Abstract:
:This analysis examines the notion of progressive deterioration in schizophrenia, using long-term followup data on hospital episodes in defined cohorts from psychiatric case registers in Victoria, Australia; Denmark; and Salford, England. The analyses differentiate heterogeneity existing at the first hospitalization for schizophrenia, which produces a widely varying natural course, from heterogeneity that develops over time, as episodes of hospitalization occur. Episodes of hospitalization for schizophrenia tend to cluster earlier rather than later in the treatment career, suggesting a progressive amelioration rather than deterioration. When overall chronicity is adjusted, each additional episode of hospitalization lowers the risk for a further hospitalization by about 10 percent.
journal_name
Schizophr Bulljournal_title
Schizophrenia bulletinauthors
Eaton WW,Bilker W,Haro JM,Herrman H,Mortensen PB,Freeman H,Burgess Pdoi
10.1093/schbul/18.2.229keywords:
subject
Has Abstractpub_date
1992-01-01 00:00:00pages
229-41issue
2eissn
0586-7614issn
1745-1701journal_volume
18pub_type
杂志文章abstract::This article examines the factors that influence antipsychotic use among youth treated in public inpatient facilities. By combining data from 11 focus groups, a survey of 43 researchers and clinicians, and a chart review of 100 closed patient charts, we investigated the interplay between physicians' and staff members'...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/oxfordjournals.schbul.a006913
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:In light of the evidence for brain white matter (WM) abnormalities in schizophrenia, study of normal WM maturation in adolescence may provide critical insights relevant to the neurodevelopment of the disorder. Voxel-wise diffusion tensor imaging (DTI) studies have consistently demonstrated increases in fract...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章,meta分析
doi:10.1093/schbul/sbs054
更新日期:2012-11-01 00:00:00
abstract::Research into tardive dyskinesia, an involuntary movement disorder secondary to chronic neuroleptic treatment, has so far produced conflicting results with no clear clinical applications. Heterogeneous diagnostic criteria, research designs, and rating scales, plus an emphasis on single-drug trials, are probably respon...
journal_title:Schizophrenia bulletin
pub_type: 临床试验,杂志文章
doi:10.1093/schbul/5.1.1
更新日期:1979-01-01 00:00:00
abstract::Although glutamate was first hypothesized to be involved in the pathophysiology of schizophrenia in the 1980s, it was the demonstration that N-methyl-D-aspartate (NMDA) receptor antagonists, the dissociative anesthetics, could replicate the full range of psychotic, negative, cognitive, and physiologic features of schi...
journal_title:Schizophrenia bulletin
pub_type: 历史文章,杂志文章
doi:10.1093/schbul/sbs076
更新日期:2012-09-01 00:00:00
abstract::Ventricle-to-brain ratio (VBR) was measured from the computed tomographic (CT) scans of 33 very recent-onset psychotic patients. Illness severity and positive and negative symptoms were also assessed in 21 of these patients with schizophreniform disorder. Forty-five neurology patients served as controls. Analyses reve...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/18.3.427
更新日期:1992-01-01 00:00:00
abstract:INTRODUCTION:Abnormalities in the neurophysiological measures P300 amplitude and latency constitute endophenotypes for psychosis. Disrupted-in-Schizophrenia-1 (DISC1) has been proposed as a promising susceptibility gene for schizophrenia, and a previous study has suggested that it is associated with P300 deficits in sc...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sbr101
更新日期:2013-01-01 00:00:00
abstract::Motor abnormalities in schizophrenia spectrum disorders (SSD) have increasingly attracted scientific interest in the past years. However, the neural mechanisms underlying parkinsonism in SSD are unclear. The present multimodal magnetic resonance imaging (MRI) study examined SSD patients with and without parkinsonism, ...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sbaa007
更新日期:2020-07-08 00:00:00
abstract::Given the rising costs of health care and the decrease in public expenditures on mental health care, policy-makers and program managers must identify cost-effective approaches for treating severely mentally ill patients. During the last year, there have been two major cost-effectiveness studies implemented in Californ...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/17.3.461
更新日期:1991-01-01 00:00:00
