mortality is found in suicide and violent death, but there seems to be an increased mortality also in cardiovascular disorders. Whether ...

journal_title：Schizophrenia bulletin

authors： Allebeck P

更新日期：1989-01-01 00:00:00

abstract：:The sex chromosomes are strong candidates for a genetic locus for schizophrenia and the affective psychoses. Gender differences in the clinical expression of illness and familial risks, concordance for gender and illness in relatives, and an association of X chromosome anomalies with psychosis suggest an X chromosome ...

journal_title：Schizophrenia bulletin

authors： DeLisi LE,Crow TJ

更新日期：1989-01-01 00:00:00

abstract：:The aim of the study was to evaluate the latent structure of DSM-IV schizotypal personality disorder (SPD) diagnostic criteria. The sample consisted of 564 consecutively admitted inpatients and outpatients. Exploratory latent class analysis identified a four-class model as the best fitting model for DSM-IV SPD criteri...

journal_title：Schizophrenia bulletin

authors： Fossati A,Maffei C,Battaglia M,Bagnato M,Donati D,Donini M,Fiorilli M,Novella L

更新日期：2001-01-01 00:00:00

abstract：:Empirical research related to ethical issues in clinical research has grown dramatically in recent years. However, little attention has been devoted to the ethical relevance of the findings from this research. In order to examine the value and limitations of ethics-related empirical research, we discuss 3 case studies...

journal_title：Schizophrenia bulletin

authors： Miller FG,Wendler D

更新日期：2006-01-01 00:00:00

abstract：:Psychotic experiences may be understood as altered information processing due to aberrant neural computations. A prominent example of such neural computations is the computation of prediction errors (PEs), which signal the difference between expected and experienced events. Among other areas showing PE coding, hippoca...

journal_title：Schizophrenia bulletin

authors： Heinz A,Murray GK,Schlagenhauf F,Sterzer P,Grace AA,Waltz JA

更新日期：2019-09-11 00:00:00

abstract：:Cognitive remediation is a behavioral intervention designed to improve cognition in people who have suffered a decline in neuropsychological functioning. The application of cognitive remediation for people with schizophrenia has become increasingly popular. In this article we attempt to determine what factors moderate...

journal_title：Schizophrenia bulletin

authors： Medalia A,Richardson R

更新日期：2005-10-01 00:00:00

abstract：:Family interventions for first-episode psychosis (FEP) are an integral component of treatment, with positive effects mainly on patients' mental state and relapse rate. However, comparatively little attention has been paid to the effects of family interventions on caregivers' stress coping and well-being, especially in...

journal_title：Schizophrenia bulletin

authors： Chien WT,Thompson DR,Lubman DI,McCann TV

更新日期：2016-11-01 00:00:00

abstract：:The current study sought to examine the underlying brain changes in individuals with high schizotypy by integrating networks derived from brain structural and functional imaging. Individuals with high schizotypy (n = 35) and low schizotypy (n = 34) controls were screened using the Schizotypal Personality Questionnaire...

journal_title：Schizophrenia bulletin

authors： Wang Y,Yan C,Yin DZ,Fan MX,Cheung EF,Pantelis C,Chan RC

更新日期：2015-03-01 00:00:00

abstract：:A series of human and animal investigations has suggested that altered expression and function of the alpha7-nicotinic cholinergic receptor may be responsible for the auditory sensory gating deficit characterized in schizophrenia patients and their relatives as diminished suppression of an auditory-evoked response (P5...

journal_title：Schizophrenia bulletin

authors： Adler LE,Olincy A,Waldo M,Harris JG,Griffith J,Stevens K,Flach K,Nagamoto H,Bickford P,Leonard S,Freedman R

更新日期：1998-01-01 00:00:00

abstract：:The prodrome of psychosis has become a target for early identification and for treatments that address both symptoms and risk for future psychosis. Interest and activity in this realm is now worldwide. Clinical trials with rigorous methodology have only just begun, making treatment guidelines premature. Despite the sp...

journal_title：Schizophrenia bulletin

authors： McGlashan TH,Addington J,Cannon T,Heinimaa M,McGorry P,O'Brien M,Penn D,Perkins D,Salokangas RK,Walsh B,Woods SW,Yung A

更新日期：2007-05-01 00:00:00

abstract：:One of the main questions related to schizophrenia is, naturally enough, what is it? Such a question may seem obvious, naive, impossible, or any combination of these. And certainly it is a bit demanding to expect that anyone could say what schizophrenia is in 1,000 words. On the other hand, we felt that it was worth t...

