Kraepelin was right: a latent class analysis of symptom dimensions in patients and controls.

abstract：Background:The diagnostic and prognostic significance of the DSM-5-defined Attenuated Psychosis Syndrome (DSM-5-APS) in individuals undergoing an ultra high risk (UHR) clinical assessment for suspicion of psychosis risk is unknown. Methods:Prospective cohort study including all consecutive help-seeking individuals und...

journal_title：Schizophrenia bulletin

authors： Fusar-Poli P,De Micheli A,Cappucciati M,Rutigliano G,Davies C,Ramella-Cravaro V,Oliver D,Bonoldi I,Rocchetti M,Gavaghan L,Patel R,McGuire P

更新日期：2018-02-15 00:00:00

abstract：:This analysis examines the notion of progressive deterioration in schizophrenia, using long-term followup data on hospital episodes in defined cohorts from psychiatric case registers in Victoria, Australia; Denmark; and Salford, England. The analyses differentiate heterogeneity existing at the first hospitalization fo...

journal_title：Schizophrenia bulletin

authors： Eaton WW,Bilker W,Haro JM,Herrman H,Mortensen PB,Freeman H,Burgess P

更新日期：1992-01-01 00:00:00

abstract：:The poverty and lack of social role in the lives of many people with schizophrenia seem similar to those of people in long-term unemployment, raising the possibility that there may be some commonalities in their time use and community functioning. To test this possibility, the social anxiety, time use, and activity pa...

journal_title：Schizophrenia bulletin

authors： Hayes RL,Halford WK

更新日期：1996-01-01 00:00:00

abstract：:Family studies of schizophrenia frequently include relatives of schizophrenia probands with diagnoses falling within the schizophrenia spectrum. As part of an ongoing genetic linkage study of schizophrenia, the authors examined case material from 50 relatives (of schizophrenia probands) who received a DSM-III-R diagno...

journal_title：Schizophrenia bulletin

authors： Gladis MM,Levinson DF,Mowry BJ

更新日期：1994-01-01 00:00:00

abstract：:Neurological soft signs (NSS) are well documented in individuals with schizophrenia (SZ), yet so far, the relationship between NSS and specific symptom expression is unclear. We studied 76 SZ patients using magnetic resonance imaging (MRI) to determine associations between NSS, positive symptoms, gray matter volume (G...

journal_title：Schizophrenia bulletin

authors： Wolf RC,Rashidi M,Schmitgen MM,Fritze S,Sambataro F,Kubera KM,Hirjak D

更新日期：2020-10-24 00:00:00

abstract：:The New York High-Risk Project began in 1971 as a prospective, longitudinal study of (1) children of one or two schizophrenic parents and (2) comparison groups of children whose parents had other or no psychiatric disorders. The former were examined because they were known to be at high risk--some 10-25 percent for ch...

journal_title：Schizophrenia bulletin

authors： Erlenmeyer-Kimling L,Cornblatt B

更新日期：1987-01-01 00:00:00

abstract：:The Seventh International Congress on Schizophrenia Research was held in Santa Fe, New Mexico, in April 1999. This was the largest Congress meeting to date, with almost 1,000 presentations that covered all aspects of schizophrenia research. This article provides an account of the Congress proceedings. Several research...

journal_title：Schizophrenia bulletin

authors： Buckley PF,Buchanan RW,Tamminga CA,Schulz SC

更新日期：2000-01-01 00:00:00

abstract：:Schizophrenia (SZ) is a devastating mental disease caused by complex genetic and environmental factors. The pathological process and clinical manifestation of SZ are heterogeneous among patients, which hampers precise diagnosis and treatment of the disease. Since no objective marker for SZ has been established today, ...

journal_title：Schizophrenia bulletin

authors： Sun L,Yang X,Jiang J,Hu X,Qing Y,Wang D,Yang T,Yang C,Zhang J,Yang P,Wang P,Cai C,Wang J,He L,Wan C

更新日期：2018-06-06 00:00:00

abstract：:This study compared the performance of 39 biological relatives of persons with schizophrenia to that of 30 normal adult controls on graphesthesia processing, a complex somatosensory processing task. The relatives performed significantly worse on the graphesthesia task compared to the healthy controls. The relatives an...

journal_title：Schizophrenia bulletin

authors： Chang BP,Lenzenweger MF

更新日期：2004-01-01 00:00:00

abstract：:Educating the public that mental illness is a brain disease is a popular strategy for combating mental illness stigma. Evidence suggests that while such an approach reduces blame for mental illness, it may unintentionally exacerbate other components of stigma, particularly the benevolence and dangerousness stigmas. Co...