abstract::The clinical importance of subtypes based on enduring deficit or negative symptoms was examined in a group of schizophrenic patients who were assessed twice over a 1-year period. Subgroups of patients with high levels of enduring negative or deficit symptoms, based on the Scale for the Assessment of Negative Symptoms ...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/17.4.565
更新日期:1991-01-01 00:00:00
abstract::The left superior temporal sulcus (STS) plays an important role in integrating audiovisual information and is functionally connected to disparate regions of the brain. For the integration of gesture information in an abstract sentence context (metaphoric gestures), intact connectivity between the left STS and the infe...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sbt110
更新日期:2014-07-01 00:00:00
abstract:OBJECTIVE:To investigate patterns of mental health service and antipsychotic use following a first-episode schizophrenia (FES) and to examine the role of the treatment setting in which individuals are first diagnosed. METHOD:Analysis of de-identified administrative claims data from the OptumLabs Data Warehouse was use...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sbz031
更新日期:2020-01-04 00:00:00
abstract::Cognitive Enhancement Therapy (CET) is a developmental approach to the rehabilitation of schizophrenia patients that attempts to facilitate an abstracting and "gistful" social cognition as a compensatory alternative to the more demanding and controlled cognitive strategies that often characterize schizophrenia as well...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/oxfordjournals.schbul.a033411
更新日期:1999-01-01 00:00:00
abstract::The author reviews a number of studies which have shown that the overall mortality among patients with schizophrenia is about twice that in the general population. The highest excess mortality is found in suicide and violent death, but there seems to be an increased mortality also in cardiovascular disorders. Whether ...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/15.1.81
更新日期:1989-01-01 00:00:00
abstract::This research studied hypotheses that positive thought disorder in schizophrenia is influenced by patients' not taking in immediate target contextual material, thereby losing vital cues that guide thought processes. We assessed 164 acute inpatients (including 55 schizophrenia and 31 bipolar disorder patients), using s...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/oxfordjournals.schbul.a033502
更新日期:2000-01-01 00:00:00
abstract::The causal mechanism underlying the well-established relation between advancing paternal age and schizophrenia is hypothesized to involve mutational errors during spermatogenesis that occur with increasing frequency as males age. Point mutations are well known to increase with advancing paternal age while other errors...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章,评审
doi:10.1093/schbul/sbm093
更新日期:2007-11-01 00:00:00
abstract::Cognitive disruption in schizophrenia is associated with altered patterns of spatiotemporal interaction associated with multiple electroencephalogram (EEG) frequency bands in cortex. In particular, changes in the generation of gamma (30-80 Hz) and beta2 (20-29 Hz) rhythms correlate with observed deficits in communicat...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章,评审
doi:10.1093/schbul/sbn059
更新日期:2008-09-01 00:00:00
abstract::Family interventions for first-episode psychosis (FEP) are an integral component of treatment, with positive effects mainly on patients' mental state and relapse rate. However, comparatively little attention has been paid to the effects of family interventions on caregivers' stress coping and well-being, especially in...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章,随机对照试验
doi:10.1093/schbul/sbw054
更新日期:2016-11-01 00:00:00
abstract::Depression frequently occurs in first-episode psychosis (FEP) and predicts longer-term negative outcomes. It is possible that this depression is seen primarily in a distinct subgroup, which if identified could allow targeted treatments. We hypothesize that patients with recent-onset psychosis (ROP) and comorbid depres...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sbaa094
更新日期:2021-01-23 00:00:00
abstract::Evaluations by families (of chronically mentally ill individuals) of mental health professionals and resources were solicited through a mail survey. The respondents, largely better educated, white, and female, indicated a generally high level of dissatisfaction. Emotional support, information, and aftercare resources ...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/8.4.626
更新日期:1982-01-01 00:00:00