journal_title：Schizophrenia bulletin

authors： Meltzer HY,Liberman RP

更新日期：1982-01-01 00:00:00

abstract：:While previous studies have found an increased incidence of schizophrenia in some immigrant groups, differences in age of onset in these groups has not been examined. The purpose of this study was to compare age of first hospitalization of (1) native-born people versus immigrants, (2) immigrants from different countri...

journal_title：Schizophrenia bulletin

authors： Rabinowitz J,Fennig S

更新日期：2002-01-01 00:00:00

abstract：:Increased latency of stimulus encoding is presented as a central deficit in schizophrenia cognition. Encoding, here, entails the internal representation of presenting stimuli in a format facilitating their implementation in other cognitive processes, such as those taking place in working memory. Historical roots of su...

journal_title：Schizophrenia bulletin

authors： Neufeld RW

更新日期：2007-07-01 00:00:00

abstract：:This cross-sectional study examined the relationships between neurocognitive and social functioning in a sample of 80 outpatients with DSM-III-R schizophrenia. The neurocognitive battery included measures of verbal ability, verbal memory, visual memory, executive functioning, visual-spatial organization, vigilance, an...

journal_title：Schizophrenia bulletin

authors： Addington J,Addington D

更新日期：1999-01-01 00:00:00

abstract：:Recent clinical and neurobehavioral evidence suggests cerebellar dysfunction in schizophrenia (SZ). We used the prism adaptation motor task (PAT) to probe specific cerebellar circuits in the disorder. PAT requires cerebellum-dependent motor adaptation, perceptual remapping, and strategic control. A failure to engage i...

journal_title：Schizophrenia bulletin

authors： Bartolomeo LA,Shin YW,Block HJ,Bolbecker AR,Breier AF,O'Donnell B,Hetrick WP

更新日期：2020-03-17 00:00:00

abstract：:Schizophrenia is a disorder of a neurodevelopmental origin manifested symptomatically after puberty. Structural neuroimaging studies show that neuroanatomical aberrations precede onset of symptoms, raising a question of whether schizophrenia can be prevented. Early treatment with atypical antipsychotics may reduce the...

journal_title：Schizophrenia bulletin

authors： Piontkewitz Y,Arad M,Weiner I

更新日期：2011-11-01 00:00:00

abstract：:This study examined the content of subscales within a multidimensional scale of self-reported schizotypy and their subsequent interrelationship by means of confirmatory factor analysis (CFA). Neither single-factor nor four-factor models provided good fits to the data; two-factor and three-factor models showed very goo...

journal_title：Schizophrenia bulletin

authors： Venables PH,Rector NA

更新日期：2000-01-01 00:00:00

abstract：:Lifetime prevalence of psychotic disorders varies widely across studies. Epidemiological surveys have rarely examined prevalences of specific psychotic disorders other than schizophrenia, and the majority used a single-phase design without employing clinical reappraisal interview for diagnostic verification. The curre...

journal_title：Schizophrenia bulletin

authors： Chang WC,Wong CSM,Chen EYH,Lam LCW,Chan WC,Ng RMK,Hung SF,Cheung EFC,Sham PC,Chiu HFK,Lam M,Lee EHM,Chiang TP,Chan LK,Lau GKW,Lee ATC,Leung GTY,Leung JSY,Lau JTF,van Os J,Lewis G,Bebbington P

更新日期：2017-10-21 00:00:00

abstract：:The psychometric high-risk strategy represents a useful methodologic adjunct to the traditional genetic high-risk research approach in the study of the etiology and development of schizophrenia. During the past 15 years, considerable research activity has focused on psychometrically identified individuals hypothesized...

journal_title：Schizophrenia bulletin

authors： Lenzenweger MF

更新日期：1994-01-01 00:00:00

abstract：:The two indices that have been proposed for quantifying the accuracy of smooth-following eye movements are shown to be interchangeable. This algebraic fact will permit comparability of values between laboratories only if workers who employ the signal-to-noise ratio (S/N) as their index measure S and N as the total sig...

journal_title：Schizophrenia bulletin

authors： Lykken DT,Iacono WG,Lykken JD

更新日期：1981-01-01 00:00:00

abstract：:Although glutamate was first hypothesized to be involved in the pathophysiology of schizophrenia in the 1980s, it was the demonstration that N-methyl-D-aspartate (NMDA) receptor antagonists, the dissociative anesthetics, could replicate the full range of psychotic, negative, cognitive, and physiologic features of schi...

