Cognitive remediation and vocational rehabilitation for schizophrenia.

Abstract:

:Cognitive deficits are a central and debilitating aspect of schizophrenia and other major mental illnesses. Although they are largely refractory to pharmacotherapy, multiple studies have now shown that large and lasting improvements in cognition can result from behavioral interventions. We will review our work over the past 10 years demonstrating that cognitive remediation treatment together with work therapy or supported employment can lead to large, lasting, and clinically relevant improvements in cognition and work functioning. While we will make some references to the work of others in these same areas, this is not a general review of these areas of research. Instead, the goal is to provide the rationale for the progression of our studies, describe the methods, and summarize the results, so that readers may understand, critique, and improve upon what we have done.

journal_name

Schizophr Bull

journal_title

Schizophrenia bulletin

authors

Wexler BE,Bell MD

doi

10.1093/schbul/sbi038

keywords:

subject

Has Abstract

pub_date

2005-10-01 00:00:00

pages

931-41

issue

4

eissn

0586-7614

issn

1745-1701

pii

sbi038

journal_volume

31

pub_type

杂志文章,评审
  • Emotional experience in negative symptoms of schizophrenia--no evidence for a generalized hedonic deficit.

    abstract:BACKGROUND:Deficits in emotion processing are thought to underlie the key negative symptoms flat affect and anhedonia observed in psychotic disorders. This study investigated emotional experience and social behavior in the realm of daily life in a sample of patients with schizophrenia and schizoaffective disorder, stra...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/sbr137

    authors: Oorschot M,Lataster T,Thewissen V,Lardinois M,Wichers M,van Os J,Delespaul P,Myin-Germeys I

    更新日期:2013-01-01 00:00:00

  • Pathways to aggression in schizophrenia affect results of treatment.

    abstract::Schizophrenia elevates the risk for aggressive behavior and violent crime, and different approaches have been used to manage this problem. The results of such treatments vary. One reason for this variation is that aggressive behavior in schizophrenia is heterogeneous in origin. This heterogeneity has usually not been ...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章,评审

    doi:10.1093/schbul/sbr041

    authors: Volavka J,Citrome L

    更新日期:2011-09-01 00:00:00

  • Using Machine Learning in Psychiatry: The Need to Establish a Framework That Nurtures Trustworthiness.

    abstract::The rapid embracing of artificial intelligence in psychiatry has a flavor of being the current "wild west"; a multidisciplinary approach that is very technical and complex, yet seems to produce findings that resonate. These studies are hard to review as the methods are often opaque and it is tricky to find the suitabl...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/sbz105

    authors: Chandler C,Foltz PW,Elvevåg B

    更新日期:2020-01-04 00:00:00

  • Dopaminergic circuitry and risk/reward decision making: implications for schizophrenia.

    abstract::Abnormal reinforcement learning and representations of reward value are present in schizophrenia, and these impairments can manifest as deficits in risk/reward decision making. These abnormalities may be due in part to dopaminergic dysfunction within cortico-limbic-striatal circuitry. Evidence from studies with labora...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/sbu165

    authors: Stopper CM,Floresco SB

    更新日期:2015-01-01 00:00:00

  • Differentiating patterns of amygdala-frontal functional connectivity in schizophrenia and bipolar disorder.

    abstract:BACKGROUND:Insight into the neural mechanisms underlying the shared and disparate features of schizophrenia (SZ) and bipolar disorder (BD) is limited. The amygdala and prefrontal cortex (PFC) appear to have crucial roles in SZ and BD, yet abnormalities appear to manifest differently in the 2 disorders. METHODS:Eightee...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/sbt044

    authors: Liu H,Tang Y,Womer F,Fan G,Lu T,Driesen N,Ren L,Wang Y,He Y,Blumberg HP,Xu K,Wang F

    更新日期:2014-03-01 00:00:00

  • Schizophrenia, psychosis, and cerebral spinal fluid homovanillic acid concentrations.

    abstract::Neuroleptic drugs block brain dopamine receptors and are effective in treating psychoses of diverse origins. This finding has become a cornerstone of the dopamine theory of schizophrenia, but clinical studies relating schizophrenia, per se, to brain dopamine metabolism have ranged from controversial to negative. This ...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/23.1.147

    authors: Maas JW,Bowden CL,Miller AL,Javors MA,Funderburg LG,Berman N,Weintraub ST

    更新日期:1997-01-01 00:00:00

  • Structural cerebral variations as useful endophenotypes in schizophrenia: do they help construct "extended endophenotypes"?