abstract::The prodrome of psychosis has become a target for early identification and for treatments that address both symptoms and risk for future psychosis. Interest and activity in this realm is now worldwide. Clinical trials with rigorous methodology have only just begun, making treatment guidelines premature. Despite the sp...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章,多中心研究
doi:10.1093/schbul/sbm025
更新日期:2007-05-01 00:00:00
abstract::Pharmacologic agents currently used or being studied for the treatment of schizophrenia are reviewed. Neuroleptic medications are still the mainstay of treatment, but recent studies suggest new approaches to dosage and to the treatment of acute psychosis. Lithium is beneficial in psychotic illnesses with acute onset a...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/9.4.504
更新日期:1983-01-01 00:00:00
abstract::The European Psychiatric Services: Inputs Linked to Outcomes and Needs (EPSILON) study was a EU BIOMED-2-funded comparative, cross-national, cross-sectional study aimed (1) to produce standardized versions of five key research instruments in five languages, and (2) to compare the characteristics, needs, and life quali...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章,多中心研究
doi:10.1093/oxfordjournals.schbul.a007029
更新日期:2003-01-01 00:00:00
abstract::Research on the effectiveness of short-term education programs in changing societal attitudes about mental illness has been mixed. Education efforts seem to be mediated by characteristics of the program participants. This study determines whether the effects of a specially prepared, semester-long course on severe ment...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/oxfordjournals.schbul.a033392
更新日期:1999-01-01 00:00:00
abstract::While the role of childhood adversity in increasing the risk of psychosis has been extensively investigated, it is not clear what the impact of early adverse experiences is on the outcomes of psychotic disorders. Therefore, we investigated associations between childhood adversity and 1-year outcomes in 285 first-prese...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sbv131
更新日期:2016-03-01 00:00:00
abstract::A critique is offered of Samuels' article suggesting that reported sex differences in concordance rates for schizophrenia are either methodological artifacts or a function of sociological processes. Evidence of sex differences in age of onset, clinical expression, concordance rates among primary relatives, and premorb...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/5.1.4
更新日期:1979-01-01 00:00:00
abstract::Recent clinical and neurobehavioral evidence suggests cerebellar dysfunction in schizophrenia (SZ). We used the prism adaptation motor task (PAT) to probe specific cerebellar circuits in the disorder. PAT requires cerebellum-dependent motor adaptation, perceptual remapping, and strategic control. A failure to engage i...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sbaa019
更新日期:2020-03-17 00:00:00
abstract:OBJECTIVE:Embodied emotions arise from interoceptive and somatosensory processes, and are essential to the development of a stable sense of self. Emotional embodiment is therefore inherently interwoven with our sense of bodily self-awareness, and allows us to navigate complex social situations. Given that the core feat...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sby179
更新日期:2019-09-11 00:00:00
abstract:BACKGROUND:Given the evidence that reasoning biases contribute to delusional persistence and change, several research groups have made systematic efforts to modify them. The current experiment tested the hypothesis that targeting reasoning biases would result in change in delusions. METHODS:One hundred and one partici...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章,随机对照试验
doi:10.1093/schbul/sbu103
更新日期:2015-03-01 00:00:00
abstract::Problems in psychiatric classification have impeded research into psychopathology for more than a century. Here, I briefly review several new approaches to solving this problem, including the internalizing-externalizing-psychosis spectra, the 5-factor model of psychotic symptoms, and the more recent network approach. ...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章,评审
doi:10.1093/schbul/sbu044
更新日期:2014-07-01 00:00:00
abstract::The chronic methamphetamine (MAP) intoxication model of schizophrenia in animals is outlined. The idea originated from the clinical and neurochemical similarities between MAP psychosis and schizophrenia that were found during the decade immediately after World War II when MAP abuse occurred in epidemic proportions in ...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/18.1.107
更新日期:1992-01-01 00:00:00