journal_title：Schizophrenia bulletin

authors： Coyle JT

更新日期：2012-09-01 00:00:00

abstract：:The circadian rest-activity cycle of schizophrenia patients stabilized for more than a year on monotherapy with a "classical" neuroleptic (haloperidol, flupentixol) or with the atypical neuroleptic clozapine was documented by continuous activity monitoring for 3-7 weeks. In this pilot study, the three patients treated...

journal_title：Schizophrenia bulletin

authors： Wirz-Justice A,Haug HJ,Cajochen C

更新日期：2001-01-01 00:00:00

abstract：:Because negative symptoms, including motivational deficits, are a critical unmet need in schizophrenia, there are many ongoing efforts to develop new pharmacological and psychosocial interventions for these impairments. A common challenge of these studies involves how to evaluate and select optimal endpoints. Currentl...

journal_title：Schizophrenia bulletin

authors： Green MF,Horan WP,Barch DM,Gold JM

更新日期：2015-09-01 00:00:00

abstract：:Identifying distinctive subtypes of schizophrenia could ultimately enhance diagnostic and prognostic accuracy. We aimed to uncover neuroanatomical subtypes of chronic schizophrenia patients to test whether stratification can enhance computer-aided discrimination of patients from control subjects. Unsupervised, data-dr...

journal_title：Schizophrenia bulletin

authors： Dwyer DB,Cabral C,Kambeitz-Ilankovic L,Sanfelici R,Kambeitz J,Calhoun V,Falkai P,Pantelis C,Meisenzahl E,Koutsouleris N

更新日期：2018-08-20 00:00:00

abstract：:Although schizophrenia affects a number of brain regions and produces a range of clinical symptoms, we believe its origins lie at the level of single neurons and simple networks. Owing to this, as well as to its high degree of heritability, we hypothesize that schizophrenia is amenable to cell-based studies in vitro. ...

journal_title：Schizophrenia bulletin

authors： Tran NN,Ladran IG,Brennand KJ

更新日期：2013-01-01 00:00:00

abstract：:Genetic variants conferring risk for schizophrenia (SCZ) have been extensively studied, but the role of posttranscriptional mechanisms in SCZ is not well studied. Here we performed the first genome-wide microRNA (miRNA) expression profiling in serum-derived exosome from 49 first-episode, drug-free SCZ patients and 46 ...

journal_title：Schizophrenia bulletin

authors： Du Y,Yu Y,Hu Y,Li XW,Wei ZX,Pan RY,Li XS,Zheng GE,Qin XY,Liu QS,Cheng Y

更新日期：2019-10-24 00:00:00

abstract：:In a sample of 75 women recruited from the community, we measured trauma/maltreatment history and symptoms of schizotypal personality disorder, using both questionnaire and interview measures. As hypothesized, individuals with histories of trauma/maltreatment had elevated levels of schizotypal symptoms. Among types of...

journal_title：Schizophrenia bulletin

authors： Berenbaum H,Valera EM,Kerns JG

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:The at-risk mental state for psychosis (ARMS) and the first episode of psychosis have been associated with structural brain abnormalities that could aid in the individualized early recognition of psychosis. However, it is unknown whether the development of these brain alterations predates the clinical deteri...

journal_title：Schizophrenia bulletin

authors： Borgwardt S,Koutsouleris N,Aston J,Studerus E,Smieskova R,Riecher-Rössler A,Meisenzahl EM

更新日期：2013-09-01 00:00:00

abstract：:Recent studies provide considerable evidence that schizophrenia and bipolar disorder may share overlapping etiologic determinants. Identifying disease-related genetic effects is a major focus in schizophrenia and bipolar disorder research, with implications for clarifying diagnosis and developing specific treatments f...

journal_title：Schizophrenia bulletin

authors： Thaker G

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVE:Stressful life events have been implicated in the onset of psychotic disorders, but there are few robust studies. We sought to examine the nature and magnitude of associations between adult life events and difficulties and first-episode psychoses, particularly focusing on contextual characteristics, including...

journal_title：Schizophrenia bulletin

authors： Beards S,Fisher HL,Gayer-Anderson C,Hubbard K,Reininghaus U,Craig TJ,Di Forti M,Mondelli V,Pariante C,Dazzan P,Murray R,Morgan C

更新日期：2020-07-08 00:00:00