journal_title：Schizophrenia bulletin

authors： Corrigan PW,Watson AC

更新日期：2004-01-01 00:00:00

abstract：:The clinical importance of subtypes based on enduring deficit or negative symptoms was examined in a group of schizophrenic patients who were assessed twice over a 1-year period. Subgroups of patients with high levels of enduring negative or deficit symptoms, based on the Scale for the Assessment of Negative Symptoms ...

journal_title：Schizophrenia bulletin

authors： Mueser KT,Douglas MS,Bellack AS,Morrison RL

更新日期：1991-01-01 00:00:00

abstract：:While the role of childhood adversity in increasing the risk of psychosis has been extensively investigated, it is not clear what the impact of early adverse experiences is on the outcomes of psychotic disorders. Therefore, we investigated associations between childhood adversity and 1-year outcomes in 285 first-prese...

journal_title：Schizophrenia bulletin

authors： Trotta A,Murray RM,David AS,Kolliakou A,O'Connor J,Di Forti M,Dazzan P,Mondelli V,Morgan C,Fisher HL

更新日期：2016-03-01 00:00:00

abstract：:With on exception, previous studies examining the familial relationship between schizotypal personality disorder (SPD) and schizophrenia have compared rates of SPD in relatives of probands with schizophrenia versus control probands. In the Roscommon Family Study, an epidemiologically based family study of major psychi...

journal_title：Schizophrenia bulletin

authors： Kendler KS,Walsh D

更新日期：1995-01-01 00:00:00

abstract：INTRODUCTION:ABT-288 is a highly potent histamine-3 receptor antagonist that has demonstrated pro-cognitive effects in preclinical models relevant to schizophrenia. This study evaluated the efficacy and safety of two doses of ABT-288 in the treatment of cognitive impairment associated with schizophrenia. METHODS:A ran...

journal_title：Schizophrenia bulletin

authors： Haig GM,Bain E,Robieson W,Othman AA,Baker J,Lenz RA

更新日期：2014-11-01 00:00:00

abstract：:Social networks of 35 mentally ill persons were studied in Lao villages. Mental illness was associated with a decrease in size of social networks, disproportionate reliance on family, and asymmetric instrumental exchange. Nonkin "sponsors" provided assistance to those alienated from or abandoned by relatives. For thos...

journal_title：Schizophrenia bulletin

authors： Westermeyer J,Pattison EM

更新日期：1981-01-01 00:00:00

abstract：:The purpose of this study was to assess how neurocognition and social cognition were associated with initial functional level and with rates of functional change in intensive community-based psychosocial rehabilitation interventions that have been shown to yield significant functional change for individuals diagnosed ...

journal_title：Schizophrenia bulletin

authors： Brekke JS,Hoe M,Long J,Green MF

更新日期：2007-09-01 00:00:00

abstract：:Evidence suggests that dissociation is associated with psychotic experiences, particularly hallucinations, but also other symptoms. However, until now, symptom-specific relationships with dissociation have not been comprehensively synthesized. This is the first prospectively registered (CRD42017058214) meta-analysis t...

journal_title：Schizophrenia bulletin

authors： Longden E,Branitsky A,Moskowitz A,Berry K,Bucci S,Varese F

更新日期：2020-03-18 00:00:00

abstract：:The goals of the project Social Cognition and Functioning in Schizophrenia (SCAF) were to (1) identify the domains to target from social neuroscience for translation to clinical schizophrenia research, (2) identify the paradigms that represent these domains for which the neural substrates are well documented, (3) adap...

journal_title：Schizophrenia bulletin

authors： Green MF,Penn DL

更新日期：2013-11-01 00:00:00

abstract：:In light of the large number of studies published since the 2004 update of Schizophrenia Patient Outcomes Research Team psychopharmacological treatment recommendations, we conducted an extensive literature review to determine whether the current psychopharmacological treatment recommendations required revision and whe...

journal_title：Schizophrenia bulletin

authors： Buchanan RW,Kreyenbuhl J,Kelly DL,Noel JM,Boggs DL,Fischer BA,Himelhoch S,Fang B,Peterson E,Aquino PR,Keller W,Schizophrenia Patient Outcomes Research Team (PORT).

