Abstract:
:Depression frequently occurs in first-episode psychosis (FEP) and predicts longer-term negative outcomes. It is possible that this depression is seen primarily in a distinct subgroup, which if identified could allow targeted treatments. We hypothesize that patients with recent-onset psychosis (ROP) and comorbid depression would be identifiable by symptoms and neuroanatomical features similar to those seen in recent-onset depression (ROD). Data were extracted from the multisite PRONIA study: 154 ROP patients (FEP within 3 months of treatment onset), of whom 83 were depressed (ROP+D) and 71 who were not depressed (ROP-D), 146 ROD patients, and 265 healthy controls (HC). Analyses included a (1) principal component analysis that established the similar symptom structure of depression in ROD and ROP+D, (2) supervised machine learning (ML) classification with repeated nested cross-validation based on depressive symptoms separating ROD vs ROP+D, which achieved a balanced accuracy (BAC) of 51%, and (3) neuroanatomical ML-based classification, using regions of interest generated from ROD subjects, which identified BAC of 50% (no better than chance) for separation of ROP+D vs ROP-D. We conclude that depression at a symptom level is broadly similar with or without psychosis status in recent-onset disorders; however, this is not driven by a separable depressed subgroup in FEP. Depression may be intrinsic to early stages of psychotic disorder, and thus treating depression could produce widespread benefit.
journal_name
Schizophr Bulljournal_title
Schizophrenia bulletinauthors
Upthegrove R,Lalousis P,Mallikarjun P,Chisholm K,Griffiths SL,Iqbal M,Pelton M,Reniers R,Stainton A,Rosen M,Ruef A,Dwyer DB,Surman M,Haidl T,Penzel N,Kambeitz-Llankovic L,Bertolino A,Brambilla P,Borgwardt S,Kambeitzdoi
10.1093/schbul/sbaa094subject
Has Abstractpub_date
2021-01-23 00:00:00pages
249-258issue
1eissn
0586-7614issn
1745-1701pii
5868437journal_volume
47pub_type
杂志文章abstract::The rate of substance-use disorders in patients with mental illnesses within the psychotic spectrum, such as schizophrenia, schizoaffective disorder, and bipolar disorder, is higher than the rate observed in the general population and is associated with significant morbidity and mortality. Although there are currently...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章,随机对照试验
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更新日期:2006-10-01 00:00:00
abstract::Evidence suggests that dissociation is associated with psychotic experiences, particularly hallucinations, but also other symptoms. However, until now, symptom-specific relationships with dissociation have not been comprehensively synthesized. This is the first prospectively registered (CRD42017058214) meta-analysis t...
journal_title:Schizophrenia bulletin
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/12.3.427
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章,评审
doi:10.1093/schbul/sbn017
更新日期:2008-07-01 00:00:00
abstract::Little is known about the neurobiological factors that determine functional outcome in people at high risk for psychosis. We use multimodal neuroimaging to investigate whether cortical responses during a cognitive task and thalamic glutamate levels were associated with subsequent functional outcome. Sixty subjects par...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sbu115
更新日期:2015-03-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sbx148
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sbaa157
更新日期:2020-10-24 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/oxfordjournals.schbul.a006974
更新日期:2002-01-01 00:00:00
abstract::Staff members from nine mental health agencies were trained in psychiatric rehabilitation technology. The trainers then received intensive followup to assist them in implementing the technology in their own agencies. Evaluation of the impact of the "training of trainers" strategy suggested that mental health workers w...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/12.4.709
更新日期:1986-01-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sbp124
更新日期:2010-05-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sby010
更新日期:2019-01-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sbz060
更新日期:2020-02-26 00:00:00
abstract::Recent clinical and neurobehavioral evidence suggests cerebellar dysfunction in schizophrenia (SZ). We used the prism adaptation motor task (PAT) to probe specific cerebellar circuits in the disorder. PAT requires cerebellum-dependent motor adaptation, perceptual remapping, and strategic control. A failure to engage i...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sbaa019
更新日期:2020-03-17 00:00:00
abstract:BACKGROUND:Genome-wide association studies (GWAS) implicate single nucleotide polymorphisms (SNPs) on chromosome 6p21.3-22.1, the human leukocyte antigen (HLA) region, as common risk factors for schizophrenia (SZ). Other studies implicate viral and protozoan exposure. Our study tests chromosome 6p SNPs for effects on S...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sbs087
更新日期:2012-11-01 00:00:00
abstract::The variability in the response to antipsychotic medication in schizophrenia may reflect between-patient differences in neurobiology. Recent cross-sectional neuroimaging studies suggest that a poorer therapeutic response is associated with relatively normal striatal dopamine synthesis capacity but elevated anterior ci...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sbaa128
更新日期:2020-09-10 00:00:00
abstract::Visual illusions allow for strong tests of perceptual functioning. Perceptual impairments can produce superior task performance on certain tasks (i.e., more veridical perception), thereby avoiding generalized deficit confounds while tapping mechanisms that are largely outside of conscious control. Using a task based o...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sbr055
更新日期:2011-07-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sbz131
更新日期:2020-07-08 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1093/schbul/sbt240
更新日期:2014-11-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/14.4.675
更新日期:1988-01-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/20.4.591
更新日期:1994-01-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/oxfordjournals.schbul.a006934
更新日期:2002-01-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sbw151
更新日期:2017-01-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sbw024
更新日期:2016-05-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sbn110
更新日期:2010-05-01 00:00:00
abstract::Ventricle-to-brain ratio (VBR) was measured from the computed tomographic (CT) scans of 33 very recent-onset psychotic patients. Illness severity and positive and negative symptoms were also assessed in 21 of these patients with schizophreniform disorder. Forty-five neurology patients served as controls. Analyses reve...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/18.3.427
更新日期:1992-01-01 00:00:00
abstract::This study examined the course of illness and factors affecting it in schizophrenias with onset between the ages of 14 and 18. Noteworthy in comparison to findings from other followup studies is the higher proportion of chronic courses of illness, about 50 percent. In addition, the type of course of illness correspond...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/19.4.831
更新日期:1993-01-01 00:00:00
abstract::The search for a treatment of tardive dyskinesia (TD) has focused largely on cholinergic and GABAergic agents that are believed to attenuate striatal imbalances and bring about symptomatic control of dyskinetic movements. While numerous reports of the partial effectiveness of acute treatment with cholinergic or GABAer...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/7.4.571
更新日期:1981-01-01 00:00:00
abstract::Disruption of sleep/wake cycles is common in patients with schizophrenia and correlates with cognitive and affective abnormalities. Mice deficient in stable tubule only polypeptide (STOP) show cognitive, behavioral, and neurobiological deficits that resemble those seen in patients with schizophrenia, but little is kno...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sbw017
更新日期:2016-09-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/oxfordjournals.schbul.a006890
更新日期:2001-01-01 00:00:00
abstract::The dopamine hypothesis of schizophrenia is usually presented in a static, rather than dynamic fashion. We propose that increased dopaminergic activity may represent a stage of a dynamic schizophrenic process rather than its cause. Dopamine, as well as other neurotransmitters, responds in an adaptive fashion to stimul...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/9.3.325
更新日期:1983-01-01 00:00:00