    abstract::Endophenotypes represent intermediate phenotypes on the putative causal pathway from the genotype to the phenotype. They offer a potentially valuable strategy to examine the molecular etiopathology of complex behavioral phenotypes such as schizophrenia. Neurocognitive and neurophysiological impairments that suggest fu...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章,评审

    doi:10.1093/schbul/sbn017

    authors: Prasad KM,Keshavan MS

    更新日期:2008-07-01 00:00:00

  • What is causing the reduced drug-placebo difference in recent schizophrenia clinical trials and what can be done about it?

    abstract::On September 18, 2007, a collaborative session between the International Society for CNS Clinical Trials and Methodology and the International Society for CNS Drug Development was held in Brussels, Belgium. Both groups, with membership from industry, academia, and governmental and nongovernmental agencies, have been f...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/sbn110

    authors: Kemp AS,Schooler NR,Kalali AH,Alphs L,Anand R,Awad G,Davidson M,Dubé S,Ereshefsky L,Gharabawi G,Leon AC,Lepine JP,Potkin SG,Vermeulen A

    更新日期:2010-05-01 00:00:00

  • Vulnerability and schizoaffective psychosis: a two-factor model.

    abstract::Remitting illness such as affective or schizoaffective disorder is appropriately described by a vulnerability model. Clinical evidence is reviewed here to clarify the relationship between the affective-disorder-like and schizophrenia-like symptoms in a schizoaffective episode. A model is proposed which treats vulnerab...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/10.1.71

    authors: Braden W

    更新日期:1984-01-01 00:00:00

  • Mortality in schizophrenia: clinical and serological predictors.

    abstract::Persons with schizophrenia have a reduced life expectancy largely due to death from natural causes. Factors that have been previously associated with excess mortality include cigarette smoking and antipsychotic medication. The role of other environmental factors such as exposure to infectious agents has been the subje...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/sbt113

    authors: Dickerson F,Stallings C,Origoni A,Schroeder J,Khushalani S,Yolken R

    更新日期:2014-07-01 00:00:00

  • Early brain wiring: activity-dependent processes.

    abstract::One of the leading theories of the neuropathology of schizophrenia is that it is a developmental disorder of "neural connectivity." To assess this theory, it is first necessary to understand how precise neural connections normally are established. Sensory-driven neural activity has been widely recognized as crucial fo...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章,评审

    doi:10.1093/oxfordjournals.schbul.a006880

    authors: Penn AA

    更新日期:2001-01-01 00:00:00

  • The Effects of Metacognition-Oriented Social Skills Training on Psychosocial Outcome in Schizophrenia-Spectrum Disorders: A Randomized Controlled Trial.

    abstract::A pilot study of the effects of metacognition-oriented social skills training (MOSST) on social functioning in patients with schizophrenia spectrum disorders (SSDs) reported promising results. The main purpose of the current trial was to compare the effectiveness and potential benefits of MOSST vs conventional social ...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/schbul/sbx168

    authors: Inchausti F,García-Poveda NV,Ballesteros-Prados A,Ortuño-Sierra J,Sánchez-Reales S,Prado-Abril J,Aldaz-Armendáriz JA,Mole J,Dimaggio G,Ottavi P,Fonseca-Pedrero E

    更新日期:2018-10-17 00:00:00

  • Schizophrenia, sensory gating, and nicotinic receptors.

    abstract::A series of human and animal investigations has suggested that altered expression and function of the alpha7-nicotinic cholinergic receptor may be responsible for the auditory sensory gating deficit characterized in schizophrenia patients and their relatives as diminished suppression of an auditory-evoked response (P5...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章,评审

    doi:10.1093/oxfordjournals.schbul.a033320

    authors: Adler LE,Olincy A,Waldo M,Harris JG,Griffith J,Stevens K,Flach K,Nagamoto H,Bickford P,Leonard S,Freedman R

    更新日期:1998-01-01 00:00:00

  • Personality and neuropsychological performance of high-risk children.

    abstract::The present article reports findings on intelligence and personality functioning during the school period and at adolescence in a sample of kibbutz and urban Israeli children at risk for schizophrenia, as measured by a standard psychological test battery. On the first round of testing it was found that the index subje...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/11.1.48

    authors: Sohlberg SC

    更新日期:1985-01-01 00:00:00

  • Recruitment and treatment practices for help-seeking "prodromal" patients.