更新日期：2010-01-01 00:00:00

abstract：:Depression frequently occurs in first-episode psychosis (FEP) and predicts longer-term negative outcomes. It is possible that this depression is seen primarily in a distinct subgroup, which if identified could allow targeted treatments. We hypothesize that patients with recent-onset psychosis (ROP) and comorbid depres...

journal_title：Schizophrenia bulletin

authors： Upthegrove R,Lalousis P,Mallikarjun P,Chisholm K,Griffiths SL,Iqbal M,Pelton M,Reniers R,Stainton A,Rosen M,Ruef A,Dwyer DB,Surman M,Haidl T,Penzel N,Kambeitz-Llankovic L,Bertolino A,Brambilla P,Borgwardt S,Kambeitz

更新日期：2021-01-23 00:00:00

abstract：:The variability in the response to antipsychotic medication in schizophrenia may reflect between-patient differences in neurobiology. Recent cross-sectional neuroimaging studies suggest that a poorer therapeutic response is associated with relatively normal striatal dopamine synthesis capacity but elevated anterior ci...

journal_title：Schizophrenia bulletin

authors： Egerton A,Murphy A,Donocik J,Anton A,Barker GJ,Collier T,Deakin B,Drake R,Eliasson E,Emsley R,Gregory CJ,Griffiths K,Kapur S,Kassoumeri L,Knight L,Lambe EJB,Lawrie SM,Lees J,Lewis S,Lythgoe DJ,Matthews J,McGuire

更新日期：2020-09-10 00:00:00

abstract：:The present article reports findings on intelligence and personality functioning during the school period and at adolescence in a sample of kibbutz and urban Israeli children at risk for schizophrenia, as measured by a standard psychological test battery. On the first round of testing it was found that the index subje...

journal_title：Schizophrenia bulletin

authors： Sohlberg SC

更新日期：1985-01-01 00:00:00

abstract：:The rate of substance-use disorders in patients with mental illnesses within the psychotic spectrum, such as schizophrenia, schizoaffective disorder, and bipolar disorder, is higher than the rate observed in the general population and is associated with significant morbidity and mortality. Although there are currently...

journal_title：Schizophrenia bulletin

authors： Petrakis IL,Nich C,Ralevski E

更新日期：2006-10-01 00:00:00

abstract：:Evidence for the existence of a genetic factor in the etiology of a significant proportion of the people diagnosed as having a schizophrenic disorder is reviewed. It is suggested that whatever is transmitted genetically need not be inherently pathologic and/or pathogenic. It is argued that only people who have certain...

journal_title：Schizophrenia bulletin

authors： Cancro R

更新日期：1979-01-01 00:00:00

abstract：:Although glutamate was first hypothesized to be involved in the pathophysiology of schizophrenia in the 1980s, it was the demonstration that N-methyl-D-aspartate (NMDA) receptor antagonists, the dissociative anesthetics, could replicate the full range of psychotic, negative, cognitive, and physiologic features of schi...

journal_title：Schizophrenia bulletin

authors： Coyle JT

更新日期：2012-09-01 00:00:00

abstract：:The article that begins below is the fifth in a series of personal accounts to be published in the Schizophrenia Bulletin. In describing his account, the author commented: "The viewpoint is solely my consciousness. The substance of every statement and the specific words in many statements actually occurred to me. Thir...

journal_title：Schizophrenia bulletin

authors： Zelt D

更新日期：1981-01-01 00:00:00

abstract：:A pilot study of the effects of metacognition-oriented social skills training (MOSST) on social functioning in patients with schizophrenia spectrum disorders (SSDs) reported promising results. The main purpose of the current trial was to compare the effectiveness and potential benefits of MOSST vs conventional social ...

journal_title：Schizophrenia bulletin

authors： Inchausti F,García-Poveda NV,Ballesteros-Prados A,Ortuño-Sierra J,Sánchez-Reales S,Prado-Abril J,Aldaz-Armendáriz JA,Mole J,Dimaggio G,Ottavi P,Fonseca-Pedrero E

更新日期：2018-10-17 00:00:00

abstract：:Pharmacologic agents currently used or being studied for the treatment of schizophrenia are reviewed. Neuroleptic medications are still the mainstay of treatment, but recent studies suggest new approaches to dosage and to the treatment of acute psychosis. Lithium is beneficial in psychotic illnesses with acute onset a...

journal_title：Schizophrenia bulletin

authors： Donaldson SR,Gelenberg AJ,Baldessarini RJ

更新日期：1983-01-01 00:00:00

abstract：:Increasing awareness of the importance of neurocognitive impairments in schizophrenia has fostered considerable interest in the prospects for cognitive rehabilitation. Nevertheless, optimism has outpaced progress. We first review recent literature on the central assumptions that underlie cognitive rehabilitation, incl...

journal_title：Schizophrenia bulletin

authors： Bellack AS,Gold JM,Buchanan RW

更新日期：1999-01-01 00:00:00

abstract：:Persistent negative symptoms represent an alternative approach for assessing negative symptoms in the context of clinical trials. Persistent negative symptoms are designed to capture those symptoms that lead to functional impairment but are currently understudied and for which there are no currently available effectiv...

journal_title：Schizophrenia bulletin

authors： Buchanan RW

更新日期：2007-07-01 00:00:00