Abstract:
BACKGROUND AND AIMS:Schizophrenia leads to significant personal costs matched by high economic costs. Cognitive function is a strong predictor of disabilities in schizophrenia, which underpin these costs. This study of cognitive remediation therapy (CRT), which has been shown to improve cognition and reduce disability in schizophrenia, aims to investigate associations between improvements in cognition and cost changes. METHODS:Eighty-five participants with schizophrenia were randomized to receive CRT or treatment as usual and were assessed at baseline, posttherapy, and 6 month follow-up. Four structural equation models investigated associations between changes in cognitive function and costs of care. RESULTS:All 4 models provided a good fit. Improvement in 3 individual cognitive variables did not predict total cost changes (model 1). But improvement in a single latent cognition factor was associated with a reduction in depression, which in turn was associated with reduced subsequent total costs (model 2). No significant associations with constituent daycare and special accommodation cost changes were apparent with 3 individual cognitive change variables (model 3). But improvement in a single latent cognitive change variable was associated with subsequent reductions in both daycare and special accommodation costs (model 4). CONCLUSION:This study exemplifies a method of using cost changes to investigate the effects and mechanisms of CRT and suggests that executive function change may be an important target if we are to reduce disability and resultant health and social care costs.
journal_name
Schizophr Bulljournal_title
Schizophrenia bulletinauthors
Reeder C,Harris V,Pickles A,Patel A,Cella M,Wykes Tdoi
10.1093/schbul/sbu046subject
Has Abstractpub_date
2014-11-01 00:00:00pages
1472-81issue
6eissn
0586-7614issn
1745-1701pii
sbu046journal_volume
40pub_type
杂志文章abstract::Identifying distinctive subtypes of schizophrenia could ultimately enhance diagnostic and prognostic accuracy. We aimed to uncover neuroanatomical subtypes of chronic schizophrenia patients to test whether stratification can enhance computer-aided discrimination of patients from control subjects. Unsupervised, data-dr...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章,评审
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更新日期:2005-10-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sbaa153
更新日期:2020-11-30 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/19.4.831
更新日期:1993-01-01 00:00:00
abstract::North American outcome studies of schizophrenia conducted within the past quarter century are reviewed if their minimum average followup is 10 years and they meet at least some modern design criteria. Ten such investigations are described and summarized. Taken as a whole, they demonstrate that schizophrenia can be a c...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章,评审
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更新日期:1988-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/schbul/sbr037
更新日期:2012-11-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type:
doi:10.1093/schbul/sby083
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更新日期:2007-01-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/4.4.480
更新日期:1978-01-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章,评审
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更新日期:2008-03-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章,评审
doi:10.1093/schbul/sbm056
更新日期:2007-07-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章,多中心研究
doi:10.1093/schbul/sbl072
更新日期:2007-09-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/oxfordjournals.schbul.a006956
更新日期:2002-01-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2011-09-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type:
doi:10.1093/oxfordjournals.schbul.a033387
更新日期:1999-01-01 00:00:00
abstract::Increasing awareness of the importance of neurocognitive impairments in schizophrenia has fostered considerable interest in the prospects for cognitive rehabilitation. Nevertheless, optimism has outpaced progress. We first review recent literature on the central assumptions that underlie cognitive rehabilitation, incl...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章,评审
doi:10.1093/oxfordjournals.schbul.a033377
更新日期:1999-01-01 00:00:00
abstract::The diagnosis of schizophrenia is thought to embrace several distinct subgroups. The manifold entities in a single clinical patient group increase the variance of biological measures, deflate the group-level estimates of causal factors, and mask the presence of treatment effects. However, reliable neurobiological boun...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sbz112
更新日期:2020-04-10 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/20.2.263
更新日期:1994-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-07-08 00:00:00
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
doi:10.1093/oxfordjournals.schbul.a006924
更新日期:2002-01-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sbp124
更新日期:2010-05-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/oxfordjournals.schbul.a033363
更新日期:1999-01-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/6.3.490
更新日期:1980-01-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sbr125
更新日期:2013-01-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1093/schbul/sbm134
更新日期:2008-11-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
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更新日期:1984-01-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/oxfordjournals.schbul.a033392
更新日期:1999-01-01 00:00:00