    abstract::The prodrome of psychosis has become a target for early identification and for treatments that address both symptoms and risk for future psychosis. Interest and activity in this realm is now worldwide. Clinical trials with rigorous methodology have only just begun, making treatment guidelines premature. Despite the sp...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章,多中心研究

    doi:10.1093/schbul/sbm025

    authors: McGlashan TH,Addington J,Cannon T,Heinimaa M,McGorry P,O'Brien M,Penn D,Perkins D,Salokangas RK,Walsh B,Woods SW,Yung A

    更新日期:2007-05-01 00:00:00

  • Diurnal weight gain in chronic psychosis.

    abstract::We found diurnal weight gain to be abnormal among 93 chronically psychotic patients, most of whom had schizophrenia. They were weighed at 7 a.m. and 4 p.m. weekly for 3 weeks. We normalized the diurnal weight gain (NDWG) as a percentage by subtracting the 7 a.m. weight from the 4 p.m. weight, multiplying the differenc...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/15.3.501

    authors: Vieweg WV,Godleski LS,Graham P,Kellogg EJ,Goldman F,Barber J,Bayliss EV,Glick JL,Hundley PL,Yank GR

    更新日期:1989-01-01 00:00:00

  • Kraepelin was right: a latent class analysis of symptom dimensions in patients and controls.

    abstract::Phenotypic heterogeneity within patients and controls may explain why the genetic variants contributing to schizophrenia risk explain only a fraction of the heritability. The aim of this study is to investigate quantitative and qualitative differences in psychosis symptoms in a sample including psychosis patients, the...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/sbq103

    authors: Derks EM,Allardyce J,Boks MP,Vermunt JK,Hijman R,Ophoff RA,GROUP.

    更新日期:2012-05-01 00:00:00

  • The Schizophrenia Patient Outcomes Research Team (PORT): updated treatment recommendations 2003.

    abstract::Since publication of the original Schizophrenia Patient Outcomes Research Team (PORT) treatment recommendations in 1998, considerable scientific advances have occurred in our knowledge about how to help persons with schizophrenia. Today an even stronger body of research supports the scientific basis of treatment. This...

    journal_title:Schizophrenia bulletin

    pub_type: 指南,杂志文章,实务指引

    doi:10.1093/oxfordjournals.schbul.a007071

    authors: Lehman AF,Kreyenbuhl J,Buchanan RW,Dickerson FB,Dixon LB,Goldberg R,Green-Paden LD,Tenhula WN,Boerescu D,Tek C,Sandson N,Steinwachs DM

    更新日期:2004-01-01 00:00:00

  • Stages of change in smokers with schizophrenia or schizoaffective disorder and in the general population.

    abstract::This study compared smoking behavior and motivation to quit smoking, assessed with a "stages of change" questionnaire, in outpatients with schizophrenia or schizoaffective disorder and in a representative sample of the general population. We conducted a mail survey in a representative sample of the general population ...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.schbul.a007092

    authors: Etter M,Mohr S,Garin C,Etter JF

    更新日期:2004-01-01 00:00:00

  • Genetic Overlap Between Schizophrenia and Volumes of Hippocampus, Putamen, and Intracranial Volume Indicates Shared Molecular Genetic Mechanisms.

    abstract::Schizophrenia (SCZ) is associated with differences in subcortical brain volumes and intracranial volume (ICV). However, little is known about the underlying etiology of these brain alterations. Here, we explored whether brain structure volumes and SCZ share genetic risk factors. Using conditional false discovery rate ...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/sbx148

    authors: Smeland OB,Wang Y,Frei O,Li W,Hibar DP,Franke B,Bettella F,Witoelar A,Djurovic S,Chen CH,Thompson PM,Dale AM,Andreassen OA

    更新日期:2018-06-06 00:00:00

  • The phenomenological critique and self-disturbance: implications for ultra-high risk ("prodrome") research.

    abstract::Recent years have witnessed widespread interest in the early phase of schizophrenia and other psychotic disorders. Strategies have been introduced to attempt to identify individuals in the prepsychotic or prodromal phase. The most widely used of these approaches is the ultra-high risk (UHR) approach, which combines kn...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章,评审

    doi:10.1093/schbul/sbm094

    authors: Nelson B,Yung AR,Bechdolf A,McGorry PD

    更新日期:2008-03-01 00:00:00

  • Practice principles of cognitive enhancement therapy for schizophrenia.

    abstract::Cognitive Enhancement Therapy (CET) is a developmental approach to the rehabilitation of schizophrenia patients that attempts to facilitate an abstracting and "gistful" social cognition as a compensatory alternative to the more demanding and controlled cognitive strategies that often characterize schizophrenia as well...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.schbul.a033411

    authors: Hogarty GE,Flesher S

    更新日期:1999-01-01 00:00:00

  • Familial risks and reproductive fitness in schizophrenia.

    abstract::Recently published data from the Roscommon Family Study show that a parental diagnosis of schizotypal disorder (SPD) has a significant and specific impact on the risk for schizophrenia in siblings of index probands with schizophrenia spectrum disorders. The distribution patterns of risks for schizophrenia and SPD in p...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章,评审

    doi:10.1093/schbul/22.2.191

    authors: Battaglia M,Bellodi L

    更新日期:1996-01-01 00:00:00

  • Abnormal EEG responses to photic stimulation in schizophrenic patients.

    abstract::Numerous studies have differentiated schizophrenic patients and normal controls in electroencephalography (EEG) spectral patterns recorded at rest. We replicated the resting EEG spectral differences between these groups and observed significant differences in periodic photic stimuli on the EEG spectra. Drug-free schiz...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/16.4.627

    authors: Jin Y,Potkin SG,Rice D,Sramek J,Costa J,Isenhart R,Heh C,Sandman CA

    更新日期:1990-01-01 00:00:00

  • Neurophysiological Correlate of Emotion Regulation by Cognitive Reappraisal and Its Association With Psychotic Symptoms in Early Psychosis.

    abstract:BACKGROUND:Emotion dysregulation is crucial to both poor social functioning and psychotic symptom formation in patients with schizophrenia. The efficient use of emotion regulation strategies, such as cognitive reappraisal, has been less frequently observed in the early phases of psychotic disorder. It is unknown whethe...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/sbaa080

    authors: Kim M,Hwang WJ,Park J,Kim T,Oh S,Kwon JS

    更新日期:2021-01-23 00:00:00

  • Measuring deviant eye tracking.

    abstract::The two indices that have been proposed for quantifying the accuracy of smooth-following eye movements are shown to be interchangeable. This algebraic fact will permit comparability of values between laboratories only if workers who employ the signal-to-noise ratio (S/N) as their index measure S and N as the total sig...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/7.2.204

    authors: Lykken DT,Iacono WG,Lykken JD

    更新日期:1981-01-01 00:00:00

  • Phase-specific brain change of spatial working memory processing in genetic and ultra-high risk groups of schizophrenia.

    abstract::Spatial working memory (WM) processing has 3 distinct phases: encoding, maintenance, and retrieval and its dysfunction is a core feature in schizophrenia. We examined phase-specific brain activations associated with spatial WM in first-degree relatives of schizophrenia (genetic high risk, GHR), ultra-high risk (UHR) s...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/sbr038

    authors: Choi JS,Park JY,Jung MH,Jang JH,Kang DH,Jung WH,Han JY,Choi CH,Hong KS,Kwon JS

    更新日期:2012-11-01 00:00:00

  • The effect of cannabis use and cognitive reserve on age at onset and psychosis outcomes in first-episode schizophrenia.

    abstract:OBJECTIVE:Cannabis use is associated with a younger age at onset of psychosis, an indicator of poor prognosis, but better cognitive function, a positive prognostic indicator. We aimed to clarify the role of age at onset and cognition on outcomes in cannabis users with first-episode schizophrenia as well as the effect o...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/sbq153

    authors: Leeson VC,Harrison I,Ron MA,Barnes TR,Joyce EM

    更新日期:2012-06-01 00:00:00

  • Can antistigma campaigns be improved? A test of the impact of biogenetic vs psychosocial causal explanations on implicit and explicit attitudes to schizophrenia.

    abstract::Antistigma campaigns have been promoting a medical view of schizophrenia. Given the growing body of research finding negative associations between biogenetic (BG) causal attributions and stigmatizing attitudes, this approach must be reappraised. The present study investigates the impact of different psychoeducational ...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/sbm131

    authors: Lincoln TM,Arens E,Berger C,Rief W

    更新日期:2008-09-01 00:00:00

  • Schizophrenia spectrum disorders in persons exposed to ionizing radiation as a result of the Chernobyl accident.

    abstract::We studied schizophrenia spectrum disorders in Chernobyl accident survivors by analyzing Chernobyl exclusion zone (EZ) archives (1986-1997) and by conducting a psychophysiological examination of 100 patients with acute radiation sickness (ARS) and 100 workers of the Chernobyl EZ who had worked as "liquidators-voluntee...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.schbul.a033492

    authors: Loganovsky KN,Loganovskaja TK

    更新日期:2000-01-01 00:00:00